Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs

References

• Prabhu P, Patravale V. Dissolution enhancement of atorvastatin calcium by co-grinding technique. Drug Delivery Transl Res. 2016;6(4):380–391. doi:10.1007/s13346-015-0271-x
   PubMed Web of Science ®Google Scholar
• Khalid Q, Ahmad M, Minhas MU, et al. Synthesis of β-cyclodextrin hydrogel nanoparticles for improving the solubility of dexibuprofen: characterization and toxicity evaluation. Drug Dev Ind Pharm 2017;43(11):1873–1884. doi:10.1080/03639045.2017.1350703
   PubMed Web of Science ®Google Scholar
• Jermain SV, Brough C, Williams RO, et al. Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery - An update. Int J Pharm. 2018;535(1–2):379–392. doi:10.1016/j.ijpharm.2017.10.051
   PubMedGoogle Scholar
• Liu Y, Wang T, Ding W, et al. Dissolution and oral bioavailability enhancement of praziquantel by solid dispersions. Drug Delivery Transl Res. 2018;8(3):580–590. doi:10.1007/s13346-018-0487-7
   PubMed Web of Science ®Google Scholar
• Baghel S, Cathcart H, O’Reilly NJ, et al. Polymeric Amorphous Solid Dispersions: a Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs. J Pharmaceut Sci. 2016;105(9):2527–2544. doi:10.1016/j.xphs.2015.10.008
   PubMed Web of Science ®Google Scholar
• Hua S. Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors. Front Pharmacol. 2020;11(524). doi:10.3389/fphar.2020.00524
   Google Scholar
• Shreya AB, Raut SY, Managuli RS, et al. Active Targeting of Drugs and Bioactive Molecules via Oral Administration by Ligand-Conjugated Lipidic Nanocarriers: recent Advances. AAPS Pharm Sci Tech. 2018;20(1):15. doi:10.1208/s12249-018-1262-2
   PubMed Web of Science ®Google Scholar
• Siddiqui K, Waris A, Akber H, et al. Physicochemical Modifications and Nano Particulate Strategies for Improved Bioavailability of Poorly Water Soluble Drugs. Pharm nanotechnol. 2017;5(4):276–284. doi:10.2174/2211738506666171226120748
   PubMedGoogle Scholar
• Rubin KM, Vona K, Madden K, et al. Side effects in melanoma patients receiving adjuvant interferon alfa-2b therapy: a nurse’s perspective. Supportive Care Cancer. 2012;20(8):1601–1611. doi:10.1007/s00520-012-1473-0
   PubMed Web of Science ®Google Scholar
• Da Silva FL, Marques MB, Kato KC, et al. Nanonization techniques to overcome poor water-solubility with drugs. Expert Opin Drug Discov. 2020;15(7):853–864. doi:10.1080/17460441.2020.1750591
   PubMed Web of Science ®Google Scholar
• Prakash S. Nano-based drug delivery system for therapeutics: a comprehensive review. Biomed Phys Eng Express. 2023;9(5). doi:10.1088/2057-1976/acedb2
   PubMed Web of Science ®Google Scholar
• Harder BG, et al. Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma. Front Oncol. 2018;8(462). doi:10.3389/fonc.2018.00462
   PubMedGoogle Scholar
• Zhai X, Lademann J, Keck CM, et al. Nanocrystals of medium soluble actives--novel concept for improved dermal delivery and production strategy. Int J Pharm. 2014;470(1–2):141–150. doi:10.1016/j.ijpharm.2014.04.060
   PubMed Web of Science ®Google Scholar
• Kataoka M, Yonehara A, Minami K, et al. Control of Dissolution and Supersaturation/Precipitation of Poorly Water-Soluble Drugs from Cocrystals Based on Solubility Products: a Case Study with a Ketoconazole Cocrystal. Mol Pharmaceut. 2023;20(8):4100–4107. doi:10.1021/acs.molpharmaceut.3c00237
   PubMed Web of Science ®Google Scholar
• Haering B, Seyferth S, Schiffter HA, et al. The tangential flow absorption model (TFAM) - A novel dissolution method for evaluating the performance of amorphous solid dispersions of poorly water-soluble actives. Eur J Pharm Biopharm 2020;154:74–88. doi:10.1016/j.ejpb.2020.06.013
   PubMed Web of Science ®Google Scholar
• Yang M, Chen T, Wang L, et al. High dispersed phyto-phospholipid complex/TPGS 1000 with mesoporous silica to enhance oral bioavailability of tanshinol. Colloids Surf B. 2018;170:187–193. doi:10.1016/j.colsurfb.2018.06.013
   PubMed Web of Science ®Google Scholar
• Kawabata Y, Wada K, Nakatani M, et al. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. Int J Pharm. 2011;420(1):1–10. doi:10.1016/j.ijpharm.2011.08.032
   PubMed Web of Science ®Google Scholar
• Takagi T, Ramachandran C, Bermejo M, et al. A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan. Mol Pharmaceut. 2006;3(6):631–643. doi:10.1021/mp0600182
   PubMed Web of Science ®Google Scholar
• Amidon GL, Lennernäs H, Shah VP, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res. 1995;12(3):413–420. doi:10.1023/a:1016212804288
   PubMed Web of Science ®Google Scholar
• Bhatt S, ROY D, KUMAR M, et al. Development and Validation of In Vitro Discriminatory Dissolution Testing Method for Fast Dispersible Tablets of BCS Class II Drug. Turkish j Pharm Sci. 2020;17(1):74–80. doi:10.4274/tjps.galenos.2018.90582
   PubMed Web of Science ®Google Scholar
• Fraser EJ, Leach RH, Poston JW, et al. Dissolution and bioavailability of digoxin tablets. J Pharm Pharmacol. 1973;25(12):968–973. doi:10.1111/j.2042-7158.1973.tb09988.x
   PubMed Web of Science ®Google Scholar
• Johnson BF, O’Grady J, Bye C, et al. The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide. Br J Clin Pharmacol 1978;5(5):465–467. doi:10.1111/j.1365-2125.1978.tb01657.x
   PubMed Web of Science ®Google Scholar
• Chi-Yuan W, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res. 2005;22(1):11–23. doi:10.1007/s11095-004-9004-4
   PubMed Web of Science ®Google Scholar
• Löbenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. Eur J Pharm Biopharm 2000;50(1):3–12. doi:10.1016/s0939-6411(00)00091-6
   PubMed Web of Science ®Google Scholar
• Hattori Y, Haruna Y, Otsuka M, et al. Dissolution process analysis using model-free Noyes-Whitney integral equation. Colloids Surf B. 2013;102:227–231. doi:10.1016/j.colsurfb.2012.08.017
   PubMed Web of Science ®Google Scholar
• Kesisoglou F, Mitra A. Crystalline nanosuspensions as potential toxicology and clinical oral formulations for BCS II/IV compounds. AAPS J. 2012;14(4):677–687. doi:10.1208/s12248-012-9383-0
   PubMed Web of Science ®Google Scholar
• Yang SG. Biowaiver extension potential and IVIVC for BCS ClassII drugs by formulation design:Case study for cyclosporine self-microemulsifying formulation. Arch Pharm Res. 2010;33(11):1835–1842. doi:10.1007/s12272-010-1116-2
   PubMed Web of Science ®Google Scholar
• Adachi M, Hinatsu Y, Kusamori K, et al. Improved dissolution and absorption of ketoconazole in the presence of organic acids as pH-modifiers. Eur j Pharm Sci. 2015;76:225–230. doi:10.1016/j.ejps.2015.05.015
   PubMed Web of Science ®Google Scholar
• Chi L, Wu D, Li Z, et al. Modified Release and Improved Stability of Unstable BCSII Drug by Using Cyclodextrin Complex as Carrier To Remotely Load Drug into Niosomes. Mol Pharm. 2016;13(1):113–124. doi:10.1021/acs.molpharmaceut.5b00566
   PubMedGoogle Scholar
• Verma H, Garg R. Development of a bio-relevant pH gradient dissolution method for a high-dose, weakly acidic drug, its optimization and IVIVC in Wistar rats: a case study of magnesium orotate dihydrate. Magnesium Res. 2022;35(3):88–95. doi:10.1684/mrh.2022.0505
   PubMed Web of Science ®Google Scholar
• Efentakis M, Dressman JB. Gastric juice as a dissolution medium: surface tension and pH. Eur j Drug Metab Pharm. 1998;23(2):97–102. doi:10.1007/BF03189322
   PubMed Web of Science ®Google Scholar
• Mithani SD, Bakatselou V, TenHoor CN, et al. Estimation of the increase in solubility of drugs as a function of bile salt concentration. Pharm Res. 1996;13(1):163–167. doi:10.1023/a:1016062224568
   PubMed Web of Science ®Google Scholar
• Bakatselou V, Oppenheim RC, Dressman JB, et al. Solubilization and wetting effects of bile salts on the dissolution of steroids. Pharm Res. 1991;8(12):1461–1469. doi:10.1023/a:1015877929381
   PubMed Web of Science ®Google Scholar
• Charman WN, Porter CJH, Mithani S, et al. Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J Pharmaceut Sci. 1997;86(3):269–282. doi:10.1021/js960085v
   PubMed Web of Science ®Google Scholar
• La Sorella G, Sperni L, Canton P, et al. Selective Hydrogenations and Dechlorinations in Water Mediated by Anionic Surfactant-Stabilized Pd Nanoparticles. J Org Chem. 2018;83(14):7438–7446. doi:10.1021/acs.joc.8b00314
   PubMed Web of Science ®Google Scholar
• Singh KK, Vingkar SK. Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine.Int. J Pharm. 2008;347(1–2):567.
   Google Scholar
• Kalepu S, Nekkanti V. Insoluble drug delivery strategies: review of recent advances and business prospects. Acta Pharma Sin. 2015;5(5):442–453. doi:10.1016/j.apsb.2015.07.003
   Web of Science ®Google Scholar
• Hirose R, Sugano K. Effect of Food Viscosity on Drug Dissolution. Pharm Res. 2024;41(1):105–112. doi:10.1007/s11095-023-03620-y
   PubMed Web of Science ®Google Scholar
• Amidon GL, Leesman GD, Elliott RL, et al. Improving intestinal absorption of water-insoluble compounds: a membrane metabolism strategy. J Pharmaceut Sci. 1980;69(12):1363–1368. doi:10.1002/jps.2600691203
   PubMed Web of Science ®Google Scholar
• Mistry A, Stolnik S, Illum L, et al. Nanoparticles for direct nose-to-brain delivery of drugs. Int J Pharm. 2009;379(1):146–157. doi:10.1016/j.ijpharm.2009.06.019
   PubMed Web of Science ®Google Scholar
• Yuan S, Zhang Q. Application of One-Dimensional Nanomaterials in Catalysis at the Single-Molecule and Single-Particle Scale. Front Chem. 2021;9(812287). doi:10.3389/fchem.2021.812287
   Google Scholar
• Hegewald AB, Breitwieser K, Ottinger SM, et al. Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis. Front Immunol. 2020;11:585282. doi:10.3389/fimmu.2020.585282
   PubMed Web of Science ®Google Scholar
• Han L, Jiang C. Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies. Acta Pharma Sin. 2021;11(8):2306–2325. doi:10.1016/j.apsb.2020.11.023
   Web of Science ®Google Scholar
• Parodi A, Quattrocchi N, van de Ven AL, et al. Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nat Nanotechnol. 2013;8(1):61–68. doi:10.1038/nnano.2012.212
   PubMed Web of Science ®Google Scholar
• Ugwoke MI, AGU R, VERBEKE N, et al. Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Adv Drug Delivery Rev 2005;57(11):1640–1665. doi:10.1016/j.addr.2005.07.009
   PubMed Web of Science ®Google Scholar
• Kanazawa T, Taki H, Tanaka K, et al. Cell-penetrating peptide-modified block copolymer micelles promote direct brain delivery via intranasal administration. Pharm Res. 2011;28(9):2130–2139. doi:10.1007/s11095-011-0440-7
   PubMed Web of Science ®Google Scholar
• Rafiei P, Haddadi A. Pharmacokinetic Consequences of PLGA Nanoparticles in Docetaxel Drug Delivery. Pharm nanotechnol. 2017;5(1):3–23. doi:10.2174/2211738505666161230110108
   PubMedGoogle Scholar
• Sridhar V, Gaud R, Bajaj A, et al. Pharmacokinetics and pharmacodynamics of intranasally administered selegiline nanoparticles with improved brain delivery in Parkinson’s disease. Nanomedicine. 2018;14(8):2609–2618. doi:10.1016/j.nano.2018.08.004
   PubMed Web of Science ®Google Scholar
• Guo Q, Chang Z, Khan NU, et al. Nanosizing Noncrystalline and Porous Silica Material-Naturally Occurring Opal Shale for Systemic Tumor Targeting Drug Delivery. ACS Appl Mater Interfaces. 2018;10(31):25994–26004. doi:10.1021/acsami.8b06275
   PubMed Web of Science ®Google Scholar
• Aslam M, Javed MN, Deeb HH, et al. Lipid Nanocarriers for Neurotherapeutics: introduction, Challenges, Blood-brain Barrier, and Promises of Delivery Approaches. CNS Neurol Disord Drug Targets. 2022;21(10):952–965. doi:10.2174/1871527320666210706104240
   PubMed Web of Science ®Google Scholar
• Large DE, Abdelmessih RG, Fink EA, et al. Liposome composition in drug delivery design, synthesis, characterization, and clinical application. Adv Drug Delivery Rev 2021;176:113851. doi:10.1016/j.addr.2021.113851
   PubMed Web of Science ®Google Scholar
• Harde H, Das M, Jain S, et al. Solid lipid nanoparticles: an oral bioavailability enhancer vehicle. Expert Opin Drug Delivery. 2011;8(11):1407–1424. doi:10.1517/17425247.2011.604311
   PubMed Web of Science ®Google Scholar
• Damgé C, Michel C, Aprahamian M, et al. New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes. 1988;37(2):246–251. doi:10.2337/diab.37.2.246
   PubMed Web of Science ®Google Scholar
• Ponchel G, Montisci M-J, Dembri A, Durrer C, Duchêne D. Assia Dembri, Carlo Durrer, Dominique Duchêne,Mucoadhesion of colloidal particulate systems in the gastro-intestinal tract,European. J Pharm Biopharmaceutics. 1997;44(1):25–31. doi:10.1016/S0939-6411(97)00098-2
   Web of Science ®Google Scholar
• Suk JS, Xu Q, Kim N, et al. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv Drug Delivery Rev 2016;99:28–51. doi:10.1016/j.addr.2015.09.012
   PubMed Web of Science ®Google Scholar
• Souto EB, Baldim I, Oliveira WP, et al. SLN and NLC for topical, dermal, and transdermal drug delivery. Expert Opin Drug Delivery. 2020;17(3):357–377. doi:10.1080/17425247.2020.1727883
   PubMed Web of Science ®Google Scholar
• Müller RH, Radtke M, Wissing SA, et al. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Delivery Rev 2002;54(1):S131–55. doi:10.1016/s0169-409x(02)00118-7
   PubMed Web of Science ®Google Scholar
• Xiu-Yan L, Guan Q-X, Shang Y-Z, et al. Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver. World j Gastroenterol. 2021;27(26):4208–4220. doi:10.3748/wjg.v27.i26.4208
   PubMed Web of Science ®Google Scholar
• Pan M-S, Cao J, Fan Y-Z, et al. Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities. ChinMed. 2020;15:55. doi:10.1186/s13020-020-00338-6
   Google Scholar
• Yan Z, Yang K, Tang X, et al. Norcantharidin Nanostructured Lipid Carrier (NCTD-NLC) Suppresses the Viability of Human Hepatocellular Carcinoma HepG2 Cells and Accelerates the Apoptosis. J Immunol Res. 2022;2022:3851604. doi:10.1155/2022/3851604
   PubMed Web of Science ®Google Scholar
• Akhter MH, Ahmad A, Ali J, et al. Formulation and Development of CoQ10-Loaded s-SNEDDS for Enhancement of Oral Bioavailability. J Pharm Innov. 2014;9:121–131. doi:10.1007/s12247-014-9179-0
   Web of Science ®Google Scholar
• Soni K, Mujtaba A, Akhter MH, et al. Optimisation of ethosomal nanogel for topical nano-CUR and sulphoraphane delivery in effective skin cancer therapy. J Microencapsulation. 2020;37(2):91–108. doi:10.1080/02652048.2019.1701114
   PubMed Web of Science ®Google Scholar
• Katari O, Jain S. Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis. Expert Opin Drug Delivery. 2021;18(12):1857–1872. doi:10.1080/17425247.2021.2011857
   PubMed Web of Science ®Google Scholar
• Carmen Gómez-Guillén M, Montero MP. Pilar Montero,Enhancement of oral bioavailability of natural compounds and probiotics by mucoadhesive tailored biopolymer-based nanoparticles: a review. Food Hydrocoll. 2021;118:106772. doi:10.1016/j.foodhyd.2021.106772
   Web of Science ®Google Scholar
• Denora N, Trapani A, Laquintana V, et al. Recent advances in medicinal chemistry and pharmaceutical technology--strategies for drug delivery to the brain. Curr Top Med Chem 2009;9(2):182–196. doi:10.2174/156802609787521571
   PubMed Web of Science ®Google Scholar
• Mikhail AS, Allen C. Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels. J Control Release. 2009;138(3):214–223. doi:10.1016/j.jconrel.2009.04.010
   PubMed Web of Science ®Google Scholar
• Lee Y. Preparation and characterization of folic acid linked poly(L-glutamate) nanoparticles for cancer targeting. Macromol Res. 2006;14:387–393. doi:10.1007/BF03219099
   Web of Science ®Google Scholar
• Wang H, Zhao Y, Wu Y, et al. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials. 2011;32(32):8281–8290. doi:10.1016/j.biomaterials.2011.07.032
   PubMed Web of Science ®Google Scholar
• Chen Q, Han X, Liu L, et al. Multifunctional Polymer Vesicles for Synergistic Antibiotic-Antioxidant Treatment of Bacterial Keratitis. Biomacromolecules. 2023;24(11):5230–5244. doi:10.1021/acs.biomac.3c00754
   PubMed Web of Science ®Google Scholar
• Md S, Alhakamy NA, Neamatallah T, et al. Development, Characterization, and Evaluation of α-Mangostin-Loaded Polymeric Nanoparticle Gel for Topical Therapy in Skin Cancer. Gels. 2021;7(4):230. doi:10.3390/gels7040230
   PubMed Web of Science ®Google Scholar
• Shumin L, Xu Z, Alrobaian M, et al. EGF-functionalized lipid-polymer hybrid nanoparticles of 5-fluorouracil and sulforaphane with enhanced bioavailability and anticancer activity against colon carcinoma. Biotechnol Appl Biochem 2022;69(5):2205–2221. doi:10.1002/bab.2279
   PubMed Web of Science ®Google Scholar
• Karim S, Akhter MH, Burzangi AS, et al. Phytosterol-Loaded Surface-Tailored Bioactive-Polymer Nanoparticles for Cancer Treatment: optimization, In Vitro Cell Viability, Antioxidant Activity, and Stability Studies. Gels. 2022;8:219. doi:10.3390/gels8040219
   PubMed Web of Science ®Google Scholar
• Mir MA, Akhter MH, Afzal O, et al. Design-of-Experiment-Assisted Fabrication of Biodegradable Polymeric Nanoparticles: in Vitro Characterization, Biological Activity, and In Vivo Assessment. ACS Omega. 2023;8(42):38806–38821. doi:10.1021/acsomega.3c01153
   PubMed Web of Science ®Google Scholar
• Vozza G, Khalid M, Byrne HJ, Ryan SM, Jesus M. Frias,Nutraceutical formulation, characterisation, and in-vitro evaluation of methylselenocysteine and selenocystine using food derived chitosan:zein nanoparticles. Food Res Int. 2019;120:295–304. doi:10.1016/j.foodres.2019.02.028
   PubMed Web of Science ®Google Scholar
• Pauluk D, Krause Padilha A, Maissar Khalil N, Mainardes RM. Rubiana Mara Mainardes,Chitosan-coated zein nanoparticles for oral delivery of resveratrol: formation, characterization, stability, mucoadhesive properties and antioxidant activity. Food Hydrocoll. 2019;94:411–417. doi:10.1016/j.foodhyd.2019.03.042
   Web of Science ®Google Scholar
• Xia L, Cong Z, Liu Z, et al. Improvement of the solubility, photostability, antioxidant activity and UVB photoprotection of trans-resveratrol by essential oil based microemulsions for topical application. J Drug Delivery Sci Technol. 2018;48:346–354. doi:10.1016/j.jddst.2018.10.017
   Web of Science ®Google Scholar
• Chatterjee B, Gorain B, Mohananaidu K, et al. Targeted drug delivery to the brain via intranasal nanoemulsion: available proof of concept and existing. Int j Pharma. 2019;565:258–268. doi:10.1016/j.ijpharm.2019.05.032
   PubMed Web of Science ®Google Scholar
• Pandey P, Gulati N, Makhija M, et al. Nanoemulsion: a Novel Drug Delivery Approach for Enhancement of Bioavailability. Recent Patents Nanotechnol. 2020;14(4):276–293. doi:10.2174/1872210514666200604145755
   PubMed Web of Science ®Google Scholar
• Jiang Y, Zhang Y, Liang R, et al. Beta-carotene chemical stability in Nanoemulsions was improved by stabilized with beta-lactoglobulin-catechin conjugates through free radical method. J Agr Food Chem. 2015;63(1):297–303. doi:10.1021/jf5056024
   PubMed Web of Science ®Google Scholar
• Ding L, Tang S, Yu A, et al. Nanoemulsion-Assisted siRNA Delivery to Modulate the Nervous Tumor Microenvironment in the Treatment of Pancreatic Cancer. ACS Appl Mater Interfaces. 2022;14(8):10015–10029. doi:10.1021/acsami.1c21997
   PubMed Web of Science ®Google Scholar
• Niu Z, Acevedo-Fani A, McDowell A, et al. Nanoemulsion structure and food matrix determine the gastrointestinal fate and in vivo bioavailability of coenzyme Q10. J Control Release. 2020;327:444–455. doi:10.1016/j.jconrel.2020.08.025
   PubMed Web of Science ®Google Scholar
• Bouchemal K, Briançon S, Perrier E, et al. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant. Int j Pharm. 2004;280(1–2):241–251. doi:10.1016/j.ijpharm.2004.05.016
   PubMed Web of Science ®Google Scholar
• Weiss M, Steiner DF, Philipson LH, et al. Insulin Biosynthesis, Secretion, Structure, and Structure-Activity Relationships. In: Feingold KR, Anawalt B, Blackman MR, editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2014.
   Google Scholar
• Leber N, Nuhn L, Zentel R, et al. Cationic Nanohydrogel Particles for Therapeutic Oligonucleotide Delivery. Macromol biosci. 2017;17(10). doi:10.1002/mabi.201700092
   PubMed Web of Science ®Google Scholar
• Deng S, Gigliobianco M, Mijit E, et al. Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox-Responsive Degradability for Intracellular Delivery. Pharmaceutics. 2021;13(12):2048. doi:10.3390/pharmaceutics13122048
   PubMed Web of Science ®Google Scholar
• Granata G, Petralia S, Forte G, et al. Injectable supramolecular nanohydrogel from a micellar self-assembling calix[4] arene derivative and curcumin for a sustained drug release. Mater Sci Eng. 2020;111:110842. doi:10.1016/j.msec.2020.110842
   Google Scholar
• Raemdonck K, Demeester J, De Smedt S. Advanced nanogel engineering for drug delivery. Soft Matter. 2009;5(4):707–715. doi:10.1039/B811923F
   Web of Science ®Google Scholar
• El-Refaie WM, Elnaggar YSR, El-Massik MA, et al. Novel Self-assembled, Gel-core Hyaluosomes for Non-invasive Management of Osteoarthritis: in-vitro Optimization, Ex-vivo and In-vivo Permeation. Pharm Res. 2015;32(9):2901–2911. doi:10.1007/s11095-015-1672-8
   PubMed Web of Science ®Google Scholar
• Udeni Gunathilake TMS, Ching YC, Chuah CH. Enhancement of Curcumin Bioavailability Using Nanocellulose Reinforced Chitosan Hydrogel. Polymers. 2017;9(2):64. doi:10.3390/polym9020064
   PubMed Web of Science ®Google Scholar
• Ahmad I, Farheen M, Kukreti A, et al. Natural Oils Enhance the Topical Delivery of Ketoconazole by Nanoemulgel for Fungal Infections. ACS omega. 2023;8(31):28233–28248. doi:10.1021/acsomega.3c01571
   PubMed Web of Science ®Google Scholar
• Yanchen H, Zhi Z, Zhao Q, et al. 3D cubic mesoporous silica microsphere as a carrier for poorly soluble drug carvedilol. Microporous Mesoporous Mater. 2012;147(1):94–101. doi:10.1016/j.micromeso.2011.06.001
   Web of Science ®Google Scholar
• Zhang Y, Wang J, Bai X, et al. Mesoporous silica nanoparticles for increasing the oral bioavailability and permeation of poorly water soluble drugs. Mol Pharmaceut. 2012;9(3):505–513. doi:10.1021/mp200287c
   PubMed Web of Science ®Google Scholar
• Pawlaczyk M, Schroeder G. Dual-Polymeric Resin Based on Poly (methyl vinyl ether-alt-maleic anhydride) and PAMAM Dendrimer as a Versatile Supramolecular Adsorbent. ACS Appl Polymer Mater. 2021;3(2):956–967. doi:10.1021/acsapm.0c01254
   Web of Science ®Google Scholar
• Liu X, Peng Y, Qu X, et al. Multi-walled carbon nanotube-chitosan/poly(amidoamine)/DNA nanocomposite modified gold electrode for determination of dopamine and uric acid under coexistence of ascorbic acid. J Electroanal Chem. 2011;654(1–2):72–78. doi:10.1016/j.jelechem.2011.01.024
   Web of Science ®Google Scholar
• Zhuo RX, Du B, Lu ZR. In vitro release of 5-fluorouracil with cyclic core dendritic polymer. J Control Release. 1999;57(3):249–257. doi:10.1016/s0168-3659(98)00120-5
   PubMed Web of Science ®Google Scholar
• Luo K, Li C, Li L, et al. Arginine functionalized peptide dendrimers as potential gene delivery vehicles. Biomaterials. 2012;33(19):4917–4927. doi:10.1016/j.biomaterials.2012.03.030
   PubMed Web of Science ®Google Scholar
• Conghua Y, Qinghe X, Yang D, Wang M. Miao Wang,A novel pH-responsive charge reversal nanospheres based on acetylated histidine-modified lignin for drug delivery. Ind Crops Prod. 2022;186:115193. doi:10.1016/j.indcrop.2022.115193
   Web of Science ®Google Scholar
• Guo F, Jiao Y, Du Y, et al. Enzyme-responsive nano-drug delivery system for combined antitumor therapy. Int J Biol Macromol. 2022;220:1133–1145. doi:10.1016/j.ijbiomac.2022.08.123
   PubMed Web of Science ®Google Scholar
• Hui Y, Jin F, Liu D, et al. ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury. Theranostics. 2020;10(5):2342–2357. doi:10.7150/thno.40395
   PubMed Web of Science ®Google Scholar
• Wang G, Maciel D, Wu Y, et al. Amphiphilic polymer-mediated formation of laponite-based nanohybrids with robust stability and pH sensitivity for anticancer drug delivery. ACS Appl Mater Interfaces. 2014;6(19):16687–16695. doi:10.1021/am5032874
   PubMed Web of Science ®Google Scholar
• Ghadiri M, Young PM, Traini D. Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes. Pharmaceutics. 2019;11(3):113. doi:10.3390/pharmaceutics11030113
   PubMed Web of Science ®Google Scholar
• Pawar B, Vasdev N, Gupta T, et al. Current Update on Transcellular Brain Drug Delivery. Pharmaceutics. 2022;14(12):2719. doi:10.3390/pharmaceutics14122719
   PubMed Web of Science ®Google Scholar
• Sosnik A, Das Neves J. Bruno Sarmento.Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review. Prog Polym Sci. 2014;39(12):2030–2075.
   Web of Science ®Google Scholar
• Costa CP, Moreira JN, Sousa Lobo JM, et al. Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: a current overview of in vivo studies. Acta Pharmaceutica Sinica B. 2021;11(4):925–940. doi:10.1016/j.apsb.2021.02.012
   PubMed Web of Science ®Google Scholar
• Bhaskar S, Tian F, Stoeger T, et al. Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging. Particle Fibre Toxicol. 2010;7:3. doi:10.1186/1743-8977-7-3
   PubMed Web of Science ®Google Scholar
• Sun W, Xie C, Wang H, et al. Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain. Biomaterials. 2004;25(15):3065–3071. doi:10.1016/j.biomaterials.2003.09.087
   PubMed Web of Science ®Google Scholar
• Wei L, Tan Y-Z, Hu K-L, et al. Cationic albumin conjugated pegylated nanoparticle with its transcytosis ability and little toxicity against blood-brain barrier. Int J Pharm. 2005;295(1–2):247–260. doi:10.1016/j.ijpharm.2005.01.043
   PubMedGoogle Scholar
• Chai Z, Hu X, Wei X, et al. A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery. J Control Release. 2017;264:102–111. doi:10.1016/j.jconrel.2017.08.027
   PubMed Web of Science ®Google Scholar
• Fang RH, Hu C-MJ, Chen KNH, et al. Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles. Nanoscale. 2013;5(19):8884–8888. doi:10.1039/c3nr03064d
   PubMed Web of Science ®Google Scholar
• Yan L, He H, Jia X, et al. A dual-targeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas. Biomaterials. 2012;33(15):3899–3908. doi:10.1016/j.biomaterials.2012.02.004
   PubMed Web of Science ®Google Scholar
• Habban Akhter M, Beg S, Tarique M, Malik A, Afaq S, Choudhry H. Salman Hosawi,Receptor-based targeting of engineered nanocarrier against solid tumors: recent progress and challenges ahead. Biochimica et Biophysica Acta. 2021;1865(2):129777. doi:10.1016/j.bbagen.2020.129777
   Web of Science ®Google Scholar
• Spanjers JM, Städler B. Cell Membrane Coated Particles. Adv Biosyst 2020;4(11):e2000174. doi:10.1002/adbi.202000174
   PubMed Web of Science ®Google Scholar
• Ricordel C, Labalette-Tiercin M, Lespagnol A, et al. EFGR-mutant lung adenocarcinoma and Li-Fraumeni syndrome: report of two cases and review of the literature. Lung Cancer. 2015;87(1):80–84. doi:10.1016/j.lungcan.2014.11.005
   PubMed Web of Science ®Google Scholar
• Farheen M, Akhter MH, Chitme H, et al. Surface-Modified Biobased Polymeric Nanoparticles for Dual Delivery of Doxorubicin and Gefitinib in Glioma Cell Lines. ACS omega. 2023;8(31):28165–28184. doi:10.1021/acsomega.3c01375
   PubMed Web of Science ®Google Scholar
• Wang Z-H, Liu J-M, Zhao N, et al. Cancer Cell Macrophage Membrane-Camouflaged Persistent-Luminescent Nanoparticles for Imaging-Guided Photothermal Therapy of Colorectal Cancer. ACS Appl Nano Mater 2020;XXXX. doi:10.1021/acsanm.0c01433
   Google Scholar
• Zhao K, Li D, Cheng G, et al. Targeted Delivery Prodigiosin to Choriocarcinoma by Peptide-Guided Dendrigraft Poly-l-lysines Nanoparticles. Int j Mol Sci. 2019;20(21):5458. doi:10.3390/ijms20215458
   PubMed Web of Science ®Google Scholar
• Wang Y, Cheng J, Zhao D, et al. Designed DNA nanostructure grafted with erlotinib for non-small-cell lung cancer therapy. Nanoscale. 2020;12(47):23953–23958. doi:10.1039/d0nr06945k
   PubMed Web of Science ®Google Scholar
• Gong Y, Mohd S, Wu S, et al. pH-responsive cellulose-based microspheres designed as an effective oral delivery system for insulin. ACSO Mega. 2021;6:2734–2741.
   PubMed Web of Science ®Google Scholar
• Cikrikci S, Mert H, Oztop MH. Development of pH sensitive alginate/gum tragacanth based hydrogels for oral insulin delivery. J Agric Food Chem. 2018;66:11784–11796. doi:10.1021/acs.jafc.8b02525
   PubMed Web of Science ®Google Scholar
• Qi X, Yuan Y, Zhang J, et al. Oral administration of salecan based hydrogels for controlled insulin delivery. J Agric Food Chem. 2018;66:10479–10489. doi:10.1021/acs.jafc.8b02879
   PubMed Web of Science ®Google Scholar
• Zhang L, Qin H, Li J, et al. Preparation and characterization of layer-by-layer hypoglycemic nanoparticles with pH-sensitivity for oral insulin delivery. J Mater Chem. 2018;6:7451–7461.
   PubMed Web of Science ®Google Scholar
• Shabana AM, Kambhampati SP, Hsia R-C, et al. Thermosensitive and Biodegradable Hydrogel Encapsulating Targeted Nanoparticles for the Sustained Co-Delivery of Gemcitabine and Paclitaxel to Pancreatic Cancer Cells. Int J Pharm. 2020;593(6):120139. doi:10.1016/j.ijpharm.2020.120139
   PubMedGoogle Scholar
• Deodhar S, Dash AK, North EJ, et al. Development and In Vitro Evaluation of Long Circulating Liposomes for Targeted Delivery of Gemcitabine and Irinotecan in Pancreatic Ductal Adenocarcinoma. AAPS Pharm Sci Tech. 2020;21(6). doi:10.1208/s12249-020-01745-6
   PubMed Web of Science ®Google Scholar
• Patra JK, Das G, Fraceto LF, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. 2018;16(1):71. doi:10.1186/s12951-018-0392-8
   PubMed Web of Science ®Google Scholar
• Ruan S, Li J, Ruan H, et al. Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer’s disease treatment. J Controlled Release. 2024;366:712–731. doi:10.1016/j.jconrel.2024.01.013
   PubMed Web of Science ®Google Scholar
• Jahangirian H, Ghasemian Lemraski E, Webster TJ, et al. A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine. Int j Nanomed. 2017;12:2957–2978. doi:10.2147/IJN.S127683
   PubMed Web of Science ®Google Scholar
• Hansen K, Kim G, Desai K-GH, et al. Feasibility Investigation of Cellulose Polymers for Mucoadhesive Nasal Drug Delivery Applications. Mol Pharmaceut. 2015;12(8):2732–2741. doi:10.1021/acs.molpharmaceut.5b00264
   PubMed Web of Science ®Google Scholar
• Mignani S, El Kazzouli S, Bousmina M, et al. Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview. Adv Drug Delivery Rev 2013;65(10):1316–1330. doi:10.1016/j.addr.2013.01.001
   PubMed Web of Science ®Google Scholar
• Miyata K, Christie RJ, Kataoka K. Polymeric micelles for nano-scale drug delivery. React Funct Polym. 2011;3(71). doi:10.1016/j.reactfunctpolym.2010.10.009
   Google Scholar
• Wei X, Ling P, Zhang T, et al. Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs. J Drug Delivery. 2013;2013:340315. doi:10.1155/2013/340315
   PubMedGoogle Scholar
• Lam P-L, Wong W-Y, Bian Z, Chui C-H, Gambari R. Gambari R.Recent advances in green nanoparticulate systems for drug delivery: efficient delivery and safety concern. Nanomedicine. 2017;12:357–385. doi:10.2217/nnm-2016-0305
   PubMed Web of Science ®Google Scholar
• Powell JJ, Faria N, Thomas-McKay E, et al. Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun. 2010;34(3):J226–33. doi:10.1016/j.jaut.2009.11.006
   PubMed Web of Science ®Google Scholar
• Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009;9(11):799–809. doi:10.1038/nri2653
   PubMed Web of Science ®Google Scholar
• Sahay G, Alakhova DY, Kabanov AV, et al. Endocytosis of nanomedicines. J Controlled Release. 2010;145(3):182–195. doi:10.1016/j.jconrel.2010.01.036
   PubMed Web of Science ®Google Scholar
• Liang Q, Bie N, Yong T, et al. The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency. Nat Biomed Eng. 2019;3(9):729–740. doi:10.1038/s41551-019-0405-4
   PubMed Web of Science ®Google Scholar
• Della Camera G, Madej M, Ferretti AM, et al. Personalised Profiling of Innate Immune Memory Induced by Nano-Imaging Particles in Human Monocytes. Front Immunol. 2021;12:692165. doi:10.3389/fimmu.2021.692165
   PubMed Web of Science ®Google Scholar
• Wang J, Chen H-J, Hang T, et al. Physical activation of innate immunity by spiky particles. Nature Nanotechnol. 2018;13(11):1078–1086. doi:10.1038/s41565-018-0274-0
   PubMed Web of Science ®Google Scholar
• Ejigah V, Owoseni O, Bataille-Backer P, et al. Approaches to Improve Macromolecule and Nanoparticle Accumulation in the Tumor Microenvironment by the Enhanced Permeability and Retention Effect. Polymers. 2022;14(13):2601. doi:10.3390/polym14132601
   PubMed Web of Science ®Google Scholar
• Xiao M, Hu M, Dong M, et al. Folic Acid Decorated Zeolitic Imidazolate Framework (ZIF-8) Loaded with Baicalin as a Nano-Drug Delivery System for Breast Cancer Therapy. Int j Nanomed. 2021;16:8337–8352. doi:10.2147/IJN.S340764
   PubMed Web of Science ®Google Scholar
• Kabanov AV, Lemieux P, Vinogradov S, et al. Pluronic block copolymers: novel functional molecules for gene therapy. Adv Drug Delivery Rev 2002;54(2):223–233. doi:10.1016/s0169-409x(02)00018-2
   PubMed Web of Science ®Google Scholar
• Jin P, Sha R, Zhang Y, et al. Blood Circulation-Prolonging Peptides for Engineered Nanoparticles Identified via Phage Display. Nano Lett. 2019;19(3):1467–1478. doi:10.1021/acs.nanolett.8b04007
   PubMed Web of Science ®Google Scholar
• Aggarwal P, Hall JB, McLeland CB, et al. Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv Drug Delivery Rev 2009;61(6):428–437. doi:10.1016/j.addr.2009.03.009
   PubMed Web of Science ®Google Scholar
• Hadidi N, Kobarfard F, Nafissi-Varcheh N, et al. PEGylated single-walled carbon nanotubes as nanocarriers for cyclosporin A delivery. AAPS Pharm Sci Tech. 2013;14(2):593–600. doi:10.1208/s12249-013-9944-2
   PubMed Web of Science ®Google Scholar
• Alimohammadi E, Nikzad A, Khedri M, et al. Molecular Tuning of the Nano-Bio Interface: alpha-Synuclein’s Surface Targeting with Doped Carbon Nanostructures. ACS Appl Bio Mater 2021;4(8):6073–6083. doi:10.1021/acsabm.1c00421
   PubMedGoogle Scholar
• Wohlfart S, Gelperina S, Kreuter J, et al. Transport of drugs across the blood-brain barrier by nanoparticles. J Controlled Release. 2012;161(2):264–273. doi:10.1016/j.jconrel.2011.08.017
   PubMed Web of Science ®Google Scholar
• Shen J, Zhao Z, Shang W, et al. Ginsenoside Rg1 nanoparticle penetrating the blood–brain barrier to improve the cerebral function of diabetic rats complicated with cerebral infarction. Int j Nanomed. 2017;12:6477–6486. doi:10.2147/IJN.S139602
   PubMed Web of Science ®Google Scholar
• Wiley DT, Webster P, Gale A, et al. Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor. Proc Natl Acad Sci USA. 2013;110(21):8662–8667. doi:10.1073/pnas.1307152110
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang T, Li G, et al. Radiosensitivity enhancement by Co-NMS-mediated mitochondrial impairment in glioblastoma. J Cell Physiol. 2020;235(12):9623–9634. doi:10.1002/jcp.29774
   PubMed Web of Science ®Google Scholar
• Slepicka P, Kasalkova NS, Siegel J, et al. Nano-structured and functionalized surfaces for cytocompatibility improvement and bactericidal action. Biotechnol Adv 2015;33(6):1120–1129. doi:10.1016/j.biotechadv.2015.01.001
   PubMed Web of Science ®Google Scholar
• Luo X, Wu S, Xiao M, et al. Advances and Prospects of Prolamine Corn Protein Zein as Promising Multifunctional Drug Delivery System for Cancer Treatment. Int j Nanomed. 2023;18:2589–2621. doi:10.2147/IJN.S402891
   PubMed Web of Science ®Google Scholar
• Canal F, Vicent MJ, Pasut G, et al. Relevance of folic acid/polymer ratio in targeted PEG-epirubicin conjugates. J Controlled Release. 2010;146(3):388–399. doi:10.1016/j.jconrel.2010.05.027
   PubMed Web of Science ®Google Scholar
• Yang Y, He Y, Deng Z, et al. Intelligent Nanoprobe: acid-Responsive Drug Release and In Situ Evaluation of Its Own Therapeutic Effect. Anal Chem 2020;92(18):12371–12378. doi:10.1021/acs.analchem.0c02099
   PubMed Web of Science ®Google Scholar
• Desai N. Challenges in development of nanoparticle-based therapeutics. AAPS J. 2012;14(2):282–295. doi:10.1208/s12248-012-9339-4
   PubMed Web of Science ®Google Scholar
• Higaki M, Ishihara T, Izumo N, et al. Treatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate. Ann Rheumatic Dis. 2005;64(8):1132–1136. doi:10.1136/ard.2004.030759
   PubMed Web of Science ®Google Scholar
• McCully M, Sanchez-Navarro M, Teixido M, et al. Peptide Mediated Brain Delivery of Nano- and Submicroparticles: a Synergistic Approach. Curr Pharm Des 2018;24(13):1366–1376. doi:10.2174/1381612824666171201115126
   PubMed Web of Science ®Google Scholar
• Tinkle S, McNeil SE, Mühlebach S, et al. Nanomedicines: addressing the scientific and regulatory gap. Ann N Y Acad Sci. 2014;1313:35–56. doi:10.1111/nyas.12403
   PubMed Web of Science ®Google Scholar
• Zcan I, et al. Effects of sterilization techniques on the PEGylated poly (γ-benzyl-L-glutamate) (PBLG) nanoparticles. Acta Pharma Sci. 2009;51(3):211–218.
   Google Scholar
• Song Y, Li X, Du X, et al. Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma. Europ resp J. 2009;34(3):559–567. doi:10.1183/09031936.00178308
   PubMed Web of Science ®Google Scholar
• Nel A, Xia T, Madler L, et al. Toxic potential of materials at the nanolevel. Science. 2006;311(5761):622–627. doi:10.1126/science.1114397
   PubMed Web of Science ®Google Scholar
• Wacker MG, Proykova A, Santos GML, et al. Dealing with nanosafety around the globe-Regulation vs. innovation. Int J Pharm. 2016;509(1–2):95–106. doi:10.1016/j.ijpharm.2016.05.015
   PubMedGoogle Scholar
• Mühlebach S. Regulatory challenges of nanomedicines and their follow-on versions: a generic or similar approach? Adv. Drug Delivery Rev. 2018;131:122–131. doi:10.1016/j.addr.2018.06.024
   PubMed Web of Science ®Google Scholar
• Paradise J. Regulating Nanomedicine at the Food and Drug Administration. AMA j Ethics. 2019;21(4):E347–355. doi:10.1001/amajethics.2019.347
   PubMedGoogle Scholar
• Resnik DB, Tinkle SS. Ethical issues in clinical trials involving nanomedicine. Contemporary Clinical Trials. 2007;28(4):433–441. doi:10.1016/j.cct.2006.11.001
   PubMed Web of Science ®Google Scholar
• Bawa R, Johnson S. The ethical dimensions of nanomedicine. Med Clin North Am. 2007;91(5):881–887. doi:10.1016/j.mcna.2007.05.007
   PubMed Web of Science ®Google Scholar
• Zhang J, Hu K, Di L, et al. Traditional herbal medicine and nanomedicine: converging disciplines to improve therapeutic efficacy and human health. Adv. Drug Delivery Rev. 2021;178:113964. doi:10.1016/j.addr.2021.113964
   PubMed Web of Science ®Google Scholar
• Majidinia M, Mirza‐Aghazadeh‐Attari M, Rahimi M, et al. Overcoming multidrug resistance in cancer: recent progress in nanotechnology and new horizons. IUBMB Life. 2020;72(5):855–871. doi:10.1002/iub.2215
   PubMed Web of Science ®Google Scholar
• Shen C-Y, Xu P-H, Shen B-D, et al. Nanogel for dermal application of the triterpenoids isolated from Ganoderma lucidum (GLT) for frostbite treatment. Drug Delivery. 2016;23(2):610–618. doi:10.3109/10717544.2014.929756
   PubMed Web of Science ®Google Scholar
• Ventola CL. Progress in Nanomedicine: approved and Investigational Nanodrugs. PT. 2017;42(12):742–755.
   PubMedGoogle Scholar
• Sainz V, Conniot J, Matos AI, et al. Regulatory aspects on nanomedicines. Biochem. Biophys. Res. Commun. 2015;468(3):504–510. doi:10.1016/j.bbrc.2015.08.023
   PubMed Web of Science ®Google Scholar
• Agrahari V, Agrahari V. Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities. Drug Discovery Today. 2018;23(5):974–991. doi:10.1016/j.drudis.2018.01.047
   PubMed Web of Science ®Google Scholar
• Zhang N, Feng N, Xin X, et al. Nano-drug delivery system with enhanced tumour penetration and layered anti-tumour efficacy. Nanomedicine. 2022;45:102592. doi:10.1016/j.nano.2022.102592
   PubMed Web of Science ®Google Scholar
• Ouyang Q, Meng Y, Zhou W, et al. New advances in brain-targeting nano-drug delivery systems for Alzheimer’s disease. J Drug Targeting. 2022;30(1):61–81. doi:10.1080/1061186X.2021.1927055
   PubMed Web of Science ®Google Scholar
• Filipczak N, Yalamarty SSK, Li X, et al. Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases. Molecules. 2021;26(11):3304. doi:10.3390/molecules26113304
   PubMed Web of Science ®Google Scholar
• Cardoso RV, Pereira PR, Freitas CS, et al. Trends in Drug Delivery Systems for Natural Bioactive Molecules to Treat Health Disorders: the Importance of Nano-Liposomes. Pharmaceutics. 2022;14(12):2808. doi:10.3390/pharmaceutics14122808
   PubMed Web of Science ®Google Scholar
• Manzari MT, Shamay Y, Kiguchi H, et al. Targeted drug delivery strategies for precision medicines. Nature Rev Mater. 2021;6(4):351–370. doi:10.1038/s41578-020-00269-6
   PubMed Web of Science ®Google Scholar
• Taylor J, Sharp A, Rannard SP, et al. Nanomedicine strategies to improve therapeutic agents for the prevention and treatment of preterm birth and future directions. Nanoscale Adv. 2023;5(7):1870–1889. doi:10.1039/d2na00834c
   PubMed Web of Science ®Google Scholar
• Savjani KT, Gajjar AK, Savjani JK, et al. Drug solubility: importance and enhancement techniques. ISRN Pharmaceutics. 2012;2012:195727. doi:10.5402/2012/195727
   PubMedGoogle Scholar
• Mistry A, Stolnik S, Illum L, et al. Nose-to-Brain Delivery: investigation of the Transport of Nanoparticles with Different Surface Characteristics and Sizes in Excised Porcine Olfactory Epithelium. Mol Pharmaceut. 2015;12(8):2755–2766. doi:10.1021/acs.molpharmaceut.5b00088
   PubMed Web of Science ®Google Scholar
• Hegewald AB, et al. Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis. Front Immunol. 2020;11(585282). doi:10.3389/fimmu.2020.585282
   PubMedGoogle Scholar
• Motoyama K, Onodera R, Okamatsu A, et al. Potential use of the complex of doxorubicin with folate-conjugated methyl- β -cyclodextrin for tumor-selective cancer chemotherapy. J Drug Targeting. 2014;22(3):211–219. doi:10.3109/1061186X.2013.856012
   PubMed Web of Science ®Google Scholar
• Date AA, Hanes J, Ensign LM, et al. Nanoparticles for oral delivery: design, evaluation and state-of-The-art. J Controlled Release. 2016;240:504–526. doi:10.1016/j.jconrel.2016.06.016
   PubMed Web of Science ®Google Scholar
• Xiao S, Tang Y, Lv Z, et al. Nanomedicine - advantages for their use in rheumatoid arthritis theranostics. J Controlled Release. 2019;316:302–316. doi:10.1016/j.jconrel.2019.11.008
   PubMed Web of Science ®Google Scholar
• Wang S, Lv J, Meng S, et al. Recent Advances in Nanotheranostics for Treat-to-Target of Rheumatoid Arthritis. Adv. Healthcare Mater. 2020;9(6):e1901541. doi:10.1002/adhm.201901541
   Web of Science ®Google Scholar