742
Views
0
CrossRef citations to date
0
Altmetric
Perspective

Pushing the Frontiers in the Fight Against Antimicrobial Resistance: The Potential of Fecal and Maggot Therapies

ORCID Icon & ORCID Icon
Article: FSO899 | Received 28 May 2023, Accepted 14 Aug 2023, Published online: 29 Aug 2023

References

  • MurrayCJ , IkutaKS , ShararaFet al.Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet399(10325), 629–655 (2022).
  • WHO. Antimicrobial resistance [Internet] (2021). https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
  • GulumbeBH , AdesolaRO. Revisiting the blind spot of substandard and fake drugs as drivers of antimicrobial resistance in LMICs. Ann. Med. Surg.85(2), 122–123 (2023).
  • AltaracD , GutchM , MuellerJ , RonsheimM , TommasiR , PerrosM. Challenges and opportunities in the discovery, development, and commercialization of pathogen-targeted antibiotics. Drug Discov. Today26(9), 2084–2089 (2021).
  • LeshoEP , Laguio-VilaM. The Slow-Motion Catastrophe of Antimicrobial Resistance and Practical Interventions for All Prescribers. Mayo Clin. Proc.94(6), 1040–1047 (2019).
  • DeGroot PF , FrissenMN , DeClercq NC , NieuwdorpM. Fecal microbiota transplantation in metabolic syndrome: history, present and future. Gut Microbes8(3), 253–267 (2017).
  • AlmeidaC , OliveiraR , BaylinaP , FernandesR , TeixeiraFG , BarataP. Current Trends and Challenges of Fecal Microbiota Transplantation–An Easy Method That Works for All?Biomedicines10(11), 2742 (2022).
  • RaeisiH , NooriM , AzimiradMet al.Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives. Gut Pathog.15(1), 21 (2023).
  • StadlerF. The maggot therapy supply chain: a review of the literature and practice. Med. Vet. Entomol.34(1), 1–9 (2020).
  • HarveyML , DadourIR , GaszNE. Maggot Therapy in Chronic Wounds: New Approaches to Historical Practices. Ann. Entomol. Soc. Am.114(4), 415–424 (2021).
  • MohdZubir MZ , HollowayS , MohdNoor N. Maggot Therapy in Wound Healing: A Systematic Review. Int. J. Environ. Res. Public Health17(17), 6103 (2020).
  • RicharteV , Sánchez-MoraC , CorralesMet al.Gut microbiota signature in treatment-naïve attention-deficit/hyperactivity disorder. Transl. Psychiatry11(1), 382 (2021).
  • ShoubridgeAP , ChooJM , MartinAMet al.The gut microbiome and mental health: advances in research and emerging priorities. Mol. Psychiatry27(4), 1908–1919 (2022).
  • PerezNB , DorsenC , SquiresA. Dysbiosis of the Gut Microbiome: A Concept Analysis. J. Holist. Nurs.38(2), 223–232 (2020).
  • KociszewskaD , VlajkovicS. Age-Related Hearing Loss: The Link between Inflammaging, Immunosenescence, and Gut Dysbiosis. Int. J. Mol. Sci.23(13), 7348 (2022).
  • MerrickB , SergakiC , EdwardsLet al.Modulation of the Gut Microbiota to Control Antimicrobial Resistance (AMR)-A Narrative Review with a Focus on fecal Microbiota Transplantation (FMT). Infect. Dis. Rep.15(3), 238–254 (2023).
  • AnthonyWE , BurnhamC-AD , DantasG , KwonJH. The Gut Microbiome as a Reservoir for Antimicrobial Resistance. J. Infect. Dis.223(Suppl. 3), S209–S213 (2021).
  • ZhengD , LiwinskiT , ElinavE. Interaction between microbiota and immunity in health and disease. Cell Res.30(6), 492–506 (2020).
  • SchmidtTSB , LiSS , MaistrenkoOMet al.Drivers and determinants of strain dynamics following fecal microbiota transplantation. Nat. Med.28(9), 1902–1912 (2022).
  • AmraneS , LagierJ-C. Fecal microbiota transplantation for antibiotic resistant bacteria decolonization. Hum. Microbiome J.16, 100071 (2020).
  • KonstantinidisT , TsigalouC , KarvelasA , StavropoulouE , VoidarouC , BezirtzoglouE. Effects of Antibiotics upon the Gut Microbiome: A Review of the Literature. Biomedicines8(11), 502 (2020).
  • BotteryMJ , PitchfordJW , FrimanV-P. Ecology and evolution of antimicrobial resistance in bacterial communities. ISME J.15(4), 939–948 (2021).
  • RoutyB , LenehanJG , MillerWHet al.Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial. Nat. Med. Doi: 10.1038/s41591-023-02453-x (2023) ( Online ahead of print).
  • ShawcrossD , EdwardsL , WoodhouseCet al.fecal microbiota transplant restores intestinal barrier function and augments ammonia metabolism in patients with cirrhosis: a randomised single-blind placebo-controlled trial [Internet]. In Review (2023). https://www.researchsquare.com/article/rs-3088449/v1
  • BaunwallSMD , TerveerEM , DahlerupJFet al.The use of fecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey. Lancet Reg. Health – Eur.9, 100181 (2021).
  • BrowneAS , KellyCR. Fecal Transplant in Inflammatory Bowel Disease. Gastroenterol. Clin. North Am.46(4), 825–837 (2017).
  • El-SalhyM , PatcharatrakulT , GonlachanvitS. Fecal microbiota transplantation for irritable bowel syndrome: an intervention for the 21st century. World J. Gastroenterol.27(22), 2921–2943 (2021).
  • ZhangZ , MocanuV , CaiCet al.Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome-A Systematic Review. Nutrients11(10), 2291 (2019).
  • HyunJ , LeeSK , CheonJHet al.fecal microbiota transplantation reduces amounts of antibiotic resistance genes in patients with multidrug-resistant organisms. Antimicrob. Resist. Infect. Control11(1), 20 (2022).
  • ElkriefA , RoutyB. First clinical proof-of-concept that FMT can overcome resistance to ICIs. Nat. Rev. Clin. Oncol.18(6), 325–326 (2021).
  • IaniroG , PunčochářM , KarcherNet al.Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases. Nat. Med.28(9), 1913–1923 (2022).
  • WangS , ZhangZ. Maggot microRNA: a new inhibitory pathway to bacterial infection. Med. Hypotheses76(2), 254–255 (2011).
  • AndersenAS , SandvangD , SchnorrKMet al.A novel approach to the antimicrobial activity of maggot debridement therapy. J. Antimicrob. Chemother.65(8), 1646–1654 (2010).
  • StadlerF ( Ed.). A Complete Guide to Maggot Therapy: Clinical Practice, Therapeutic Principles, Production, Distribution, and Ethics [Internet]. (1st ed.).Open Book Publishers, Cambridge, UK (2022). https://www.openbookpublishers.com/books/10.11647/obp.0300
  • SyamK , JoiyaSA , KhanS , UnnikrishnanPN. Maggot Debridement Therapy for Chronic Leg and Foot Ulcers: A Review of Randomized Controlled Trials. Adv. Skin Wound Care34(11), 603–607 (2021).
  • DaviesCE , WoolfreyG , HoggNet al.Maggots as a wound debridement agent for chronic venous leg ulcers under graduated compression bandages: a randomised controlled trial. Phlebology30(10), 693–699 (2015).
  • BazalińskiD , WięchP , SzymańskaP , MusterM , KózkaM. Application of Lucilia sericata Larvae in Debridement of Pressure Wounds in Outpatient Settings. J. Vis. Exp. JoVE (178), e62590 (2021).
  • SirekbasanS , PolatE , CangelU. The Effect of Bacterial Colonization and Maggot Debridement Treatment on Wound Healing in Chronic Venous Leg Ulcers. Clin. Lab.67(5), 3–6 (2021).
  • UruénC , Chopo-EscuinG , TommassenJ , Mainar-JaimeRC , ArenasJ. Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance. Antibiotics10(1), 3 (2020).
  • MorrisD , FloresM , HarrisL , GammonJ , NigamY. Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review. Microorganisms11(2), 457 (2023).
  • WHO. Antimicrobial resistance [Internet] (2019). https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
  • MaY , LiuJ , RhodesC , NieY , ZhangF. Ethical Issues in Fecal Microbiota Transplantation in Practice. Am. J. Bioeth. AJOB17(5), 34–45 (2017).
  • GilesEM , D'AdamoGL , ForsterSC. The future of fecal transplants. Nat. Rev. Microbiol.17(12), 719 (2019).
  • Saint-RaymondA , ValentinM , NakashimaNet al.Reliance is key to effective access and oversight of medical products in case of public health emergencies. Expert Rev. Clin. Pharmacol.15(7), 805–810 (2022).