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OncoImmunology Volume 12, 2023 - Issue 1
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The significance of the omentum in locoregional immunotherapy for peritoneal carcinomatosis

Ángela Bellaa Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain;b Navarra Institute for Health Research (IDISNA), Pamplona, SpainView further author information
,
Ignacio Meleroa Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain;b Navarra Institute for Health Research (IDISNA), Pamplona, Spain;c Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain;d Department of Oncology and Department of Immunology and Immunotherapy, Clínica Universidad de Navarra, Pamplona, Spain;e Nuffield Department of Medicine and Oxford Center for Immuno-Oncology, University of Oxford, Oxford, UKView further author information
,
Pedro Berraondoa Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain;b Navarra Institute for Health Research (IDISNA), Pamplona, Spain;c Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, SpainCorrespondence[email protected]
View further author information
&
Fernando Arandaa Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain;b Navarra Institute for Health Research (IDISNA), Pamplona, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9364-474XView further author information
ORCID Icon
Article: 2285106 | Received 03 Nov 2023, Accepted 14 Nov 2023, Published online: 20 Nov 2023

References

  • Coccolini F, Gheza F, Lotti M, Virzì S, Iusco D, Ghermandi C, Melotti R, Baiocchi G, Giulini, S.M, Ansaloni L, et al. Peritoneal carcinomatosis. World J Gastroenterol. 2013;19(41):6979–3. doi:10.3748/wjg.v19.i41.6979.
  • Platell C, Cooper D, Papadimitriou JM, Hall JC. The omentum. World J Gastroenterol. 2000;6(2):169–176. doi:10.3748/wjg.v6.i2.169.
  • Meza-Perez S, Randall TD. Immunological functions of the omentum. Trends Immunol. 2017;38(7):526–536. doi:10.1016/j.it.2017.03.002.
  • Katz SC, Point GR, Cunetta M, Thorn M, Guha P, Espat NJ, Boutros C, Hanna N, Junghans RP. Regional CAR-T cell infusions for peritoneal carcinomatosis are superior to systemic delivery. Cancer Gene Ther. 2016;23(5):142–148. doi:10.1038/cgt.2016.14.
  • Rodriguez-Ruiz ME, Rodriguez I, Garasa S, Barbes B, Solorzano JL, Perez-Gracia JL, Labiano S, Sanmamed MF, Azpilikueta A, Bolaños E, et al. Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming. Cancer Res. 2016;76(20):5994–6005. doi:10.1158/0008-5472.CAN-16-0549.
  • Lauer UM, Schell M, Beil J, Berchtold S, Koppenhöfer U, Glatzle J, Königsrainer A, Möhle R, Nann D, Fend F, et al. Phase I study of oncolytic vaccinia virus GL-ONC1 in patients with Peritoneal Carcinomatosis. Clin Cancer Res. 2018;24(18):4388–4398. doi:10.1158/1078-0432.CCR-18-0244.
  • Di Trani CA, Cirella A, Arrizabalaga L, Bella Á, Fernandez-Sendin M, Russo-Cabrera JS, Gomar C, Olivera I, Bolaños E, González-Gomariz J, et al. Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8 +T cells eradicates peritoneal metastases in mouse models. Oncoimmunology. 2023;12(1):2147317. doi:10.1080/2162402X.2022.2147317.
  • Bella Á, Arrizabalaga L, Di Trani CA, Cirella A, Fernandez-Sendin M, Gomar C, Russo-Cabrera JS, Rodríguez I, González-Gomariz J, Alvarez M, et al. Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis. Oncoimmunology. 2022;11(1):2098657. doi:10.1080/2162402X.2022.2098657.
  • Bella Á, Arrizabalaga L, Di Trani CA, Gonzalez-Gomariz J, Gomar C, Russo-Cabrera JS, Olivera I, Cirella A, Fernandez-Sendin M, Alvarez M, et al. Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis. J Immunother Cancer. 2023;11(11):e006702. doi:10.1136/jitc-2023-006702.
  • Christian DA, Adams TA, Shallberg LA, Phan AT, Smith TE, Abraha M, Perry J, Ruthel G, Clark JT, Pritchard GH, et al. cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory. Sci Immunol. 2022;7(75):eabq7432. doi:10.1126/sciimmunol.abq7432.

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