111
Views
0
CrossRef citations to date
0
Altmetric
Original Research

Hypoxia Suppresses High Fat Diet-Induced Steatosis And Development Of Hepatic Adenomas

, , , , &
Pages 53-63 | Published online: 21 Oct 2019

References

  • Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends–an update. Cancer Epidemiol Biomarkers Prev. 2016;25(1):16–27. doi:10.1158/1055-9965.EPI-15-0578
  • Alkhouri N, Dixon LJ, Feldstein AE. Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Rev Gastroenterol Hepatol. 2009;3(4):445–451. doi:10.1586/egh.09.32
  • Basen-Engquist K, Chang M. Obesity and cancer risk: recent review and evidence. Curr Oncol Rep. 2011;13(1):71–76. doi:10.1007/s11912-010-0139-7
  • Cao Y. Adipocyte and lipid metabolism in cancer drug resistance. J Clin Invest. 2019;129(8):3006–3017. doi:10.1172/JCI127201
  • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348(17):1625–1638. doi:10.1056/NEJMoa021423
  • Lee W, Nagubadi S, Kryger MH, Mokhlesi B. Epidemiology of obstructive sleep apnea: a population-based perspective. Expert Rev Respir Med. 2008;2(3):349–364. doi:10.1586/17476348.2.3.349
  • Campos-Rodriguez F, Martinez-Garcia MA, Martinez M, et al. Association between obstructive sleep apnea and cancer incidence in a large multicenter spanish cohort. Am J Respir Crit Care Med. 2013;187(1):99–105. doi:10.1164/rccm.201209-1671OC
  • Corey KE, Misdraji J, Gelrud L, et al. Obstructive sleep apnea is associated with nonalcoholic steatohepatitis and advanced liver histology. Dig Dis Sci. 2015;60(8):2523–2528. doi:10.1007/s10620-015-3650-8
  • Suzuki T, Shinjo S, Arai T, Kanai M, Goda N. Hypoxia and fatty liver. World J Gastroenterol. 2014;20(41):15087–15097. doi:10.3748/wjg.v20.i41.15087
  • Iwamoto H, Abe M, Yang Y, et al. Cancer lipid metabolism confers antiangiogenic drug resistance. Cell Metab. 2018;28(1):104–117.e5. doi:10.1016/j.cmet.2018.05.005
  • Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51(2):679–689. doi:10.1002/hep.23280
  • Dixon JB, Bhathal PS, O ’brien PE. Liver, pancreas, and biliary tract nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology. 2001;121(1):91–100. doi:10.1053/gast.2001.25540
  • Drager LF, Li J, Reinke C, Bevans-Fonti S, Jun JC, Polotsky VY. Intermittent hypoxia exacerbates metabolic effects of diet-induced obesity. Obesity. 2011;19(11):2167–2174. doi:10.1038/oby.2011.240
  • Calzadilla Bertot L, Adams LA. The natural course of non-alcoholic fatty liver disease. Int J Mol Sci. 2016;17:5. doi:10.3390/ijms17050774
  • Huang G-W, Yang L-Y, Lu W-Q. Expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: impact on neovascularization and survival. World J Gastroenterol. 2005;11(11):1705–1708. doi:10.3748/wjg.v11.i11.1705
  • Klaunig JE, Pereira MA, Ruch RJ, Weghorst CM. Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal Balb/c mice: effect of phenobarbital promotion. Toxicol Pathol. 1988;16(3):381–385. doi:10.1177/019262338801600310
  • Sweeney N, Marchant S, Martinez JD. Intraperitoneal injections as an alternative method for micro-CT contrast enhanced detection of murine liver tumors. Biotechniques. 2019;66(5):214–217. doi:10.2144/btn-2018-0162
  • Kaanders JH, Wijffels KI, Marres HA, et al. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Res. 2002;62(23):7066–7074.
  • Olive PL, Aquino-Parsons C, MacPhail SH, et al. Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer. Cancer Res. 2001;61(24):8924–8929.
  • Casillas AL, Toth RK, Sainz AG, et al. Hypoxia-inducible PIM kinase expression promotes resistance to antiangiogenic agents. Clin Cancer Res. 2018;24(1):169–180. doi:10.1158/1078-0432.CCR-17-1318
  • Thoolen B, Maronpot RR, Harada T, et al. Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicol Pathol. 2010;38:5–81. doi:10.1177/0192623310386499
  • Drager LF, Brunoni AR, Jenner R, Lorenzi-Filho G, Bensenor IM, Lotufo PA. Effects of CPAP on body weight in patients with obstructive sleep apnoea: a meta-analysis of randomised trials. Thorax. 2015;70(3):258–264. doi:10.1136/thoraxjnl-2014-205361
  • Yoon DW, So D, Min S, et al. Accelerated tumor growth under intermittent hypoxia is associated with hypoxia-inducible factor-1-dependent adaptive responses to hypoxia. Oncotarget. 2017;8(37):61592–61603. doi:10.18632/oncotarget.18644
  • Krock BL, Skuli N, Simon MC. Hypoxia-induced angiogenesis: good and evil. Genes Cancer. 2011;2(12):1117–1133. doi:10.1177/1947601911423654
  • Mesarwi OA, Shin M-K, Bevans-Fonti S, et al. Hepatocyte hypoxia inducible factor-1 mediates the development of liver fibrosis in a mouse model of nonalcoholic fatty liver disease. PLoS One. 2016;11(12):e0168572. doi:10.1371/journal.pone.0168572
  • Shin M-K, Drager LF, Yao Q, et al. Metabolic consequences of high-fat diet are attenuated by suppression of HIF-1α. Ye J, ed. PLoS One. 2012;7(10):e46562. doi:10.1371/journal.pone.0046562
  • Ju C, Colgan SP, Eltzschig HK. Hypoxia-inducible factors as molecular targets for liver diseases. J Mol Med (Berl). 2016;94:613. doi:10.1007/S00109-016-1408-1
  • Lippl FJ, Neubauer S, Schipfer S, et al. Hypobaric hypoxia causes body weight reduction in obese subjects. Obesity. 2010;18(4):675–681. doi:10.1038/oby.2009.509
  • Palmer BF, Clegg DJ. Ascent to altitude as a weight loss method: the good and bad of hypoxia inducible factor activation. Obesity (Silver Spring). 2014;22(2):311–317. doi:10.1002/oby.20499