Efflux pump inhibitor chlorpromazine effectively increases the susceptibility of Escherichia coli to antimicrobial peptide Brevinin-2CE

References

• Boparai JK, Sharma PK. Mini Review on antimicrobial peptides, sources, mechanism and recent applications. Protein Pept. Lett. 27(1), 4–16 (2020).
   PubMed Web of Science ®Google Scholar
• Rai A, Ferrao R, Palma P et al. Antimicrobial peptide-based materials: opportunities and challenges. J. Mater Chem. B. 10(14), 2384–2429 (2022).
   PubMed Web of Science ®Google Scholar
• Büyükkiraz ME, Kesmen Z. Antimicrobial peptides (AMPs): a promising class of antimicrobial compounds. J. Appl. Microbiol. 132(3), 1573–1596 (2022).
   PubMed Web of Science ®Google Scholar
• Moravej H, Moravej Z, Yazdanparast M et al. Antimicrobial peptides: features, action, and their resistance mechanisms in bacteria. Microb. Drug Resist. 24(6), 747–767 (2018).
   PubMed Web of Science ®Google Scholar
• Mhlongo JT, Waddad AY, Albericio F et al. Antimicrobial peptide synergies for fighting infectious diseases. Adv. Sci. (Weinh) 10(26), e2300472 (2023).
   PubMedGoogle Scholar
• Konwar AN, Hazarika SN, Bharadwaj P et al. Emerging non-traditional approaches to combat antibiotic resistance. Curr. Microbiol. 79(11), 330 (2022).
   PubMed Web of Science ®Google Scholar
• Blodkamp S, Kadlec K, Gutsmann T et al. Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus. Vet. Microbiol. 200, 52–58 (2017).
   PubMed Web of Science ®Google Scholar
• Patocka J, Nepovimova E, Klimova B et al. Antimicrobial peptides: amphibian host defense peptides. Curr. Med. Chem. 26(32), 5924–5946 (2019).
   PubMed Web of Science ®Google Scholar
• Zhao J, Sun Y, Li Z et al. Molecular cloning of novel antimicrobial peptide genes from the skin of the Chinese brown frog, Rana chensinensis. Zoolog. Sci. 28(2), 112–117 (2011).
   PubMed Web of Science ®Google Scholar
• Zhang Y, Liu YK, Sun Y et al. In vitro synergistic activities of antimicrobial peptide brevinin-2CE with five kinds of antibiotics against multidrug-resistant clinical isolates. Curr. Microbiol. 68(6), 685–692 (2014).
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang XY, Sun Y et al. Truncated analog Brevinin2-CE-N26V5K: revelation the augmentation of antimicrobial activity. World J. Microbiol. Biotechnol. 38(9), 162 (2022).
   PubMed Web of Science ®Google Scholar
• Perron GG, Zasloff M, Bell G. Experimental evolution of resistance to an antimicrobial peptide. Proc. Biol. Sci. 273(1583), 251–256 (2006).
   PubMed Web of Science ®Google Scholar
• Shazely BEL, Yu GZ, Johnston PR et al. Resistance evolution against antimicrobial peptides in Staphylococcus aureus alters pharmacodynamics beyond the MIC. Front. Microbiol. 11, 103 (2020).
   PubMedGoogle Scholar
• Jiang Y, Chen B, Duan CL et al. Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system. Appl. Environ. Microbiol. 81(7), 2506–2514 (2015).
   PubMed Web of Science ®Google Scholar
• Andersson DI, Hughes D. Microbiological effects of sublethal levels of antibiotics. Nat. Rev. Microbiol. 12(7), 465–478 (2014).
   PubMed Web of Science ®Google Scholar
• Oh JT, Cajal Y, Skowronska EM et al. Cationic peptide antimicrobials induce selective transcription of micF and osmY in Escherichia coli. Biochim. Biophys. Acta 1463(1), 43–54 (2000).
   PubMed Web of Science ®Google Scholar
• Tomasinsig L, Scocchi M, Mettulio R et al. Genome-wide transcriptional profiling of the Escherichia coli response to a proline-rich antimicrobial peptide. Antimicrob. Agents Chemother. 48(9), 3260–3267 (2004).
   PubMed Web of Science ®Google Scholar
• Hong RW, Shchepetov M, Weiser JN et al. Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A. Antimicrob. Agents Chemother. 47(1), 1–6 (2003).
   PubMed Web of Science ®Google Scholar
• Bolt EL, Jenkins T, Russo VM et al. Identification of Escherichia coli ygaQ and rpmG as novel mitomycin C resistance factors implicated in DNA repair. Biosci. Rep. 36(1), e00290 (2015).
   PubMedGoogle Scholar
• Zhou J, Cai Y, Liu Y et al. Breaking down the cell wall: still an attractive antibacterial strategy. Front Microbiol. 13, 952633 (2022).
   PubMed Web of Science ®Google Scholar
• Roy A, Ray S. An in-silico study to understand the effect of lineage diversity on cold shock response: unveiling protein-RNA interactions among paralogous CSPs of E. coli. 3 Biotech. 13(7), 236 (2023).
   PubMedGoogle Scholar
• Weber MM, French CL, Barnes MB et al. A previously uncharacterized gene, yjfO (bsmA), influences Escherichia coli biofilm formation and stress response. Microbiology (Reading) 156(Pt 1), 139–147 (2010).
   PubMedGoogle Scholar
• Cattoir V, Pourbaix A, Magnan M et al. Novel chromosomal mutations responsible for fosfomycin resistance in Escherichia coli. Front. Microbiol. 11, 575031 (2020).
   PubMed Web of Science ®Google Scholar
• Hrovat K, Zupančič JČ, Seme K et al. QAC Resistance genes in ESBL-Producing E. coli isolated from patients with lower respiratory tract infections in the central slovenia region-a 21-year survey. Trop. Med. Infect Dis. 8(5), 273 (2023).
   PubMedGoogle Scholar
• Alobaidallah MSA, García V, Wellner SM et al. Enhancing the efficacy of chloramphenicol therapy for Escherichia coli by targeting the secondary resistome. Antibiotics (Basel) 13(1), 73 (2024).
   PubMed Web of Science ®Google Scholar
• Fan Z, Fu T, Li Z et al. The role of integration host factor in biofilm and virulence of high-alcohol-producing Klebsiella pneumoniae. Microbiol. Spectr. 11(5), e0117023 (2023).
   PubMed Web of Science ®Google Scholar
• Hyun JC, Monk JM, Szubin R et al. Global pathogenomic analysis identifies known and candidate genetic antimicrobial resistance determinants in twelve species. Nat. Commun. 14(1), 7690 (2023).
   PubMed Web of Science ®Google Scholar
• Ratliff AC, Buchanan SK, Celia H. Ton motor complexes. Curr. Opin. Struct. Biol. 67, 95–100 (2021).
   PubMed Web of Science ®Google Scholar
• Sudharsan M, Rajendra Prasad N, Rajendrasozhan S. Bacterial redox response factors in the management of environmental oxidative stress. World J. Microbiol. Biotechnol. 39(1), 11 (2022).
   PubMed Web of Science ®Google Scholar
• Cardoza E, Singh H. Involvement of CspC in response to diverse environmental stressors in Escherichia coli. J. Appl. Microbiol. 132(2), 785–801 (2022).
   PubMed Web of Science ®Google Scholar
• Munita JM, Arias CA. Mechanisms of antibiotic resistance. Microbiol. Spectr. 4(2), 101128 (2016).
   Web of Science ®Google Scholar
• Shi DY, Hao H, Wei ZL et al. Combined exposure to non-antibiotic pharmaceutics and antibiotics in the gut synergistically promote the development of multi-drug-resistance in Escherichia coli. Gut Microbes 14(1), 2018901 (2022).
   PubMed Web of Science ®Google Scholar
• Slipski CJ, Jamieson TR, Zhanel GG et al. Riboswitch-associated guanidinium-selective efflux pumps frequently transmitted on proteobacterial plasmids increase Escherichia coli biofilm tolerance to disinfectants. J. Bacteriol. 202(23), e00104–20 (2020).
   PubMed Web of Science ®Google Scholar
• Chiu CH, Lee JJ, Wang MH et al. Genetic analysis and plasmid-mediated blaCMY-2 in Salmonella and Shigella and the ceftriaxone susceptibility regulated by the ISEcp-1 tnpA-blaCMY-2-blc-sugE. J. Microbiol. Immunol. Infect. 54(4), 649–657 (2021).
   PubMedGoogle Scholar
• He GX, Zhang C, Crow RR et al. SugE, a new member of the SMR family of transporters, contributes to antimicrobial resistance in Enterobacter cloacae. Antimicrob. Agents Chemother. 55(8), 3954–3957 (2011).
   PubMed Web of Science ®Google Scholar
• Paul D, Mallick S, Das S et al. Colistin induced assortment of antimicrobial resistance in a clinical isolate of Acinetobacter baumannii SD01. Infect Disord. Drug Targets 20(4), 501–505 (2020).
   PubMedGoogle Scholar
• Zou LK, Meng JH, McDermott PF et al. Presence of disinfectant resistance genes in Escherichia coli isolated from retail meats in the USA. J. Antimicrob. Chemother. 69(10), 2644–2649 (2014).
   PubMed Web of Science ®Google Scholar
• Teelucksingh T, Thompson LK, Cox G. The Evolutionary conservation of Escherichia coli drug efflux pumps supports physiological functions. J. Bacteriol. 202(22), e00367–20 (2020).
   PubMed Web of Science ®Google Scholar
• Grimsey EM, Piddock LJV. Do phenothiazines possess antimicrobial and efflux inhibitory properties? FEMS Microbiol. Rev. 43(6), 577–590 (2019).
   PubMed Web of Science ®Google Scholar
• Reens AL, Crooks AL, Su CC et al. A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load. PLOS Pathog. 14(6), e1007115 (2018).
   PubMed Web of Science ®Google Scholar
• El-Sayed Ahmed MAE, Zhong LL, Shen C et al. Colistin and its role in the Era of antibiotic resistance: an extended review (2000–2019). Emerg. Microbes Infect. 9(1), 868–885 (2020).
   PubMed Web of Science ®Google Scholar
• Baron SA, Rolain JM. Efflux pump inhibitor CCCP to rescue colistin susceptibility in mcr-1 plasmid-mediated colistin-resistant strains and Gram-negative bacteria. J. Antimicrob. Chemother. 73(7), 1862–1871 (2018).
   PubMed Web of Science ®Google Scholar
• Zoaiter M, Zeaiter Z, Mediannikov O et al. Carbonyl cyanide 3-chloro phenyl hydrazone (CCCP) restores the colistin sensitivity in Brucella intermedia. Int. J. Mol. Sci. 24(3), 2106 (2023).
   PubMed Web of Science ®Google Scholar
• Sundaramoorthy S, Sivasubramanian A, Nagarajan S. Simultaneous inhibition of MarR by salicylate and efflux pumps by curcumin sensitizes colistin resistant clinical isolates of Enterobacteriaceae. Microb. Pathog. 148, 104445 (2020).
   PubMed Web of Science ®Google Scholar
• Cui XD, Zhang JK, Sun YW et al. Synergistic antibacterial activity of baicalin and EDTA in combination with colistin against colistin-resistant Salmonella. Poult. Sci. 102(2), 102346 (2023).
   PubMed Web of Science ®Google Scholar