Drug Design, Development and Therapy, Volume 18, Issue (2024)

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Drug Design, Development and Therapy, Volume 18, Issue (2024)

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REVIEW

Review
Pristimerin Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
Jian Sun, Zhaochun Tian, Jing Wu, Jiafei Li, Qixia Wang, Shuhong Huang & Meng Wang
Pages: 1673-1694
Published online: 18 May 2024
AbstractforPristimerin Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review | Full Text | References | PDF (2.6 MB) | EPUB
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ORIGINAL RESEARCH

Article
Integrated Approaches Revealed the Therapeutic Mechanisms of Zuojin Pill Against Gastric Mucosa Injury in a Rat Model with Chronic Atrophic Gastritis
Lisheng Chen, Tingting He, Ruilin Wang, Honghong Liu, Xin Wang, Haotian Li, Manyi Jing, Xuelin Zhou, Shizhang Wei, Wenjun Zou & Yanling Zhao
Pages: 1651-1672
Published online: 17 May 2024
AbstractforIntegrated Approaches Revealed the Therapeutic Mechanisms of Zuojin Pill Against Gastric Mucosa Injury in a Rat Model with Chronic Atrophic Gastritis | Full Text | References | PDF (16.1 MB) | EPUB
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REVIEW

Review
Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis
JiuLing Deng, Jing Liu, WanSheng Chen, Qing Liang, YuQiong He & GuangChun Sun
Pages: 1627-1650
Published online: 16 May 2024
AbstractforEffects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis | Full Text | References | PDF (4.6 MB) | EPUB
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ORIGINAL RESEARCH

Article
Preoperative Anxiolytic and Sedative Effects of Intranasal Remimazolam and Dexmedetomidine: A Randomized Controlled Clinical Study in Children Undergoing General Surgeries
Yu-Hang Cai, Cheng-Yu Wang, Yu-Bo Fang, Hong-Yu Ma, Yu-Qing Gao, Zhen Wang, Junzheng Wu, Han Lin & Hua-Cheng Liu
Pages: 1613-1625
Published online: 16 May 2024
AbstractforPreoperative Anxiolytic and Sedative Effects of Intranasal Remimazolam and Dexmedetomidine: A Randomized Controlled Clinical Study in Children Undergoing General Surgeries | Full Text | References | PDF (2.5 MB) | EPUB
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CLINICAL TRIAL REPORT

Low-Dose Alfentanil Inhibits Sufentanil-Induced Cough During Anesthesia Induction: A Prospective, Randomized, Double-Blind Study
Qiaomin Xu, Xintong Zou, Jimin Wu, Gongchen Duan, Haiyan Lan & Liangrong Wang
Pages: 1603-1612
Published online: 18 May 2024
AbstractforLow-Dose Alfentanil Inhibits Sufentanil-Induced Cough During Anesthesia Induction: A Prospective, Randomized, Double-Blind Study | Full Text | References | PDF (2.4 MB) | EPUB
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ORIGINAL RESEARCH

Article
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis
Lang Liu, Binghua Zhang, Zhenwei Zhou, Jie Yang, Ailin Li, Yongji Wu, Zeyu Peng, Xiangyan Li, Zhonghua Liu, Xiangyang Leng, Changwei Zhao, Haisi Dong & Wenhai Zhao
Pages: 1583-1602
Published online: 15 May 2024
AbstractforIntegrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis | Full Text | References | PDF (16.2 MB) | EPUB
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Open Access
Article
Comparative Bleeding Risk of Brand Vs Generic Rivaroxaban in Elderly Inpatients with Atrial Fibrillation
Guoquan Chen, Jiale Chen, Qiang Zhao & Yalan Zhu
Pages: 1573-1582
Published online: 16 May 2024
AbstractforComparative Bleeding Risk of Brand Vs Generic Rivaroxaban in Elderly Inpatients with Atrial Fibrillation | Full Text | References | PDF (3.6 MB) | EPUB
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REVIEW

Review
A Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds
Muhammad Shahid Nazir, Matloob Ahmad, Sana Aslam, Ayesha Rafiq, Sami A Al-Hussain & Magdi EA Zaki
Pages: 1547-1571
Published online: 07 May 2024
AbstractforA Comprehensive Update of Anti-COVID-19 Activity of Heterocyclic Compounds | Full Text | References | PDF (17.6 MB) | EPUB
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ORIGINAL RESEARCH

Article
A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK
Yan Ma, Qian Cui, Wenjing Zhu, Mei Wang, Li Zhai, Wenmin Hu, Dongdong Liu, Min Liu, Yongchun Li, Meng Li & Wei Han
Pages: 1531-1546
Published online: 06 May 2024
AbstractforA Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK | Full Text | References | PDF (9.1 MB) | EPUB
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LETTER

Letter to the Editor
Impact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy: A Randomized Controlled Trial [Letter]
Bai Xue
Pages: 1529-1530
Published online: 05 May 2024
CitationforImpact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy: A Randomized Controlled Trial [Letter] | Full Text | References | PDF (273.6 KB) | EPUB
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ORIGINAL RESEARCH

Article
ED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis
Ke Wang, Yuying Kou, Xing Rong, Lingling Wei, Jingyuan Li, Hongrui Liu, Minqi Li & Hui Song
Pages: 1515-1528
Published online: 05 May 2024
AbstractforED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis | Full Text | References | PDF (12 MB) | EPUB
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Article
Naodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway
Yong-Yu Yang, Rong-Rong Deng & Da-Xiong Xiang
Pages: 1499-1514
Published online: 02 May 2024
AbstractforNaodesheng Pills Ameliorate Cerebral Ischemia Reperfusion-Induced Ferroptosis via Inhibition of the ERK1/2 Signaling Pathway | Full Text | References | PDF (10.2 MB) | EPUB
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LETTER

Letter to the Editor
Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease [Letter]
Rizky Yulion, Lili Andriani & Siti Hamidatul Aliyah
Pages: 1497-1498
Published online: 01 May 2024
CitationforNetwork Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease [Letter] | Full Text | References | PDF (283.4 KB) | EPUB
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REVIEW

Review
Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
Yifan Liu, Yushan Liang, Jing Yuhong, Peng Xin, Jia Li Han, Yongle Du, Xinru Yu, Runhe Zhu, Mingxun Zhang, Wen Chen & Yingjie Ma
Pages: 1469-1495
Published online: 02 May 2024
AbstractforAdvances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs | Full Text | References | PDF (11.9 MB) | EPUB
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CLINICAL TRIAL REPORT

Dose-Response Study of Phenylephrine for Preventing Spinal-Induced Hypotension During Cesarean Delivery with Combined Spinal-Epidural Anesthesia Under the Effect of Prophylactic Intravenous Ondansetron
Xiao-Xia Sun, Jing Qian, Jia-Ming Fan, Lin Liu, Xia-Fang Jin & Fei Xiao
Pages: 1459-1467
Published online: 01 May 2024
AbstractforDose-Response Study of Phenylephrine for Preventing Spinal-Induced Hypotension During Cesarean Delivery with Combined Spinal-Epidural Anesthesia Under the Effect of Prophylactic Intravenous Ondansetron | Full Text | References | PDF (2.1 MB) | EPUB
  • 22 Views
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ORIGINAL RESEARCH

Article
Integrated Network Pharmacology Analysis and Experimental Validation to Elucidate the Mechanism of Acteoside in Treating Diabetic Kidney Disease
Shu Jiao Zhang, Yi Fei Zhang, Xue Hui Bai, Meng Qi Zhou, Ze Yu Zhang, Shuai Xing Zhang, Zi Jing Cao, Lin Wang, Shao Wei Ding, Hui Juan Zheng, Yu Ning Liu, Guo Yong Yu & Wei Jing Liu
Pages: 1439-1457
Published online: 01 May 2024
AbstractforIntegrated Network Pharmacology Analysis and Experimental Validation to Elucidate the Mechanism of Acteoside in Treating Diabetic Kidney Disease | Full Text | References | PDF (16.8 MB) | EPUB
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Article
Network and Experimental Pharmacology on Mechanism of Yixintai Regulates the TMAO/PKC/NF-κB Signaling Pathway in Treating Heart Failure
Ziyan Wang, Chengxin Liu, Jiaming Wei, Hui Yuan, Min Shi, Fei Zhang, Qinghua Zeng, Aisi Huang, Lixin Du, Ya Li & Zhihua Guo
Pages: 1415-1438
Published online: 29 Apr 2024
AbstractforNetwork and Experimental Pharmacology on Mechanism of Yixintai Regulates the TMAO/PKC/NF-κB Signaling Pathway in Treating Heart Failure | Full Text | References | PDF (16.9 MB) | EPUB
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REVIEW

Review
The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury
Quan Hu, Yingxiao Li, Zhaochen Lin, Hao Zhang, Haoyue Chen, Cui Chao & Chuanliang Zhao
Pages: 1399-1414
Published online: 29 Apr 2024
AbstractforThe Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury | Full Text | References | PDF (3.2 MB) | EPUB
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Review
Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm
Jing Zhang, Le Wu, Chenchen Wang, Xin Xie & Yuying Han
Pages: 1385-1398
Published online: 25 Apr 2024
AbstractforResearch Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm | Full Text | References | PDF (1.7 MB) | EPUB
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ORIGINAL RESEARCH

Article
Dynasore Alleviates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis
Mengtian Shan, Huimin Wan, Linyu Ran, Jihui Ye, Wang Xie, Jingjing Lu, Xueping Hu, Shengjie Deng, Wenyu Zhang, Miao Chen, Feilong Wang & Zhongliang Guo
Pages: 1369-1384
Published online: 22 Apr 2024
AbstractforDynasore Alleviates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis | Full Text | References | PDF (9.8 MB) | EPUB
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Open Access
Article
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis
Ye Zhou, Yangliang Yang, Liang Yi, Mengzhi Pan, Weiqing Tang & Hongwei Duan
Pages: 1349-1368
Published online: 23 Apr 2024
AbstractforPropofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis | Full Text | References | PDF (14.1 MB) | EPUB
  • 62 Views
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Article
Effect of Fluid Therapy in Early Morning on the Incidence of Post-Induction Hypotension During Non-Cardiac Surgery After Noon: A Single-Center Retrospective Study
Ying Zhang, Xinxin Wang, Xiaoqiao Sang, Zhou Zhou, Guangrong Dai & Xiaobao Zhang
Pages: 1339-1347
Published online: 22 Apr 2024
AbstractforEffect of Fluid Therapy in Early Morning on the Incidence of Post-Induction Hypotension During Non-Cardiac Surgery After Noon: A Single-Center Retrospective Study | Full Text | References | PDF (490.4 KB) | EPUB
  • 37 Views
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Article
Validation of Core Ingredients and Molecular Mechanism of Cinobufotalin Injection Against Liver Cancer
Shipeng Chen, Mengna Li, Changning Xue, Xiangting Zhou, Jianxia Wei, Lemei Zheng, Yumei Duan, Hongyu Deng, Faqing Tang, Wei Xiong, Bo Xiang & Ming Zhou
Pages: 1321-1338
Published online: 24 Apr 2024
AbstractforValidation of Core Ingredients and Molecular Mechanism of Cinobufotalin Injection Against Liver Cancer | Full Text | References | PDF (16 MB) | EPUB
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CLINICAL TRIAL REPORT

The Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude
Chen Yang, Wangjun Dong, Jianbo Luo, Mengzhao Ma, Yeyue Gao, Lijie Ni, Huixing Liu, Chengjun Cha, Yangli Xiao & Shaoqiang Huang
Pages: 1313-1319
Published online: 23 Apr 2024
AbstractforThe Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude | Full Text | References | PDF (851.9 KB) | EPUB
  • 48 Views
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REVIEW

Review
Natural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade
Cszahreyloren Vitamia, Ghina Nadhifah Iftinan, Irma Rahayu Latarissa, Gofarana Wilar, Arief Cahyanto, Khaled M Elamin & Nasrul Wathoni
Pages: 1297-1312
Published online: 22 Apr 2024
AbstractforNatural and Synthetic Drugs Approached for the Treatment of Recurrent Aphthous Stomatitis Over the Last Decade | Full Text | References | PDF (2.3 MB) | EPUB
  • 68 Views
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Review
RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models
Zih-Chan Lin, Chi-Feng Hung, Ibrahim A Aljuffali, Ming-Hsien Lin & Jia-You Fang
Pages: 1277-1296
Published online: 22 Apr 2024
AbstractforRNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models | Full Text | References | PDF (4.4 MB) | EPUB
  • 49 Views
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ORIGINAL RESEARCH

Article
Obacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO-1 Signaling Pathway
Fubei Nan, Qingxin Tian & Shuangdong Chen
Pages: 1265-1275
Published online: 17 Apr 2024
AbstractforObacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO-1 Signaling Pathway | Full Text | References | PDF (5.8 MB) | EPUB
  • 38 Views
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RETRACTION

Retraction
Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways [Retraction]
Pages: 1263-1264
Published online: 18 Apr 2024
CitationforCinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways [Retraction] | Full Text | PDF (260 KB) | EPUB
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ORIGINAL RESEARCH

Article
Sinomenine Hydrochloride Protects IgA Nephropathy Through Regulating Cell Growth and Apoptosis of T and B Lymphocytes
Jun-Jian Li, Li Li, Shuang Li, Xin-Yi Tang, Hui-Feng Sun & Jian-Xin Liu
Pages: 1247-1262
Published online: 18 Apr 2024
AbstractforSinomenine Hydrochloride Protects IgA Nephropathy Through Regulating Cell Growth and Apoptosis of T and B Lymphocytes | Full Text | References | PDF (11.3 MB) | EPUB
  • 39 Views
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Article
Dexamethasone versus Dexmedetomidine as Adjuvants in Ultrasound Popliteal Sciatic Nerve Block for Hallux Valgus Surgery: A Mono-Centric Retrospective Comparative Study
Antonio Coviello, Carmine Iacovazzo, Dario Cirillo, Alessio Bernasconi, Annachiara Marra, Francesco Squillacioti, Marco Martone, Eleonora Garone, Filomena Coppola, Andrea Uriel de Siena, Maria Vargas & Giuseppe Servillo
Pages: 1231-1245
Published online: 18 Apr 2024
AbstractforDexamethasone versus Dexmedetomidine as Adjuvants in Ultrasound Popliteal Sciatic Nerve Block for Hallux Valgus Surgery: A Mono-Centric Retrospective Comparative Study | Full Text | References | PDF (6.8 MB) | EPUB
  • 74 Views
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REVIEW

Review
Clinical Application and Research Progress of Remimazolam for Pediatric Patients
Chen Bai, Mingcan Xu, Yan Guo, Yanwu Jin & Xin Zhao
Pages: 1221-1229
Published online: 18 Apr 2024
AbstractforClinical Application and Research Progress of Remimazolam for Pediatric Patients | Full Text | References | PDF (2.5 MB) | EPUB
  • 62 Views
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ORIGINAL RESEARCH

Article
Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease
Yutao Peng & Chanjuan Zhou
Pages: 1199-1219
Published online: 18 Apr 2024
AbstractforNetwork Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer’s Disease | Full Text | References | PDF (18.2 MB) | EPUB
  • 138 Views
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CLINICAL TRIAL REPORT

Effect of S-Ketamine on Postoperative Nausea and Vomiting in Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial
Yu Qi, Meiyan Zhou, Wenting Zheng, Yaqi Dong, Weihua Li, Long Wang, Haijun Xu, Miao Zhang, Dunpeng Yang, Liwei Wang & Hai Zhou
Pages: 1189-1198
Published online: 17 Apr 2024
AbstractforEffect of S-Ketamine on Postoperative Nausea and Vomiting in Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial | Full Text | References | PDF (2.3 MB) | EPUB
  • 35 Views
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ORIGINAL RESEARCH

Article
A Novel Network Pharmacology Strategy Based on the Universal Effectiveness-Common Mechanism of Medical Herbs Uncovers Therapeutic Targets in Traumatic Brain Injury
Zhe Yu, Ruoqi Ding, Qiuju Yan, Menghan Cheng, Teng Li, Fei Zheng, Lin Zhu, Yang Wang, Tao Tang & En Hu
Pages: 1175-1188
Published online: 16 Apr 2024
AbstractforA Novel Network Pharmacology Strategy Based on the Universal Effectiveness-Common Mechanism of Medical Herbs Uncovers Therapeutic Targets in Traumatic Brain Injury | Full Text | References | PDF (11 MB) | EPUB
  • 60 Views
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Open Access
Article
Citric Acid Controls the Activity of YopH Bacterial Tyrosine Phosphatase
Joanna Styszko, Tomasz Kostrzewa, Magdalena Gorska-Ponikowska & Alicja Kuban-Jankowska
Pages: 1165-1174
Published online: 11 Apr 2024
AbstractforCitric Acid Controls the Activity of YopH Bacterial Tyrosine Phosphatase | Full Text | References | PDF (4.2 MB) | EPUB
  • 47 Views
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Article
Outcome of Darunavir–Cobicistat-Based Regimens in HIV-Infected People Who Have Experienced Virological Failure
Francesca Alberton, Laura Galli, Riccardo Lolatto, Caterina Candela, Nicola Gianotti, Matteo Chiurlo, Martina Ranzenigo, Martina Strano, Alessia Uglietti & Antonella Castagna
Pages: 1153-1163
Published online: 09 Apr 2024
AbstractforOutcome of Darunavir–Cobicistat-Based Regimens in HIV-Infected People Who Have Experienced Virological Failure | Full Text | References | PDF (2 MB) | EPUB
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Article
The Promise of Therapeutic Psilocybin: An Evaluation of the 134 Clinical Trials, 54 Potential Indications, and 0 Marketing Approvals on ClinicalTrials.gov
Sarah A Norring & Michael G Spigarelli
Pages: 1143-1151
Published online: 11 Apr 2024
AbstractforThe Promise of Therapeutic Psilocybin: An Evaluation of the 134 Clinical Trials, 54 Potential Indications, and 0 Marketing Approvals on ClinicalTrials.gov | Full Text | References | PDF (1.1 MB) | EPUB
  • 631 Views
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RAPID COMMUNICATION

Rapid Communication
Synthesis and Anti-Diabetic Activity of an 8-Purine Derivative as a Novel DPP-4 Inhibitor in Obese Diabetic Zücker Rats
Meriem Chayah, Angélica Luque-González, Verónica Gómez-Pérez, Diego Salagre, Amjad Al-Shdaifat, Joaquín María Campos, Ana Conejo-García & Ahmad Agil
Pages: 1133-1141
Published online: 09 Apr 2024
AbstractforSynthesis and Anti-Diabetic Activity of an 8-Purine Derivative as a Novel DPP-4 Inhibitor in Obese Diabetic Zücker Rats | Full Text | References | PDF (3.4 MB) | EPUB
  • 69 Views
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ORIGINAL RESEARCH

Article
Unveiling the Mechanism of the ChaiShao Shugan Formula Against Triple-Negative Breast Cancer
Teng Fan, Yuanyuan Huang, Zeyu Liu, Jinsheng Huang, Bin Ke, Yuming Rong, Huijuan Qiu & Bei Zhang
Pages: 1115-1131
Published online: 09 Apr 2024
AbstractforUnveiling the Mechanism of the ChaiShao Shugan Formula Against Triple-Negative Breast Cancer | Full Text | References | PDF (8.9 MB) | EPUB
  • 49 Views
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Article
Dexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current
Tongtong Zhang, Xincheng Liao, Yuzhi Chen, Xinru Shu, Deshan Liu & Yusheng Yao
Pages: 1103-1114
Published online: 09 Apr 2024
AbstractforDexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current | Full Text | References | PDF (7.1 MB) | EPUB
  • 40 Views
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REVIEW

Review
Updated Evaluation of Agalsidase Alfa Enzyme Replacement Therapy for Patients with Fabry Disease: Insights from Real-World Data
Sandro Feriozzi, Cristina Chimenti & Ricardo Claudio Reisin
Pages: 1083-1101
Published online: 04 Apr 2024
AbstractforUpdated Evaluation of Agalsidase Alfa Enzyme Replacement Therapy for Patients with Fabry Disease: Insights from Real-World Data | Full Text | References | PDF (627.3 KB) | EPUB
  • 96 Views
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Review
Mapping the Research of Ferroptosis in Parkinson’s Disease from 2013 to 2023: A Scientometric Review
Yingfan Chen, Zhenhui Wu, Shaodan Li, Qi Chen, Liang Wang, Xiaorong Qi, Chujiao Tian & Minghui Yang
Pages: 1053-1081
Published online: 03 Apr 2024
AbstractforMapping the Research of Ferroptosis in Parkinson’s Disease from 2013 to 2023: A Scientometric Review | Full Text | References | PDF (14.1 MB) | EPUB
  • 67 Views
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ORIGINAL RESEARCH

Article
Molecular Modeling, Synthesis, and Antihyperglycemic Activity of the New Benzimidazole Derivatives – Imidazoline Receptor Agonists
Artur Martynov, Boris Farber, Tatyana Bomko, Daniel L Beckles & Ilya Kleyn
Pages: 1035-1052
Published online: 03 Apr 2024
AbstractforMolecular Modeling, Synthesis, and Antihyperglycemic Activity of the New Benzimidazole Derivatives – Imidazoline Receptor Agonists | Full Text | References | PDF (7 MB) | EPUB
  • 81 Views
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CLINICAL TRIAL REPORT

Exploring the Median Effective Dose of Ciprofol for Anesthesia Induction in Elderly Patients: Impact of Frailty on ED50
Jingjing Yuan, Zenghui Liang, Muhoza Bertrand Geoffrey, Yanle Xie, Shuhan Chen, Jing Liu, Yuzhong Xia, Huixin Li, Yanling Zhao, Yuanyuan Mao, Na Xing, Jianjun Yang, Zhongyu Wang & Fei Xing
Pages: 1025-1034
Published online: 03 Apr 2024
AbstractforExploring the Median Effective Dose of Ciprofol for Anesthesia Induction in Elderly Patients: Impact of Frailty on ED50 | Full Text | References | PDF (3.9 MB) | EPUB
  • 40 Views
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LETTER

Letter to the Editor
Forsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling [LETTER]
Agriani Dini Pasiana, Hasta Handayani Idrus & Istianah Purnamasari
Pages: 1023-1024
Published online: 02 Apr 2024
CitationforForsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling [LETTER] | Full Text | References | PDF (279.7 KB) | EPUB
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REVIEW

Review
The Emerging Roles of Nanocarrier Drug Delivery System in Treatment of Intervertebral Disc Degeneration-Current Knowledge, Hot Spots, Challenges and Future Perspectives
Yunxiang Hu, Rui Yang, Sanmao Liu, Zefeng Song & Hong Wang
Pages: 1007-1022
Published online: 29 Mar 2024
AbstractforThe Emerging Roles of Nanocarrier Drug Delivery System in Treatment of Intervertebral Disc Degeneration-Current Knowledge, Hot Spots, Challenges and Future Perspectives | Full Text | References | PDF (5.7 MB) | EPUB
  • 129 Views
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Review
Revolutionizing Stroke Recovery: Unveiling the Promise of Stem Cell Therapy
Leonidas D Panos, Panagiotis Bargiotas, Marcel Arnold, Georgios Hadjigeorgiou & Georgios D Panos
Pages: 991-1006
Published online: 28 Mar 2024
AbstractforRevolutionizing Stroke Recovery: Unveiling the Promise of Stem Cell Therapy | Full Text | References | PDF (587.3 KB) | EPUB
  • 210 Views
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Review
The Potential of Exosomes for Osteoporosis Treatment: A Review
Yinxi He & Yanxia Chen
Pages: 979-989
Published online: 28 Mar 2024
AbstractforThe Potential of Exosomes for Osteoporosis Treatment: A Review | Full Text | References | PDF (2.4 MB) | EPUB
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Article
The Safety and Efficacy of Remimazolam Compared to Dexmedetomidine for Awake Tracheal Intubation by Flexible Bronchoscopy: A Randomized, Double-Blind, Controlled Trial
Qiumiao Chen, Bin Qin, Manqing Zhang, Yumei Zhou, Xiaotong Shi & Yubo Xie
Pages: 967-978
Published online: 28 Mar 2024
AbstractforThe Safety and Efficacy of Remimazolam Compared to Dexmedetomidine for Awake Tracheal Intubation by Flexible Bronchoscopy: A Randomized, Double-Blind, Controlled Trial | Full Text | References | PDF (2.5 MB) | EPUB
  • 59 Views
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Article
Neurophysiological Characteristics in Type II and Type III 5q Spinal Muscular Atrophy Patients: Impact of Nusinersen Treatment
Dan Li, Na Sun, Li Xiang, Jingjie Liu, Xueying Wang, Lin Yang & Shaoping Huang
Pages: 953-965
Published online: 27 Mar 2024
AbstractforNeurophysiological Characteristics in Type II and Type III 5q Spinal Muscular Atrophy Patients: Impact of Nusinersen Treatment | Full Text | References | PDF (3.1 MB) | EPUB
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REVIEW

Review
A Review of Dupilumab in the Treatment of Atopic Dermatitis in Infants and Children
Mingyue Wang, Xing-Hua Gao & Li Zhang
Pages: 941-951
Published online: 27 Mar 2024
AbstractforA Review of Dupilumab in the Treatment of Atopic Dermatitis in Infants and Children | Full Text | References | PDF (1.4 MB) | EPUB
  • 173 Views
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ORIGINAL RESEARCH

Article
The Impact of Baohuoside I on the Metabolism of Tofacitinib in Rats
Yaru Shi, Zebei Lu, Wei Song, Yu Wang, Quan Zhou, Peiwu Geng, Yunfang Zhou, Shuanghu Wang & Aixia Han
Pages: 931-939
Published online: 25 Mar 2024
AbstractforThe Impact of Baohuoside I on the Metabolism of Tofacitinib in Rats | Full Text | References | PDF (2.4 MB) | EPUB
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CLINICAL TRIAL REPORT

Effect of Intraoperative infusion Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial
Hai Xu, Conghui Hao, Xinxin Wang, Jingjing Du, Tianyu Zhang & Xiaobao Zhang
Pages: 919-929
Published online: 25 Mar 2024
AbstractforEffect of Intraoperative infusion Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial | Full Text | References | PDF (2.3 MB) | EPUB
  • 58 Views
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ORIGINAL RESEARCH

Article
Intracranial Efficacy of Pyrotinib and Capecitabine Combination Therapy in HER2-Positive Breast Cancer with Brain Metastases
Congcong Wang, Jinyu Xiang, Qingyu Zhang, Jing Li, Yanqing Liu & Jiannan Liu
Pages: 909-917
Published online: 23 Mar 2024
AbstractforIntracranial Efficacy of Pyrotinib and Capecitabine Combination Therapy in HER2-Positive Breast Cancer with Brain Metastases | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Harmonising IV Oxycodone with Paediatric Perioperative Medications: A Compatibility Study Through Y-Type Connectors
Souha H Youssef, Alka Garg, Yunmei Song, Nicole E Wylie & Sanjay Garg
Pages: 899-908
Published online: 23 Mar 2024
AbstractforHarmonising IV Oxycodone with Paediatric Perioperative Medications: A Compatibility Study Through Y-Type Connectors | Full Text | References | PDF (1.4 MB) | EPUB
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CLINICAL TRIAL REPORT

The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial
Tao Wen, Xuan Liu, Tao Pang, Mingming Li, Guangyang Jiao, Xiangcheng Fan, Jigui Tang, Ci’an Zhang, Zhipeng Wang, Xiaoqiang Yue, Wansheng Chen & Feng Zhang
Pages: 881-897
Published online: 21 Mar 2024
AbstractforThe Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial | Full Text | References | PDF (10.2 MB) | EPUB
  • 78 Views
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ORIGINAL RESEARCH

Article
Optimal Once-Daily Busulfan Administration in Pediatric Patients: A Simulation-Based Investigation of Intravenous Infusion Times
Yun Kim, Sungha Moon & Su-Jin Rhee
Pages: 871-879
Published online: 20 Mar 2024
AbstractforOptimal Once-Daily Busulfan Administration in Pediatric Patients: A Simulation-Based Investigation of Intravenous Infusion Times | Full Text | References | PDF (3.9 MB) | EPUB
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Article
A Novel DNA Aptamer Probe Recognizing Castration Resistant Prostate Cancer in vitro and in vivo Based on Cell-SELEX
Jinman Zhong, Duoduo Liu, Quanxin Yang, Jianke Ding & Xin Chen
Pages: 859-870
Published online: 18 Mar 2024
AbstractforA Novel DNA Aptamer Probe Recognizing Castration Resistant Prostate Cancer in vitro and in vivo Based on Cell-SELEX | Full Text | References | PDF (6.9 MB) | EPUB
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Article
Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice
Ji-Eun Song, Hae-Jin Ko & A-Sol Kim
Pages: 845-858
Published online: 18 Mar 2024
AbstractforComparison of the Efficacy of Anti-Obesity Medications in Real-World Practice | Full Text | References | PDF (5 MB) | EPUB
  • 367 Views
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REVIEW

Review
Understanding Sorafenib-Induced Cardiovascular Toxicity: Mechanisms and Treatment Implications
Jue Li, Lusha Zhang, Teng Ge, Jiping Liu, Chuan Wang & Qi Yu
Pages: 829-843
Published online: 18 Mar 2024
AbstractforUnderstanding Sorafenib-Induced Cardiovascular Toxicity: Mechanisms and Treatment Implications | Full Text | References | PDF (2.5 MB) | EPUB
  • 158 Views
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ORIGINAL RESEARCH

Article
Development and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds
Yanli Wang, Yan Liu, Yongle Wang, Ping Bai, Madelyn Rose Hallisey, Breanna Lizeth Varela, Anne Siewko, Changning Wang & Yulong Xu
Pages: 819-827
Published online: 14 Mar 2024
AbstractforDevelopment and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds | Full Text | References | PDF (3.8 MB) | EPUB
  • 105 Views
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Article
Model-Informed Precision Dosing of Isoniazid: Parametric Population Pharmacokinetics Model Repository
Gehang Ju, Xin Liu, Wenyu Yang, Nuo Xu, Lulu Chen, Chenchen Zhang, Qingfeng He, Xiao Zhu & Dongsheng Ouyang
Pages: 801-818
Published online: 15 Mar 2024
AbstractforModel-Informed Precision Dosing of Isoniazid: Parametric Population Pharmacokinetics Model Repository | Full Text | References | PDF (6 MB) | EPUB
  • 104 Views
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Article
Qifu Yixin Formula Improves Heart Failure by Enhancing β-Arrestin2 Mediated the SUMOylation of SERCA2a
Xinting Wang, Jiahui Yang, Cheng Lu, Yinqin Hu, Zhaohui Xu, Qiqi Wan, Meng Zhang, Tianyun Shi, Zhirui Liu & Yongming Liu
Pages: 781-799
Published online: 11 Mar 2024
AbstractforQifu Yixin Formula Improves Heart Failure by Enhancing β-Arrestin2 Mediated the SUMOylation of SERCA2a | Full Text | References | PDF (19.2 MB) | EPUB
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Article
Forsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling
Jiying Liu, Guangyao Fang, Cong Lan, Chenming Qiu, Li Yao, Qian Zhang, Jingtang Hu, Yaolei Zhang, Yongjian Yang & Yan Zhang
Pages: 767-780
Published online: 11 Mar 2024
AbstractforForsythoside B Mitigates Monocrotaline-Induced Pulmonary Arterial Hypertension via Blocking the NF-κB Signaling Pathway to Attenuate Vascular Remodeling | Full Text | References | PDF (7.5 MB) | EPUB
  • 119 Views
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Article
Mechanisms of Action of Potentilla discolor Bunge in Type 2 Diabetes Mellitus Based on Network Pharmacology and Experimental Verification in Drosophila
Yinghong Li, Fanwu Wu, Jianbo Zhang, Ye Xu, Hong Chang, Yueyue Yu, Chunhua Jiang, Xiujuan Gao, Huijuan Liu, Zhen Chen, Chenxi Wu & Ji-An Li
Pages: 747-766
Published online: 11 Mar 2024
AbstractforMechanisms of Action of Potentilla discolor Bunge in Type 2 Diabetes Mellitus Based on Network Pharmacology and Experimental Verification in Drosophila | Full Text | References | PDF (16 MB) | EPUB
  • 139 Views
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Article
Bibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction
Taotao Sun, Yipiao Liu, Penghui Yuan, Zhankui Jia & Jinjian Yang
Pages: 731-746
Published online: 09 Mar 2024
AbstractforBibliometric and Visualization Analysis of Stem Cell Therapy for Erectile Dysfunction | Full Text | References | PDF (11.3 MB) | EPUB
  • 158 Views
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Article
UHPLC-qTOF-MS-Based Nontargeted Metabolomics to Characterize the Effects of Capsaicin on Plasma and Skin Metabolic Profiles of C57BL/6 Mice-An In vivo Experimental Study
Zhen Xiao, Simin Yu, Deng Zhang & Chunming Li
Pages: 719-729
Published online: 05 Mar 2024
AbstractforUHPLC-qTOF-MS-Based Nontargeted Metabolomics to Characterize the Effects of Capsaicin on Plasma and Skin Metabolic Profiles of C57BL/6 Mice-An In vivo Experimental Study | Full Text | References | PDF (6.1 MB) | EPUB
  • 104 Views
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Article
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats
Xuqing Zhou, Xu Wang, Jiaqi Li, Mengxue Zhang, Yi Yang, Shihui Lei, Ying He, Hua Yang, Desheng Zhou & Chun Guo
Pages: 699-717
Published online: 04 Mar 2024
AbstractforIntegrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats | Full Text | References | PDF (17.6 MB) | EPUB
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CLINICAL TRIAL REPORT

Penehyclidine for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Laparoscopic Surgery Under Combined Intravenous and Inhalation Anesthesia: A Randomized, Double-Blind, Placebo-Controlled Trial
Kai Zhao, Yali Gao, Jianping Zhang, Shan Wang, Jiaqi Chen, Fenglin Guo & Sheng Wang
Pages: 685-697
Published online: 02 Mar 2024
AbstractforPenehyclidine for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Gynecological Laparoscopic Surgery Under Combined Intravenous and Inhalation Anesthesia: A Randomized, Double-Blind, Placebo-Controlled Trial | Full Text | References | PDF (748.5 KB) | EPUB
  • 125 Views
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ORIGINAL RESEARCH

Article
Safety and Effectiveness of a Biosimilar Recombinant Human Growth Hormone in Children Requiring Growth Hormone Treatment: Analysis of Final Data from PATRO Children, an International, Post-Marketing Surveillance Study
Sandro Loche, Shankar Kanumakala, Philippe Backeljauw, Karl Otfried Schwab, Alfonso M Lechuga-Sancho, Altaher Esmael, Dragan Urosevic, Anca Boldea & Markus Zabransky
Pages: 667-684
Published online: 02 Mar 2024
AbstractforSafety and Effectiveness of a Biosimilar Recombinant Human Growth Hormone in Children Requiring Growth Hormone Treatment: Analysis of Final Data from PATRO Children, an International, Post-Marketing Surveillance Study | Full Text | References | PDF (721.5 KB) | EPUB
  • 167 Views
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Article
Exploration of the in vitro Antiviral Effects and the Active Components of Changyanning Tablets Against Enterovirus 71
Qiong Ge, Zhewen Zhang, Zhiming Cao, Dan Wu, Changping Xu, Jianbiao Yao, Jian Gao & Yan Feng
Pages: 651-665
Published online: 01 Mar 2024
AbstractforExploration of the in vitro Antiviral Effects and the Active Components of Changyanning Tablets Against Enterovirus 71 | Full Text | References | PDF (2.3 MB) | EPUB
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CLINICAL TRIAL REPORT

Case Report
Randomized Double-Blinded Comparison of Intermittent Boluses Phenylephrine and Norepinephrine for the Treatment of Postspinal Hypotension in Patients with Severe Pre-Eclampsia During Cesarean Section
Zheng-Bin Pan, Zhi-Min Sheng, Miao Zhu, Zhong Mei, Yan-Ping Shen, Jin-Ping Liu & Xiao-Wei Qian
Pages: 639-650
Published online: 29 Feb 2024
AbstractforRandomized Double-Blinded Comparison of Intermittent Boluses Phenylephrine and Norepinephrine for the Treatment of Postspinal Hypotension in Patients with Severe Pre-Eclampsia During Cesarean Section | Full Text | References | PDF (2.7 MB) | EPUB
  • 103 Views
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Case Report
Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery
Yaxin Wei, Min Zhu, Yan Man, Hongyi Xiao, Guimin Dong, Xinyuan Shi & Fanceng Ji
Pages: 631-638
Published online: 05 Mar 2024
AbstractforClinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery | Full Text | References | PDF (529.7 KB) | EPUB
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REVIEW

Review
A Window for Enhanced Oral Delivery of Therapeutics via Lipid Nanoparticles
Hilda Amekyeh, Rayan Sabra & Nashiru Billa
Pages: 613-630
Published online: 29 Feb 2024
AbstractforA Window for Enhanced Oral Delivery of Therapeutics via Lipid Nanoparticles | Full Text | References | PDF (2.3 MB) | EPUB
  • 198 Views
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ORIGINAL RESEARCH

Article
Synthesis of a New Series of Anthraquinone-Linked Cyclopentanone Derivatives: Investigating the Antioxidant, Antibacterial, Cytotoxic and Tyrosinase Inhibitory Activities of the Mushroom Tyrosinase Enzyme Using Molecular Docking
Janani Mullaivendhan, Idhayadhulla Akbar, Anis Ahamed, Mansour K Gatasheh, Ashraf Atef Hatamleh, Gurusamy Raman, Aseer Manilal & Sabu Kuzhunellil Raghavanpillai
Pages: 597-612
Published online: 26 Feb 2024
AbstractforSynthesis of a New Series of Anthraquinone-Linked Cyclopentanone Derivatives: Investigating the Antioxidant, Antibacterial, Cytotoxic and Tyrosinase Inhibitory Activities of the Mushroom Tyrosinase Enzyme Using Molecular Docking | Full Text | References | PDF (8.9 MB) | EPUB
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CLINICAL TRIAL REPORT

Effects of Remifentanil Gradual Withdrawal Combined with Postoperative Infusion on Postoperative Hyperalgesia in Patients Undergoing Laparoscopic hysterectomy: A Factorial Design, Double-Blind, Randomized Controlled Trial
Meng Luo, Xue Han, Huan Li, Guangyue Zhou, Haoxuan Chen & Fang Gao
Pages: 583-595
Published online: 27 Feb 2024
AbstractforEffects of Remifentanil Gradual Withdrawal Combined with Postoperative Infusion on Postoperative Hyperalgesia in Patients Undergoing Laparoscopic hysterectomy: A Factorial Design, Double-Blind, Randomized Controlled Trial | Full Text | References | PDF (3.8 MB) | EPUB
  • 58 Views
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Pharmacokinetics, Pharmacodynamics, and Safety of Evocalcet (KHK7580), a Novel Calcimimetic Agent: An Open-Label, Single- and Multiple-Dose, Phase I Trial in Healthy Chinese Subjects
Xuemei He, Kazuya Narushima, Masahiro Kojima, Chisato Nagai & Kexin Li
Pages: 567-581
Published online: 26 Feb 2024
AbstractforPharmacokinetics, Pharmacodynamics, and Safety of Evocalcet (KHK7580), a Novel Calcimimetic Agent: An Open-Label, Single- and Multiple-Dose, Phase I Trial in Healthy Chinese Subjects | Full Text | References | PDF (8.7 MB) | EPUB
  • 86 Views
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ORIGINAL RESEARCH

Article
Protective Effects of Red Ginseng Against Tacrine-Induced Hepatotoxicity: An Integrated Approach with Network Pharmacology and Experimental Validation
Bong-Jo Kim, Seon-Been Bak, Su-Jin Bae, Hyo-Jung Jin, Sang Mi Park, Ye-Rim Kim, Dae-Hwa Jung, Chang-Hyun Song, Young-Woo Kim, Sang-Chan Kim, Won-Yung Lee & Sun-Dong Park
Pages: 549-566
Published online: 23 Feb 2024
AbstractforProtective Effects of Red Ginseng Against Tacrine-Induced Hepatotoxicity: An Integrated Approach with Network Pharmacology and Experimental Validation | Full Text | References | PDF (11.1 MB) | EPUB
  • 140 Views
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Article
The Effects of Different Doses of Sufentanil on Intraoperative Cardiovascular Response and Postoperative Recovery in Patients Undergoing Cardiac Surgery: A Retrospective Cohort Study
Meng Li, Xue Li, Yong Wu, Tianyu Zhang, Mengya Li & Ying Chen
Pages: 535-547
Published online: 23 Feb 2024
AbstractforThe Effects of Different Doses of Sufentanil on Intraoperative Cardiovascular Response and Postoperative Recovery in Patients Undergoing Cardiac Surgery: A Retrospective Cohort Study | Full Text | References | PDF (1.2 MB) | EPUB
  • 90 Views
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REVIEW

Review
Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review
Raden Maya Febriyanti, Jutti Levita & Ajeng Diantini
Pages: 513-534
Published online: 23 Feb 2024
AbstractforImmunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review | Full Text | References | PDF (2.8 MB) | EPUB
  • 164 Views
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ORIGINAL RESEARCH

Article
Network Pharmacology with Metabolomics Study to Reveal the Mechanisms of Bushen Huoxue Formula in Intervertebral Disc Degeneration Treatment
Ji Guo, Shengqi Yang, Weifeng Zhai, Yue Xie, Zhan Shen, Jianpo Zhang & Yongwei Jia
Pages: 493-512
Published online: 20 Feb 2024
AbstractforNetwork Pharmacology with Metabolomics Study to Reveal the Mechanisms of Bushen Huoxue Formula in Intervertebral Disc Degeneration Treatment | Full Text | References | PDF (12.9 MB) | EPUB
  • 128 Views
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Article
Hydroxy-Safflower Yellow A Mitigates Vascular Remodeling in Rat Pulmonary Arterial Hypertension
Xiang-Yu Ji, Cheng-Jing Lei, Shuang Kong, Han-Fei Li, Si-Yu Pan, Yu-Jing Chen, Fan-Rong Zhao & Tian-Tian Zhu
Pages: 475-491
Published online: 19 Feb 2024
AbstractforHydroxy-Safflower Yellow A Mitigates Vascular Remodeling in Rat Pulmonary Arterial Hypertension | Full Text | References | PDF (13.7 MB) | EPUB
  • 118 Views
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CLINICAL TRIAL REPORT

Efficacy of Intravenous Administration of Esketamine in Preventing and Treating Rebound Pain After Thoracic Paravertebral Nerve Block: A Prospective Randomized, Double-Blind, Placebo-Controlled Trial
Xu Zeng, Xianjie Zhang, Wencai Jiang & Xinyu Zhou
Pages: 463-473
Published online: 16 Feb 2024
AbstractforEfficacy of Intravenous Administration of Esketamine in Preventing and Treating Rebound Pain After Thoracic Paravertebral Nerve Block: A Prospective Randomized, Double-Blind, Placebo-Controlled Trial | Full Text | References | PDF (1.7 MB) | EPUB
  • 98 Views
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ORIGINAL RESEARCH

Article
The Protective Effect of Roflumilast Against Acute Hepatotoxicity Caused by Methotrexate in Wistar Rats: In vivo Evaluation
Riyadh S Almalki
Pages: 453-462
Published online: 15 Feb 2024
AbstractforThe Protective Effect of Roflumilast Against Acute Hepatotoxicity Caused by Methotrexate in Wistar Rats: In vivo Evaluation | Full Text | References | PDF (2.5 MB) | EPUB
  • 120 Views
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CLINICAL TRIAL REPORT

Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia: A Prospective, Double-Blind, Randomized Controlled Trial
Longbin Zheng, Tao Fang, Wei Zhang, Xiaojing Zhang, Zhiqiang Ren, Weimin Qin, Wenbo Liang, Qing Ma & Ning Yin
Pages: 443-452
Published online: 14 Feb 2024
AbstractforBeneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia: A Prospective, Double-Blind, Randomized Controlled Trial | Full Text | References | PDF (2.1 MB) | EPUB
  • 168 Views
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ORIGINAL RESEARCH

Article
Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology
Yi-Ling Jiang & Yi Xun
Pages: 425-441
Published online: 12 Feb 2024
AbstractforMolecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology | Full Text | References | PDF (13.2 MB) | EPUB
  • 122 Views
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Article
Zishen Yutai Pills Promote Angiogenesis at the Maternal-Fetal Interface in Recurrent Spontaneous Abortion Mice by Regulating miR-187/VEGF Axis
Xiaoli Wang, Heng Hu, Xinhui Yu, Chengcheng Liang, Yanquan Han, Hongxia Chen & Jijun Chu
Pages: 407-423
Published online: 12 Feb 2024
AbstractforZishen Yutai Pills Promote Angiogenesis at the Maternal-Fetal Interface in Recurrent Spontaneous Abortion Mice by Regulating miR-187/VEGF Axis | Full Text | References | PDF (10.3 MB) | EPUB
  • 106 Views
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Article
Pharmacokinetic Comparison Between a Fixed-Dose Combination of Atorvastatin/Omega-3-Acid Ethyl Esters and the Corresponding Loose Combination in Healthy Korean Male Subjects
Juyoung Khwarg, Soyoung Lee, In-Jin Jang, Won-Ho Kang, Hye Jung Lee, Kyu Yeon Kim, Ki-Sun Jeong, Chongho Won, Youn Woong Choi, Dae Chul Ha, RaeHoon Jung, Min-Gu Han, Won Tae Jung, Kyu-Yeol Nam, YeSeul Kim, Kyung-Sang Yu & Jaeseong Oh
Pages: 395-406
Published online: 08 Feb 2024
AbstractforPharmacokinetic Comparison Between a Fixed-Dose Combination of Atorvastatin/Omega-3-Acid Ethyl Esters and the Corresponding Loose Combination in Healthy Korean Male Subjects | Full Text | References | PDF (8.6 MB) | EPUB
  • 114 Views
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Article
A Comprehensive Study to Investigate the Tumor-Suppressive Role of Radix Bupleuri on Gastric Cancer with Network Pharmacology and Molecular Docking
Long Lv, Jinghu Du, Daorong Wang & Zeqiang Yan
Pages: 375-394
Published online: 07 Feb 2024
AbstractforA Comprehensive Study to Investigate the Tumor-Suppressive Role of Radix Bupleuri on Gastric Cancer with Network Pharmacology and Molecular Docking | Full Text | References | PDF (21.8 MB) | EPUB
  • 164 Views
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REVIEW

Review
Ranibizumab Biosimilars in Treating Retinal Disorders: A Cost-Effective Revolution?
Eleftherios Chatzimichail, Kristina Pfau, Zisis Gatzioufas & Georgios D Panos
Pages: 365-374
Published online: 07 Feb 2024
AbstractforRanibizumab Biosimilars in Treating Retinal Disorders: A Cost-Effective Revolution? | Full Text | References | PDF (440 KB) | EPUB
  • 160 Views
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CLINICAL TRIAL REPORT

Comparative Study Between Dexmedetomidine with Bupivacaine and Bupivacaine Alone in Erector Spinae Plane Block for Postoperative Pain Control of Posterior Lumbosacral Spine Fixation Surgeries: A Randomized Controlled Trial
Sawsan HA Abu El Hassan, Engy A Wahsh, Abdelmaksod Mohammed Mousa, Ahmed RN Ibrahim & Emad Lotfy Mohammed
Pages: 351-363
Published online: 07 Feb 2024
AbstractforComparative Study Between Dexmedetomidine with Bupivacaine and Bupivacaine Alone in Erector Spinae Plane Block for Postoperative Pain Control of Posterior Lumbosacral Spine Fixation Surgeries: A Randomized Controlled Trial | Full Text | References | PDF (3.9 MB) | EPUB
  • 205 Views
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ORIGINAL RESEARCH

Article
Remifentanil is Superior to Propofol for Treating Emergence Agitation in Adults After General Anesthesia
Jun Li, Hongrui Zhu, Yu Wang, Jiaqi Chen, Keqiang He & Sheng Wang
Pages: 341-350
Published online: 06 Feb 2024
AbstractforRemifentanil is Superior to Propofol for Treating Emergence Agitation in Adults After General Anesthesia | Full Text | References | PDF (2.6 MB) | EPUB
  • 115 Views
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CLINICAL TRIAL REPORT

The Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Thoracoscopic Surgery for Lung Cancer: A Prospective, Randomized, Controlled Trial
Zhaohui Liu, Yi Jin, Lingfei Wang & Zeqing Huang
Pages: 325-339
Published online: 05 Feb 2024
AbstractforThe Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Thoracoscopic Surgery for Lung Cancer: A Prospective, Randomized, Controlled Trial | Full Text | References | PDF (1 MB) | EPUB
  • 127 Views
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REVIEW

Review
The Potential Application of Aloe Barbadensis Mill. as Chinese Medicine for Constipation: Mini-Review
Wei-Rui Huang, Quan-Hui Fang, Xiang-Bin Yu, Wei-Hong Ge & Yue Yu
Pages: 307-324
Published online: 02 Feb 2024
AbstractforThe Potential Application of Aloe Barbadensis Mill. as Chinese Medicine for Constipation: Mini-Review | Full Text | References | PDF (5.3 MB) | EPUB
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Review
Developments in the Management of Growth Hormone Deficiency: Clinical Utility of Somapacitan
Bradley S Miller, Jo Blair, Reiko Horikawa, Agnès Linglart & Kevin CJ Yuen
Pages: 291-306
Published online: 05 Feb 2024
AbstractforDevelopments in the Management of Growth Hormone Deficiency: Clinical Utility of Somapacitan | Full Text | References | PDF (2.2 MB) | EPUB
  • 216 Views
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Review
Dupilumab Treatment in Pediatric Patients Aged 6–11 Years with Severe Atopic Dermatitis Whose Disease Is Not Adequately Controlled: A Review
Michael J Cork, Simon G Danby, Ana B Rossi & Ashish Bansal
Pages: 277-289
Published online: 05 Feb 2024
AbstractforDupilumab Treatment in Pediatric Patients Aged 6–11 Years with Severe Atopic Dermatitis Whose Disease Is Not Adequately Controlled: A Review | Full Text | References | PDF (1.3 MB) | EPUB
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ORIGINAL RESEARCH

Article
Systematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis
Kai Chen, Yaohui Yu, Yishu Wang, Yi Zhu, Chaoren Qin, Jintao Xu, Xiangjie Zou, Tianqi Tao, Yang Li & Yiqiu Jiang
Pages: 259-275
Published online: 01 Feb 2024
AbstractforSystematic Pharmacology and Experimental Validation to Reveal the Alleviation of Astragalus membranaceus Regulating Ferroptosis in Osteoarthritis | Full Text | References | PDF (9.4 MB) | EPUB
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RETRACTION

Retraction
Berberine Nanoparticles with Enhanced in vitro Bioavailability: Characterization and Antimicrobial Activity [Retraction]
Pages: 257-258
Published online: 02 Feb 2024
CitationforBerberine Nanoparticles with Enhanced in vitro Bioavailability: Characterization and Antimicrobial Activity [Retraction] | Full Text | PDF (235.1 KB) | EPUB
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EXPERT OPINION

Article
Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch
Qiang Fu, Na Han, Na Li, Ling Gui, Chen Shi, Peipei Rong, Fan Zeng, He Rao, Yuan Chen & On behalf of Cancer Rehabilitation and Palliative Treatment Professional Committee of Hubei Anti Cancer Association
Pages: 233-255
Published online: 15 Feb 2024
AbstractforGuidelines for Rational Clinical Use of Fentanyl Transdermal Patch | Full Text | References | PDF (1.1 MB) | EPUB
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ORIGINAL RESEARCH

Article
Effect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study
Yuye Chen, Yue Liu, Hong Lv, Qian Li, Jingjia Shen, Weiyun Chen, Jia Shi & Chenghui Zhou
Pages: 223-231
Published online: 31 Jan 2024
AbstractforEffect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Synthesis and Characterization of a New Carbon-11 Labeled Positron Emission Tomography Radiotracer for Orexin 2 Receptors Neuroimaging
Yanli Wang, Yongle Wang, Yan Liu, Hua Cheng, Tewodros Mulugeta Dagnew, Yulong Xu & Changning Wang
Pages: 215-222
Published online: 31 Jan 2024
AbstractforSynthesis and Characterization of a New Carbon-11 Labeled Positron Emission Tomography Radiotracer for Orexin 2 Receptors Neuroimaging | Full Text | References | PDF (2.4 MB) | EPUB
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REVIEW

Review
Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies
Deshanda Kurniawan Prayoga, Diah Lia Aulifa, Arif Budiman & Jutti Levita
Pages: 193-213
Published online: 31 Jan 2024
AbstractforPlants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies | Full Text | References | PDF (1.3 MB) | EPUB
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Review
Review of the Protective Mechanism of Curcumin on Cardiovascular Disease
Chunkun Yang, Qinwei Zhu, Yanbo Chen, Kui Ji, Shuanghong Li, Qian Wu, Qingquan Pan & Jun Li
Pages: 165-192
Published online: 29 Jan 2024
AbstractforReview of the Protective Mechanism of Curcumin on Cardiovascular Disease | Full Text | References | PDF (6.7 MB) | EPUB
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PERSPECTIVES

Article Commentary
Interactive Nutrient Process (INP) in a Generative AI of a New Drug—6-Shogaol as a Potential Case
Vladimir Badmaev
Pages: 161-163
Published online: 27 Jan 2024
AbstractforInteractive Nutrient Process (INP) in a Generative AI of a New Drug—6-Shogaol as a Potential Case | Full Text | References | PDF (270.8 KB) | EPUB
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ORIGINAL RESEARCH

Article
In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’s Disease
Shu-Tong Huang, Jin-Chong Luo, Guo-Hui Zhong, Li-Ping Teng, Cai-Yan Yang, Chun-Li Tang, Lin Jing, Zhong-Bo Zhou, Jing Liu & Neng Jiang
Pages: 133-159
Published online: 23 Jan 2024
AbstractforIn vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’s Disease | Full Text | References | PDF (10.6 MB) | EPUB
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CLINICAL TRIAL REPORT

Comparison of Remimazolam versus Sevoflurane on the Postoperative Quality of Recovery in Cervical Spine Surgery: A Prospective Randomized Controlled Double-Blind Trial
Jiwon Lee, Dong Woo Han, Na Young Kim, Keun-Su Kim, Yunil Yang, Juyeon Yang, Hye Sun Lee & Myoung Hwa Kim
Pages: 121-132
Published online: 23 Jan 2024
AbstractforComparison of Remimazolam versus Sevoflurane on the Postoperative Quality of Recovery in Cervical Spine Surgery: A Prospective Randomized Controlled Double-Blind Trial | Full Text | References | PDF (3.5 MB) | EPUB
  • 143 Views
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ORIGINAL RESEARCH

Article
The Effect of Platelet Activity, ABCB1 Genetic Polymorphism, and Renal Function on the Development of Ticagrelor-Related Dyspnea in Patients with Acute Coronary Syndrome
Vytenis Tamakauskas, Remigijus Žaliūnas, Vaiva Lesauskaitė, Nora Kupstytė-Krištaponė, Ieva Čiapienė, Gintarė Šakalytė, Jurgita Plisienė, Vilius Skipskis & Vacis Tatarūnas
Pages: 109-119
Published online: 23 Jan 2024
AbstractforThe Effect of Platelet Activity, ABCB1 Genetic Polymorphism, and Renal Function on the Development of Ticagrelor-Related Dyspnea in Patients with Acute Coronary Syndrome | Full Text | References | PDF (2.6 MB) | EPUB
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REVIEW

Review
The Role of Rho Kinase Inhibitors in Corneal Diseases
Stefan Futterknecht, Eleftherios Chatzimichail, Konstantin Gugleta, Georgios D Panos & Zisis Gatzioufas
Pages: 97-108
Published online: 18 Jan 2024
AbstractforThe Role of Rho Kinase Inhibitors in Corneal Diseases | Full Text | References | PDF (550.9 KB) | EPUB
  • 181 Views
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ORIGINAL RESEARCH

Article
Population Pharmacokinetics and Model-Based Dose Optimization of Vancomycin in Sudanese Adult Patients with Renal Impairment
Khalid Altigani Ahmed, Alnada Ibrahim, Daniel Gonzalez & Abubakr O Nur
Pages: 81-95
Published online: 15 Jan 2024
AbstractforPopulation Pharmacokinetics and Model-Based Dose Optimization of Vancomycin in Sudanese Adult Patients with Renal Impairment | Full Text | References | PDF (8.3 MB) | EPUB
  • 165 Views
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Article
Nicotine Diminishes Alpha2-Adrenergic Receptor-Dependent Protection Against Oxidative Stress in H9c2 Cardiomyocytes
Giselle Del Calvo, Celina M Pollard, Teresa Baggio Lopez, Jordana I Borges, Malka S Suster & Anastasios Lymperopoulos
Pages: 71-80
Published online: 26 Feb 2024
AbstractforNicotine Diminishes Alpha2-Adrenergic Receptor-Dependent Protection Against Oxidative Stress in H9c2 Cardiomyocytes | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Immunosuppression with Generics in Liver and Kidney Transplantation: A Real-World Evidence Study
Marco Finocchietti, Maria Lucia Marino, Alessandro C Rosa, Arianna Bellini, Lucia Masiero, Massimo Cardillo, Marco Massari, Stefania Spila Alegiani, Silvia Pierobon, Eliana Ferroni, Martina Zanforlini, Olivia Leoni, Stefano Ledda, Donatella Garau, Marina Davoli, Antonio Addis, Valeria Belleudi & On behalf of CESIT Study Group
Pages: 53-69
Published online: 11 Jan 2024
AbstractforImmunosuppression with Generics in Liver and Kidney Transplantation: A Real-World Evidence Study | Full Text | References | PDF (5.4 MB) | EPUB
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CLINICAL TRIAL REPORT

Effect of High-Fat Meal on the Pharmacokinetics and Safety of Valsartan/Amlodipine Fixed Dose Combination Tablets in Healthy Subjects
Haojing Song, Bo Qiu, Xue Sun, Caihui Guo, Yiting Hu, Wanjun Bai & Zhanjun Dong
Pages: 43-51
Published online: 11 Jan 2024
AbstractforEffect of High-Fat Meal on the Pharmacokinetics and Safety of Valsartan/Amlodipine Fixed Dose Combination Tablets in Healthy Subjects | Full Text | References | PDF (2 MB) | EPUB
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ORIGINAL RESEARCH

Article
Synthesis and Application of a Near-Infrared Light-Emitting Fluorescent Probe for Specific Imaging of Cancer Cells with High Sensitivity and Selectivity
Shaoguang Li, Zhan Lin, Haobo Chen, Qiu Luo, Shengnan Han, Kunlong Huang, Ruichan Chen, Yuying Zhan, Bing Chen & Hong Yao
Pages: 29-41
Published online: 09 Jan 2024
AbstractforSynthesis and Application of a Near-Infrared Light-Emitting Fluorescent Probe for Specific Imaging of Cancer Cells with High Sensitivity and Selectivity | Full Text | References | PDF (8.9 MB) | EPUB
  • 184 Views
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Article
Huang Gan Formula Alleviates Systemic Inflammation and Uremia in Adenine-Induced Chronic Kidney Disease Rats May Associate with Modification of Gut Microbiota and Colonic Microenvironment
Jingqian Zhao, Chenyu Zhao, Tianrong Xun, Xiaokang Wang, Sui Wei, Chunxiao Ye, Mimi Zhang, Dan Guo & Xixiao Yang
Pages: 13-28
Published online: 05 Jan 2024
AbstractforHuang Gan Formula Alleviates Systemic Inflammation and Uremia in Adenine-Induced Chronic Kidney Disease Rats May Associate with Modification of Gut Microbiota and Colonic Microenvironment | Full Text | References | PDF (12.4 MB) | EPUB
  • 171 Views
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Article
Pharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS
Pan Lei, Wanying Shen, Huijuan Tang, Li You, Guoyi Chen, Yijun Tang & Wei Lu
Pages: 1-12
Published online: 04 Jan 2024
AbstractforPharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS | Full Text | References | PDF (5.4 MB) | EPUB
  • 159 Views
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