The Hedgehog signalling pathway as a therapeutic target in early breast cancer development

Bibliography

• Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365(9472):1687-717
   PubMed Web of Science ®Google Scholar
• Smith I, Procter M, Gelber RD, et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007;369(9555):29-36
   PubMed Web of Science ®Google Scholar
• Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353(16):1659-72
   PubMed Web of Science ®Google Scholar
• Zardawi SJ, O'Toole SA, Sutherland RL, Musgrove EA. Dysregulation of Hedgehog, Wnt and Notch signalling pathways in breast cancer. Histol Histopathol 2009;24(3):385-98
   PubMed Web of Science ®Google Scholar
• Liu S, Dontu G, Wicha MS. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res 2005;7(3):86-95
   PubMed Web of Science ®Google Scholar
• Liu S, Dontu G, Mantle ID, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006;66(12):6063-71
   PubMed Web of Science ®Google Scholar
• Hatsell S, Frost AR. Hedgehog signaling in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia 2007;12(2-3):163-73
   PubMed Web of Science ®Google Scholar
• Clement V, Sanchez P, de Tribolet N, et al. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 2007;17(2):165-72
   PubMed Web of Science ®Google Scholar
• Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432(7015):324-31
   PubMed Web of Science ®Google Scholar
• Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003;425(6960):851-6
   PubMed Web of Science ®Google Scholar
• Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004;431(7009):707-12
   PubMed Web of Science ®Google Scholar
• Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003;425(6960):846-51
   PubMed Web of Science ®Google Scholar
• Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002;297(5586):1559-61
   PubMed Web of Science ®Google Scholar
• Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea–a paradigm shift. Cancer Res 2006;66(4):1883-90
   PubMed Web of Science ®Google Scholar
• Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980;287(5785):795-801
   PubMed Web of Science ®Google Scholar
• McMahon AP, Ingham PW, Tabin CJ. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 2003;53:1-114
   PubMed Web of Science ®Google Scholar
• Cohen MM Jr. The hedgehog signaling network. Am J Med Genet A 2003;123A(1):5-28
   PubMed Web of Science ®Google Scholar
• Machold R, Hayashi S, Rutlin M, et al. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 2003;39(6):937-50
   PubMed Web of Science ®Google Scholar
• van den Brink GR, Bleuming SA, Hardwick JC, et al. Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet 2004;36(3):277-82
   PubMed Web of Science ®Google Scholar
• Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008;22(18):2454-72
   PubMed Web of Science ®Google Scholar
• Dillon R, Gadgil C, Othmer HG. Short- and long-range effects of Sonic hedgehog in limb development. Proc Natl Acad Sci USA 2003;100(18):10152-7
   PubMed Web of Science ®Google Scholar
• Gallet A, Ruel L, Staccini-Lavenant L, Therond PP. Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. Development 2006;133(3):407-18
   PubMed Web of Science ®Google Scholar
• Goetz JA, Suber LM, Zeng X, Robbins DJ. Sonic Hedgehog as a mediator of long-range signaling. Bioessays 2002;24(2):157-65
   PubMed Web of Science ®Google Scholar
• Lewis PM, Dunn MP, McMahon JA, et al. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 2001;105(5):599-612
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang H, Litingtung Y, Chiang C. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci USA 2006;103(17):6548-53
   PubMed Web of Science ®Google Scholar
• Zeng X, Goetz JA, Suber LM, et al. A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature 2001;411(6838):716-20
   PubMed Web of Science ®Google Scholar
• Kawakami T, Kawcak T, Li YJ, et al. Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development 2002;129(24):5753-65
   PubMed Web of Science ®Google Scholar
• Riobo NA, Manning DR. Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem J 2007;403(3):369-79
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhou Z, Walsh CT, McMahon AP. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci USA 2009;106(8):2623-8
   PubMed Web of Science ®Google Scholar
• Huangfu D, Liu A, Rakeman AS, et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 2003;426(6962):83-7
   PubMed Web of Science ®Google Scholar
• Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001;15(23):3059-87
   PubMed Web of Science ®Google Scholar
• Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 2002;417(6886):299-304
   PubMed Web of Science ®Google Scholar
• Ingram WJ, Wicking CA, Grimmond SM, et al. Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells. Oncogene 2002;21(53):8196-205
   PubMed Web of Science ®Google Scholar
• Garber K. Hedgehog drugs begin to show results. J Natl Cancer Inst 2008;100(10):692-7
   PubMed Web of Science ®Google Scholar
• Cooper MK, Porter JA, Young KE, Beachy PA. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 1998;280(5369):1603-7
   PubMed Web of Science ®Google Scholar
• Keeler RF, Binns W. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology 1968;1(1):5-10
   PubMedGoogle Scholar
• Chen JK, Taipale J, Young KE, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci USA 2002;99(22):14071-6
   PubMed Web of Science ®Google Scholar
• Mahindroo N, Punchihewa C, Fujii N. Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J Med Chem 2009;52(13):3829-45
   PubMed Web of Science ®Google Scholar
• Ericson J, Morton S, Kawakami A, et al. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 1996;87(4):661-73
   PubMed Web of Science ®Google Scholar
• Unden AB, Stahle-Backdahl M, Holmberg E, et al. Fine mapping of the locus for nevoid basal cell carcinoma syndrome on chromosome 9q. Acta Derm Venereol 1997;77(1):4-9
   PubMed Web of Science ®Google Scholar
• Unden AB, Zaphiropoulos PG, Bruce K, et al. Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma. Cancer Res 1997;57(12):2336-40
   PubMed Web of Science ®Google Scholar
• Xie J, Murone M, Luoh SM, et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998;391(6662):90-2
   PubMed Web of Science ®Google Scholar
• Watkins DN, Berman DM, Burkholder SG, et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422(6929):313-7
   PubMed Web of Science ®Google Scholar
• Watkins DN, Berman DM, Baylin SB. Hedgehog signaling: progenitor phenotype in small-cell lung cancer. Cell Cycle 2003;2(3):196-8
   PubMed Web of Science ®Google Scholar
• Shaw A, Bushman W. Hedgehog signaling in the prostate. J Urol 2007;177(3):832-8
   PubMed Web of Science ®Google Scholar
• Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer. Nature 2008;455(7211):406-10
   PubMed Web of Science ®Google Scholar
• Daniel VC, Marchionni L, Hierman JS, et al. A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res 2009;69(8):3364-73
   PubMed Web of Science ®Google Scholar
• De Witt Hamer PC, Van Tilborg AA, Eijk PP, et al. The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids. Oncogene 2008;27(14):2091-6
   PubMed Web of Science ®Google Scholar
• Ruiz i Altaba A. Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets? Cancer Cell 2008;14(4):281-3
   PubMed Web of Science ®Google Scholar
• Kasper M, Jaks V, Fiaschi M, Toftgard R. Hedgehog signalling in breast cancer. Carcinogenesis 2009;30(6):903-11
   PubMed Web of Science ®Google Scholar
• Lewis MT, Ross S, Strickland P, et al. Defects in mouse mammary gland development cuased by conditional haploinsufficiency of Patched-1. Development 1999;126:5181-93
   PubMed Web of Science ®Google Scholar
• Moraes RC, Zhang X, Harrington N, et al. Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia. Development 2007;134(6):1231-42
   PubMed Web of Science ®Google Scholar
• Lewis MT, Ross S, Strickland PA, et al. The Gli2 transcription factor is required for normal mouse mammary gland development. Dev Biol 2001;238(1):133-44
   PubMed Web of Science ®Google Scholar
• O'Toole S, Swarbrick A, Millar E, et al. Aberrant hedgehog signaling is an early event in breast cancer development. Cancer Res 2009;69:70s
   Google Scholar
• Wicking C, Evans T, Henk B, et al. No evidence for the H133Y mutation in Sonic Hedgehog in a collection of common tumour types. Oncogene 1998;16(8):1091-3
   PubMed Web of Science ®Google Scholar
• Vorechovsky I, Benediktsson KP, Toftgard R. The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations. Eur J Cancer 1999;35(5):711-3
   PubMed Web of Science ®Google Scholar
• Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 2004;64(17):6071-4
   PubMed Web of Science ®Google Scholar
• Sinha S, Singh RK, Alam N, et al. Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma. Mol Cancer 2008;7:84. Published online 6 November 2008, doi:10.1186/1476-4598-7-84
   PubMed Web of Science ®Google Scholar
• Nessling M, Richter K, Schwaenen C, et al. Candidate genes in breast cancer revealed by microarray-based comparative genomic hybridization of archived tissue. Cancer Res 2005;65(2):439-47
   PubMed Web of Science ®Google Scholar
• Wolf I, Bose S, Desmond JC, et al. Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer. Breast Cancer Res Treat 2007;105(2):139-55
   PubMed Web of Science ®Google Scholar
• Zhang X, Harrington N, Moraes RC, et al. Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo). Breast Cancer Res Treat 2009;115(3):505-21
   PubMed Web of Science ®Google Scholar
• Zhao J, Chen G, Cao D, et al. Expression of Gli1 correlates with the transition of breast cancer cells to estrogen-independent growth. Breast Cancer Res Treat 2009;115:505-21
   PubMed Web of Science ®Google Scholar