Drug Design, Development and Therapy, Volume 17, Issue (2023)

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Drug Design, Development and Therapy, Volume 17, Issue (2023)

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ORIGINAL RESEARCH

Article
Binary Nanodrug-Delivery System Designed for Leukemia Therapy: Aptamer- and Transferrin-Codecorated Daunorubicin- and Luteolin-Coloaded Nanoparticles
Yuanyuan Zhu, Wei Zhang & Jing Chen
Pages: 1-13
Published online: 06 Jan 2023
AbstractforBinary Nanodrug-Delivery System Designed for Leukemia Therapy: Aptamer- and Transferrin-Codecorated Daunorubicin- and Luteolin-Coloaded Nanoparticles | Full Text | References | PDF (4.8 MB) | EPUB
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REVIEW

Review
Review on the Diverse Biological Effects of Glabridin
Jianhong Zhang, Xinhui Wu, Baiyin Zhong, Qicheng Liao, Xin Wang, Yuankang Xie & Xiao He
Pages: 15-37
Published online: 10 Jan 2023
AbstractforReview on the Diverse Biological Effects of Glabridin | Full Text | References | PDF (3.8 MB) | EPUB
  • 1075 Views
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ORIGINAL RESEARCH

Article
Network Pharmacology and Experimental Validation to Explore the Molecular Mechanisms of Compound Huangbai Liquid for the Treatment of Acne
Huifeng Di, Hui Liu, Shuna Xu, Na Yi & Guangchen Wei
Pages: 39-53
Published online: 11 Jan 2023
AbstractforNetwork Pharmacology and Experimental Validation to Explore the Molecular Mechanisms of Compound Huangbai Liquid for the Treatment of Acne | Full Text | References | PDF (10.4 MB) | EPUB
  • 406 Views
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Open Access
Article
Pharmacological Mechanism of Sancao Yuyang Decoction in the Treatment of Oral Mucositis Based on Network Pharmacology and Experimental Validation
Yunxia Liu, Yun Ye, Guanqun Xie, Yefeng Xu, Miao Cheng, Chunling Li, Mengqi Qu & Feiye Zhu
Pages: 55-74
Published online: 13 Jan 2023
AbstractforPharmacological Mechanism of Sancao Yuyang Decoction in the Treatment of Oral Mucositis Based on Network Pharmacology and Experimental Validation | Full Text | References | PDF (18.3 MB) | EPUB
  • 308 Views
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Open Access
Article
A Pharmacodynamic Evaluation of the Protective Effects of Roxadustat Against Hypoxic Injury at High Altitude
Qianwen Guo, Xue Li, Wenbin Li, Rong Wang, Anpeng Zhao & Zihan Wang
Pages: 75-85
Published online: 15 Jan 2023
AbstractforA Pharmacodynamic Evaluation of the Protective Effects of Roxadustat Against Hypoxic Injury at High Altitude | Full Text | References | PDF (5.3 MB) | EPUB
  • 273 Views
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Open Access
Article
The Benefits of Molnupiravir Treatment in Healthcare Facilities Patients with COVID-19
Shih-Lung Cheng, Ping-Huai Wang, Cheng-Yu Chang, Hsu-Hui Wang, Chung-Jen Wang & Kuan-Ming Chiu
Pages: 87-92
Published online: 19 Jan 2023
AbstractforThe Benefits of Molnupiravir Treatment in Healthcare Facilities Patients with COVID-19 | Full Text | References | PDF (374.8 KB) | EPUB
  • 337 Views
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Open Access
Article
Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening
Julita Chlebowicz, Radha Akella, John M Humphreys, Haixia He, Ashari R Kannangara, Shuguang Wei, Bruce Posner & Elizabeth J Goldsmith
Pages: 93-105
Published online: 20 Jan 2023
AbstractforIdentification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening | Full Text | References | PDF (7.7 MB) | EPUB
  • 279 Views
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Open Access
Article
A Novel Approach Based on Gut Microbiota Analysis and Network Pharmacology to Explain the Mechanisms of Action of Cichorium intybus L. Formula in the Improvement of Hyperuricemic Nephropathy in Rats
Mukaram Amatjan, Na Li, Pengke He, Boheng Zhang, Xianyan Mai, Qianle Jiang, Haochen Xie & Xiaoni Shao
Pages: 107-128
Published online: 20 Jan 2023
AbstractforA Novel Approach Based on Gut Microbiota Analysis and Network Pharmacology to Explain the Mechanisms of Action of Cichorium intybus L. Formula in the Improvement of Hyperuricemic Nephropathy in Rats | Full Text | References | PDF (16.8 MB) | EPUB
  • 487 Views
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CLINICAL TRIAL REPORT

Effect of Remimazolam on Postoperative Delirium in Older Adult Patients Undergoing Orthopedic Surgery: A Prospective Randomized Controlled Clinical Trial
Jin-Jin Yang, Lei Lei, Di Qiu, Sai Chen, Li-Ka Xing, Jing-Wei Zhao, Yuan-Yuan Mao & Jian-Jun Yang
Pages: 143-153
Published online: 20 Jan 2023
AbstractforEffect of Remimazolam on Postoperative Delirium in Older Adult Patients Undergoing Orthopedic Surgery: A Prospective Randomized Controlled Clinical Trial | Full Text | References | PDF (1.9 MB) | EPUB
  • 608 Views
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ORIGINAL RESEARCH

Article
10-Gingerol Enhances the Effect of Taxol in Triple-Negative Breast Cancer via Targeting ADRB2 Signaling
Yuqi Liang, Guosong Wu, Tianyu Luo, Haimei Xie, Qian Zuo, Ping Huang, Huachao Li, Liushan Chen, Hai Lu & Qianjun Chen
Pages: 129-142
Published online: 20 Jan 2023
Abstractfor10-Gingerol Enhances the Effect of Taxol in Triple-Negative Breast Cancer via Targeting ADRB2 Signaling | Full Text | References | PDF (10.1 MB) | EPUB
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REVIEW

Review
Bulevirtide in the Treatment of Hepatitis Delta: Drug Discovery, Clinical Development and Place in Therapy
Vicente Soriano, Victor Moreno-Torres, Ana Treviño, Octavio Corral & Carmen de Mendoza
Pages: 155-166
Published online: 21 Jan 2023
AbstractforBulevirtide in the Treatment of Hepatitis Delta: Drug Discovery, Clinical Development and Place in Therapy | Full Text | References | PDF (1 MB) | EPUB
  • 605 Views
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ORIGINAL RESEARCH

Article
Evaluation of Chitosan-Oleuropein Nanoparticles on the Durability of Dentin Bonding
Shuya Zhao, Yunyang Zhang, Yun Chen, Xianghui Xing, Yu Wang & Guofeng Wu
Pages: 167-180
Published online: 22 Jan 2023
AbstractforEvaluation of Chitosan-Oleuropein Nanoparticles on the Durability of Dentin Bonding | Full Text | References | PDF (3.6 MB) | EPUB
  • 321 Views
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REVIEW

Review
Research Progress on the Efficacy and Safety of Spironolactone in Reversing Left Ventricular Hypertrophy in Hemodialysis Patients
Zuoya Sun, Zhiyuan Chen, Ruihong Liu, Gang Lu, Zhuo Li & Yi Sun
Pages: 181-190
Published online: 23 Jan 2023
AbstractforResearch Progress on the Efficacy and Safety of Spironolactone in Reversing Left Ventricular Hypertrophy in Hemodialysis Patients | Full Text | References | PDF (430.4 KB) | EPUB
  • 313 Views
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ORIGINAL RESEARCH

Article
Mucoadhesive Nanoparticles Enhance the Therapeutic Effect of Dexamethasone on Experimental Ulcerative Colitis by the Local Administration as an Enema
Kai Dong, Shu-Jing Deng, Bin-Yang He, Zi-Yang Guo, Ze-Lin Guan, Xue Leng, Rui-Rui Ma, Dan-Yang Wang, Jian-Feng Xing & Cui-Yu You
Pages: 191-207
Published online: 24 Jan 2023
AbstractforMucoadhesive Nanoparticles Enhance the Therapeutic Effect of Dexamethasone on Experimental Ulcerative Colitis by the Local Administration as an Enema | Full Text | References | PDF (7.2 MB) | EPUB
  • 465 Views
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Article
Menthone Exerts its Antimicrobial Activity Against Methicillin Resistant Staphylococcus aureus by Affecting Cell Membrane Properties and Lipid Profile
Wenming Zhao, Chengwei Yang, Ning Zhang, Yuanyuan Peng, Ying Ma, Keru Gu, Xia Liu, Xiaohui Liu, Xijian Liu, Yumin Liu, Songkai Li & Linjing Zhao
Pages: 219-236
Published online: 25 Jan 2023
AbstractforMenthone Exerts its Antimicrobial Activity Against Methicillin Resistant Staphylococcus aureus by Affecting Cell Membrane Properties and Lipid Profile | Full Text | References | PDF (13.7 MB) | EPUB
  • 397 Views
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Open Access
Article
Safety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants
Tommy Tsang Cheung, Tu H Mai, Yen Lin Chia, Desmond YH Yap, Chi-Ho Lee, Cecil Chi-Keung Chen, Ying Huang, Yuwen Jin, James Johnston, Viktoria Werkström, Yuhui Yao, Xiaoyun Ge & Wenying Zheng
Pages: 209-218
Published online: 26 Jan 2023
AbstractforSafety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants | Full Text | References | PDF (1.2 MB) | EPUB
  • 317 Views
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Article
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy
Yalan Huang, Yanling Zhang, Yongjun Wu, Qin Xiang & Rong Yu
Pages: 237-260
Published online: 26 Jan 2023
AbstractforAn Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy | Full Text | References | PDF (16 MB) | EPUB
  • 254 Views
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Article
Development and Evaluation of Self-Emulsifying Drug-Delivery System–Based Tablets for Simvastatin, a BCS Class II Drug
Muhammad Anwar Bashir, Amjad Khan, Sayyed Ibrahim Shah, Majeed Ullah, Fazli Khuda, Muhammad Abbas, Khang Wen Goh & Long Chiau Ming
Pages: 261-272
Published online: 26 Jan 2023
AbstractforDevelopment and Evaluation of Self-Emulsifying Drug-Delivery System–Based Tablets for Simvastatin, a BCS Class II Drug | Full Text | References | PDF (3 MB) | EPUB
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REVIEW

Review
Clinical Evaluation of Risankizumab in the Treatment of Adults with Moderately to Severely Active Crohn’s Disease: Patient Selection and Reported Outcomes
Sara Horst & Raymond K Cross
Pages: 273-282
Published online: 31 Jan 2023
AbstractforClinical Evaluation of Risankizumab in the Treatment of Adults with Moderately to Severely Active Crohn’s Disease: Patient Selection and Reported Outcomes | Full Text | References | PDF (1.7 MB) | EPUB
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ORIGINAL RESEARCH

Article
Vancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides
Xuedong Yin, Qiaoling Yang, Hongjing Li, Yulin Kang & Zhiling Li
Pages: 283-295
Published online: 01 Feb 2023
AbstractforVancomycin Induced Ferroptosis in Renal Injury Through the Inactivation of Recombinant Glutathione Peroxidase 4 and the Accumulation of Peroxides | Full Text | References | PDF (9.1 MB) | EPUB
  • 270 Views
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Article
Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways
Li-Shan Yan, Shuang Cui, Brian Chi-Yan Cheng, Xing-Bin Yin, Yi-Wei Wang, Xin-Yu Qiu, Ci-Ren Nima, Yi Zhang & Shuo-Feng Zhang
Pages: 297-312
Published online: 02 Feb 2023
AbstractforSichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways | Full Text | References | PDF (12.2 MB) | EPUB
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Open Access

LETTER

Letter to the Editor
Liquiritin Protects Against Cardiac Fibrosis After Myocardial Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway [Letter]
Hasta Handayani Idrus & Sunarno
Pages: 331-332
Published online: 05 Feb 2023
CitationforLiquiritin Protects Against Cardiac Fibrosis After Myocardial Fibrosis After Myocardial Infarction by Inhibiting CCL5 Expression and the NF-κB Signaling Pathway [Letter] | Full Text | References | PDF (294.8 KB) | EPUB
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ORIGINAL RESEARCH

Article
Shensong Yangxin Capsule Reduces the Susceptibility of Arrhythmia in db/db Mice via Inhibiting the Inflammatory Response Induced by Endothelium Dysfunction
Jiehan Zhang, Hongrong Li, Dandong Wang, Jiaojiao Gu, Yunlong Hou & Yiling Wu
Pages: 313-330
Published online: 05 Feb 2023
AbstractforShensong Yangxin Capsule Reduces the Susceptibility of Arrhythmia in db/db Mice via Inhibiting the Inflammatory Response Induced by Endothelium Dysfunction | Full Text | References | PDF (17.2 MB) | EPUB
  • 226 Views
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REVIEW

Review
Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms
Xiao-Xing Liu, Chun-Yu Chen, Li Li, Miao-Miao Guo, Yi-Fan He, Hong Meng, Yin-Mao Dong, Pei-Gen Xiao & Fan Yi
Pages: 341-361
Published online: 06 Feb 2023
AbstractforBibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms | Full Text | References | PDF (6.3 MB) | EPUB
  • 899 Views
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Review
Tebentafusp in the Treatment of Metastatic Uveal Melanoma: Patient Selection and Special Considerations
Kamaneh Montazeri, Vikram Pattanayak & Ryan J Sullivan
Pages: 333-339
Published online: 07 Feb 2023
AbstractforTebentafusp in the Treatment of Metastatic Uveal Melanoma: Patient Selection and Special Considerations | Full Text | References | PDF (1 MB) | EPUB
  • 416 Views
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Review
Ibrexafungerp for the Treatment of Vulvovaginal Candidiasis: Design, Development and Place in Therapy
Nancy A Phillips, Maria Rocktashel & Lena Merjanian
Pages: 363-367
Published online: 07 Feb 2023
AbstractforIbrexafungerp for the Treatment of Vulvovaginal Candidiasis: Design, Development and Place in Therapy | Full Text | References | PDF (461.3 KB) | EPUB
  • 411 Views
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Review
Profile of Linzagolix in the Management of Endometriosis, Including Design, Development and Potential Place in Therapy: A Narrative Review
Jacques Donnez, Luciana Cacciottola, Jean-Luc Squifflet & Marie-Madeleine Dolmans
Pages: 369-380
Published online: 08 Feb 2023
AbstractforProfile of Linzagolix in the Management of Endometriosis, Including Design, Development and Potential Place in Therapy: A Narrative Review | Full Text | References | PDF (5.4 MB) | EPUB
  • 328 Views
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ORIGINAL RESEARCH

Article
Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway
Xiaolong Tang, YingYing Guo, Sijia Zhang, Xin Wang, Yuhao Teng, Qingjiang Jin, Qinglei Jin, Wei Shen & Ruiping Wang
Pages: 389-402
Published online: 08 Feb 2023
AbstractforSolanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway | Full Text | References | PDF (10.7 MB) | EPUB
  • 316 Views
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Article
Comparison of Remimazolam Tosilate and Etomidate on Hemodynamics in Cardiac Surgery: A Randomised Controlled Trial
Bailong Hu, Mei Zhang, Zhen Wu, Xiaoyuan Zhang, Xiaohua Zou, Li Tan, Tao Song & Xingyu Li
Pages: 381-388
Published online: 08 Feb 2023
AbstractforComparison of Remimazolam Tosilate and Etomidate on Hemodynamics in Cardiac Surgery: A Randomised Controlled Trial | Full Text | References | PDF (2.1 MB) | EPUB
  • 347 Views
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Article
Dual Sensitization Anti-Resistant Nanoparticles for Treating Refractory Breast Cancers via Apoptosis-Inducing
Ruijun Ju, Faliang Wu, Yanzhao Tian, Jiahao Chu, Xiaoming Peng & Xiaobo Wang
Pages: 403-418
Published online: 10 Feb 2023
AbstractforDual Sensitization Anti-Resistant Nanoparticles for Treating Refractory Breast Cancers via Apoptosis-Inducing | Full Text | References | PDF (9 MB) | EPUB
  • 256 Views
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Article
Preparation of Cod Skin Collagen Peptides/Chitosan-Based Temperature-Sensitive Gel and Its Anti-Photoaging Effect in Skin
Songzhi Kong, Lijiao Lv, Jiaqi Guo, Xiaohong Yang, Mingneng Liao, Tianyang Zhao, Haiyang Sun, Shuqun Zhang & Wenjie Li
Pages: 419-437
Published online: 10 Feb 2023
AbstractforPreparation of Cod Skin Collagen Peptides/Chitosan-Based Temperature-Sensitive Gel and Its Anti-Photoaging Effect in Skin | Full Text | References | PDF (7.1 MB) | EPUB
  • 495 Views
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Article
The Underling Mechanisms Exploration of Rubia cordifolia L. Extract Against Rheumatoid Arthritis by Integrating Network Pharmacology and Metabolomics
Weiya Zeng, Yuan Fang, Suifen Mo, Caihong Shen, Huiling Yang, Guihua Luo, Luhua Xiao, Ruoting Zhan & Ping Yan
Pages: 439-457
Published online: 11 Feb 2023
AbstractforThe Underling Mechanisms Exploration of Rubia cordifolia L. Extract Against Rheumatoid Arthritis by Integrating Network Pharmacology and Metabolomics | Full Text | References | PDF (10.6 MB) | EPUB
  • 522 Views
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Article
Exploring the Active Compounds of Traditional Mongolian Medicine Baolier Capsule (BLEC) in Patients with Coronary Artery Disease (CAD) Based on Network Pharmacology Analysis, Molecular Docking and Experimental Validation
Mengqiu Wei, Fengjin Li, Kai Guo & Tianxiao Yang
Pages: 459-476
Published online: 14 Feb 2023
AbstractforExploring the Active Compounds of Traditional Mongolian Medicine Baolier Capsule (BLEC) in Patients with Coronary Artery Disease (CAD) Based on Network Pharmacology Analysis, Molecular Docking and Experimental Validation | Full Text | References | PDF (13.6 MB) | EPUB
  • 344 Views
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Article
Development of a Fast Onset Proton Pump Inhibitor: Comparison of Fixed-Dose Combination of Rabeprazole and Sodium Bicarbonate (YPI-011) to the Conventional Enteric-Coated Rabeprazole
Sungyeun Bae, Jihoon Kwon, Mi-Hye Lee, Kyung-Sang Yu & SeungHwan Lee
Pages: 497-506
Published online: 15 Feb 2023
AbstractforDevelopment of a Fast Onset Proton Pump Inhibitor: Comparison of Fixed-Dose Combination of Rabeprazole and Sodium Bicarbonate (YPI-011) to the Conventional Enteric-Coated Rabeprazole | Full Text | References | PDF (5.2 MB) | EPUB
  • 480 Views
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Article
The Therapeutic Mechanism of Schisandrol A and Its Metabolites on Pulmonary Fibrosis Based on Plasma Metabonomics and Network Analysis
Xijier Qiaolongbatu, Wenjuan Zhao, Xucong Huang, Feng Qian, Xinyi Yang, Jiaqi Wu, Cui Ma, Han Qu, Li Wang, Guorong Fan & Zhenghua Wu
Pages: 477-496
Published online: 15 Feb 2023
AbstractforThe Therapeutic Mechanism of Schisandrol A and Its Metabolites on Pulmonary Fibrosis Based on Plasma Metabonomics and Network Analysis | Full Text | References | PDF (14.5 MB) | EPUB
  • 269 Views
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Article
Efficacy and Prognostic Factors of Regorafenib in the Treatment of BCLC Stage C Hepatocellular Carcinoma After Failure of the First-Line Therapy
Beibei Xu, Dong Lu, Kaicai Liu, Weifu Lv, Jingkun Xiao, Xingming Zhang, Zhengfeng Zhang, Jie Chai & Lijun Wang
Pages: 507-518
Published online: 16 Feb 2023
AbstractforEfficacy and Prognostic Factors of Regorafenib in the Treatment of BCLC Stage C Hepatocellular Carcinoma After Failure of the First-Line Therapy | Full Text | References | PDF (3 MB) | EPUB
  • 237 Views
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Article
Anti-Arthritic Effect of Edaravone Against Complete Freund Adjuvant Induced Arthritis via Osteoclast Differentiation and HIF-1α–VEGF–ANG-1 Axis
Jichao Liu, Nan Zhao, Shi-Han Su, Yun Gao & Bo Qi
Pages: 519-534
Published online: 18 Feb 2023
AbstractforAnti-Arthritic Effect of Edaravone Against Complete Freund Adjuvant Induced Arthritis via Osteoclast Differentiation and HIF-1α–VEGF–ANG-1 Axis | Full Text | References | PDF (6.7 MB) | EPUB
  • 304 Views
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Article
Andrographolide Inhibits Static Mechanical Pressure-Induced Intervertebral Disc Degeneration via the MAPK/Nrf2/HO-1 Pathway
Cunxin Zhang, Ziang Lu, Chaoliang Lyu, Shanshan Zhang & Dechun Wang
Pages: 535-550
Published online: 20 Feb 2023
AbstractforAndrographolide Inhibits Static Mechanical Pressure-Induced Intervertebral Disc Degeneration via the MAPK/Nrf2/HO-1 Pathway | Full Text | References | PDF (11.2 MB) | EPUB
  • 397 Views
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Article
Assessment of Response to Different Induction Chemotherapy Regimens in Locally Advanced Nasopharyngeal Carcinoma
Chen-Lu Lian, Rui Zhou, Yuan Zhou, Ping Zhou & San-Gang Wu
Pages: 551-562
Published online: 22 Feb 2023
AbstractforAssessment of Response to Different Induction Chemotherapy Regimens in Locally Advanced Nasopharyngeal Carcinoma | Full Text | References | PDF (3.3 MB) | EPUB
  • 220 Views
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Article
Efficacy and Mechanism of Qianshan Huoxue Gao in Acute Coronary Syndrome via Regulation of Intestinal Flora and Metabolites
Ning Zhao, Yan Ma, Xiaoxue Liang, Yu Zhang, Dacheng Hong, Ying Wang & Dong Bai
Pages: 579-595
Published online: 22 Feb 2023
AbstractforEfficacy and Mechanism of Qianshan Huoxue Gao in Acute Coronary Syndrome via Regulation of Intestinal Flora and Metabolites | Full Text | References | PDF (13 MB) | EPUB
  • 324 Views
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Article
α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously
Yi-Jin Wu, Sa-Sa Zhang, Qin Yin, Ming Lei, Qi-Hai Wang, Wen-Gang Chen, Ting-Ting Luo, Peng Zhou & Cong-Lan Ji
Pages: 563-577
Published online: 23 Feb 2023
Abstractforα-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously | Full Text | References | PDF (16.7 MB) | EPUB
  • 286 Views
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Article
Effects and Potential Mechanism of Zhuyu Pill Against Atherosclerosis: Network Pharmacology and Experimental Validation
Yingying Pan, Xianrong Feng, Wei Song, Xin Zhou, Zhen Zhou, Gaoyang Chen, Tao Shen & Xiaobo Zhang
Pages: 597-612
Published online: 23 Feb 2023
AbstractforEffects and Potential Mechanism of Zhuyu Pill Against Atherosclerosis: Network Pharmacology and Experimental Validation | Full Text | References | PDF (14.4 MB) | EPUB
  • 255 Views
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Article
Mechanistic Study of Schisandra chinensis Fruit Mixture Based on Network Pharmacology, Molecular Docking and Experimental Validation to Improve the Inflammatory Response of DKD Through AGEs/RAGE Signaling Pathway
Hongdian Li, Ao Dong, Na Li, Yu Ma, Sai Zhang, Yuanyuan Deng, Shu Chen & Mianzhi Zhang
Pages: 613-632
Published online: 27 Feb 2023
AbstractforMechanistic Study of Schisandra chinensis Fruit Mixture Based on Network Pharmacology, Molecular Docking and Experimental Validation to Improve the Inflammatory Response of DKD Through AGEs/RAGE Signaling Pathway | Full Text | References | PDF (14 MB) | EPUB
  • 348 Views
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Article
New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats
Yuqin Li, Changlin Tian, Xiaofei Song, Mengying Du, Guoning Zhang & Hongtao Liu
Pages: 649-657
Published online: 28 Feb 2023
AbstractforNew IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats | Full Text | References | PDF (4.1 MB) | EPUB
  • 203 Views
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RETRACTION

Retraction
Therapeutic Effects of Tyroserleutide on Lung Metastasis of Human Hepatocellular Carcinoma SK-HEP-1 and Its Mechanism Affecting ICAM-1 and MMP-2 and -9 [Retraction]
Pages: 647-648
Published online: 28 Feb 2023
CitationforTherapeutic Effects of Tyroserleutide on Lung Metastasis of Human Hepatocellular Carcinoma SK-HEP-1 and Its Mechanism Affecting ICAM-1 and MMP-2 and -9 [Retraction] | Full Text | PDF (238.5 KB) | EPUB
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ORIGINAL RESEARCH

Article
Chondroprotective Mechanism of Eucommia ulmoides Oliv.-Glycyrrhiza uralensis Fisch. Couplet Medicines in Knee Osteoarthritis via Experimental Study and Network Pharmacology Analysis
Pinger Wang, Jianbo Xu, Qi Sun, Qinwen Ge, Min Qiu, Kaiao Zou, Jun Ying, Wenhua Yuan, Jiali Chen, Qinghe Zeng, Qi Cui, Hongting Jin, Chunchun Zhang & Fanzhu Li
Pages: 633-646
Published online: 27 Feb 2023
AbstractforChondroprotective Mechanism of Eucommia ulmoides Oliv.-Glycyrrhiza uralensis Fisch. Couplet Medicines in Knee Osteoarthritis via Experimental Study and Network Pharmacology Analysis | Full Text | References | PDF (10.8 MB) | EPUB
  • 363 Views
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Article
Integrating Network Pharmacology and Bioinformatics to Explore the Effects of Dangshen (Codonopsis pilosula) Against Hepatocellular Carcinoma: Validation Based on the Active Compound Luteolin
Yaping Yu, Shun Ding, Xiaoqing Xu, Dongming Yan, Yonghao Fan, Banzhan Ruan, Xiaodian Zhang, Liping Zheng, Wei Jie & Shaojiang Zheng
Pages: 659-673
Published online: 01 Mar 2023
AbstractforIntegrating Network Pharmacology and Bioinformatics to Explore the Effects of Dangshen (Codonopsis pilosula) Against Hepatocellular Carcinoma: Validation Based on the Active Compound Luteolin | Full Text | References | PDF (14.7 MB) | EPUB
  • 381 Views
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Article
Wuling San Based on Network Pharmacology and in vivo Evidence Against Hyperuricemia via Improving Oxidative Stress and Inhibiting Inflammation
Jing Huang, Zhijian Lin, Yu Wang, Xueli Ding & Bing Zhang
Pages: 675-690
Published online: 04 Mar 2023
AbstractforWuling San Based on Network Pharmacology and in vivo Evidence Against Hyperuricemia via Improving Oxidative Stress and Inhibiting Inflammation | Full Text | References | PDF (10.8 MB) | EPUB
  • 313 Views
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Article
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Stigmasterol in the Treatment of Rheumatoid Arthritis
Wendong Xie, Hua Yang, Chun Guo, Rui Xie, Guoliang Yu & Yifu Li
Pages: 691-706
Published online: 07 Mar 2023
AbstractforIntegrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Stigmasterol in the Treatment of Rheumatoid Arthritis | Full Text | References | PDF (13.5 MB) | EPUB
  • 477 Views
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Article
Inhalational Anesthesia is Noninferior to Total Intravenous Anesthesia in Terms of Surgical Field Visibility in Endoscopic Sinus Surgery: A Randomized, Double-Blind Study
He Li, Yingjie Du, Wenjing Yang, Yue Wang, Shaofei Su, Xiaoyan Zhao & Guyan Wang
Pages: 707-716
Published online: 09 Mar 2023
AbstractforInhalational Anesthesia is Noninferior to Total Intravenous Anesthesia in Terms of Surgical Field Visibility in Endoscopic Sinus Surgery: A Randomized, Double-Blind Study | Full Text | References | PDF (2 MB) | EPUB
  • 274 Views
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Article
Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression
Junhui He, Dongbo Han, Chunlian Jia, Jiaxiu Xie, Fucui Zhu, Jie Wei, Dongmei Li, Dongmei Wei, Yi Li, Li Tang, Guining Wei, Jing Yan, Yuanming Tong, Lifang Yang & Xuecai Tan
Pages: 717-735
Published online: 09 Mar 2023
AbstractforIntegrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression | Full Text | References | PDF (18.7 MB) | EPUB
  • 412 Views
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REVIEW

Review
Kimyrsa and Orbactiv – A Tale of Two Formulations
Brittany T Jackson, David B Cluck, Andrés F Henao-Martínez & Daniel B Chastain
Pages: 737-742
Published online: 09 Mar 2023
AbstractforKimyrsa and Orbactiv – A Tale of Two Formulations | Full Text | References | PDF (373.5 KB) | EPUB
  • 243 Views
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ORIGINAL RESEARCH

Article
Computational Systems Pharmacology and Molecular Docking Reveal an Anti-Apoptosis and Anti-Inflammatory Mechanism of Compound Angelica Ligusticum Wallichii Granules in the Treatment of Endometriosis
Yueyan Li, Jialei Zhu & Jing Tang
Pages: 743-759
Published online: 09 Mar 2023
AbstractforComputational Systems Pharmacology and Molecular Docking Reveal an Anti-Apoptosis and Anti-Inflammatory Mechanism of Compound Angelica Ligusticum Wallichii Granules in the Treatment of Endometriosis | Full Text | References | PDF (9.8 MB) | EPUB
  • 377 Views
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Article
Effect of Food on the Pharmacokinetics and Safety of a Novel c-Met Inhibitor SCC244: A Randomized Phase I Study in Healthy Subjects
Juan Wu, Hongrong Xu, Hui Li, Lei Ma, Juan Chen, Fei Yuan, Lei Sheng, Chao Liu, Weili Chen & Xuening Li
Pages: 761-769
Published online: 10 Mar 2023
AbstractforEffect of Food on the Pharmacokinetics and Safety of a Novel c-Met Inhibitor SCC244: A Randomized Phase I Study in Healthy Subjects | Full Text | References | PDF (4 MB) | EPUB
  • 220 Views
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REVIEW

Review
The Molecular Basis of the Anti-Inflammatory Property of Astragaloside IV for the Treatment of Diabetes and Its Complications
Lin Li, Yuwei Zhang, Yudan Luo, Xianghui Meng, Guixiang Pan, Han Zhang, Yuhong Li & Boli Zhang
Pages: 771-790
Published online: 10 Mar 2023
AbstractforThe Molecular Basis of the Anti-Inflammatory Property of Astragaloside IV for the Treatment of Diabetes and Its Complications | Full Text | References | PDF (5.1 MB) | EPUB
  • 286 Views
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ORIGINAL RESEARCH

Article
Glucagon-Like Peptide-1 Receptor Agonist Protects Against Diabetic Cardiomyopathy by Modulating microRNA-29b-3p/SLMAP
Ping Fang, Zhengqin Ye, Ran Li, Dunmin She, Guannan Zong, Liya Zhang, Ying Xue & Keqin Zhang
Pages: 791-806
Published online: 12 Mar 2023
AbstractforGlucagon-Like Peptide-1 Receptor Agonist Protects Against Diabetic Cardiomyopathy by Modulating microRNA-29b-3p/SLMAP | Full Text | References | PDF (10.2 MB) | EPUB
  • 309 Views
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RETRACTION

Retraction
Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation [Retraction]
Pages: 807-808
Published online: 13 Mar 2023
CitationforEvaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation [Retraction] | Full Text | PDF (234.9 KB) | EPUB
  • 157 Views
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ORIGINAL RESEARCH

Article
Personalized Dose of Adjuvant Imatinib in Patients with Gastrointestinal Stromal Tumors: Results from a Population Pharmacokinetic Analysis
Xuehui Jiang, Qun Fu, Yan Jing, Ying Kong, Hong Liu, Hongwei Peng, Kaisaner Rexiti & Xiaohua Wei
Pages: 809-820
Published online: 14 Mar 2023
AbstractforPersonalized Dose of Adjuvant Imatinib in Patients with Gastrointestinal Stromal Tumors: Results from a Population Pharmacokinetic Analysis | Full Text | References | PDF (3.3 MB) | EPUB
  • 233 Views
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LETTER

Letter to the Editor
Critical Response to Article “Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Stigmasterol in the Treatment of Rheumatoid Arthritis” [Letter]
Ratih Rinendyaputri & Novaria Sari Dewi Panjaitan
Pages: 837-838
Published online: 20 Mar 2023
CitationforCritical Response to Article “Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Stigmasterol in the Treatment of Rheumatoid Arthritis” [Letter] | Full Text | References | PDF (302.5 KB) | EPUB
  • 178 Views
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ORIGINAL RESEARCH

Article
Icariin Induces Triple-Negative Breast Cancer Cell Apoptosis and Suppresses Invasion by Inhibiting the JNK/c-Jun Signaling Pathway
Shenghan Gao, Xinyu Zhang, Jie Liu, Fuqing Ji, Zhihao Zhang, Qingjie Meng, Qi Zhang, Xiaogang Han, He Wu, Yulong Yin, Yonggang Lv & Wenzhen Shi
Pages: 821-836
Published online: 20 Mar 2023
AbstractforIcariin Induces Triple-Negative Breast Cancer Cell Apoptosis and Suppresses Invasion by Inhibiting the JNK/c-Jun Signaling Pathway | Full Text | References | PDF (13.8 MB) | EPUB
  • 342 Views
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Article
Effect of Different Doses of Butorphanol on Postoperative Shivering in Elderly Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
Yaolin Wang, Kai Zhao, Nanling Wu, Tao Ji, Gaowei Su, Xiaojie Cui, Yushan Dong & Xiuxia Chen
Pages: 839-849
Published online: 20 Mar 2023
AbstractforEffect of Different Doses of Butorphanol on Postoperative Shivering in Elderly Patients: A Randomized, Double-Blind, Placebo-Controlled Trial | Full Text | References | PDF (505.2 KB) | EPUB
  • 296 Views
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Article
Effect of Subanesthetic Dose of Esketamine on Perioperative Neurocognitive Disorders in Elderly Undergoing Gastrointestinal Surgery: A Randomized Controlled Trial
Chao Han, Haiyan Ji, Yaxin Guo, Yuanhui Fei, Chunhui Wang, Yanbo Yuan, Zhihui Ruan & Tieliang Ma
Pages: 863-873
Published online: 21 Mar 2023
AbstractforEffect of Subanesthetic Dose of Esketamine on Perioperative Neurocognitive Disorders in Elderly Undergoing Gastrointestinal Surgery: A Randomized Controlled Trial | Full Text | References | PDF (1.6 MB) | EPUB
  • 373 Views
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REVIEW

Review
Tapentadol: A Review of Experimental Pharmacology Studies, Clinical Trials, and Recent Findings
Fahad S Alshehri
Pages: 851-861
Published online: 21 Mar 2023
AbstractforTapentadol: A Review of Experimental Pharmacology Studies, Clinical Trials, and Recent Findings | Full Text | References | PDF (1.1 MB) | EPUB
  • 688 Views
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Review
Oliceridine for the Management of Moderate to Severe Acute Postoperative Pain: A Narrative Review
Neil Daksla, Ashley Wang, Zhaosheng Jin, Abhishek Gupta & Sergio D Bergese
Pages: 875-886
Published online: 22 Mar 2023
AbstractforOliceridine for the Management of Moderate to Severe Acute Postoperative Pain: A Narrative Review | Full Text | References | PDF (726.8 KB) | EPUB
  • 451 Views
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ORIGINAL RESEARCH

Article
Network Pharmacology and Experimental Validation to Explore That Celastrol Targeting PTEN is the Potential Mechanism of Tripterygium wilfordii (Lév.) Hutch Against IgA Nephropathy
Juanyong Zhao, Haiyang Liu, Ming Xia, Qian Chen, Lili Wan, Bin Leng, Chengyuan Tang, Guochun Chen, Yu Liu, Lei Zhang & Hong Liu
Pages: 887-900
Published online: 23 Mar 2023
AbstractforNetwork Pharmacology and Experimental Validation to Explore That Celastrol Targeting PTEN is the Potential Mechanism of Tripterygium wilfordii (Lév.) Hutch Against IgA Nephropathy | Full Text | References | PDF (9.9 MB) | EPUB
  • 352 Views
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Article
Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer
Mei Zhao, Lijuan Fu, Panling Xu, Ting Wang & Ping Li
Pages: 901-917
Published online: 23 Mar 2023
AbstractforNetwork Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer | Full Text | References | PDF (13.7 MB) | EPUB
  • 350 Views
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Article
Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity
Guojin Ren, Qili Zhang, Pengfei Xia, Jie Wang, Pengxia Fang, Xiaojie Jin, Xuejing Peng, Yanli Xu, Jian Zhang & Lei Zhao
Pages: 919-935
Published online: 23 Mar 2023
AbstractforSynthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity | Full Text | References | PDF (7.1 MB) | EPUB
  • 230 Views
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LETTER

Letter to the Editor
Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial [Letter]
Yi Cheng, Fu-Shan Xue & Cheng-Wen Li
Pages: 937-938
Published online: 27 Mar 2023
CitationforEffects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial [Letter] | Full Text | References | PDF (300.5 KB) | EPUB
  • 174 Views
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ORIGINAL RESEARCH

Article
Investigating the Mechanism of Action of Schisandra chinensis Combined with Coenzyme Q10 in the Treatment of Heart Failure Based on PI3K-AKT Pathway
Sihua Wen, Kai Yang, Yunfeng Bai, Yanan Wu, Ding Liu, Xu Wu, Xiaofei Zhang & Jing Sun
Pages: 939-957
Published online: 27 Mar 2023
AbstractforInvestigating the Mechanism of Action of Schisandra chinensis Combined with Coenzyme Q10 in the Treatment of Heart Failure Based on PI3K-AKT Pathway | Full Text | References | PDF (12.8 MB) | EPUB
  • 293 Views
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RETRACTION

Retraction
Orcinol Glucoside Facilitates the Shift of MSC Fate to Osteoblast and Prevents Adipogenesis via Wnt/β-Catenin Signaling Pathway [Retraction]
Pages: 959-960
Published online: 28 Mar 2023
CitationforOrcinol Glucoside Facilitates the Shift of MSC Fate to Osteoblast and Prevents Adipogenesis via Wnt/β-Catenin Signaling Pathway [Retraction] | Full Text | PDF (233.9 KB) | EPUB
  • 120 Views
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REVIEW

Review
Intravitreal Fluocinolone Acetonide Implant (ILUVIEN®) for the Treatment of Retinal Conditions. A Review of Clinical Studies
Yusuf Mushtaq, Maryam M Mushtaq, Zisis Gatzioufas, Matteo Ripa, Lorenzo Motta & Georgios D Panos
Pages: 961-975
Published online: 30 Mar 2023
AbstractforIntravitreal Fluocinolone Acetonide Implant (ILUVIEN®) for the Treatment of Retinal Conditions. A Review of Clinical Studies | Full Text | References | PDF (520.6 KB) | EPUB
  • 322 Views
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ORIGINAL RESEARCH

Article
Antimicrobial Peptide Cec4 Eradicates Multidrug-Resistant Acinetobacter baumannii in vitro and in vivo
Jian Peng, Yue Wang, Zhaoyin Wu, Chengju Mao, Lu Li, Huijun Cao, Zhilang Qiu, Guo Guo, Guiyou Liang & Feng Shen
Pages: 977-992
Published online: 30 Mar 2023
AbstractforAntimicrobial Peptide Cec4 Eradicates Multidrug-Resistant Acinetobacter baumannii in vitro and in vivo | Full Text | References | PDF (12.1 MB) | EPUB
  • 485 Views
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Article
5-Fluorouracil Combined with Rutaecarpine Synergistically Suppresses the Growth of Colon Cancer Cells by Inhibiting STAT3
Zhen Yu, Shixin Chan, Xu Wang, Rui Sun, Ming Wang, Zhenglin Wang, Xiaomin Zuo, Jiajie Chen, Huabing Zhang & Wei Chen
Pages: 993-1006
Published online: 30 Mar 2023
Abstractfor5-Fluorouracil Combined with Rutaecarpine Synergistically Suppresses the Growth of Colon Cancer Cells by Inhibiting STAT3 | Full Text | References | PDF (10.3 MB) | EPUB
  • 277 Views
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Article
Therapeutic Mechanism of Baicalin in Experimental Colitis Analyzed Using Network Pharmacology and Metabolomics
Qi Wu, Xingxing Wu, Mao Wang, Kexin Liu, Yuge Li, Xiaoyu Ruan, Lin Qian, Lingchang Meng, Zhiting Sun, Lei Zhu, Jing Wu & Genglin Mu
Pages: 1007-1024
Published online: 31 Mar 2023
AbstractforTherapeutic Mechanism of Baicalin in Experimental Colitis Analyzed Using Network Pharmacology and Metabolomics | Full Text | References | PDF (11.9 MB) | EPUB
  • 383 Views
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CLINICAL TRIAL REPORT

Effects of Combined Use of Salbutamol/Budesonide in Thoracic Surgery on Postoperative Myocardial Injury (MINS) – A Prospective Randomized Clinical Trial
Shuchi Lin, Ying Zhang, Xiaofan Huang, Xiaohan Zhang, Erhong Cheng, Zhaoyun Zhou & Jindong Liu
Pages: 1025-1036
Published online: 01 Apr 2023
AbstractforEffects of Combined Use of Salbutamol/Budesonide in Thoracic Surgery on Postoperative Myocardial Injury (MINS) – A Prospective Randomized Clinical Trial | Full Text | References | PDF (1.9 MB) | EPUB
  • 245 Views
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ORIGINAL RESEARCH

Article
Antitumor Effects of Hydromorphone on Human Gastric Cancer Cells in vitro
Beiwei Liang, Chunlai Li, Zhan Zhou & Yubo Xie
Pages: 1037-1045
Published online: 06 Apr 2023
AbstractforAntitumor Effects of Hydromorphone on Human Gastric Cancer Cells in vitro | Full Text | References | PDF (5.2 MB) | EPUB
  • 257 Views
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Article
Effectiveness and Safety of a Fixed-Dose Combination of Valsartan and Rosuvastatin (Rovatitan® Tablet) in Patients with Concomitant Hypertension and Hyperlipidemia: An Observational Study
Kwang Je Lee, Jae-Kean Ryu, Yun-Hyeong Cho, Won Yong Shin, Jeong Su Kim, Young Won Yoon, Ji Yong Jang, Won Ho Kim, Jong Wook Beom, Seok-Min Kang & On behalf of LG-VROS001 STUDY INVESTIGATOR GROUP
Pages: 1047-1062
Published online: 06 Apr 2023
AbstractforEffectiveness and Safety of a Fixed-Dose Combination of Valsartan and Rosuvastatin (Rovatitan® Tablet) in Patients with Concomitant Hypertension and Hyperlipidemia: An Observational Study | Full Text | References | PDF (2.9 MB) | EPUB
  • 326 Views
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RETRACTION

Retraction
TMF Inhibits miR-29a/Wnt/β-Catenin Signaling Through Upregulating Foxo3a Activity in Osteoarthritis Chondrocytes [Retraction]
Pages: 1063-1064
Published online: 07 Apr 2023
CitationforTMF Inhibits miR-29a/Wnt/β-Catenin Signaling Through Upregulating Foxo3a Activity in Osteoarthritis Chondrocytes [Retraction] | Full Text | PDF (255.6 KB) | EPUB
  • 181 Views
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REVIEW

Review
Chemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy
Naurah Nabihah Nasir, Mahendran Sekar, Subban Ravi, Ling Shing Wong, Sreenivas Patro Sisinthy, Siew Hua Gan, Vetriselvan Subramaniyan, Kumarappan Chidambaram, Nur Najihah Izzati Mat Rani, M Yasmin Begum, Mohankumar Ramar, Sher Zaman Safi, Siddharthan Selvaraj, Senthil Kumar Chinna Maruthu, Shivkanya Fuloria, Neeraj Kumar Fuloria, Pei Teng Lum & Sinouvassane Djearamane
Pages: 1065-1078
Published online: 08 Apr 2023
AbstractforChemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy | Full Text | References | PDF (8.6 MB) | EPUB
  • 487 Views
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Review
Review of Mavacamten for Obstructive Hypertrophic Cardiomyopathy and Future Directions
Tiffany Dong, Ben Alencherry, Susan Ospina & Milind Y Desai
Pages: 1097-1106
Published online: 08 Apr 2023
AbstractforReview of Mavacamten for Obstructive Hypertrophic Cardiomyopathy and Future Directions | Full Text | References | PDF (2.6 MB) | EPUB
  • 523 Views
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Review
Celastrol: A Potential Natural Lead Molecule for New Drug Design, Development and Therapy for Memory Impairment
Muhamad Azrul Amir Yusri, Mahendran Sekar, Ling Shing Wong, Siew Hua Gan, Subban Ravi, Vetriselvan Subramaniyan, Nur Najihah Izzati Mat Rani, Kumarappan Chidambaram, M Yasmin Begum, Mohankumar Ramar, Sher Zaman Safi, Siddharthan Selvaraj, Yuan Seng Wu, Palanisamy Revathy, Shivkanya Fuloria, Neeraj Kumar Fuloria, Pei Teng Lum & Sinouvassane Djearamane
Pages: 1079-1096
Published online: 08 Apr 2023
AbstractforCelastrol: A Potential Natural Lead Molecule for New Drug Design, Development and Therapy for Memory Impairment | Full Text | References | PDF (10.9 MB) | EPUB
  • 493 Views
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ORIGINAL RESEARCH

Article
Pharmacokinetic Interactions Between Bazedoxifene and Cholecalciferol: An Open-Label, Randomized, Crossover Study in Healthy Male Volunteers
Moon Hee Lee, Seok-Kyu Yoon, Hyungsub Kim, Yong-Soon Cho, Sungpil Han, Shi Hyang Lee, Kyun-Seop Bae, Jina Jung, Sung Hee Hong & Hyeong-Seok Lim
Pages: 1107-1114
Published online: 12 Apr 2023
AbstractforPharmacokinetic Interactions Between Bazedoxifene and Cholecalciferol: An Open-Label, Randomized, Crossover Study in Healthy Male Volunteers | Full Text | References | PDF (883.4 KB) | EPUB
  • 267 Views
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Article
Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization
Xin Liu, Miao Tang, Tian-Yi He, Shuang Zhao, Hui-Zhou Li, Zhao Li, Yue-Xian Guo & Xiu-Li Wang
Pages: 1125-1138
Published online: 12 Apr 2023
AbstractforResveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization | Full Text | References | PDF (7.9 MB) | EPUB
  • 317 Views
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Article
Pharmacokinetics and Pharmacodynamics of Esomezol DR, a New Dual Delayed-Release Formulation of Esomeprazole 20 Mg or 40 Mg, in Healthy Subjects
Hyun Chul Kim, Eunsol Yang, Mu Seong Ban, Yu Kyong Kim, Sung Hee Hong, Jina Jung, In-Jin Jang & SeungHwan Lee
Pages: 1115-1124
Published online: 12 Apr 2023
AbstractforPharmacokinetics and Pharmacodynamics of Esomezol DR, a New Dual Delayed-Release Formulation of Esomeprazole 20 Mg or 40 Mg, in Healthy Subjects | Full Text | References | PDF (2.7 MB) | EPUB
  • 567 Views
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Article
Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-κB Signaling
Longwang Chen, Xinyong Liu, Xuetao Wang, Zhongqiu Lu & Yumei Ye
Pages: 1139-1151
Published online: 13 Apr 2023
AbstractforBerberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-κB Signaling | Full Text | References | PDF (10.5 MB) | EPUB
  • 300 Views
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RETRACTION

Retraction
Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling [Retraction]
Pages: 1153-1154
Published online: 13 Apr 2023
CitationforUmbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling [Retraction] | Full Text | PDF (234.6 KB) | EPUB
  • 144 Views
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REVIEW

Review
Knowledge Mapping of Drug Repositioning’s Theme and Development
Xiaona Lang, Jinlei Liu, Guangzhong Zhang, Xin Feng & Wenchao Dan
Pages: 1157-1174
Published online: 18 Apr 2023
AbstractforKnowledge Mapping of Drug Repositioning’s Theme and Development | Full Text | References | PDF (9 MB) | EPUB
  • 339 Views
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RESPONSE TO LETTER

Reply
Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial [Response to Letter]
Min Zhu, Siqi Xu, Xia Ju, Shengbin Wang & Xitong Yu
Pages: 1155-1156
Published online: 18 Apr 2023
CitationforEffects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial [Response to Letter] | Full Text | References | PDF (287.9 KB) | EPUB
  • 174 Views
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ORIGINAL RESEARCH

Article
Up-Regulation of miR-9-5p Inhibits Hypoxia-Ischemia Brain Damage Through the DDIT4-Mediated Autophagy Pathways in Neonatal Mice
Chengcheng Gai, Xiaohui Xing, Yan Song, Yijing Zhao, Zige Jiang, Yahong Cheng, Yilei Xiao & Zhen Wang
Pages: 1175-1189
Published online: 21 Apr 2023
AbstractforUp-Regulation of miR-9-5p Inhibits Hypoxia-Ischemia Brain Damage Through the DDIT4-Mediated Autophagy Pathways in Neonatal Mice | Full Text | References | PDF (14.4 MB) | EPUB
  • 241 Views
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CLINICAL TRIAL REPORT

A Comparison of the Pharmacokinetics and Safety of Dapagliflozin Formate, an Ester Prodrug of Dapagliflozin, to Dapagliflozin Propanediol Monohydrate in Healthy Subjects
Hyun Chul Kim, Sangmi Lee, Siyoung Sung, Eunjin Kim, In-Jin Jang & Jae-Yong Chung
Pages: 1203-1210
Published online: 21 Apr 2023
AbstractforA Comparison of the Pharmacokinetics and Safety of Dapagliflozin Formate, an Ester Prodrug of Dapagliflozin, to Dapagliflozin Propanediol Monohydrate in Healthy Subjects | Full Text | References | PDF (3.1 MB) | EPUB
  • 509 Views
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ORIGINAL RESEARCH

Article
Virtual Screening and Biological Evaluation of Novel Low Molecular Weight Protein Tyrosine Phosphatase Inhibitor for the Treatment of Insulin Resistance
Bo Feng, Xu Dong, Zhen Liu, Jie Zhang, Hongyu Liu & Yuan Xu
Pages: 1191-1201
Published online: 21 Apr 2023
AbstractforVirtual Screening and Biological Evaluation of Novel Low Molecular Weight Protein Tyrosine Phosphatase Inhibitor for the Treatment of Insulin Resistance | Full Text | References | PDF (5.9 MB) | EPUB
  • 254 Views
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Article
Development of Verapamil Hydrochloride-loaded Biopolymer-based Composite Electrospun Nanofibrous Mats: In vivo Evaluation of Enhanced Burn Wound Healing without Scar Formation
Hebatallah S Barakat, May S Freag, Sarah M Gaber, Affaf Al Oufy & Ossama Y Abdallah
Pages: 1211-1231
Published online: 21 Apr 2023
AbstractforDevelopment of Verapamil Hydrochloride-loaded Biopolymer-based Composite Electrospun Nanofibrous Mats: In vivo Evaluation of Enhanced Burn Wound Healing without Scar Formation | Full Text | References | PDF (10.5 MB) | EPUB
  • 496 Views
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CLINICAL TRIAL REPORT

Cardiopulmonary Adverse Events of Remimazolam versus Propofol During Cervical Conization: A Randomized Controlled Trial
Lini Wang, Yi Wang, Li Ma, Yiting Wang, Xiaoxiao Mu, Zhaoxu Huang, Ziyu Zheng & Huang Nie
Pages: 1233-1243
Published online: 22 Apr 2023
AbstractforCardiopulmonary Adverse Events of Remimazolam versus Propofol During Cervical Conization: A Randomized Controlled Trial | Full Text | References | PDF (3.8 MB) | EPUB
  • 287 Views
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LETTER

Letter to the Editor
Thinkful of Icariin Induces Triple-Negative Breast Cancer Cell Apoptosis and Suppresses Invasion by Inhibiting the JNK/c-Jun Signaling Pathway [Letter]
Sela Septima Mariya, Ratih Rinendyaputri & Uly Alfi Nikmah
Pages: 1245-1246
Published online: 24 Apr 2023
CitationforThinkful of Icariin Induces Triple-Negative Breast Cancer Cell Apoptosis and Suppresses Invasion by Inhibiting the JNK/c-Jun Signaling Pathway [Letter] | Full Text | References | PDF (299.3 KB) | EPUB
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ORIGINAL RESEARCH

Article
Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4
Sebastian Vaas, Markus O Zimmermann, Theresa Klett & Frank M Boeckler
Pages: 1247-1274
Published online: 25 Apr 2023
AbstractforSynthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4 | Full Text | References | PDF (10.7 MB) | EPUB
  • 377 Views
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REVIEW

Review
Clinical Utility of Osilodrostat in Cushing’s Disease: Review of Currently Available Literature
Milica Perosevic & Nicholas A Tritos
Pages: 1303-1312
Published online: 27 Apr 2023
AbstractforClinical Utility of Osilodrostat in Cushing’s Disease: Review of Currently Available Literature | Full Text | References | PDF (914.5 KB) | EPUB
  • 305 Views
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ORIGINAL RESEARCH

Article
AS-605240 Blunts Osteoporosis by Inhibition of Bone Resorption
Jiacheng Sun, Guoping Cai, Jinlong Shen, Pu Cheng, Jiapeng Zhang, Dengteng Jiang, Xianquan Xu, Fangying Lu, Lihua Chen & Haixiao Chen
Pages: 1275-1288
Published online: 27 Apr 2023
AbstractforAS-605240 Blunts Osteoporosis by Inhibition of Bone Resorption | Full Text | References | PDF (11.3 MB) | EPUB
  • 231 Views
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Article
Integrating Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanism of Astragaloside IV in Treating Bleomycin-Induced Pulmonary Fibrosis
Su Yuan, Biao Zuo, Si-Cong Zhou, Meng Wang, Kai-Yue Tan, Zhi-Wei Chen & Wen-Fu Cao
Pages: 1289-1302
Published online: 27 Apr 2023
AbstractforIntegrating Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanism of Astragaloside IV in Treating Bleomycin-Induced Pulmonary Fibrosis | Full Text | References | PDF (11.3 MB) | EPUB
  • 257 Views
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REVIEW

Review
The Application of Dupilumab to Pediatric Patients Aged 6–11yrs with Moderate-to-Severe Atopic Dermatitis Whose Disease is Not Adequately Controlled: The Clinical Data so Far
Sarah Balboul, Julia Kahn, Alexis Tracy, Anjelica Peacock & Abigail Cline
Pages: 1323-1327
Published online: 01 May 2023
AbstractforThe Application of Dupilumab to Pediatric Patients Aged 6–11yrs with Moderate-to-Severe Atopic Dermatitis Whose Disease is Not Adequately Controlled: The Clinical Data so Far | Full Text | References | PDF (313.9 KB) | EPUB
  • 262 Views
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ORIGINAL RESEARCH

Article
Feasibility and Safety of Remazolam versus Propofol When Inserting Laryngeal Masks Without Muscle Relaxants During Hysteroscopy
Shan Tang, Jingxiao Lu, Cheng Xu, Lu Wei, Shenglan Mei, Rong Chen & Qing-Tao Meng
Pages: 1313-1322
Published online: 01 May 2023
AbstractforFeasibility and Safety of Remazolam versus Propofol When Inserting Laryngeal Masks Without Muscle Relaxants During Hysteroscopy | Full Text | References | PDF (1.8 MB) | EPUB
  • 280 Views
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REVIEW

Review
A Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date
Panagiotis Peitsidis, Panagiotis Tsikouras, Antonio Simone Laganà, Alexandros Laios, Ioannis D Gkegkes & Christos Iavazzo
Pages: 1329-1346
Published online: 04 May 2023
AbstractforA Systematic Review of Systematic Reviews on the Use of Aromatase Inhibitors for the Treatment of Endometriosis: The Evidence to Date | Full Text | References | PDF (3.8 MB) | EPUB
  • 456 Views
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CLINICAL TRIAL REPORT

Efficacy and Safety of a Subanesthetic Dose of Esketamine Combined with Propofol in Patients with Obesity Undergoing Painless Gastroscopy: A Prospective, Double-Blind, Randomized Controlled Trial
Longbin Zheng, Yiteng Wang, Qing Ma, Wenbo Liang, Xiaojing Zhang, Zhiqiang Ren, Weimin Qin, Fan Meng, Yuhong Li, Guoxiang Fan & Ning Yin
Pages: 1347-1356
Published online: 04 May 2023
AbstractforEfficacy and Safety of a Subanesthetic Dose of Esketamine Combined with Propofol in Patients with Obesity Undergoing Painless Gastroscopy: A Prospective, Double-Blind, Randomized Controlled Trial | Full Text | References | PDF (2.5 MB) | EPUB
  • 282 Views
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ORIGINAL RESEARCH

Article
UBE2T Promotes Temozolomide Resistance of Glioblastoma Through Regulating the Wnt/β-Catenin Signaling Pathway
Yang Wang, Ge Gao, Xiangpin Wei, Yang Zhang & Jian Yu
Pages: 1357-1369
Published online: 05 May 2023
AbstractforUBE2T Promotes Temozolomide Resistance of Glioblastoma Through Regulating the Wnt/β-Catenin Signaling Pathway | Full Text | References | PDF (9.5 MB) | EPUB
  • 243 Views
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Article
16S rRNA and Metagenomics Combined with UPLC-Q/TOF-MS Metabolomics Analysis Reveals the Potential Mechanism of Radix Astragali Against Hyperuricemia in Mice
Song Deng, Kaiwei Cai, Chaoying Pei, Xingyuan Zhang, Xiaoyi Xiao, Ye Chen, Ying Chen, Rongyao Liang, Yanlong Chen, Pei Li, Zhiyong Xie & Qiongfeng Liao
Pages: 1371-1386
Published online: 06 May 2023
Abstractfor16S rRNA and Metagenomics Combined with UPLC-Q/TOF-MS Metabolomics Analysis Reveals the Potential Mechanism of Radix Astragali Against Hyperuricemia in Mice | Full Text | References | PDF (10 MB) | EPUB
  • 356 Views
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Article
Identification of Piperlongumine as Potent Inhibitor of Necroptosis
Xiaoyan He, Min Li, Zhi Ye, Xiaoling You, Jia Wang, Xin Xiao, Guofeng Zhu, Jun Wei & Yunhong Zha
Pages: 1387-1394
Published online: 08 May 2023
AbstractforIdentification of Piperlongumine as Potent Inhibitor of Necroptosis | Full Text | References | PDF (4 MB) | EPUB
  • 269 Views
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Article
Prolonged Anesthesia Induction to Delivery Time Did Not Influence Plasma Remifentanil Concentration in Neonates
Meng Cai, Hao Liu, Yong Peng, Jing-Kun Miao, Xiao-Feng Lei & Jin Yu
Pages: 1395-1403
Published online: 08 May 2023
AbstractforProlonged Anesthesia Induction to Delivery Time Did Not Influence Plasma Remifentanil Concentration in Neonates | Full Text | References | PDF (1.1 MB) | EPUB
  • 227 Views
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Article
Nalbuphine May Be Superior to Sufentanil in Relieving Postcesarean Uterine Contraction Pain in Multiparas: A Retrospective Cohort Study
Kang Zheng, Bingwei Chen & Jie Sun
Pages: 1405-1415
Published online: 08 May 2023
AbstractforNalbuphine May Be Superior to Sufentanil in Relieving Postcesarean Uterine Contraction Pain in Multiparas: A Retrospective Cohort Study | Full Text | References | PDF (1.7 MB) | EPUB
  • 291 Views
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Article
Cinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis
Huan Xue, Hao-Jie Xing, Bin Wang, Chao Fu, Yu-Shan Zhang, Xi Qiao, Chao Guo, Xiao-Li Zhang, Bin Hu, Xin Zhao, Li-Jiao Deng, Xiao-Chan Zhu, Yi Zhang & Yun-Feng Liu
Pages: 1417-1432
Published online: 11 May 2023
AbstractforCinchonine, a Potential Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist, Lowers Blood Glucose and Ameliorates Non-Alcoholic Steatohepatitis | Full Text | References | PDF (11.3 MB) | EPUB
  • 343 Views
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LETTER

Letter to the Editor
Thoughtful Discussion on Article “Antimicrobial Peptide Cec4 Eradicates Multidrug-Resistant Acinetobacter baumannii in vitro and in vivo” [Letter]
Syarif Hidayat, Rina Isnawati & Novaria Sari Dewi Panjaitan
Pages: 1433-1434
Published online: 15 May 2023
CitationforThoughtful Discussion on Article “Antimicrobial Peptide Cec4 Eradicates Multidrug-Resistant Acinetobacter baumannii in vitro and in vivo” [Letter] | Full Text | References | PDF (277.3 KB) | EPUB
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ORIGINAL RESEARCH

Article
Nano-Emulsion Based Gel for Topical Delivery of an Anti-Inflammatory Drug: In vitro and in vivo Evaluation
Dalia A Gaber, Amal M Alsubaiyel, Alanoud K Alabdulrahim, Hanan Z Alharbi, Rama M Aldubaikhy, Rawan S Alharbi, Wades K Albishr & Heba A Mohamed
Pages: 1435-1451
Published online: 15 May 2023
AbstractforNano-Emulsion Based Gel for Topical Delivery of an Anti-Inflammatory Drug: In vitro and in vivo Evaluation | Full Text | References | PDF (2.9 MB) | EPUB
  • 747 Views
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REVIEW

Review
Dexmedetomidine as an Adjuvant in Peripheral Nerve Block
Zheping Chen, Zhenzhen Liu, Chang Feng, Yanwu Jin & Xin Zhao
Pages: 1463-1484
Published online: 17 May 2023
AbstractforDexmedetomidine as an Adjuvant in Peripheral Nerve Block | Full Text | References | PDF (1.3 MB) | EPUB
  • 598 Views
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ORIGINAL RESEARCH

Article
Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease
Çağrı Özdemir, Mustafa Arslan, Ayşegül Küçük, Zeynep Yığman & Ali Doğan Dursun
Pages: 1453-1462
Published online: 17 May 2023
AbstractforTherapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease | Full Text | References | PDF (2.1 MB) | EPUB
  • 449 Views
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Article
Genetic Diversity and Characteristics of Drug Resistance Among Treatment-Naive People Living with HIV in Xi’an, China
Huan Xia, Juan Jin, Huanhuan Ba, Yuan Zhang, Jiajia Li, Rui Guo, Ying Li, Ping Ma & Yan Zhang
Pages: 1485-1494
Published online: 17 May 2023
AbstractforGenetic Diversity and Characteristics of Drug Resistance Among Treatment-Naive People Living with HIV in Xi’an, China | Full Text | References | PDF (1.5 MB) | EPUB
  • 194 Views
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STUDY PROTOCOL

Effects of Empagliflozin on Gut Microbiota in Heart Failure with a Preserved Ejection Fraction: The Design of a Pragmatic Randomized, Open-Label Controlled Trial (EMPAGUM)
Xue-Qing Guan, Chuan-He Wang, Peng Cheng, Ling-Yu Fu, Qi-Jun Wu, Gong Cheng, Lin Guan & Zhi-Jun Sun
Pages: 1495-1502
Published online: 18 May 2023
AbstractforEffects of Empagliflozin on Gut Microbiota in Heart Failure with a Preserved Ejection Fraction: The Design of a Pragmatic Randomized, Open-Label Controlled Trial (EMPAGUM) | Full Text | References | PDF (1.3 MB) | EPUB
  • 292 Views
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ORIGINAL RESEARCH

Article
Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease
Chao Tang, Xiaoqing Deng, Jingru Qu, Yahui Miao, Lei Tian, Man Zhang, Xiaoyu Li, Bei Sun & Liming Chen
Pages: 1503-1514
Published online: 18 May 2023
AbstractforFenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease | Full Text | References | PDF (10 MB) | EPUB
  • 199 Views
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Article
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies
Yong Li, Senbo Zhu, Junchao Luo, Yu Tong, Yixuan Zheng, Lichen Ji, Zeju He, Qiangan Jing, Jiaqing Huang, Yinjun Zhang & Qing Bi
Pages: 1515-1529
Published online: 22 May 2023
AbstractforThe Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies | Full Text | References | PDF (7.7 MB) | EPUB
  • 435 Views
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Article
Network Pharmacology Study of Bioactive Components and Molecular Mechanisms of the Glycoside Fraction from Picrorhiza scrophulariiflora Against Experimental Colitis
Peigen Wu, Churui Chang, Guanglin Zhu, Lixiang Zhai, Xu Zhang, Qiuchan Huan, Zhengxian Gao, Huan Deng, Yue Liang & Haitao Xiao
Pages: 1531-1546
Published online: 23 May 2023
AbstractforNetwork Pharmacology Study of Bioactive Components and Molecular Mechanisms of the Glycoside Fraction from Picrorhiza scrophulariiflora Against Experimental Colitis | Full Text | References | PDF (10.3 MB) | EPUB
  • 254 Views
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Article
Prophylactic Norepinephrine and Phenylephrine Boluses to Prevent Postspinal Anesthesia Hypotension During Cesarean Section: A Randomized Sequential Allocation Dose-Finding Study
Lei Guo, Xiangzhao Xu, Rui Qin, Yongqiang Shi, Wei Xue, Ling He, Shuqin Ma & Yi Chen
Pages: 1547-1555
Published online: 23 May 2023
AbstractforProphylactic Norepinephrine and Phenylephrine Boluses to Prevent Postspinal Anesthesia Hypotension During Cesarean Section: A Randomized Sequential Allocation Dose-Finding Study | Full Text | References | PDF (1.5 MB) | EPUB
  • 264 Views
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Article
Paeonol Promotes Reendothelialization After Vascular Injury Through Activation of c-Myc/VEGFR2 Signaling Pathway
Yang Wang, Zheng Wang, Xiao Wu, Song Zhu, Qiru Guo, Zhong Jin, Zixian Chen, Delai Zhang, Wangming Hu, Huan Xu, Liangqin Shi, Lan Yang & Yong Wang
Pages: 1567-1582
Published online: 24 May 2023
AbstractforPaeonol Promotes Reendothelialization After Vascular Injury Through Activation of c-Myc/VEGFR2 Signaling Pathway | Full Text | References | PDF (16.6 MB) | EPUB
  • 173 Views
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STUDY PROTOCOL

Effect of Flexible Half-Dose Gonadotropin-Releasing Hormone Antagonist Protocol on in vitro Fertilization Outcome in Predicted Normal Responder: A Study Protocol for a Multicentered, Randomized, Non-Inferiority, Parallel Controlled Trial
Ying-Jie Ma, Meng-Yao Li, Jing-Yan Song & Zhen-Gao Sun
Pages: 1557-1566
Published online: 24 May 2023
AbstractforEffect of Flexible Half-Dose Gonadotropin-Releasing Hormone Antagonist Protocol on in vitro Fertilization Outcome in Predicted Normal Responder: A Study Protocol for a Multicentered, Randomized, Non-Inferiority, Parallel Controlled Trial | Full Text | References | PDF (1.8 MB) | EPUB
  • 204 Views
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REVIEW

Review
Profile of Luspatercept in the Treatment of Anemia in Adults with Non-Transfusion-Dependent β-Thalassemia (NTDT): Design, Development and Potential Place in Therapy
Khaled M Musallam, Ali T Taher, Antonis Kattamis, Kevin HM Kuo, Sujit Sheth & Maria Domenica Cappellini
Pages: 1583-1591
Published online: 25 May 2023
AbstractforProfile of Luspatercept in the Treatment of Anemia in Adults with Non-Transfusion-Dependent β-Thalassemia (NTDT): Design, Development and Potential Place in Therapy | Full Text | References | PDF (1.9 MB) | EPUB
  • 336 Views
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ORIGINAL RESEARCH

Article
0.5–5% Supramolecular Salicylic Acid Hydrogel is Safe for Long-Term Topical Application and Improves the Expression of Genes Related to Skin Barrier Homeostasis in Mice Models
Can Zhou, Chunting Hua, Qichang Liang, Mus’ab Al Rudaisat, Siji Chen, Yinjing Song, Jiang Zhu & Hao Cheng
Pages: 1593-1609
Published online: 26 May 2023
Abstractfor0.5–5% Supramolecular Salicylic Acid Hydrogel is Safe for Long-Term Topical Application and Improves the Expression of Genes Related to Skin Barrier Homeostasis in Mice Models | Full Text | References | PDF (13.5 MB) | EPUB
  • 304 Views
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RESPONSE TO LETTER

Thinkful of Icariin Induces Triple-Negative Breast Cancer Cell Apoptosis and Suppresses Invasion by Inhibiting the JNK/c-Jun Signaling Pathway [Response to Letter]
Shenghan Gao, Xinyu Zhang, Jie Liu, Yonggang Lv & Wenzhen Shi
Pages: 1611-1612
Published online: 29 May 2023
CitationforThinkful of Icariin Induces Triple-Negative Breast Cancer Cell Apoptosis and Suppresses Invasion by Inhibiting the JNK/c-Jun Signaling Pathway [Response to Letter] | Full Text | References | PDF (265.7 KB) | EPUB
  • 146 Views
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ORIGINAL RESEARCH

Article
Tuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study
Mingsheng Lyu, Jingbo Qin, Shuaiyang Huang, Dongmei Shao, Guirui Huang, Fan Yang, Xuefeng Gong, Shiyu Zhang, Zhijie Zhang, Ji Wang & Hongsheng Cui
Pages: 1613-1630
Published online: 02 Jun 2023
AbstractforTuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study | Full Text | References | PDF (12.8 MB) | EPUB
  • 249 Views
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Article
Dexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy
Jingjing Huang, Minju Qin, Weisha Lu & Xia Shen
Pages: 1631-1640
Published online: 02 Jun 2023
AbstractforDexmedetomidine Improved Sleep Quality in the Intensive Care Unit After Laryngectomy | Full Text | References | PDF (4.2 MB) | EPUB
  • 189 Views
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Article
Metastasis Related Epithelial-Mesenchymal Transition Signature Predicts Prognosis and Response to Chemotherapy in Acute Myeloid Leukemia
Shuang Qu, Xiaoli Huang, Xiaoling Guo, Zhihai Zheng, Tiannan Wei & Biyun Chen
Pages: 1651-1663
Published online: 06 Jun 2023
AbstractforMetastasis Related Epithelial-Mesenchymal Transition Signature Predicts Prognosis and Response to Chemotherapy in Acute Myeloid Leukemia | Full Text | References | PDF (9.4 MB) | EPUB
  • 207 Views
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Article
A Novel Opioid-Sparing Analgesia Following Thoracoscopic Surgery: A Non-Inferiority Trial
Jing-jing Sun, Xiao-bing Xiang, Guang-hong Xu & Xin-qi Cheng
Pages: 1641-1650
Published online: 06 Jun 2023
AbstractforA Novel Opioid-Sparing Analgesia Following Thoracoscopic Surgery: A Non-Inferiority Trial | Full Text | References | PDF (3.1 MB) | EPUB
  • 181 Views
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CLINICAL TRIAL REPORT

Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study
Lin Jin, Yafen Liang, Ying Yu, Peng Miao, Yihao Huang, Liying Xu, Huilin Wang, Chunsheng Wang, Jiapeng Huang & Kefang Guo
Pages: 1665-1677
Published online: 07 Jun 2023
AbstractforEvaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study | Full Text | References | PDF (4.7 MB) | EPUB
  • 262 Views
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ORIGINAL RESEARCH

Article
Exploration of Artemisinin Against IgA Nephropathy via AKT/Nrf2 Pathway by Bioinformatics and Experimental Validation
Wei-guang Yang, Ao Sun, Rong Zhu, Nan Liu, Wei-jie He & Lin-lin Liu
Pages: 1679-1697
Published online: 07 Jun 2023
AbstractforExploration of Artemisinin Against IgA Nephropathy via AKT/Nrf2 Pathway by Bioinformatics and Experimental Validation | Full Text | References | PDF (15.1 MB) | EPUB
  • 280 Views
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Article
Perioperative Administration of Pregabalin and Esketamine to Prevent Chronic Pain After Breast Cancer Surgery: A Randomized Controlled Trial
Miao Wang, Hua-Ping Xiong, Kai Sheng, Xing-Bing Sun, Xiao-Qian Zhao & Qing-Ren Liu
Pages: 1699-1706
Published online: 08 Jun 2023
AbstractforPerioperative Administration of Pregabalin and Esketamine to Prevent Chronic Pain After Breast Cancer Surgery: A Randomized Controlled Trial | Full Text | References | PDF (3.1 MB) | EPUB
  • 260 Views
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Article
Efficacy and Safety of Ciprofol for Sedation/Anesthesia in Patients Undergoing Hysteroscopy: A Randomized, Parallel-Group, Controlled Trial
Haiyan Lan, Weifeng Shan, Yini Wu, Qiaomin Xu, Xiaoli Dong, Peiyi Mei, Gongchen Duan, Minji You, Linfei Jin & Jimin Wu
Pages: 1707-1717
Published online: 11 Jun 2023
AbstractforEfficacy and Safety of Ciprofol for Sedation/Anesthesia in Patients Undergoing Hysteroscopy: A Randomized, Parallel-Group, Controlled Trial | Full Text | References | PDF (3.5 MB) | EPUB
  • 242 Views
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Article
Sevoflurane Improves Ventricular Conduction by Exosomes Derived from Rat Cardiac Fibroblasts After Hypothermic Global Ischemia-Reperfusion Injury
Yanyan Ma, Ying Cao, Hong Gao, Rui Tong, Jing Yi, Zhongwei Zhang, Rui Chen & Zhijun Pan
Pages: 1719-1732
Published online: 12 Jun 2023
AbstractforSevoflurane Improves Ventricular Conduction by Exosomes Derived from Rat Cardiac Fibroblasts After Hypothermic Global Ischemia-Reperfusion Injury | Full Text | References | PDF (11.1 MB) | EPUB
  • 209 Views
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CLINICAL TRIAL REPORT

The Effect of Different Doses of Ciprofol in Patients with Painless Gastrointestinal Endoscopy
Lini Chen, Yongguo Xie, Xueke Du, Weiyong Qin, Lifu Huang, Junmin Dai, Ke Qin & Jianfeng Huang
Pages: 1733-1740
Published online: 12 Jun 2023
AbstractforThe Effect of Different Doses of Ciprofol in Patients with Painless Gastrointestinal Endoscopy | Full Text | References | PDF (2.9 MB) | EPUB
  • 212 Views
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ORIGINAL RESEARCH

Article
Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Gandouling Tablets Against Copper-Overload-Induced Neuronal Injury in Rats with Wilson’s Disease
Li Chen, Wang-Yang Xu, Hao Chen, Yan-Quan Han & Yu-Ting Zhang
Pages: 1763-1782
Published online: 13 Jun 2023
AbstractforIntegrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Gandouling Tablets Against Copper-Overload-Induced Neuronal Injury in Rats with Wilson’s Disease | Full Text | References | PDF (15.1 MB) | EPUB
  • 257 Views
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Article
Determination of the 50% and 95% Effective Dose of Remimazolam Combined with Propofol for Intravenous Sedation During Day-Surgery Hysteroscopy
Hua Tan, Ai-Fei Lou, Jian-Er Wu, Xin-Zhong Chen & Xiao-Wei Qian
Pages: 1753-1761
Published online: 13 Jun 2023
AbstractforDetermination of the 50% and 95% Effective Dose of Remimazolam Combined with Propofol for Intravenous Sedation During Day-Surgery Hysteroscopy | Full Text | References | PDF (2 MB) | EPUB
  • 229 Views
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CLINICAL TRIAL REPORT

Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair
Tingting Li, Wenjing Han, Xinlu Yang, Yu Wang, Li Peng, Lingwei He, Lianjia Hu, Jiayuan Liu, Min Xia & Sheng Wang
Pages: 1741-1752
Published online: 13 Jun 2023
AbstractforEffects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair | Full Text | References | PDF (2.7 MB) | EPUB
  • 246 Views
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REVIEW

Review
CAR T Cell Therapy: Remedies of Current Challenges in Design, Injection, Infiltration and Working
Yuxuan Zhu, Jianguo Feng, Rongxue Wan & Wenhua Huang
Pages: 1783-1792
Published online: 14 Jun 2023
AbstractforCAR T Cell Therapy: Remedies of Current Challenges in Design, Injection, Infiltration and Working | Full Text | References | PDF (1.5 MB) | EPUB
  • 248 Views
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ORIGINAL RESEARCH

Article
Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition
Aneela Gohar, Gowhar Ali, Umer Rashid, Khalid Rauf, Mehreen Arif, Muhammad Sona Khan, Yasser MSA Alkahramaan & Robert DE Sewell
Pages: 1793-1803
Published online: 16 Jun 2023
AbstractforEffect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition | Full Text | References | PDF (3.2 MB) | EPUB
  • 371 Views
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Article
Network Pharmacology Analysis of the Mechanisms Underlying the Therapeutic Effects of Yangjing Zhongyu Tang on Thin Endometrium
Lei Zhang, Honglin Li, Liang Zhang, Zhihui Zu, Dinglin Xu & Jianwei Zhang
Pages: 1805-1818
Published online: 17 Jun 2023
AbstractforNetwork Pharmacology Analysis of the Mechanisms Underlying the Therapeutic Effects of Yangjing Zhongyu Tang on Thin Endometrium | Full Text | References | PDF (11.4 MB) | EPUB
  • 210 Views
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Article
Luteolin Alleviates Liver Fibrosis in Rat Hepatic Stellate Cell HSC-T6: A Proteomic Analysis
Batudeligen, Zhiqiang Han, Hongmei Chen, Narisu, Yanhua Xu, Anda & Gegentaoli Han
Pages: 1819-1829
Published online: 17 Jun 2023
AbstractforLuteolin Alleviates Liver Fibrosis in Rat Hepatic Stellate Cell HSC-T6: A Proteomic Analysis | Full Text | References | PDF (8.5 MB) | EPUB
  • 243 Views
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Article
Insight into Nephrotoxicity and Processing Mechanism of Arisaema erubescens (Wall.) Schott by Metabolomics and Network Analysis
Min Wang, Na Yang, Xu Wu, Ting Zou, Jiahui Zheng, Huaijun Zhu, Chongbo Zhao & Jing Wang
Pages: 1831-1846
Published online: 19 Jun 2023
AbstractforInsight into Nephrotoxicity and Processing Mechanism of Arisaema erubescens (Wall.) Schott by Metabolomics and Network Analysis | Full Text | References | PDF (9.1 MB) | EPUB
  • 219 Views
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Article
Sanqi Qushi Granule Alleviates Proteinuria and Podocyte Damage in NS Rat: A Network Pharmacology Study and in vivo Experimental Validation
Lijuan Wang, Huoliang Liu, Yi Wang, XiaoFan Hong, Xiaoyan Huang, Miaoru Han, Dan Wang, Wenjun Shan, Ping Li, Haowen Gu, Bo Liu & Kun Bao
Pages: 1847-1861
Published online: 19 Jun 2023
AbstractforSanqi Qushi Granule Alleviates Proteinuria and Podocyte Damage in NS Rat: A Network Pharmacology Study and in vivo Experimental Validation | Full Text | References | PDF (11.6 MB) | EPUB
  • 178 Views
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Article
Clinical Trials in Hypertrophic Cardiomyopathy Therapy: A Comprehensive Analysis of Trials Registered in Global Clinical Databases
Huan Zhang, Cheng Yu, Yuanling Cheng, Zhi Chen, Min Chen, Wangan He, Zhigang Jin, Shaoqian Cai & Lijuan Yu
Pages: 1863-1877
Published online: 21 Jun 2023
AbstractforClinical Trials in Hypertrophic Cardiomyopathy Therapy: A Comprehensive Analysis of Trials Registered in Global Clinical Databases | Full Text | References | PDF (4.4 MB) | EPUB
  • 281 Views
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RETRACTION

Retraction
Endoplasmic Reticulum Stress-Induced Autophagy Determines the Susceptibility of Melanoma Cells to Dabrafenib [Retraction]
Pages: 1879-1880
Published online: 22 Jun 2023
CitationforEndoplasmic Reticulum Stress-Induced Autophagy Determines the Susceptibility of Melanoma Cells to Dabrafenib [Retraction] | Full Text | PDF (242.9 KB) | EPUB
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CLINICAL TRIAL REPORT

Evaluation of Pharmacokinetics and Safety with Bioequivalence of Ibuprofen Sustained-Release Capsules of Two Formulations, in Chinese Healthy Volunteers: Bioequivalence Study
Chunqi Huang, Zhou Yin, Yeqing Yang, Nan Mo, Hui Yang & Ying Wang
Pages: 1881-1888
Published online: 23 Jun 2023
AbstractforEvaluation of Pharmacokinetics and Safety with Bioequivalence of Ibuprofen Sustained-Release Capsules of Two Formulations, in Chinese Healthy Volunteers: Bioequivalence Study | Full Text | References | PDF (2 MB) | EPUB
  • 333 Views
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ORIGINAL RESEARCH

Article
Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines
Xiang-Zhe Shi, Sheng Zhao, Yan Wang, Meng-Yao Wang, Su-Wen Su, Yan-Zhao Wu & Chen Xiong
Pages: 1889-1906
Published online: 26 Jun 2023
AbstractforAntitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines | Full Text | References | PDF (13.6 MB) | EPUB
  • 226 Views
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REVIEW

Review
Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
Siddhartha Dutta, Rima B Shah, Shubha Singhal, Sudeshna Banerjee Dutta, Sumit Bansal, Susmita Sinha & Mainul Haque
Pages: 1907-1932
Published online: 26 Jun 2023
AbstractforMetformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes | Full Text | References | PDF (2.7 MB) | EPUB
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Review
Informatics on Drug Repurposing for Breast Cancer
Hui Zhou, Hongdou Liu, Yan Yu, Xiao Yuan & Ling Xiao
Pages: 1933-1943
Published online: 28 Jun 2023
AbstractforInformatics on Drug Repurposing for Breast Cancer | Full Text | References | PDF (595.4 KB) | EPUB
  • 492 Views
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ORIGINAL RESEARCH

Article
The Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Gastrointestinal Tumors: A Randomized Controlled Trial
Jiamin Ma, Fuquan Wang, Jingxu Wang, Pengcheng Wang, Xiaoke Dou, Shanglong Yao & Yun Lin
Pages: 1945-1957
Published online: 29 Jun 2023
AbstractforThe Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Gastrointestinal Tumors: A Randomized Controlled Trial | Full Text | References | PDF (1.5 MB) | EPUB
  • 525 Views
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EDITORIAL

Editorial
Statistical Analysis in Clinical and Experimental Medical Research: Simplified Guidance for Authors and Reviewers
Georgios D Panos & Frank M Boeckler
Pages: 1959-1961
Published online: 03 Jul 2023
First Page PreviewforStatistical Analysis in Clinical and Experimental Medical Research: Simplified Guidance for Authors and Reviewers | Full Text | References | PDF (316 KB) | EPUB
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REVIEW

Review
Untapping the Potential of Astragaloside IV in the Battle Against Respiratory Diseases
Junlan Tan, Jian Yi, Xianya Cao, Feiying Wang, Silin Xie & Aiguo Dai
Pages: 1963-1978
Published online: 03 Jul 2023
AbstractforUntapping the Potential of Astragaloside IV in the Battle Against Respiratory Diseases | Full Text | References | PDF (4.7 MB) | EPUB
  • 233 Views
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Review
Profile of Lasmiditan in the Acute Treatment of Migraine in Adults: Design, Development, and Place in Therapy
Christopher C Anderson & Juliana H VanderPluym
Pages: 1979-1993
Published online: 03 Jul 2023
AbstractforProfile of Lasmiditan in the Acute Treatment of Migraine in Adults: Design, Development, and Place in Therapy | Full Text | References | PDF (869.3 KB) | EPUB
  • 269 Views
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Review
Antimalarial Drug Resistance: A Brief History of Its Spread in Indonesia
Loeki Enggar Fitri, Aulia Rahmi Pawestri, Nuning Winaris, Agustina Tri Endharti, Alif Raudhah Husnul Khotimah, Hafshah Yasmina Abidah & John Thomas Rayhan Huwae
Pages: 1995-2010
Published online: 05 Jul 2023
AbstractforAntimalarial Drug Resistance: A Brief History of Its Spread in Indonesia | Full Text | References | PDF (3.2 MB) | EPUB
  • 741 Views
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ORIGINAL RESEARCH

Article
Efficacy and Safety of Anlotinib in Overall and Disease-Specific Advanced Gynecological Cancer: A Real-World Study
Xinyi Hong, Shanhu Qiu, Xia Wu, Sizhen Chen, Xiaoxiang Chen, Bei Zhang, Aiqin He, Yun Xu, Jianqing Wang, Yingchun Gao, Xizhong Xu, Li Sun, Yang Zhang, Libing Xiang, Jundong Zhou, Qun Guan, Yanling Zhu, Haiyan Liu, Hao Xu, Ying Zhou, Bingwei Chen & Yang Shen
Pages: 2025-2033
Published online: 06 Jul 2023
AbstractforEfficacy and Safety of Anlotinib in Overall and Disease-Specific Advanced Gynecological Cancer: A Real-World Study | Full Text | References | PDF (1.7 MB) | EPUB
  • 223 Views
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REVIEW

Review
SGLT1: A Potential Drug Target for Cardiovascular Disease
Mengnan Zhao, Na Li & Hong Zhou
Pages: 2011-2023
Published online: 06 Jul 2023
AbstractforSGLT1: A Potential Drug Target for Cardiovascular Disease | Full Text | References | PDF (3.6 MB) | EPUB
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Review
Mapping Research Trends of Medications for Multidrug-Resistant Pulmonary Tuberculosis Based on the Co-Occurrence of Specific Semantic Types in the MeSH Tree: A Bibliometric and Visualization-Based Analysis of PubMed Literature (1966–2020)
Shuang Xu, Yi Fu, Dan Xu, Shuang Han, Mingzhi Wu, Xinrong Ju, Meng Liu, De-Sheng Huang & Peng Guan
Pages: 2035-2049
Published online: 10 Jul 2023
AbstractforMapping Research Trends of Medications for Multidrug-Resistant Pulmonary Tuberculosis Based on the Co-Occurrence of Specific Semantic Types in the MeSH Tree: A Bibliometric and Visualization-Based Analysis of PubMed Literature (1966–2020) | Full Text | References | PDF (5.4 MB) | EPUB
  • 289 Views
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ORIGINAL RESEARCH

Article
Phase I, Single-Dose Study to Assess the Pharmacokinetics and Safety of Suramin in Healthy Chinese Volunteers
Guolan Wu, Huili Zhou, Duo Lv, Ruling Zheng, Lihua Wu, Songxia Yu, Jiejing Kai, Nana Xu, Lie Gu, Nanfang Hong & Jianzhong Shentu
Pages: 2051-2061
Published online: 11 Jul 2023
AbstractforPhase I, Single-Dose Study to Assess the Pharmacokinetics and Safety of Suramin in Healthy Chinese Volunteers | Full Text | References | PDF (1.9 MB) | EPUB
  • 192 Views
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Article
Design, Synthesis and Biological Evaluation of Glycosylated Derivatives of Silibinin as Potential Anti-Tumor Agents
Jian-Jun Xi, Yu Cao, Ruo-Yu He, Jian-Kang Zhang, Yan-Mei Zhao, Qiao Tong, Jian-Feng Bao, Yi-Chen Dong, Rang-Xiao Zhuang, Jin-Song Huang, Yongping Chen & Shou-Rong Liu
Pages: 2063-2076
Published online: 11 Jul 2023
AbstractforDesign, Synthesis and Biological Evaluation of Glycosylated Derivatives of Silibinin as Potential Anti-Tumor Agents | Full Text | References | PDF (6.3 MB) | EPUB
  • 256 Views
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CLINICAL TRIAL REPORT

Comparison of Dural Puncture Epidural, Epidural and Combined Spinal-Epidural Anesthesia for Cesarean Delivery: A Randomized Controlled Trial
Wan-Yi Rao, Fang Xu, Shao-Bing Dai, Zhong Mei, Xiao-Ping Chen, Chang-Cheng Lv, Chun-Lei Liu, Warwick Ngan Kee & Xin-Zhong Chen
Pages: 2077-2085
Published online: 18 Jul 2023
AbstractforComparison of Dural Puncture Epidural, Epidural and Combined Spinal-Epidural Anesthesia for Cesarean Delivery: A Randomized Controlled Trial | Full Text | References | PDF (642.9 KB) | EPUB
  • 472 Views
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ORIGINAL RESEARCH

Article
Astragalus Polysaccharide Ameliorates Renal Inflammatory Responses in a Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway
Mingfei Guo, Jiarong Gao, Lei Jiang & Yaji Dai
Pages: 2107-2118
Published online: 19 Jul 2023
AbstractforAstragalus Polysaccharide Ameliorates Renal Inflammatory Responses in a Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway | Full Text | References | PDF (9.7 MB) | EPUB
  • 234 Views
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Article
Dendritic Cell-Derived Exosomes Driven Drug Co-Delivery Biomimetic Nanosystem for Effective Combination of Malignant Melanoma Immunotherapy and Gene Therapy
Jiecheng Lin, Na Huang, Mingjuan Li, Mengyuan Zheng, Zhuoxiang Wang, Xiaojuan Zhang, Huan Gao, Yunzhe Lao, Jie Zhang & Baoyue Ding
Pages: 2087-2106
Published online: 19 Jul 2023
AbstractforDendritic Cell-Derived Exosomes Driven Drug Co-Delivery Biomimetic Nanosystem for Effective Combination of Malignant Melanoma Immunotherapy and Gene Therapy | Full Text | References | PDF (11.8 MB) | EPUB
  • 389 Views
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Article
Bibliometric Analysis of Global Trends in Remimazolam-Related Research Over the Past 15 Years: Compared with Propofol
Xinyue Hu, Beibei Wang, Li Hu, Dong Han & Jing Wu
Pages: 2119-2135
Published online: 20 Jul 2023
AbstractforBibliometric Analysis of Global Trends in Remimazolam-Related Research Over the Past 15 Years: Compared with Propofol | Full Text | References | PDF (12.9 MB) | EPUB
  • 232 Views
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Article
Investigation of the Mechanisms and Experimental Verification of Yulin Formula in the Treatment of Diminished Ovarian Reserve via Network Pharmacology
Ruye Wang, Ying Zhao, Chenyun Miao, Yun Chen, Ning Ren, Liuqin Yang, Wei Cheng, Qin Zhang & Xiaohong Fang
Pages: 2147-2163
Published online: 24 Jul 2023
AbstractforInvestigation of the Mechanisms and Experimental Verification of Yulin Formula in the Treatment of Diminished Ovarian Reserve via Network Pharmacology | Full Text | References | PDF (15.6 MB) | EPUB
  • 192 Views
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Article
Comparison of the Pharmacokinetics, Safety, and Tolerability of Two Empagliflozin Formulations in Healthy Korean Subjects
Xu Jiang, Sungyeun Bae, Deok Yong Yoon, Shin Jung Park, Jaeseong Oh, Joo-Youn Cho & Kyung-Sang Yu
Pages: 2137-2145
Published online: 24 Jul 2023
AbstractforComparison of the Pharmacokinetics, Safety, and Tolerability of Two Empagliflozin Formulations in Healthy Korean Subjects | Full Text | References | PDF (590.8 KB) | EPUB
  • 371 Views
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Article
Probiotics Alleviate Chemotherapy-Associated Intestinal Mucosal Injury via the TLR4–NFκB Signaling Pathway
Xiaochong Li, Bowen Hu, Jiachen Zheng, Zhiyong Pan, Yuxiang Cai, Mingjuan Zhao, Xiaoqing Jin & Zhi-Qiang Li
Pages: 2183-2192
Published online: 25 Jul 2023
AbstractforProbiotics Alleviate Chemotherapy-Associated Intestinal Mucosal Injury via the TLR4–NFκB Signaling Pathway | Full Text | References | PDF (4.1 MB) | EPUB
  • 221 Views
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Article
A Bibliometric Analysis of Mesenchymal Stem Cell-Derived Exosomes in Acute Lung Injury/Acute Respiratory Distress Syndrome from 2013 to 2022
Wenyu Zhou, Song Hu, Yutong Wu, Huan Xu, Lina Zhu, Huimin Deng, Sheng Wang, Yuanli Chen, Huanping Zhou, Xin Lv, Quanfu Li & Hao Yang
Pages: 2165-2181
Published online: 25 Jul 2023
AbstractforA Bibliometric Analysis of Mesenchymal Stem Cell-Derived Exosomes in Acute Lung Injury/Acute Respiratory Distress Syndrome from 2013 to 2022 | Full Text | References | PDF (12.5 MB) | EPUB
  • 220 Views
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REVIEW

Review
Review of the Protective Mechanism of Paeonol on Cardiovascular Disease
Chunkun Yang, Jiawen Cheng, Qinwei Zhu, Qingquan Pan, Kui Ji & Jun Li
Pages: 2193-2208
Published online: 26 Jul 2023
AbstractforReview of the Protective Mechanism of Paeonol on Cardiovascular Disease | Full Text | References | PDF (5 MB) | EPUB
  • 227 Views
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ORIGINAL RESEARCH

Article
Elucidating the Mechanism of Agrimonolide in Treating Colon Cancer Based on Network Pharmacology
Lei Yu & Yun Gai
Pages: 2209-2222
Published online: 27 Jul 2023
AbstractforElucidating the Mechanism of Agrimonolide in Treating Colon Cancer Based on Network Pharmacology | Full Text | References | PDF (10.6 MB) | EPUB
  • 260 Views
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Article
The First Discovery of a Microstructure in Black Plaster and Its Performance Characterization
Yingpeng Li, Ting Zhu, Jingxian Liang, Yuanqun Wu, Xiantong Guan, Tingting Liu, Shaowa Lü, Yongji Li, Yanhong Wang & Yang Ping
Pages: 2223-2237
Published online: 28 Jul 2023
AbstractforThe First Discovery of a Microstructure in Black Plaster and Its Performance Characterization | Full Text | References | PDF (9.3 MB) | EPUB
  • 180 Views
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Article
Zhiqiao Gancao Decoction Ameliorates Hyperalgesia in Lumbar Disc Herniation via the CCL2/CCR2 Signaling Pathway
Zeling Huang, Binjie Lu, Xianda Zhang, Jiangping Wang, Xuefeng Cai, Yujiang Liu, Jianxiong Mo, Yuwei Li, Bo Xu & Xiaofeng Shen
Pages: 2239-2257
Published online: 28 Jul 2023
AbstractforZhiqiao Gancao Decoction Ameliorates Hyperalgesia in Lumbar Disc Herniation via the CCL2/CCR2 Signaling Pathway | Full Text | References | PDF (14.6 MB) | EPUB
  • 230 Views
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Article
Optimal Teicoplanin Dosage Regimens in Critically Ill Patients: Population Pharmacokinetics and Dosing Simulations Based on Renal Function and Infection Type
Yifan Wang, Fen Yao, Shenglong Chen, Xin Ouyang, Jinhua Lan, Zheng Wu, Yirong Wang, Jingchun Chen, Xipei Wang & Chunbo Chen
Pages: 2259-2271
Published online: 01 Aug 2023
AbstractforOptimal Teicoplanin Dosage Regimens in Critically Ill Patients: Population Pharmacokinetics and Dosing Simulations Based on Renal Function and Infection Type | Full Text | References | PDF (5.9 MB) | EPUB
  • 200 Views
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Article
Dispelling Dampness, Relieving Turbidity and Dredging Collaterals Decoction, Attenuates Potassium Oxonate-Induced Hyperuricemia in Rat Models
Hai-bo Liu, Min Yang, Wan Li, Ting Luo, Yang Wu, Xiang-yu Huang, Yao-lei Zhang, Tao Liu & Yong Luo
Pages: 2287-2301
Published online: 02 Aug 2023
AbstractforDispelling Dampness, Relieving Turbidity and Dredging Collaterals Decoction, Attenuates Potassium Oxonate-Induced Hyperuricemia in Rat Models | Full Text | References | PDF (12.6 MB) | EPUB
  • 184 Views
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Article
Dioscin Ameliorates Experimental Autoimmune Thyroiditis via the mTOR and TLR4/NF-κB Signaling
Chengfei Zhang, Qiue Zhang, Lingling Qin, Zhiyi Yan, Lili Wu & Tonghua Liu
Pages: 2273-2285
Published online: 02 Aug 2023
AbstractforDioscin Ameliorates Experimental Autoimmune Thyroiditis via the mTOR and TLR4/NF-κB Signaling | Full Text | References | PDF (6.4 MB) | EPUB
  • 198 Views
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Article
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Novel Intravenous Formulation of Meloxicam (QP001) in Healthy Chinese Subjects
Junlong Ma, Jie Huang, Chan Zou, Qian Wu, Jinlian Xie, Xingfei Zhang, Xiaoyan Yang, Shuang Yang, Ziteng Wu, Yan Jiang, Sen Yu, Xuqing Zhang, Guoping Yang & Mingyuan Li
Pages: 2303-2313
Published online: 03 Aug 2023
AbstractforA Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Novel Intravenous Formulation of Meloxicam (QP001) in Healthy Chinese Subjects | Full Text | References | PDF (3.3 MB) | EPUB
  • 223 Views
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Article
Changes in Drug Clinical Trials of Thyroid Diseases in China, 2009–2022
Chen Li, Jun Hao, Chuangshi Wang, Jie Yang, Yitian Zheng, Kuo Zhang, Wen Hui, Xiangbin Meng, Jun Gao, Wei Li & Yi-Da Tang
Pages: 2315-2324
Published online: 03 Aug 2023
AbstractforChanges in Drug Clinical Trials of Thyroid Diseases in China, 2009–2022 | Full Text | References | PDF (4.1 MB) | EPUB
  • 193 Views
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REVIEW

Review
Profile of Relugolix in the Management of Advanced Hormone-Sensitive Prostate Cancer: Design, Development, and Place in Therapy
Tomoyuki Tatenuma & Hiroshi Miyamoto
Pages: 2325-2333
Published online: 04 Aug 2023
AbstractforProfile of Relugolix in the Management of Advanced Hormone-Sensitive Prostate Cancer: Design, Development, and Place in Therapy | Full Text | References | PDF (1,009.1 KB) | EPUB
  • 226 Views
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ORIGINAL RESEARCH

Article
Network Pharmacology and Molecular Docking Reveal the Mechanism of Isodon ternifolius (D. Don) Kudo Against Liver Fibrosis
Jiasheng Deng, Le Qin & Zhipin Zhou
Pages: 2335-2351
Published online: 07 Aug 2023
AbstractforNetwork Pharmacology and Molecular Docking Reveal the Mechanism of Isodon ternifolius (D. Don) Kudo Against Liver Fibrosis | Full Text | References | PDF (13.3 MB) | EPUB
  • 213 Views
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LETTER

Letter to the Editor
Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study [Letter]
Pei-Shan Chen, Fu-Shan Xue & Cheng-Wen Li
Pages: 2353-2354
Published online: 10 Aug 2023
CitationforEvaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study [Letter] | Full Text | References | PDF (276.2 KB) | EPUB
  • 155 Views
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ORIGINAL RESEARCH

Article
Renzhu Ointment Regulates L-Type Voltage-Dependent Calcium Channel in Mice Model of Senna-Induced Diarrhea by Transdermal Administration
Lian Zhong, Xiaoyu Cao, Li Li, Yuanyuan He, Yanxia Liu, Weiwei Chen, Fuzhen Yang, Ni Xiao, Jun Zhang & Huifen He
Pages: 2355-2368
Published online: 11 Aug 2023
AbstractforRenzhu Ointment Regulates L-Type Voltage-Dependent Calcium Channel in Mice Model of Senna-Induced Diarrhea by Transdermal Administration | Full Text | References | PDF (7 MB) | EPUB
  • 191 Views
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Article
Paroxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis Progression
Xiaohang Zheng, Jianxin Qiu, Ning Gao, Ting Jiang, Ze Li, Weikang Zhang, Yuhang Gong, Zhenghua Hong & Huaxing Hong
Pages: 2383-2399
Published online: 16 Aug 2023
AbstractforParoxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis Progression | Full Text | References | PDF (12.2 MB) | EPUB
  • 287 Views
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Article
Comparative Pharmacokinetics and Bioequivalence Evaluation of Two Formulations of Pramipexole Dihydrochloride Extended-Release Tablets in Healthy Chinese Subjects Under Fasted and Fed States: A Randomized, Open-Label, Single-Dose, Two-Period Crossover Clinical Trial
Ling Yang, Liangliang Zhang & Zhu Luo
Pages: 2369-2381
Published online: 15 Aug 2023
AbstractforComparative Pharmacokinetics and Bioequivalence Evaluation of Two Formulations of Pramipexole Dihydrochloride Extended-Release Tablets in Healthy Chinese Subjects Under Fasted and Fed States: A Randomized, Open-Label, Single-Dose, Two-Period Crossover Clinical Trial | Full Text | References | PDF (5 MB) | EPUB
  • 191 Views
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Article
An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine
Xin Zhao, Pingyuan Ge, Shaohua Lei, Siqi Guo, Peng Zhou, Li Zhao, Yiyu Qi, Xiaotong Wei, Weizhen Wu, Ningjing Wang, Rui Guo, Nianyun Yang, Qingqing Xiao, Qichun Zhang & Huaxu Zhu
Pages: 2401-2420
Published online: 17 Aug 2023
AbstractforAn Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine | Full Text | References | PDF (12.6 MB) | EPUB
  • 389 Views
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CLINICAL TRIAL REPORT

Pharmacokinetic Study of Enteric-Coated Sustained-Release Aspirin Tablets in Healthy Chinese Participants
Duanduan Cong, Wenyuan Qi, Xiaohui Liu, Xiaoyu Xu, Lingyun Dong, Wei Xue & Kexin Li
Pages: 2421-2429
Published online: 18 Aug 2023
AbstractforPharmacokinetic Study of Enteric-Coated Sustained-Release Aspirin Tablets in Healthy Chinese Participants | Full Text | References | PDF (1.7 MB) | EPUB
  • 342 Views
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LETTER

Letter to the Editor
Critical Response to Article “Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer” [Letter]
Frans Dany, Uly Alfi Nikmah & Lisa Andriani Lienggonegoro
Pages: 2455-2456
Published online: 21 Aug 2023
CitationforCritical Response to Article “Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Kanglaite Injection Against Triple-Negative Breast Cancer” [Letter] | Full Text | References | PDF (280.5 KB) | EPUB
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ORIGINAL RESEARCH

Article
In vitro and in vivo Efficacies of Novel Harmine Derivatives in the Treatment of Cystic Echinococcosis
Bei Chen, Mingzhi Yan, Huijing Gao, Qin Ma, Lihua Li, Guodong Lü, Yuehong Gong, Limei Wen, Shaoquan Xu, Jianhua Wang & Jun Zhao
Pages: 2441-2454
Published online: 21 Aug 2023
AbstractforIn vitro and in vivo Efficacies of Novel Harmine Derivatives in the Treatment of Cystic Echinococcosis | Full Text | References | PDF (8.3 MB) | EPUB
  • 177 Views
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CLINICAL TRIAL REPORT

Intravenous Lidocaine Decreased the Median Effective Concentration of Sufentanil for Tracheal Intubation in Obese Patients
Dong Jia, Xueying Yuan, Chaoqun He & Faping Tu
Pages: 2431-2439
Published online: 21 Aug 2023
AbstractforIntravenous Lidocaine Decreased the Median Effective Concentration of Sufentanil for Tracheal Intubation in Obese Patients | Full Text | References | PDF (585.4 KB) | EPUB
  • 193 Views
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ORIGINAL RESEARCH

Article
Ursolic Acid Ameliorated Neuronal Damage by Restoring Microglia-Activated MMP/TIMP Imbalance in vitro
Luying Qiu, Yaxuan Wang, Yuye Wang, Fang Liu, Shumin Deng, Weishuang Xue & Yanzhe Wang
Pages: 2481-2493
Published online: 22 Aug 2023
AbstractforUrsolic Acid Ameliorated Neuronal Damage by Restoring Microglia-Activated MMP/TIMP Imbalance in vitro | Full Text | References | PDF (8.8 MB) | EPUB
  • 221 Views
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Article
Galangin Attenuates Myocardial Ischemic Reperfusion-Induced Ferroptosis by Targeting Nrf2/Gpx4 Signaling Pathway
Tao Yang, Haiqiong Liu, Chaobo Yang, Huaqiang Mo, Xianbao Wang, Xudong Song, Luping Jiang, Ping Deng, Ran Chen, Pengcui Wu, Aihua Chen & Jing Yan
Pages: 2495-2511
Published online: 22 Aug 2023
AbstractforGalangin Attenuates Myocardial Ischemic Reperfusion-Induced Ferroptosis by Targeting Nrf2/Gpx4 Signaling Pathway | Full Text | References | PDF (11.3 MB) | EPUB
  • 346 Views
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Article
Integrating Network Pharmacology and Experimental Validation to Explore the Effects and Mechanisms of Qinghao Biejia Decoction and Its Active Compound Artemisinin B Against Non-Small-Cell Lung Cancer
Yonghua Ye, Yuping Yang, Li Yan, Li Zhou, Shihui Yu, Quan Du, Xiaoqiao Dong, Qiang Yuan, Letian Shan & Le Guo
Pages: 2461-2479
Published online: 22 Aug 2023
AbstractforIntegrating Network Pharmacology and Experimental Validation to Explore the Effects and Mechanisms of Qinghao Biejia Decoction and Its Active Compound Artemisinin B Against Non-Small-Cell Lung Cancer | Full Text | References | PDF (12.3 MB) | EPUB
  • 213 Views
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RESPONSE TO LETTER

Letter
Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study [Response to Letter]
Lin Jin & Kefang Guo
Pages: 2457-2460
Published online: 22 Aug 2023
First Page PreviewforEvaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study [Response to Letter] | Full Text | References | PDF (367.8 KB) | EPUB
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ORIGINAL RESEARCH

Article
Recombinant Neorudin for the Prevention of Deep-Vein Thrombosis After Spinal-Cord Injury
Yu-Bin Liu, Yun Liu, Lin Zhang, Xing-Chen Zhou, Bo-Yuan Ren, Can Zheng, Chun-Hua Hao, Wei-Ting Wang, Xia Xia, Gang-Qiao Zhou, Chu-Tse Wu & Ji-De Jin
Pages: 2523-2535
Published online: 23 Aug 2023
AbstractforRecombinant Neorudin for the Prevention of Deep-Vein Thrombosis After Spinal-Cord Injury | Full Text | References | PDF (9.5 MB) | EPUB
  • 154 Views
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Article
ABCG2 Gene Polymorphisms May Affect the Bleeding Risk in Patients on Apixaban and Rivaroxaban
Hamin Kim, Tae-Jin Song, Jeong Yee, Dong-Hyeok Kim, Junbeom Park & Hye Sun Gwak
Pages: 2513-2522
Published online: 23 Aug 2023
AbstractforABCG2 Gene Polymorphisms May Affect the Bleeding Risk in Patients on Apixaban and Rivaroxaban | Full Text | References | PDF (1.4 MB) | EPUB
  • 221 Views
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Article
New Target for Minoxidil in the Treatment of Androgenetic Alopecia
Yuqing Shen, Yuqi Zhu, Li Zhang, Jiayi Sun, Bo Xie, Hongyan Zhang & Xiuzu Song
Pages: 2537-2547
Published online: 24 Aug 2023
AbstractforNew Target for Minoxidil in the Treatment of Androgenetic Alopecia | Full Text | References | PDF (6.8 MB) | EPUB
  • 516 Views
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REVIEW

Review
Tracking Research on Hemoglobin-Based Oxygen Carriers: A Scientometric Analysis and In-Depth Review
Qi Zhang, Yue-Xiang Ma, Zheng Dai, Bin Zhang, Shan-Shou Liu, Wen-Xiu Li, Chuan-Qing Fu, Qian-Mei Wang & Wen Yin
Pages: 2549-2571
Published online: 24 Aug 2023
AbstractforTracking Research on Hemoglobin-Based Oxygen Carriers: A Scientometric Analysis and In-Depth Review | Full Text | References | PDF (9.1 MB) | EPUB
  • 343 Views
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Review
Oral Isotretinoin and Its Uses in Dermatology: A Review
Anon Paichitrojjana & Anand Paichitrojjana
Pages: 2573-2591
Published online: 25 Aug 2023
AbstractforOral Isotretinoin and Its Uses in Dermatology: A Review | Full Text | References | PDF (693.2 KB) | EPUB
  • 1477 Views
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ORIGINAL RESEARCH

Article
Comprehensive Analysis to Identify Rh Family C Glycoprotein (RHCG) as the Causative Gene for Psoriasis and Search for Alternative Treatment Modalities
Qian Zhang, Jia Liu, Dan Yao, Jian-Xin Shi, Yuan-Jie Liu, Yue-Gang Wei & Shun Guo
Pages: 2593-2611
Published online: 28 Aug 2023
AbstractforComprehensive Analysis to Identify Rh Family C Glycoprotein (RHCG) as the Causative Gene for Psoriasis and Search for Alternative Treatment Modalities | Full Text | References | PDF (18.2 MB) | EPUB
  • 268 Views
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Article
Effect of Dexmedetomidine and Two Different Doses of Esketamine Combined Infusion on the Quality of Recovery in Patients Undergoing Modified Radical Mastectomy for Breast Cancer - A Randomised Controlled Study
Zheng Huang, Ning Liu, Shenghong Hu, Xia Ju, Siqi Xu & Shengbin Wang
Pages: 2613-2621
Published online: 28 Aug 2023
AbstractforEffect of Dexmedetomidine and Two Different Doses of Esketamine Combined Infusion on the Quality of Recovery in Patients Undergoing Modified Radical Mastectomy for Breast Cancer - A Randomised Controlled Study | Full Text | References | PDF (430.8 KB) | EPUB
  • 204 Views
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REVIEW

Review
Coenzyme Q10 Stimulate Reproductive Vatality
Xinyu Nie, Xinru Dong, Yuge Hu, Fangjun Xu, Cong Hu & Chang Shu
Pages: 2623-2637
Published online: 30 Aug 2023
AbstractforCoenzyme Q10 Stimulate Reproductive Vatality | Full Text | References | PDF (1.6 MB) | EPUB
  • 672 Views
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Review
Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics
He Ma, Zhenxiang Pan, Bingjie Lai, Chunfang Zan & He Liu
Pages: 2639-2655
Published online: 30 Aug 2023
AbstractforRecent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics | Full Text | References | PDF (4.6 MB) | EPUB
  • 531 Views
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ORIGINAL RESEARCH

Article
The Effect of Dihydromyricetin on the Pharmacokinetics of Fluconazole in Sprague-Dawley Rat Plasma, Based on High-Performance Liquid Chromatography–Tandem Mass Spectrometry
Hongchuan Liu, Huaihuai Dong, Liangjun Guo, Yongsheng Jin & Lihong Liu
Pages: 2657-2667
Published online: 31 Aug 2023
AbstractforThe Effect of Dihydromyricetin on the Pharmacokinetics of Fluconazole in Sprague-Dawley Rat Plasma, Based on High-Performance Liquid Chromatography–Tandem Mass Spectrometry | Full Text | References | PDF (2.6 MB) | EPUB
  • 177 Views
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Article
Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study
Jinjuan Duan, Xia Ju, Xing Wang, Ning Liu, Siqi Xu & Shengbin Wang
Pages: 2669-2678
Published online: 01 Sep 2023
AbstractforEffects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study | Full Text | References | PDF (2 MB) | EPUB
  • 333 Views
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REVIEW

Review
Inhibition of LPA-LPAR1 and VEGF-VEGFR2 Signaling in IPF Treatment
Ya-Li Luo, Yan Li, Wen Zhou, Si-Yu Wang & Yong-Qi Liu
Pages: 2679-2690
Published online: 02 Sep 2023
AbstractforInhibition of LPA-LPAR1 and VEGF-VEGFR2 Signaling in IPF Treatment | Full Text | References | PDF (3.6 MB) | EPUB
  • 181 Views
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PERSPECTIVES

Article Commentary
The Coming of Age of AI/ML in Drug Discovery, Development, Clinical Testing, and Manufacturing: The FDA Perspectives
Sarfaraz K Niazi
Pages: 2691-2725
Published online: 06 Sep 2023
AbstractforThe Coming of Age of AI/ML in Drug Discovery, Development, Clinical Testing, and Manufacturing: The FDA Perspectives | Full Text | References | PDF (1 MB) | EPUB
  • 1064 Views
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LETTER

Letter to the Editor
More Smart Use of Direct Oral Anticoagulants in Geriatric Patients [Letter]
Ling-Ling Zhu & Quan Zhou
Pages: 2747-2748
Published online: 06 Sep 2023
CitationforMore Smart Use of Direct Oral Anticoagulants in Geriatric Patients [Letter] | Full Text | References | PDF (270.9 KB) | EPUB
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ORIGINAL RESEARCH

Article
Exploring the Mechanisms of Modified Bu-Shen-Yi-Qi Decoction for COPD-Related Osteoporosis Therapy via Transcriptomics and Network Pharmacology Approach
Yuanyuan Zhong, Bin Wang, Wenjing Chen, Hongying Zhang, Jing Sun & Jingcheng Dong
Pages: 2727-2745
Published online: 06 Sep 2023
AbstractforExploring the Mechanisms of Modified Bu-Shen-Yi-Qi Decoction for COPD-Related Osteoporosis Therapy via Transcriptomics and Network Pharmacology Approach | Full Text | References | PDF (19.9 MB) | EPUB
  • 228 Views
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Article
Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-β1/Smad2/3 Signaling Pathway in Spontaneously Hypertensive Rats
Mengying Yao, Dawei Lian, Meizhu Wu, Yuting Zhou, Yi Fang, Siyu Zhang, Wenqiang Zhang, Yanyan Yang, Renfeng Li, Hong Chen, Youqin Chen, Aling Shen & Jun Peng
Pages: 2749-2762
Published online: 07 Sep 2023
AbstractforIsoliensinine Attenuates Renal Fibrosis and Inhibits TGF-β1/Smad2/3 Signaling Pathway in Spontaneously Hypertensive Rats | Full Text | References | PDF (9.5 MB) | EPUB
  • 182 Views
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REVIEW

Review
Recent Advances in the Nanoshells Approach for Encapsulation of Single Probiotics
Cheng Chen & Ziyu Zhu
Pages: 2763-2774
Published online: 08 Sep 2023
AbstractforRecent Advances in the Nanoshells Approach for Encapsulation of Single Probiotics | Full Text | References | PDF (5.2 MB) | EPUB
  • 313 Views
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ORIGINAL RESEARCH

Article
Pharmacological Activity of Matrine in Inhibiting Colon Cancer Cells VM Formation, Proliferation, and Invasion by Downregulating Claudin-9 Mediated EMT Process and MAPK Signaling Pathway
Qiu Du, Yingda Lin, Changping Ding, Ling Wu, Yuan Xu & Qingling Feng
Pages: 2787-2804
Published online: 11 Sep 2023
AbstractforPharmacological Activity of Matrine in Inhibiting Colon Cancer Cells VM Formation, Proliferation, and Invasion by Downregulating Claudin-9 Mediated EMT Process and MAPK Signaling Pathway | Full Text | References | PDF (13.8 MB) | EPUB
  • 193 Views
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Article
Melatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy
Jianmin Ling, Shanshan Yu, Feng Xiong, Tingting Xu & Shusheng Li
Pages: 2775-2786
Published online: 11 Sep 2023
AbstractforMelatonin Attenuates Sepsis-Induced Acute Lung Injury via Inhibiting Excessive Mitophagy | Full Text | References | PDF (8.8 MB) | EPUB
  • 189 Views
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Article
Deciphering the Mechanism of Xijiao Dihuang Decoction in Treating Psoriasis by Network Pharmacology and Experimental Validation
Yicheng Guo, Huiqun Gan, Shigui Xu, Guosheng Zeng, Lili Xiao, Zhijun Ding, Jie Zhu, Xinglong Xiong & Zhiyuan Fu
Pages: 2805-2819
Published online: 12 Sep 2023
AbstractforDeciphering the Mechanism of Xijiao Dihuang Decoction in Treating Psoriasis by Network Pharmacology and Experimental Validation | Full Text | References | PDF (12.8 MB) | EPUB
  • 183 Views
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Article
Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88
Chunyan Luan, Zhipeng Lu, Juan Chen, Mengxing Chen, Ran Zhao & Xiaolan Li
Pages: 2821-2839
Published online: 12 Sep 2023
AbstractforThalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88 | Full Text | References | PDF (14.4 MB) | EPUB
  • 163 Views
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Article
Integrating Network Pharmacology and Component Analysis to Study the Potential Mechanisms of Qi-Fu-Yin Decoction in Treating Alzheimer’s Disease
Xia Lei, Hongdan Xu, Yan Wang, Hainan Gao, Deping Zhao, Jinfeng Zhang, Ziyue Zhu, Kun Zuo, Ying Liu, Xiaoliang Li & Ning Zhang
Pages: 2841-2858
Published online: 14 Sep 2023
AbstractforIntegrating Network Pharmacology and Component Analysis to Study the Potential Mechanisms of Qi-Fu-Yin Decoction in Treating Alzheimer’s Disease | Full Text | References | PDF (10.5 MB) | EPUB
  • 205 Views
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LETTER

Letter to the Editor
The Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Gastrointestinal Tumors: A Randomized Controlled Trial [Letter]
Yongjian Lin & Mingyang Jiang
Pages: 2859-2860
Published online: 15 Sep 2023
CitationforThe Effect of Low-Dose Esketamine on Postoperative Neurocognitive Dysfunction in Elderly Patients Undergoing General Anesthesia for Gastrointestinal Tumors: A Randomized Controlled Trial [Letter] | Full Text | References | PDF (278.9 KB) | EPUB
  • 131 Views
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REVIEW

Review
Faricimab: Transforming the Future of Macular Diseases Treatment - A Comprehensive Review of Clinical Studies
Georgios D Panos, Arun Lakshmanan, Panagiotis Dadoukis, Matteo Ripa, Lorenzo Motta & Winfried M Amoaku
Pages: 2861-2873
Published online: 18 Sep 2023
AbstractforFaricimab: Transforming the Future of Macular Diseases Treatment - A Comprehensive Review of Clinical Studies | Full Text | References | PDF (925.7 KB) | EPUB
  • 579 Views
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ORIGINAL RESEARCH

Article
The Efficacy and Safety of Remimazolam Besylate Combined with Esketamine for Outpatient Colonoscopy: A Prospective, Randomized, Controlled Clinical Trial
Wei Li, Jun Zhao, Ruiping Hao, Shujuan Wang, Ming Chen, Huijun Liu, Le Qi & Zaijun Hao
Pages: 2875-2887
Published online: 18 Sep 2023
AbstractforThe Efficacy and Safety of Remimazolam Besylate Combined with Esketamine for Outpatient Colonoscopy: A Prospective, Randomized, Controlled Clinical Trial | Full Text | References | PDF (6.2 MB) | EPUB
  • 210 Views
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RETRACTION

Retraction
Impact of Postoperative Dexmedetomidine Infusion on Incidence of Delirium in Elderly Patients Undergoing Major Elective Noncardiac Surgery: a Randomized Clinical Trial [Retraction]
Pages: 2897-2898
Published online: 20 Sep 2023
CitationforImpact of Postoperative Dexmedetomidine Infusion on Incidence of Delirium in Elderly Patients Undergoing Major Elective Noncardiac Surgery: a Randomized Clinical Trial [Retraction] | Full Text | PDF (234 KB) | EPUB
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ORIGINAL RESEARCH

Article
Efficacy and Safety of Different Doses of Remimazolam Tosilate Applied in Upper Gastrointestinal Endoscopy: A Prospective Randomized Controlled Double-Blind Trial
Xiaozhen Cui, Zhi Cheng, Han Li, Xiaobao Zhang, Hengfei Luan, Zhibin Zhao & Pin Zhu
Pages: 2889-2896
Published online: 20 Sep 2023
AbstractforEfficacy and Safety of Different Doses of Remimazolam Tosilate Applied in Upper Gastrointestinal Endoscopy: A Prospective Randomized Controlled Double-Blind Trial | Full Text | References | PDF (2.9 MB) | EPUB
  • 148 Views
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REVIEW

Review
Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
Zhichao Xing, Anping Su, Li Mi, Yujie Zhang, Ting He, Yuxuan Qiu, Tao Wei, Zhihui Li, Jingqiang Zhu & Wenshuang Wu
Pages: 2909-2929
Published online: 21 Sep 2023
AbstractforWithaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms | Full Text | References | PDF (3.7 MB) | EPUB
  • 417 Views
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ORIGINAL RESEARCH

Article
Efficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial
Manjunath M Shenoy, Abhishek De, Bela Shah, Anupam Das, Abir Saraswat, Koushik Lahiri, Sheetal Yadav, Aarti Sarda, Disha Chakraborty, Dharmender J, Shruti Kamat, Yashika Doshi, Nelry Gonsalves, Ankita Choudhary, Dhiraj Dhoot, Namrata Mahadkar, Sumit Bhushan, Rujuta Gadkari & Hanmant Barkate
Pages: 2899-2908
Published online: 21 Sep 2023
AbstractforEfficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial | Full Text | References | PDF (1.4 MB) | EPUB
  • 466 Views
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Article
Effect of Intraoperative Dexmedetomidine Use on Postoperative Delirium in the Elderly After Laryngectomy: A Randomized Controlled Clinical Trial
Weiwei Liu, Yiru Wang, Kaizheng Chen, Min Ye, Weisha Lu, Keyu Chen & Xia Shen
Pages: 2933-2941
Published online: 22 Sep 2023
AbstractforEffect of Intraoperative Dexmedetomidine Use on Postoperative Delirium in the Elderly After Laryngectomy: A Randomized Controlled Clinical Trial | Full Text | References | PDF (1.7 MB) | EPUB
  • 159 Views
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CORRIGENDUM

Correction
Neuroprotective Effects of Melatonin and Celecoxib against Ethanol-Induced Neurodegeneration: A Computational and Pharmacological Approach [Corrigendum]
Pages: 2931-2932
Published online: 22 Sep 2023
CitationforNeuroprotective Effects of Melatonin and Celecoxib against Ethanol-Induced Neurodegeneration: A Computational and Pharmacological Approach [Corrigendum] | Full Text | PDF (1.3 MB) | EPUB
  • 85 Views
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CLINICAL TRIAL REPORT

Remimazolam vs Etomidate: Haemodynamic Effects in Hypertensive Elderly Patients Undergoing Non-Cardiac Surgery
Jiejuan Chen, Xiaohua Zou, Bailong Hu, Yang Yang, Feng Wang, Qian Zhou & Minhuan Shen
Pages: 2943-2953
Published online: 27 Sep 2023
AbstractforRemimazolam vs Etomidate: Haemodynamic Effects in Hypertensive Elderly Patients Undergoing Non-Cardiac Surgery | Full Text | References | PDF (630.6 KB) | EPUB
  • 201 Views
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ORIGINAL RESEARCH

Article
How Tongxie-Yaofang Regulates Intestinal Synaptic Plasticity by Activating Enteric Glial Cells and NGF/TrkA Pathway in Diarrhea-Predominant Irritable Bowel Syndrome Rats
Xiaofang Lu & Shengsheng Zhang
Pages: 2969-2983
Published online: 27 Sep 2023
AbstractforHow Tongxie-Yaofang Regulates Intestinal Synaptic Plasticity by Activating Enteric Glial Cells and NGF/TrkA Pathway in Diarrhea-Predominant Irritable Bowel Syndrome Rats | Full Text | References | PDF (11.9 MB) | EPUB
  • 168 Views
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REVIEW

Review
Escitalopram Personalized Dosing: A Population Pharmacokinetics Repository Method
Xin Liu, Gehang Ju, Wenyu Yang, Lulu Chen, Nuo Xu, Qingfeng He, Xiao Zhu & Dongsheng Ouyang
Pages: 2955-2967
Published online: 27 Sep 2023
AbstractforEscitalopram Personalized Dosing: A Population Pharmacokinetics Repository Method | Full Text | References | PDF (4.9 MB) | EPUB
  • 326 Views
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Review
Macro, Micro, and Nano-Inspired Bioactive Polymeric Biomaterials in Therapeutic, and Regenerative Orofacial Applications
Gamal A Atia, Hany K Shalaby, Ali B Roomi, Mohamed M Ghobashy, Hager A Attia, Sara Z Mohamed, Ahmed Abdeen, Mohamed Abdo, Liana Fericean, Ioan Bănățean Dunea, Ahmed M Atwa, Tabinda Hasan, Wessam Mady, Afaf Abdelkader, Susan A Ali, Ola A Habotta, Rehab A Azouz, Farag Malhat, Mustafa Shukry, Tarek Foda & Stefania Dinu
Pages: 2985-3021
Published online: 27 Sep 2023
AbstractforMacro, Micro, and Nano-Inspired Bioactive Polymeric Biomaterials in Therapeutic, and Regenerative Orofacial Applications | Full Text | References | PDF (8.6 MB) | EPUB
  • 549 Views
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CORRIGENDUM

Correction
Efficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial [Corrigendum]
Pages: 3033-3034
Published online: 28 Sep 2023
CitationforEfficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial [Corrigendum] | Full Text | PDF (235.2 KB) | EPUB
  • 81 Views
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REVIEW

Review
Lurasidone for the Treatment of Schizophrenia: Design, Development, and Place in Therapy
Itaru Miura, Sho Horikoshi, Mizue Ichinose, Yuhei Suzuki & Kenya Watanabe
Pages: 3023-3031
Published online: 28 Sep 2023
AbstractforLurasidone for the Treatment of Schizophrenia: Design, Development, and Place in Therapy | Full Text | References | PDF (790.3 KB) | EPUB
  • 405 Views
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CLINICAL TRIAL REPORT

Bioequivalence Study of Vortioxetine Hydrobromide Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions
Wanjun Bai, Haojing Song, Yiting Hu, Xueyuan Zhang, Xiaoru Wang, Caihui Guo, Bo Qiu & Zhanjun Dong
Pages: 3035-3046
Published online: 29 Sep 2023
AbstractforBioequivalence Study of Vortioxetine Hydrobromide Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions | Full Text | References | PDF (2.9 MB) | EPUB
  • 188 Views
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ORIGINAL RESEARCH

Article
Si-Ni-San Reduces Hepatic Lipid Deposition in Rats with Metabolic Associated Fatty Liver Disease by AMPK/SIRT1 Pathway
Ning Zhang, Tong Liu, Jianan Wang, Yingying Xiao, Ying Zhang, Jun Dai, Zhihong Ma & Donglai Ma
Pages: 3047-3060
Published online: 03 Oct 2023
AbstractforSi-Ni-San Reduces Hepatic Lipid Deposition in Rats with Metabolic Associated Fatty Liver Disease by AMPK/SIRT1 Pathway | Full Text | References | PDF (8.8 MB) | EPUB
  • 194 Views
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Article
Effect of Food on the Pharmacokinetics of Tenofovir Amibufenamide: A Phase I, Randomized, Open-Label, Two-Period Crossover Trial in Healthy Adult Subjects
Jian Liu, Minglan Wu, Jiejing Kai, Meihua Lin, Yunliang Zheng, Yiya Jiang, Qian Huang, You Zhai & Yunqing Qiu
Pages: 3061-3072
Published online: 09 Oct 2023
AbstractforEffect of Food on the Pharmacokinetics of Tenofovir Amibufenamide: A Phase I, Randomized, Open-Label, Two-Period Crossover Trial in Healthy Adult Subjects | Full Text | References | PDF (4.3 MB) | EPUB
  • 143 Views
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Article
The Anti-Inflammatory Mediator 17(R)-Resolvin D1 Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis
Menglong Wang, Wei Pan, Cheng Wei, Jianfang Liu, Jishou Zhang, Junping Yu, Mengmeng Zhao, Shuwan Xu, Jing Ye, Zhen Wang, Di Ye, Yongqi Feng, Yao Xu & Jun Wan
Pages: 3073-3083
Published online: 11 Oct 2023
AbstractforThe Anti-Inflammatory Mediator 17(R)-Resolvin D1 Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis | Full Text | References | PDF (4.7 MB) | EPUB
  • 138 Views
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Article
Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS)
Linghang Zhou, Jin Tan, Yuzhe Dai, Keke Zhu, Yanbo Xiao, Dan Wu, Zongkang Wang, Yisi Tan & Yijie Qin
Pages: 3085-3101
Published online: 13 Oct 2023
AbstractforJiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS) | Full Text | References | PDF (12.2 MB) | EPUB
  • 154 Views
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Article
Sijunzi Decoction Targets IL1B and TNF to Reduce Neutrophil Extracellular Traps (NETs) in Ulcerative Colitis: Evidence from Silicon Prediction and Experiment Validation
Dong Zhang, Siwei Duan, Zhangyou He, Zeming Zhu, Zhiping Li, Qincheng Yi, Tiantian Cai, Juanjuan Li, Nan Chen & Shaoju Guo
Pages: 3103-3128
Published online: 17 Oct 2023
AbstractforSijunzi Decoction Targets IL1B and TNF to Reduce Neutrophil Extracellular Traps (NETs) in Ulcerative Colitis: Evidence from Silicon Prediction and Experiment Validation | Full Text | References | PDF (22.1 MB) | EPUB
  • 167 Views
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Article
A Drug–Drug Interaction Study to Evaluate the Impact of Simvastatin and Itraconazole on Erlotinib Pharmacokinetics in Rats by UPLC-MS/MS
Zaiwen Fan, Xiaonan Gao, Mingxia Wang & Ziqiang Tian
Pages: 3129-3138
Published online: 18 Oct 2023
AbstractforA Drug–Drug Interaction Study to Evaluate the Impact of Simvastatin and Itraconazole on Erlotinib Pharmacokinetics in Rats by UPLC-MS/MS | Full Text | References | PDF (2.6 MB) | EPUB
  • 144 Views
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Article
Effect of Esketamine Gargle on Postoperative Sore Throat in Patients Undergoing Double-Lumen Endobronchial Intubation: A Randomised Controlled Trial
Jianfen Liang, Jun Liu, Zhuolin Qiu, Guoliang Sun, Ping Xiang, Ziqing Hei & Xiang Li
Pages: 3139-3149
Published online: 19 Oct 2023
AbstractforEffect of Esketamine Gargle on Postoperative Sore Throat in Patients Undergoing Double-Lumen Endobronchial Intubation: A Randomised Controlled Trial | Full Text | References | PDF (1.5 MB) | EPUB
  • 136 Views
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Article
Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway
Yan Lan, Yu-Kun Zheng, Liu-Yi Wu, Zi-Jun Zhou, Ruo-Xin Guan, Heng Xu, Ji-Yuan Tu, Xin Gu, Rui Wang, Nan Jiang, Yuan Wu, Cheng-Ren Shu & Zhong-Shi Zhou
Pages: 3151-3167
Published online: 19 Oct 2023
AbstractforPolygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway | Full Text | References | PDF (10.2 MB) | EPUB
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Article
Effect of Sevoflurane on the Deep Neuromuscular Blockade in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Single Center Prospective Randomized Controlled Study
Liujiazi Shao, Yang Liu, Junqiang Hao, Jiayi Li, Hongyu Wang, Fu-Shan Xue, Bijia Song & Lei Wan
Pages: 3193-3203
Published online: 24 Oct 2023
AbstractforEffect of Sevoflurane on the Deep Neuromuscular Blockade in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy: A Single Center Prospective Randomized Controlled Study | Full Text | References | PDF (2 MB) | EPUB
  • 130 Views
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Article
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis
MinChao Feng, Fang Luo, HuiMin Wu, Yushan Chen, Jinjin Zuo, Xueying Weng, Guozhong Chen & Jian Zhong
Pages: 3169-3192
Published online: 24 Oct 2023
AbstractforNetwork Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis | Full Text | References | PDF (22 MB) | EPUB
  • 248 Views
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Article
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway
Hong He, Peng Liu & Peng Li
Pages: 3205-3218
Published online: 25 Oct 2023
AbstractforDexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway | Full Text | References | PDF (5.2 MB) | EPUB
  • 133 Views
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Article
Bibliometric Analysis of Anesthetic Drugs’ Effects on Immune Function- Current Knowledge, Hotspots and Future Perspectives
Yufei Wang, Ye Sun, Yunxiang Hu & Zhaoyang Xiao
Pages: 3219-3230
Published online: 26 Oct 2023
AbstractforBibliometric Analysis of Anesthetic Drugs’ Effects on Immune Function- Current Knowledge, Hotspots and Future Perspectives | Full Text | References | PDF (5.4 MB) | EPUB
  • 134 Views
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CORRIGENDUM

Correction
Efficacy and Safety of a Subanesthetic Dose of Esketamine Combined with Propofol in Patients with Obesity Undergoing Painless Gastroscopy: A Prospective, Double-Blind, Randomized Controlled Trial [Corrigendum]
Pages: 3231-3232
Published online: 01 Nov 2023
CitationforEfficacy and Safety of a Subanesthetic Dose of Esketamine Combined with Propofol in Patients with Obesity Undergoing Painless Gastroscopy: A Prospective, Double-Blind, Randomized Controlled Trial [Corrigendum] | Full Text | PDF (231.9 KB) | EPUB
  • 58 Views
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ORIGINAL RESEARCH

Article
The Efficacy and Safety of Dotinurad on Uric Acid and Renal Function in Patients with Hyperuricemia and Advanced Chronic Kidney Disease: A Single Center, Retrospective Analysis
Katsunori Yanai, Keiji Hirai, Shohei Kaneko, Yuko Mutsuyoshi, Taisuke Kitano, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara & Yoshiyuki Morishita
Pages: 3233-3248
Published online: 02 Nov 2023
AbstractforThe Efficacy and Safety of Dotinurad on Uric Acid and Renal Function in Patients with Hyperuricemia and Advanced Chronic Kidney Disease: A Single Center, Retrospective Analysis | Full Text | References | PDF (913.9 KB) | EPUB
  • 496 Views
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Article
Panax quinquefolium L. and Salvia miltiorrhiza Bunge. Enhances Angiogenesis by Regulating the miR-155-5p/HIF-1α/VEGF Axis in Acute Myocardial Infarction
Xingxing Li, Rongpeng Liu, Wei Liu, Xin Liu, Zongjing Fan, Jie Cui, Yang Wu, Huijun Yin & Quan Lin
Pages: 3249-3267
Published online: 06 Nov 2023
AbstractforPanax quinquefolium L. and Salvia miltiorrhiza Bunge. Enhances Angiogenesis by Regulating the miR-155-5p/HIF-1α/VEGF Axis in Acute Myocardial Infarction | Full Text | References | PDF (11.8 MB) | EPUB
  • 119 Views
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Article
Metabolomics Profiles Reveal the Efficacy of Wuzhuyu Decoction on Patients with Chronic Non-Atrophic Gastritis
Qichao Hu, Jinhao Zeng, Xiaomei Zhang, Tingting He, Aozhe Zhang, Jianyu Li, Shizhang Wei, Manyi Jing, Haotian Li, Xin Wang, Lei Chang, Xiao Ma & Yanling Zhao
Pages: 3269-3280
Published online: 07 Nov 2023
AbstractforMetabolomics Profiles Reveal the Efficacy of Wuzhuyu Decoction on Patients with Chronic Non-Atrophic Gastritis | Full Text | References | PDF (6.5 MB) | EPUB
  • 140 Views
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Article
Effects of Subcostal Anterior Quadratus Lumborum Block with and without Dexmedetomidine on Postoperative Rehabilitation in Patients Undergoing Laparoscopic Renal Surgery: A Prospective Double-Blinded Randomized Controlled Study
Youqin Li, Lulu Wang, Jing Sun, Tian Xie, Jia Fu, Chang Feng & Guodong Lu
Pages: 3281-3293
Published online: 09 Nov 2023
AbstractforEffects of Subcostal Anterior Quadratus Lumborum Block with and without Dexmedetomidine on Postoperative Rehabilitation in Patients Undergoing Laparoscopic Renal Surgery: A Prospective Double-Blinded Randomized Controlled Study | Full Text | References | PDF (3.4 MB) | EPUB
  • 202 Views
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REVIEW

Review
The Role of Traditional Chinese Medicine Natural Products in β-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer’s Disease
Huiying Yan, Lina Feng & Mingquan Li
Pages: 3295-3323
Published online: 12 Nov 2023
AbstractforThe Role of Traditional Chinese Medicine Natural Products in β-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer’s Disease | Full Text | References | PDF (5.7 MB) | EPUB
  • 319 Views
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ORIGINAL RESEARCH

Article
An Integrative Approach to Study the Inhibition of Providencia vermicola FabD Using C2-Quaternary Indolinones
Ankita Khataniar, Abhichandan Das, Manash J Baruah, Kusum K Bania, Sanchaita Rajkhowa, Sami A Al-Hussain & Magdi EA Zaki
Pages: 3325-3347
Published online: 13 Nov 2023
AbstractforAn Integrative Approach to Study the Inhibition of Providencia vermicola FabD Using C2-Quaternary Indolinones | Full Text | References | PDF (10.8 MB) | EPUB
  • 175 Views
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Article
Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway
Xiaoming Jin, Riming He, Yunxin Lin, Jiahui Liu, Yuzhi Wang, Zhongtang Li, Yijiao Liao & Shudong Yang
Pages: 3363-3383
Published online: 13 Nov 2023
AbstractforShenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway | Full Text | References | PDF (17.3 MB) | EPUB
  • 185 Views
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Article
Analgesic Efficacy of Nalbuphine as an Adjuvant to Ropivacaine in Erector Spinae Plane Block for Percutaneous Nephrolithotomy: A Randomized, Double-Blinded, Clinical Trial
Meng Sun, Zhouyang Wu, Rong Wang, Rui Xia, Yi Sun, Elham Esmaeili, Zhengyuan Xia, Zhilin Wu & Tingting Wang
Pages: 3385-3395
Published online: 13 Nov 2023
AbstractforAnalgesic Efficacy of Nalbuphine as an Adjuvant to Ropivacaine in Erector Spinae Plane Block for Percutaneous Nephrolithotomy: A Randomized, Double-Blinded, Clinical Trial | Full Text | References | PDF (4.4 MB) | EPUB
  • 155 Views
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Article
Therapeutic Effects of Hydrogel Formulations Incorporating Troxipide Nanoparticles on Oral Mucositis in Hamsters
Reita Kadowaki, Fumihiko Ogata, Miku Nishida, Miri Komatsu, Hiroko Otake, Yosuke Nakazawa, Naoki Yamamoto, Naohito Kawasaki & Noriaki Nagai
Pages: 3349-3361
Published online: 14 Nov 2023
AbstractforTherapeutic Effects of Hydrogel Formulations Incorporating Troxipide Nanoparticles on Oral Mucositis in Hamsters | Full Text | References | PDF (5.9 MB) | EPUB
  • 149 Views
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Article
Mechanism of the Effect of Compound Anoectochilus roxburghii (Wall.) Lindl. Oral Liquid in Treating Alcoholic Rat Liver Injury by Metabolomics
Tingxuan Huang, Youjia Wu, Lingyi Huang, Renyi Lin, Zhenyue Li, Xiaoxiao Wang, Pingping Wu & Liying Huang
Pages: 3409-3428
Published online: 14 Nov 2023
AbstractforMechanism of the Effect of Compound Anoectochilus roxburghii (Wall.) Lindl. Oral Liquid in Treating Alcoholic Rat Liver Injury by Metabolomics | Full Text | References | PDF (8.3 MB) | EPUB
  • 159 Views
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REVIEW

Review
Research Progress on Mechanism and Management of Adverse Drug Reactions of Anlotinib
Shiting Li & Hongqin Wang
Pages: 3429-3437
Published online: 15 Nov 2023
AbstractforResearch Progress on Mechanism and Management of Adverse Drug Reactions of Anlotinib | Full Text | References | PDF (1.5 MB) | EPUB
  • 164 Views
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Review
Research Trends and Hot Spots of Allopregnanolone Research in the Last 20 Years: A Bibliometric Analysis
Kunlin Guo, Mingjie Mao, Susu Zhang, Shiqin Xu, Liping Zhao, Xian Wang & Shanwu Feng
Pages: 3397-3408
Published online: 14 Nov 2023
AbstractforResearch Trends and Hot Spots of Allopregnanolone Research in the Last 20 Years: A Bibliometric Analysis | Full Text | References | PDF (5.5 MB) | EPUB
  • 134 Views
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ORIGINAL RESEARCH

Article
Fenofibrate Ameliorates Retinal Pigment Epithelium Injury Induced by Excessive Fat Through Upregulation of PI3K/AKT Signaling
Xue Wang, Xiaomei Liu, Radouil Tzekov, Chaofeng Yu, Jiasong Yang, Yuliang Feng, Yajun Wu, Yali Xu, Shiying Li & Wensheng Li
Pages: 3439-3452
Published online: 20 Nov 2023
AbstractforFenofibrate Ameliorates Retinal Pigment Epithelium Injury Induced by Excessive Fat Through Upregulation of PI3K/AKT Signaling | Full Text | References | PDF (8.1 MB) | EPUB
  • 133 Views
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Article
Integrated Network Pharmacology, Molecular Docking and Animal Experiment to Explore the Efficacy and Potential Mechanism of Baiyu Decoction Against Ulcerative Colitis by Enema
Yuan Cui, Jingyi Hu, Yanan Li, Ryan Au, Yulai Fang, Cheng Cheng, Feng Xu, Weiyang Li, Yuguang Wu, Lei Zhu & Hong Shen
Pages: 3453-3472
Published online: 22 Nov 2023
AbstractforIntegrated Network Pharmacology, Molecular Docking and Animal Experiment to Explore the Efficacy and Potential Mechanism of Baiyu Decoction Against Ulcerative Colitis by Enema | Full Text | References | PDF (13.4 MB) | EPUB
  • 193 Views
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REVIEW

Review
Pharmacological and Clinical Studies of Medicinal Plants That Inhibit Dipeptidyl Peptidase-IV
Rohani, Ellin Febrina, Indah Suasani Wahyuni & Jutti Levita
Pages: 3473-3491
Published online: 22 Nov 2023
AbstractforPharmacological and Clinical Studies of Medicinal Plants That Inhibit Dipeptidyl Peptidase-IV | Full Text | References | PDF (2.7 MB) | EPUB
  • 287 Views
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ORIGINAL RESEARCH

Article
Mechanism of ShuiJingDan in Treating Acute Gouty Arthritis Flares Based on Network Pharmacology and Molecular Docking
Qingsong Liu, Lunyu Li, Dan Zheng, Songlin Jin, Xiaotian Guan, Zeting Fu, Zhigang Xiong & Haili Ding
Pages: 3493-3505
Published online: 24 Nov 2023
AbstractforMechanism of ShuiJingDan in Treating Acute Gouty Arthritis Flares Based on Network Pharmacology and Molecular Docking | Full Text | References | PDF (8.5 MB) | EPUB
  • 166 Views
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Article
Comparative Study on the Efficacy of Two Perioperative Chemotherapy Regimens for Lumbar Brucellosis
Jie Wang, Lei Deng, Zihao Ding, Yaosheng Zhang, Yao Zhang, Kangpeng Li, Changsong Zhao & Qiang Zhang
Pages: 3523-3536
Published online: 26 Nov 2023
AbstractforComparative Study on the Efficacy of Two Perioperative Chemotherapy Regimens for Lumbar Brucellosis | Full Text | References | PDF (3.2 MB) | EPUB
  • 129 Views
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CORRIGENDUM

Correction
The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique [Corrigendum]
Pages: 3537-3538
Published online: 26 Nov 2023
CitationforThe Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique [Corrigendum] | Full Text | PDF (223.2 KB) | EPUB
  • 59 Views
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ORIGINAL RESEARCH

Article
Recombinant Human Adenovirus Type 5 (H101) Intra-Tumor Therapy in Patients with Persistent, Recurrent, or Metastatic Cervical Cancer: Genomic Profiling Relating to Clinical Efficacy
Qiying Zhang, Jing Zhang, Zi Liu, Juan Wang, Fei Wang, Tao Wang, Fan Shi, Jin Su & Yalong Zhao
Pages: 3507-3522
Published online: 26 Nov 2023
AbstractforRecombinant Human Adenovirus Type 5 (H101) Intra-Tumor Therapy in Patients with Persistent, Recurrent, or Metastatic Cervical Cancer: Genomic Profiling Relating to Clinical Efficacy | Full Text | References | PDF (8.7 MB) | EPUB
  • 129 Views
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Article
Impact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy-A Randomized Controlled Trial
Conghui Hao, Hai Xu, Jingjing Du, Tianyu Zhang, Xiaobao Zhang, Zhibin Zhao & Hengfei Luan
Pages: 3539-3547
Published online: 27 Nov 2023
AbstractforImpact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy-A Randomized Controlled Trial | Full Text | References | PDF (3.2 MB) | EPUB
  • 257 Views
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Article
Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect
Yuxiang Xu, Xiaonan Gao, Yunfang Zhu, Qi Zhang, Hongxin Qie, Haopeng Zhao, Jinglin Gao & Mingxia Wang
Pages: 3551-3561
Published online: 28 Nov 2023
AbstractforDevelopment and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect | Full Text | References | PDF (2.8 MB) | EPUB
  • 84 Views
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RETRACTION

Retraction
The Antiulcer Effect of Cibotium barometz Leaves in Rats with Experimentally Induced Acute Gastric Ulcer [Retraction]
Pages: 3549-3550
Published online: 28 Nov 2023
CitationforThe Antiulcer Effect of Cibotium barometz Leaves in Rats with Experimentally Induced Acute Gastric Ulcer [Retraction] | Full Text | PDF (253.4 KB) | EPUB
  • 60 Views
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ORIGINAL RESEARCH

Article
The Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial
Huan He, Qichun Cui, Hengheng Chen, Xiao Huang, Shuai Wang, Tian Yu, Jinqiu Feng & Yun Shao
Pages: 3563-3570
Published online: 29 Nov 2023
AbstractforThe Effect of Intranasal Dexmedetomidine on Emergence Delirium Prevention in Pediatric Ambulatory Dental Rehabilitation Under General Anesthesia: A Randomized Clinical Trial | Full Text | References | PDF (2 MB) | EPUB
  • 157 Views
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Article
Naotaifang III Protects Against Cerebral Ischemia Injury Through LPS/TLR4 Signaling Pathway in the Microbiota–Gut–Brain Axis
Huifang Nie, Jinwen Ge, Kailin Yang, Zhuli Peng, Haihui Wu, Tong Yang & Zhigang Mei
Pages: 3571-3588
Published online: 01 Dec 2023
AbstractforNaotaifang III Protects Against Cerebral Ischemia Injury Through LPS/TLR4 Signaling Pathway in the Microbiota–Gut–Brain Axis | Full Text | References | PDF (13 MB) | EPUB
  • 160 Views
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Article
Linarin Protects Against CCl4-Induced Acute Liver Injury via Activating Autophagy and Inhibiting the Inflammatory Response: Involving the TLR4/MAPK/Nrf2 Pathway
Lulu Li, Yan Lan, Fuqian Wang & Tiexiang Gao
Pages: 3589-3604
Published online: 01 Dec 2023
AbstractforLinarin Protects Against CCl4-Induced Acute Liver Injury via Activating Autophagy and Inhibiting the Inflammatory Response: Involving the TLR4/MAPK/Nrf2 Pathway | Full Text | References | PDF (13.6 MB) | EPUB
  • 124 Views
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REVIEW

Review
Biomaterial-Based Gene Delivery: Advanced Tools for Enhanced Cartilage Regeneration
Hongfeng Chen, Zhen Li, Xiaoqi Li, Jiongjiong Lu, Beibei Chen, Qiongchao Wang & Guangliang Wu
Pages: 3605-3624
Published online: 03 Dec 2023
AbstractforBiomaterial-Based Gene Delivery: Advanced Tools for Enhanced Cartilage Regeneration | Full Text | References | PDF (10.2 MB) | EPUB
  • 203 Views
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Review
Caged Polyprenylated Xanthones in Garcinia hanburyi and the Biological Activities of Them
Ruixi He, Buyun Jia, Daiyin Peng & Weidong Chen
Pages: 3625-3660
Published online: 05 Dec 2023
AbstractforCaged Polyprenylated Xanthones in Garcinia hanburyi and the Biological Activities of Them | Full Text | References | PDF (2.5 MB) | EPUB
  • 154 Views
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ORIGINAL RESEARCH

Article
Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design
Amina Alam Kotha, Shihab Uddin Ahmad, Irin Dewan, Mohiuddin Ahmed Bhuiyan, Fahad Imtiaz Rahman, Isa Naina Mohamed & Md Selim Reza
Pages: 3661-3684
Published online: 05 Dec 2023
AbstractforMetformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design | Full Text | References | PDF (8 MB) | EPUB
  • 229 Views
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RETRACTION

Retraction
Solasodine, Isolated from Solanum Sisymbriifolium Fruits, Has a Potent Anti-Tumor Activity Against Pancreatic Cancer [Retraction]
Pages: 3685-3686
Published online: 06 Dec 2023
CitationforSolasodine, Isolated from Solanum Sisymbriifolium Fruits, Has a Potent Anti-Tumor Activity Against Pancreatic Cancer [Retraction] | Full Text | PDF (270.5 KB) | EPUB
  • 78 Views
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ORIGINAL RESEARCH

Article
The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine
Yong-Kang Gui, Xiao-Hui Zeng, Rui Xiao, Wen-Feng Xi, Dan Zhang, Yang Liu, Si-Hui Zhu, Xin Da, De-Wen Shi, Xu-Dong Hu & Guang-Hong Xu
Pages: 3687-3696
Published online: 07 Dec 2023
AbstractforThe Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine | Full Text | References | PDF (3.9 MB) | EPUB
  • 132 Views
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Article
Bictegravir/Emtricitabine/Tenofovir Alafenamide Treatment: Efficacy and Tolerability in Clinical Practice
Diana Canetti, Laura Galli, Riccardo Lolatto, Silvia Nozza, Vincenzo Spagnuolo, Camilla Muccini, Benedetta Trentacapilli, Elena Bruzzesi, Martina Ranzenigo, Matteo Chiurlo, Antonella Castagna & Nicola Gianotti
Pages: 3697-3706
Published online: 08 Dec 2023
AbstractforBictegravir/Emtricitabine/Tenofovir Alafenamide Treatment: Efficacy and Tolerability in Clinical Practice | Full Text | References | PDF (2.4 MB) | EPUB
  • 99 Views
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RETRACTION

Retraction
The Gastroprotective Effects of Hydroalcoholic Extract of Monolluma quadrangula against Ethanol-Induced Gastric Mucosal Injuries in Sprague Dawley Rats [Retraction]
Pages: 3707-3708
Published online: 08 Dec 2023
CitationforThe Gastroprotective Effects of Hydroalcoholic Extract of Monolluma quadrangula against Ethanol-Induced Gastric Mucosal Injuries in Sprague Dawley Rats [Retraction] | Full Text | PDF (268.2 KB) | EPUB
  • 81 Views
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ORIGINAL RESEARCH

Article
Identification of cholest-4-ene-3,6-dione as a Novel Neuroprotectant in Ischemic Stroke and Its Lipidomics
Xiaoshuai Ren, Feng Lin, Chaogang Tang, Yao Liu, Guolei Liao, Jiabi Liang, Wenji Luo, Lei Zhang & Wenli Chen
Pages: 3709-3722
Published online: 10 Dec 2023
AbstractforIdentification of cholest-4-ene-3,6-dione as a Novel Neuroprotectant in Ischemic Stroke and Its Lipidomics | Full Text | References | PDF (8.6 MB) | EPUB
  • 123 Views
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Article
Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway
Tengfei Chen, Sihan Li, Dongyin Lian, Qin Hu, Hongping Hou, Delian Niu, Han Li, Ling Song, Yunhang Gao, Ying Chen, Xiaoru Hu, Jianrong Li, Zuguang Ye, Bo Peng & Guangping Zhang
Pages: 3723-3748
Published online: 12 Dec 2023
AbstractforIntegrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway | Full Text | References | PDF (12.7 MB) | EPUB
  • 264 Views
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CLINICAL TRIAL REPORT

Effect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients with Hip Fracture: A Prospective Randomized Controlled Trial
Xiaofen Li, Jimin Wu, Haiyan Lan, Weifeng Shan, Qiaomin Xu, Xiaoli Dong & Gongchen Duan
Pages: 3749-3756
Published online: 15 Dec 2023
AbstractforEffect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients with Hip Fracture: A Prospective Randomized Controlled Trial | Full Text | References | PDF (1.1 MB) | EPUB
  • 142 Views
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ORIGINAL RESEARCH

Article
Application of Butorphanol versus Sufentanil in Multimode Analgesia via Patient Controlled Intravenous Analgesia After Hepatobiliary Surgery: A Retrospective Cohort Study
Xiaodong Xu, Yuan Tao, Yitian Yang, Jiaqiang Zhang & Mingyang Sun
Pages: 3757-3766
Published online: 19 Dec 2023
AbstractforApplication of Butorphanol versus Sufentanil in Multimode Analgesia via Patient Controlled Intravenous Analgesia After Hepatobiliary Surgery: A Retrospective Cohort Study | Full Text | References | PDF (1.8 MB) | EPUB
  • 135 Views
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REVIEW

Review
Tripterygium wilfordii Hook. F. and Its Extracts for Psoriasis: Efficacy and Mechanism
Yingchao Wang, Zhaochun Tian, Shuhong Huang & Ningning Dang
Pages: 3767-3781
Published online: 19 Dec 2023
AbstractforTripterygium wilfordii Hook. F. and Its Extracts for Psoriasis: Efficacy and Mechanism | Full Text | References | PDF (2.5 MB) | EPUB
  • 153 Views
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ORIGINAL RESEARCH

Article
Immunoinformatics Prediction and Protective Efficacy of Vaccine Candidate PiuA-PlyD4 Against Streptococcus Pneumoniae
Chenglin Miao, Yali Cui, Yingying Li, Qianqian Qi, Wenling Shang, Huilian Chen, Yujie Gao, Ruomei Yuan, Qichen Long, Wenjing Wu, Xia Wang, Ziyi Yan & Yongmei Jiang
Pages: 3783-3801
Published online: 20 Dec 2023
AbstractforImmunoinformatics Prediction and Protective Efficacy of Vaccine Candidate PiuA-PlyD4 Against Streptococcus Pneumoniae | Full Text | References | PDF (9.9 MB) | EPUB
  • 107 Views
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REVIEW

Review
A Review on the Pharmacological Aspects of Engeletin as Natural Compound
Xing Zhong, Rui Huang, Xin Chen & Yuhua Lei
Pages: 3833-3843
Published online: 22 Dec 2023
AbstractforA Review on the Pharmacological Aspects of Engeletin as Natural Compound | Full Text | References | PDF (2.2 MB) | EPUB
  • 110 Views
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Review
Co-Housing and Fecal Microbiota Transplantation: Technical Support for TCM Herbal Treatment of Extra-Intestinal Diseases Based on Gut Microbial Ecosystem Remodeling
Xian Sun, Xi Zhou, Weiming He, Wei Sun & Zheng Xu
Pages: 3803-3831
Published online: 23 Dec 2023
AbstractforCo-Housing and Fecal Microbiota Transplantation: Technical Support for TCM Herbal Treatment of Extra-Intestinal Diseases Based on Gut Microbial Ecosystem Remodeling | Full Text | References | PDF (6.5 MB) | EPUB
  • 156 Views
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ORIGINAL RESEARCH

Article
Different Sedation Strategies in Older Patients Receiving Spinal Anesthesia for Hip Surgery on Postoperative Delirium: A Randomized Clinical Trial
Shuxing Zhu, Yaqing Liu, Xiuli Wang, Liang Wang, Jinru Li, Xiaoming Xue, Zhao Li, Jiaxin Liu, Xin Liu & Shuang Zhao
Pages: 3845-3854
Published online: 28 Dec 2023
AbstractforDifferent Sedation Strategies in Older Patients Receiving Spinal Anesthesia for Hip Surgery on Postoperative Delirium: A Randomized Clinical Trial | Full Text | References | PDF (595 KB) | EPUB
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REVIEW

Review
The Role of AMPK Signaling in Ulcerative Colitis
Yuyi Yuan, Fang Wang, Xingxing Liu, Bo Shuai & Heng Fan
Pages: 3855-3875
Published online: 28 Dec 2023
AbstractforThe Role of AMPK Signaling in Ulcerative Colitis | Full Text | References | PDF (3 MB) | EPUB
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