Utilizing research into electrical double layers as a basis for the development of label-free biosensors based on nanomaterial transistors

References

• Lyon LA, Musick MD, Natan MJ. Colloidal au-enhanced surface plasmon resonance immunosensing. Anal Chem. 1998;70:5177–5183.
   PubMed Web of Science ®Google Scholar
• Nice EC, Catimel B. Instrumental biosensors: new perspectives for the analysis of biomolecular interactions. Bioessays. 1999;21:339–352.
   PubMed Web of Science ®Google Scholar
• Tess ME, Cox JA. Chemical and biochemical sensors based on advances in materials chemistry. J Pharm Biomed Anal. 1999;19:55–68.
   PubMed Web of Science ®Google Scholar
• Brekkan E, Lundqvist A, Lundahl P. Immobilized membrane vesicle or proteoliposome affinity chromatography. Frontal analysis of interactions of cytochalasin b and d-glucose with the human red cell glucose transporter. Biochemistry. 1996;35:12141–12145.
   Web of Science ®Google Scholar
• Willardson BM, Wilkins JF, Rand TA, et al. Development and testing of a bacterial biosensor for toluene-based environmental contaminants. Appl Environ Microbiol. 1998;64:1006–1012.
   PubMed Web of Science ®Google Scholar
• Okuno J, Maehashi K, Kerman K, et al. Label-free immunosensor for prostate-specific antigen based on single-walled carbon nanotube array-modified microelectrodes. Biosens Bioelectron. 2007;22:2377–2381.
   PubMed Web of Science ®Google Scholar
• Drummond TG, Hill MG, Barton JK. Electrochemical DNA sensors. Nat Biotechnol. 2003;21:1192–1199.
   PubMed Web of Science ®Google Scholar
• Cheng AKH, Ge B, Yu H-Z. Aptamer-based biosensors for label-free voltammetric detection of lysozyme. Anal Chem. 2007;79:5158–5164.
   PubMed Web of Science ®Google Scholar
• Daniels JS, Pourmand N. Label-free impedance biosensors: opportunities and challenges. Electroanalysis. 2007;19:1239–1257.
   PubMed Web of Science ®Google Scholar
• Macdonald DD. Reflections on the history of electrochemical impedance spectroscopy. Electrochim Acta. 2006;51:1376–1388.
   Web of Science ®Google Scholar
• Minot ED, Janssens AM, Heller I, et al. Carbon nanotube biosensors: the critical role of the reference electrode. Appl Phys Lett. 2007;91:093507.
   Web of Science ®Google Scholar
• Kim A, Ah CS, Yu HY, et al. Ultrasensitive, label-free, and real-time immunodetection using silicon field-effect transistors. Appl Phys Lett. 2007;91:103901.
   Web of Science ®Google Scholar
• Okamoto S, Ohno Y, Maehashi K, et al. Immunosensors based on graphene field-effect transistors fabricated using antigen-binding fragment. Jpn J Appl Phys. 2012;51:06FD08.
   Web of Science ®Google Scholar
• Novoselov KS, Geim AK, Morozov SV, et al. Electric field effect in atomically thin carbon films. Science. 2004;306:666–669.
   PubMed Web of Science ®Google Scholar
• Maehashi K, Sofue Y, Okamoto S, et al. Selective ion sensors based on ionophore-modified graphene field-effect transistors. Sensors Actuators B: Chem. 2013;187:45–49.
   Web of Science ®Google Scholar
• Debye P. Dieletric properties of pure liquids. Chem Rev. 1936;19:171–182.
   Google Scholar
• Rudikoff S, Potter M. Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins. Proc Natl Acad Sci U S A. 1976;73:2109–2112.
   PubMed Web of Science ®Google Scholar
• Teillaud J, Desaymard C, Giusti A, et al. Monoclonal antibodies reveal the structural basis of antibody diversity. Science. 1983;222:721–726.
   PubMed Web of Science ®Google Scholar
• Stern E, Wagner R, Sigworth FJ, et al. Importance of the debye screening length on nanowire field effect transistor sensors. Nano Lett. 2007;7:3405–3409.
   PubMed Web of Science ®Google Scholar
• Zheng G, Patolsky F, Cui Y, et al. Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nat Biotechnol. 2005;23:1294–1301.
   PubMed Web of Science ®Google Scholar
• Patolsky F, Zheng G, Hayden O, et al. Electrical detection of single viruses. Proc Natl Acad Sci U S A. 2004;101:14017–14022.
   PubMed Web of Science ®Google Scholar
• Wang WU, Chen C, Lin K-h, et al. Label-free detection of small-molecule–protein interactions by using nanowire nanosensors. Proc Natl Acad Sci U S A. 2005;102:3208–3212.
   PubMed Web of Science ®Google Scholar
• Tuerk C, Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science. 1990;249:505–510.
   PubMed Web of Science ®Google Scholar
• Robertson DL, Joyce GF. Selection in vitro of an rna enzyme that specifically cleaves single-stranded DNA. Nature. 1990;344:467–468.
   PubMed Web of Science ®Google Scholar
• Ellington AD, Szostak JW. In vitro selection of rna molecules that bind specific ligands. Nature. 1990;346:818–822.
   PubMed Web of Science ®Google Scholar
• O’Sullivan C. Aptasensors: the future of biosensing? Anal Bioanal Chem. 2002;372:44–48.
   PubMed Web of Science ®Google Scholar
• So H-M, Won K, Kim YH, et al. Single-walled carbon nanotube biosensors using aptamers as molecular recognition elements. J Am Chem Soc. 2005;127:11906–11907.
   PubMed Web of Science ®Google Scholar
• Maehashi K, Katsura T, Kerman K, et al. Label-free protein biosensor based on aptamer-modified carbon nanotube field-effect transistors. Anal Chem. 2007;79:782–787.
   PubMed Web of Science ®Google Scholar
• Ohno Y, Maehashi K, Matsumoto K. Label free biosensors based on aptamer modified graphene field effect transistors. J Am Chem Soc. 2010;132:18012–18013.
   PubMed Web of Science ®Google Scholar
• Maehashi K, Matsumoto K. Label-free electrical detection using carbon nanotube-based biosensors. Sensors. 2009;9:5368–5378.
   Web of Science ®Google Scholar
• Maehashi K, Matsumoto K, Takamura Y, et al. Aptamer-based label-free immunosensors using carbon nanotube field-effect transistors. Electroanalysis. 2009;21:1285–1290.
   Web of Science ®Google Scholar
• Pilz I, Schwarz E, Palm W. Small-angle x-ray studies of the fab and fc fragments from the human immunoglobulin molecule kol. Eur J Biochem. 1976;71:239–247.
   PubMedGoogle Scholar
• Ng PC, Osawa Y. Preparation and characterization of the fab and F(ab′)2 fragments of an aromatase activity-suppressing monoclonal antibody. Steroids. 1997;62:776–781.
   Web of Science ®Google Scholar
• Kim JP, Lee BY, Hong S, et al. Ultrasensitive carbon nanotube-based biosensors using antibody-binding fragments. Anal Biochem. 2008;381:193–198.
   PubMed Web of Science ®Google Scholar
• Li C, Curreli M, Lin H, et al. Complementary detection of prostate-specific antigen using In2O3 nanowires and carbon nanotubes. J Am Chem Soc. 2005;127:12484–12485.
   PubMed Web of Science ®Google Scholar
• Stern E, Klemic JF, Routenberg DA, et al. Label-free immunodetection with CMOS-compatible semiconducting nanowires. Nature. 2007;445:519–522.
   PubMed Web of Science ®Google Scholar
• Ohno Y, Maehashi K, Yamashiro Y, et al. Electrolyte-gated graphene field-effect transistors for detecting ph and protein adsorption. Nano Lett. 2009;9:3318–3322.
   PubMed Web of Science ®Google Scholar
• Kim JP, Lee BY, Lee J, et al. Enhancement of sensitivity and specificity by surface modification of carbon nanotubes in diagnosis of prostate cancer based on carbon nanotube field effect transistors. Biosens Bioelectron. 2009;24:3372–3378.
   Web of Science ®Google Scholar
• Reyes DR, Iossifidis D, Auroux P-A, et al. Micro total analysis systems. 1. Introduction, theory, and technology. Anal Chem. 2002;74:2623–2636.
   PubMed Web of Science ®Google Scholar
• Manz A, Graber N, Widmer HM. Miniaturized total chemical analysis systems: a novel concept for chemical sensing. Sensors Actuators B: Chem. 1990;1:244–248.
   Web of Science ®Google Scholar
• Harrison DJ, Fluri K, Seiler K, et al. Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip. Science. 1993;261:895–897.
   PubMed Web of Science ®Google Scholar
• Hahm J-I, Lieber CM. Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors. Nano Lett. 2003;4:51–54.
   Web of Science ®Google Scholar
• He RX, Lin P, Liu ZK, et al. Solution-gated graphene field effect transistors integrated in microfluidic systems and used for flow velocity detection. Nano Lett. 2012;12:1404–1409.
   Web of Science ®Google Scholar
• Tsujita Y, Maehashi K, Matsumoto K, et al. Carbon nanotube amperometric chips with pneumatic micropumps. Jpn J Appl Phys. 2008;47:2064–2067.
   Web of Science ®Google Scholar
• Tsujita Y, Maehashi K, Matsumoto K, et al. Microfluidic and label-free multi-immunosensors based on carbon nanotube microelectrodes. Jpn J Appl Phys. 2009;48:06FJ02.
   Web of Science ®Google Scholar
• Chang H-K, Ishikawa FN, Zhang R, et al. Rapid, label-free, electrical whole blood bioassay based on nanobiosensor systems. ACS Nano. 2011;5:9883–9891.
   Web of Science ®Google Scholar
• Patolsky F, Zheng G, Lieber CM. Fabrication of silicon nanowire devices for ultrasensitive, label-free, real-time detection of biological and chemical species. Nature Protoc. 2006;1:1711–1724.
   PubMed Web of Science ®Google Scholar
• Li Z, Chen Y, Li X, et al. Sequence-specific label-free DNA sensors based on silicon nanowires. Nano Lett. 2004;4:245–247.
   Web of Science ®Google Scholar
• Saito R, Fujita M, Dresselhaus G, et al. Electronic structure of chiral graphene tubules. Appl Phys Lett. 1992;60:2204–2206.
   Web of Science ®Google Scholar
• Tans SJ, Verschueren ARM, Dekker C. Room-temperature transistor based on a single carbon nanotube. Nature. 1998;393:49–52.
   Web of Science ®Google Scholar
• Martel R, Schmidt T, Shea HR, et al. Single- and multi-wall carbon nanotube field-effect transistors. Appl Phys Lett. 1998;73:2447–2449.
   Web of Science ®Google Scholar
• Kong J, Soh HT, Cassell AM, et al. Synthesis of individual single-walled carbon nanotubes on patterned silicon wafers. Nature. 1998;395:878–881.
   Web of Science ®Google Scholar
• Kaminishi D, Ozaki H, Ohno Y, et al. Air-stable n-type carbon nanotube field-effect transistors with Si3N4 passivation films fabricated by catalytic chemical vapor deposition. Appl Phys Lett. 2005;86:113115.
   Web of Science ®Google Scholar
• Chen RJ, Bangsaruntip S, Drouvalakis KA, et al. Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proc Natl Acad Sci U S A. 2003;100:4984–4989.
   PubMed Web of Science ®Google Scholar
• Star A, Gabriel J-CP, Bradley K, et al. Electronic detection of specific protein binding using nanotube fet devices. Nano Lett. 2003;3:459–463.
   Web of Science ®Google Scholar
• Gui EL, Li L-J, Zhang K, et al. DNA sensing by field-effect transistors based on networks of carbon nanotubes. J Am Chem Soc. 2007;129:14427–14432.
   Web of Science ®Google Scholar
• So H-M, Park D-W, Jeon E-K, et al. Detection and titer estimation of escherichia coli using aptamer-functionalized single-walled carbon-nanotube field-effect transistors. Small. 2008;4:197–201.
   PubMed Web of Science ®Google Scholar
• Han S, Liu X, Zhou C. Template-free directional growth of single-walled carbon nanotubes on a- and r-plane sapphire. J Am Chem Soc. 2005;127:5294–5295.
   PubMed Web of Science ®Google Scholar
• Kang SJ, Kocabas C, Ozel T, et al. High-performance electronics using dense, perfectly aligned arrays of single-walled carbon nanotubes. Nat Nanotechnol. 2007;2:230–236.
   PubMed Web of Science ®Google Scholar
• Okuda S, Okamoto S, Ohno Y, et al. Horizontally aligned carbon nanotubes on a quartz substrate for chemical and biological sensing. J Phys Chem C 2012;116:19490–19495.
   Web of Science ®Google Scholar
• Chen RJ, Zhang Y, Wang D, et al. Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J Am Chem Soc. 2001;123:3838–3839.
   PubMed Web of Science ®Google Scholar
• Geim AK, Novoselov KS. The rise of graphene. Nat Mater. 2007;6:183–191.
   PubMed Web of Science ®Google Scholar
• Balandin AA, Ghosh S, Bao W, et al. Superior thermal conductivity of single-layer graphene. Nano Lett. 2008;8:902–907.
   PubMed Web of Science ®Google Scholar
• Bolotin K, Sikes K, Jiang Z, et al. Ultrahigh electron mobility in suspended graphene. Solid State Commun. 2008;146:351–355.
   Web of Science ®Google Scholar
• Nair RR, Blake P, Grigorenko AN, et al. Fine structure constant defines visual transparency of graphene. Science. 2008;320:1308.
   PubMed Web of Science ®Google Scholar
• Lin Y-M, Jenkins KA, Valdes-Garcia A, et al. Operation of graphene transistors at gigahertz frequencies. Nano Lett. 2009;9:422–426.
   PubMed Web of Science ®Google Scholar
• Liao L, Lin YC, Bao M, et al. High-speed graphene transistors with a self-aligned nanowire gate. Nature. 2010;467:305–308.
   PubMed Web of Science ®Google Scholar
• Schedin F, Geim AK, Morozov SV, et al. Detection of individual gas molecules adsorbed on graphene. Nat Mater. 2007;6:652–655.
   PubMed Web of Science ®Google Scholar
• Novoselov KS, Geim AK, Morozov SV, et al. Two-dimensional gas of massless dirac fermions in graphene. Nature. 2005;438:197–200.
   PubMed Web of Science ®Google Scholar
• Sofue Y, Ohno Y, Maehashi K, et al. Highly sensitive electrical detection of sodium ions based on graphene field-effect transistors. Jpn J Appl Phys. 2011;50:06GE07.
   Google Scholar
• Cheng Z, Li Q, Li Z, et al. Suspended graphene sensors with improved signal and reduced noise. Nano Lett. 2010;10:1864–1868.
   PubMed Web of Science ®Google Scholar
• Gómez-Navarro C, Weitz RT, Bittner AM, et al. Electronic transport properties of individual chemically reduced graphene oxide sheets. Nano Lett. 2007;7:3499–3503.
   PubMed Web of Science ®Google Scholar
• Mohanty N, Berry V. Graphene-based single-bacterium resolution biodevice and DNA transistor: interfacing graphene derivatives with nanoscale and microscale biocomponents. Nano Lett. 2008;8:4469–4476.
   PubMed Web of Science ®Google Scholar
• Mao S, Lu G, Yu K, et al. Specific protein detection using thermally reduced graphene oxide sheet decorated with gold nanoparticle-antibody conjugates. Adv Mater. 2010;22:3521–3526.
   PubMed Web of Science ®Google Scholar
• Ohta T, Bostwick A, Seyller T, et al. Controlling the electronic structure of bilayer graphene. Science. 2006;313:951–954.
   PubMed Web of Science ®Google Scholar
• Berger C, Song Z, Li X, et al. Electronic confinement and coherence in patterned epitaxial graphene. Science. 2006;312:1191–1196.
   PubMed Web of Science ®Google Scholar
• Ang PK, Chen W, Wee AT, et al. Solution-gated epitaxial graphene as ph sensor. J Am Chem Soc. 2008;130:14392–14393.
   PubMed Web of Science ®Google Scholar
• Reina A, Jia X, Ho J, et al. Large area, few-layer graphene films on arbitrary substrates by chemical vapor deposition. Nano Lett. 2008;9:30–35.
   Web of Science ®Google Scholar
• Li X, Cai W, Colombo L, et al. Evolution of graphene growth on Ni and Cu by carbon isotope labeling. Nano Lett. 2009;9:4268–4272.
   PubMed Web of Science ®Google Scholar
• Yu Q, Lian J, Siriponglert S, et al. Graphene segregated on Ni surfaces and transferred to insulators. Appl Phys Lett. 2008;93:113103–113103.
   Web of Science ®Google Scholar
• Li X, Cai W, An J, et al. Large-area synthesis of high-quality and uniform graphene films on copper foils. Science. 2009;324:1312–1314.
   PubMed Web of Science ®Google Scholar
• Huang Y, Dong X, Shi Y, et al. Nanoelectronic biosensors based on CVD grown graphene. Nanoscale. 2010;2:1485–1488.
   PubMed Web of Science ®Google Scholar
• Kwak YH, Choi DS, Kim YN, et al. Flexible glucose sensor using CVD-grown graphene-based field effect transistor. Biosens Bioelectron. 2012;37:82–87.
   PubMed Web of Science ®Google Scholar
• Zaifuddin NM, Okamoto S, Ikuta T, et al. pH sensor based on chemical-vapor-deposition-synthesized graphene transistor array. Jpn J Appl Phys. 2013;52:06GK04.
   Web of Science ®Google Scholar
• Park J-U, Nam S, Lee M-S, et al. Synthesis of monolithic graphene–graphite integrated electronics. Nat Mater. 2012;11:120–125.
   Web of Science ®Google Scholar