Nephroprotective Effect of the Leaf Extract of Ajuga remota Benth Against Gentamicin-Induced Nephrotoxicity in Swiss Albino Mice

References

• Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases. Kidney Int. 2019;96(5):1048–1050. doi:10.1016/j.kint.2019.07.012
   PubMed Web of Science ®Google Scholar
• Pazhayattil GS, Shirali AC. Drug-induced impairment of renal function. Int J Nephrol Renovasc Dis. 2014;7:457–468. doi:10.2147/IJNRD.S39747
   PubMedGoogle Scholar
• UNAIDS. FACT SHEET 2021 global HIV statistics. End AIDS Epidemic. 2021:1–3.
   Google Scholar
• Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabet Res Clin Pract. 2019;157:107843. doi:10.1016/j.diabres.2019.107843
   PubMed Web of Science ®Google Scholar
• Bikbov B, Purcell CA, Levey AS, et al. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395(10225):709–733. doi:10.1016/S0140-6736(20)30045-3
   PubMed Web of Science ®Google Scholar
• Miyahara T, Assadi F. Drug-induced renal disorders. J Ren Inj Prev. 2015;4(3):57–60. doi:10.12861/jrip.2015.12
   PubMedGoogle Scholar
• Salazar JH. Overview of urea and creatinine. Lab Med. 2014;45(1):e19–20. doi:10.1309/LM920SBNZPJRJGUT
   Google Scholar
• Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J Med Toxicol. 2008;4(1):2–6. doi:10.1007/BF03160941
   PubMedGoogle Scholar
• Sandhu JS, Sehgal A, Gupta O, Singh A. Aminoglycoside nephrotoxicity revisited. J Indian Acad Clin Med. 2007;8(4):331–333.
   Google Scholar
• Perazella MA, Navis G, Faber HJ, de Zeeuw D, de Jong PE. ACE inhibitors and the kidney. Drug Safety. 1996;15(3):200–211. doi:10.2165/00002018-199615030-00005
   PubMed Web of Science ®Google Scholar
• Fang CY, Lou DY, Zhou LQ, et al. Natural products: potential treatments for cisplatin-induced nephrotoxicity. Acta Pharmacol Sin. 2021;1–19.
   Web of Science ®Google Scholar
• Bryan CS, Stone WJ. “Comparably massive” penicillin G therapy in renal failure. Ann Intern Med. 1975;82(2):189–195. doi:10.7326/0003-4819-82-2-189
   PubMed Web of Science ®Google Scholar
• Emovon OE, King JAC, Holt CO, Browne BJ. Ranitidine-induced acute interstitial nephritis in a cadaveric renal allograft. Am J Kidney Dis. 2001;38(1):169–172. doi:10.1053/ajkd.2001.25211
   PubMed Web of Science ®Google Scholar
• Selby NM, Shaw S, Woodier N, Fluck RJ, Kolhe NV. Gentamicin-associated acute kidney injury. Qjm. 2009;102(12):873–880. doi:10.1093/qjmed/hcp143
   PubMed Web of Science ®Google Scholar
• Sales GTM, Foresto RD. Drug-induced nephrotoxicity. Rev Assoc Med Bras. 2020;66(Suppl 1):82–90. doi:10.1590/1806-9282.66.s1.82
   Web of Science ®Google Scholar
• Walther CP, Podoll AS, Finkel KW. Summary of clinical practice guidelines for acute kidney injury. Hosp Pract. 2014;42(1):7–14. doi:10.3810/hp.2014.02.1086
   Google Scholar
• Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney Int. 2011;79(1):33–45. doi:10.1038/ki.2010.337
   PubMed Web of Science ®Google Scholar
• USAID. Module III gentamicin. Man Procure Supply Qual MNCH Commod. 2019;4(1):121–140.
   Google Scholar
• Oliveira JFP, Silva CA, Barbieri CD, Oliveira GM, Zanetta DMT, Burdmann EA. Prevalence and risk factors for aminoglycoside nephrotoxicity in intensive care units. Antimicrob Agents Chemother. 2009;53(7):2887–2891. doi:10.1128/AAC.01430-08
   PubMed Web of Science ®Google Scholar
• Randjelović P, Veljković S, Stojiljković N, Sokolović D, Ilić I. Gentamicin nephrotoxicity in animals: current knowledge and future perspectives. EXCLI J. 2017;16:388–399. doi:10.17179/excli2017-165
   PubMed Web of Science ®Google Scholar
• Dhodi JB, Thanekar DR, Mestry SN, Juvekar AR. Carissa carandas Linn. fruit extract ameliorates gentamicin–induced nephrotoxicity in rats via attenuation of oxidative stress. J Acute Dis. 2015;4(2):135–140. doi:10.1016/S2221-6189(15)30023-8
   Google Scholar
• Duffy CR, Huang Y, Andrikopoulou M, et al. Clindamycin, gentamicin, and risk of clostridium difficile infection and acute kidney injury during delivery hospitalizations. Obstet Gynecol. 2020;135(1):59–67. doi:10.1097/AOG.0000000000003568
   PubMed Web of Science ®Google Scholar
• National Institute for Health and Care Excellence. Clostridium difficile infection: risk with broad-spectrum antibiotics. NICE Guidel. 2015;3(March):1–30.
   Google Scholar
• Seifu A. Bioprospecting Potential of Ajuga Integrifolia for Access and Benefit Sharing. Vol. 2017. Rome, Italy: FAO; 2017.
   Google Scholar
• Freshet A, Daniel S, Eyasu M. Antihyperglycemic and antihyperlipidemic activities of ethanol extract of Ajuga remota Benth (Harmegusa) leaves in streptozotocin induced diabetic rats. Afr J Pharm Pharmacol. 2017;11(2):17–24. doi:10.5897/AJPP2014.4699
   Google Scholar
• Cocquyt K, Cos P, Herdewijn P, et al. Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria. Phytomedicine. 2011;18(14):1229–1237. doi:10.1016/j.phymed.2011.08.063
   PubMed Web of Science ®Google Scholar
• Kuria KAM, De Coster S, Muriuki G, et al. Antimalarial activity of Ajuga remota Benth (Labiatae) and Caesalpinia volkensii Harms (Caesalpiniaceae): in vitro confirmation of ethnopharmacological use. J Ethnopharmacol. 2001;74(2):141–148. doi:10.1016/S0378-8741(00)00367-6
   PubMed Web of Science ®Google Scholar
• Yacob T, Shibeshi W, Nedi T. Antidiarrheal activity of 80 % methanol extract of the aerial part of Ajuga remota Benth (Lamiaceae) in mice. BMC Complement Altern Med. 2016;16(1):1–8. doi:10.1186/s12906-016-1277-8
   PubMedGoogle Scholar
• Kuria KAM, Chepkwony H, Govaerts C, et al. The antiplasmodial activity of isolates from Ajuga remota. J Nat Prod. 2002;65(5):789–793. doi:10.1021/np0104626
   PubMed Web of Science ®Google Scholar
• Tafesse TB, Hymete A, Mekonnen Y, Tadesse M. Antidiabetic activity and phytochemical screening of extracts of the leaves of Ajuga remota Benth on alloxan-induced diabetic mice. BMC Complement Altern Med. 2017;17(1). doi:10.1186/s12906-017-1757-5
   PubMedGoogle Scholar
• Ajuga L, Lamiaceae AL, Toiu A, et al. Comparative phytochemical profile, antioxidant, antimicrobial and in Vivo anti-inflammatory activity of different Extracts of traditionally used Romanian Ajuga genevensis L. and A. reptans L. (Lamiaceae). Molecules. 2019;24:1–21.
   Web of Science ®Google Scholar
• Giday M, Asfaw Z, Woldu Z. Medicinal plants of the Meinit ethnic group of Ethiopia: an ethnobotanical study. J Ethnopharmacol. 2009;124(3):513–521. doi:10.1016/j.jep.2009.05.009
   PubMed Web of Science ®Google Scholar
• Nardos A, Makonnen E. In vivo antiplasmodial activity and toxicological assessment of hydroethanolic crude extract of Ajuga remota. Malar J. 2017;16(1):1–8. doi:10.1186/s12936-017-1677-3
   PubMedGoogle Scholar
• Ragunathan M, Abay SM. Ethnomedicinal survey of folk drugs used in Bahirdar Zuria district, Northwestern Ethiopia. Indian J Tradit Knowl. 2009;8(2):281–284.
   Web of Science ®Google Scholar
• Hamden K, Ayadi F, Jamoussi K, Masmoudi H, Elfeki A. Therapeutic effect of phytoecdysteroids rich extract from Ajuga iva on alloxan induced diabetic rats liver, kidney and pancreas. BioFactors. 2008;33(3):165–175. doi:10.1002/biof.5520330302
   PubMed Web of Science ®Google Scholar
• Subhashini SVSNJP. Pharmacognostic analysis and phytochemical screening of methanolic extract of ipomoea batata leaves; 2017:2016–2018.
   Google Scholar
• Banu KS, Cathrine L. General techniques involved in phytochemical analysis. Int J Adv Res Chem Sci. 2015;2(4):25–32.
   Google Scholar
• Ezeonu CS, Ejikeme CM. Qualitative and quantitative determination of phytochemical contents of indigenous Nigerian softwoods. New J Sci. 2016;2016:1–9. doi:10.1155/2016/5601327
   Google Scholar
• Khalid S, Shahzad A, Basharat N, Abubakar M, Anwar P. Phytochemical screening and analysis of selected medicinal plants in Gujrat. J Phytochem Biochem. 2018;2(1):2–4.
   Google Scholar
• Linn T, Convolvulaceae HF. Standardization of aerial parts of merremia; 2013:99–105.
   Google Scholar
• Auwal MS, Saka S, Mairiga IA, Sanda KA, Shuaibu A, Ibrahim A. Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica (Thorn mimosa). Vet Res Forum. 2014;5(2):95–100.
   PubMedGoogle Scholar
• Latifat AT, Teli PK, Tiwari S, Gupta VK. Quantitative and qualitative analysis of Eucalyptus grandis, Moringa oleifera Leaf, Punica granatum Pericarp and Syzygium aromaticum Dried Bud. J Emerg Technol Innov Res. 2018;5(8):551–560.
   Google Scholar
• Gul R, Jan SU, Faridullah S, Sherani S, Jahan N. Preliminary Phytochemical screening, quantitative analysis of alkaloids, and antioxidant activity of crude plant extracts from Ephedra intermedia indigenous to Balochistan. Sci World J. 2017;2017:1–7. doi:10.1155/2017/5873648
   Google Scholar
• Fitokimia P, Asai J, Flavonoid K, Ekstrak P, Tepal P. Phytochemical screening, total flavonoid and phenolic content assays of various solvent extracts of tepal of Musa paradisiaca. Malays J Anal Sci. 2016;20(5):1181–1190.
   Google Scholar
• Benkova M, Soukup O, Marek J. Antimicrobial susceptibility testing: currently used methods and devices and the near future in clinical practice. J Appl Microbiol. 2020;129(4):806–822.
   PubMed Web of Science ®Google Scholar
• Zohra FT, Program B, Sciences N. Extraction of secondary metabolites, phytochemical screening and the analysis of antibacterial activity in Stevia rebaudiana; 2015.
   Google Scholar
• National Research Council (US) Institute for Laboratory Animal Research. Guidance for the description of animal research in scientific publications. ILAR J. 2014;55(3):536–540. doi:10.1093/ilar/ilu070
   Google Scholar
• Festing MFW, Altman DG. Guidelines for the design and statistical analysis of experiments using laboratory animals. ILAR J. 2002;43(4):244–257. doi:10.1093/ilar.43.4.244
   PubMedGoogle Scholar
• Canadian Council on Animal Care. CCAC Guidelines: Mice. Canadian Council on Animal Welfare; 2019:1–127.
   Google Scholar
• Document D, Of P, Test THE, On I. October 2001 OECD guideline for testing of chemicals; 2001:1–11.
   Google Scholar
• Chinedu E, Arome D, Ameh FS. A new method for determining acute toxicity in animal models. Toxicol Int. 2013;20(3):224–226. doi:10.4103/0971-6580.121674
   PubMedGoogle Scholar
• Huang H, Jin WW, Huang M, et al. Gentamicin-induced acute kidney injury in an animal model involves programmed necrosis of the collecting duct. J Am Soc Nephrol. 2020;31(9):2097–2115. doi:10.1681/ASN.2019020204
   PubMed Web of Science ®Google Scholar
• Ali BH. Effect of dimethyl sulfoxide on gentamicin-induced nephrotoxicity in rats. Hum Exp Toxicol. 2001;20(4):199–203. doi:10.1191/096032701678766859
   PubMed Web of Science ®Google Scholar
• Kitchens JL. The effects of blood storage time on the accuracy of comprehensive metabolic panel results. Maryv Coll. 2006;2006:1.
   Google Scholar
• Stevens M, Oltean S. Assessment of kidney function in mouse models of glomerular disease. J Vis Exp. 2018;2018(136):1–10.
   Google Scholar
• Shepherd C. Guidelines for collection of blood from laboratory animals; 2017:1–5.
   Google Scholar
• Morales AI, Buitrago JM, Santiago JM, Fernández-Tagarro M, López-Novoa JM, Pérez-Barriocanal F. Protective effect of trans-resveratrol on gentamicin-induced nephrotoxicity. Antioxid Redox Signal. 2002;4(6):893–898. doi:10.1089/152308602762197434
   PubMed Web of Science ®Google Scholar
• Lau SK. Basic and advanced laboratory techniques in histopathology and cytology. J Histotechnol. 2019;42:52. doi:10.1080/01478885.2019.1559501
   Google Scholar
• Slaoui M, Fiette L. Histopathology procedures: from tissue sampling to histopathological evaluation. Methods Mol Biol. 2011;691(January):69–82.
   PubMedGoogle Scholar
• Perazella MA. Pharmacology behind common drug nephrotoxicities. Clin J Am Soc Nephrol. 2018;13(12):1897–1908. doi:10.2215/CJN.00150118
   PubMed Web of Science ®Google Scholar
• Tam VH, Kabbara S, Vo G, Schilling AN, Coyle EA. Comparative pharmacodynamics of gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2006;50(8):2626–2631. doi:10.1128/AAC.01165-05
   PubMed Web of Science ®Google Scholar
• Abouzed TK, Sherif EAE, Barakat MES, et al. Assessment of gentamicin and cisplatin-induced kidney damage mediated via necrotic and apoptosis genes in albino rats. BMC Vet Res. 2021;17(1):1–9. doi:10.1186/s12917-021-03023-4
   PubMed Web of Science ®Google Scholar
• Kedir WM, Dubiwak AD, Ahmed ET. Nephroprotective effect of Asparagus africanus Lam. Root Extract against Gentamicin-Induced Nephrotoxicity in Swiss Albino Mice. J Toxicol. 2022;2022(4):8.
   Google Scholar
• Karahan I, Ateşşahin A, Yilmaz S, Çeribaşi AO, Sakin F. Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicology. 2005;215(3):198–204. doi:10.1016/j.tox.2005.07.007
   PubMed Web of Science ®Google Scholar
• Jeyanthi T, Subramanian P. Nephroprotective effect of withania somnifera: a dose-dependent study. Ren Fail. 2009;31(9):814–821. doi:10.3109/08860220903150320
   PubMed Web of Science ®Google Scholar
• Sadidi M, Bakhtiyari M, Alirezaei A. Effects of the Portulaca oleracea extract on gentamicin-induced nephrotoxicity in male rats. J Nuts. 2018;9(2):92–100.
   Google Scholar
• Ansar S, Hamed S, AlGhosoon HT, AlSaedan RA, Iqbal M. The protective effect of rutin against renal toxicity induced by lead acetate. Toxin Rev. 2016;35(1–2):58–62. doi:10.3109/15569543.2016.1155623
   Web of Science ®Google Scholar
• Zhu W, Pang M, Dong L, Huang X, Wang S, Zhou L. Anti-inflammatory and immunomodulatory effects of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats. Life Sci. 2012;91(11–12):369–376. doi:10.1016/j.lfs.2012.08.013
   PubMed Web of Science ®Google Scholar
• Bouhrim M, Bencheikh N, Imtara H, et al. Protective effect of Opuntia dillenii (Ker Gawl.) Haw. Seed Oil on gentamicin-induced nephrotoxicity: a biochemical and histological analysis. Sci World J. 2021;2021(2):1–45. doi:10.1155/2021/2173012
   Google Scholar
• Raghavan V, Weisz OA. Discerning the role of mechanosensors in regulating proximal tubule function. Am J Physiol Ren Physiol. 2015;310(1):F1–F5. doi:10.1152/ajprenal.00373.2015
   PubMed Web of Science ®Google Scholar
• Rhee WJ, Lee SY, Lee JH, et al. The effect of high concentration of magnesium with ropivacaine, gentamicin, rocuronium, and their combination on neuromuscular blockade. Korean J Anesthesiol. 2015;3(1):12–56.
   Google Scholar
• Kidney Health Australia. Fact sheet calcium and phosphate balance with kidney disease; 2017. Available from: www.kidney.org.au. Accessed March 20, 2024.
   Google Scholar
• Ali BH, Gayoum AAA, Bashir AA. Gentamicin nephrotoxicity in rat: some biochemical correlates. Pharmacol Toxicol. 1992;70(6):419–423. doi:10.1111/j.1600-0773.1992.tb00500.x
   PubMedGoogle Scholar
• Feyissa T, Asres K, Engidawork E. Renoprotective effects of the crude extract and solvent fractions of the leaves of Euclea divinorum Hierns against gentamicin-induced nephrotoxicity in rats. J Ethnopharmacol. 2013;145(3):758–766. doi:10.1016/j.jep.2012.12.006
   PubMed Web of Science ®Google Scholar
• Israili ZH, Lyoussi B. Ethnopharmacology of the plants of genus Ajuga. Pak J Pharm Sci. 2009;22:425–462.
   PubMed Web of Science ®Google Scholar
• Liu Y, Huang Y, Xiao Z, Ren X, Yang C. Guide for the care and use of laboratory animals Eighth Edition. In: Fenmo Yejin Cailiao Kexue Yu Gongcheng/Materials Science and Engineering of Powder Metallurgy. Vol. 21. national academies press; 2016:408–414.
   Google Scholar
• Romare J. Principles and approaches in ethics assessment human subjects research; 2015:1–14.
   Google Scholar