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Materials Engineering

Graphene-based electrodes for ECG signal monitoring: Fabrication methodologies, challenges and future directions

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Article: 2246750 | Received 30 May 2023, Accepted 07 Aug 2023, Published online: 17 Aug 2023
 

Abstract

Electrocardiogram (ECG) is the most common and simple technique to diagnose cardiovascular diseases. Cardiovascular diseases can be detected effectively if ECG signals are monitored for a long time, producing innovative clinical outcomes to diagnose and treat cardiovascular diseases. Due to skin irritation and degradation of signal quality with time, traditional wet electrodes are unsuitable for long-term ECG monitoring. Researchers are trying to fabricate flexible, wearable, highly conductive and lightweight ECG sensors, which can be applied for long-term monitoring of ECG signals and the detection of several cardiovascular diseases. Graphene is used for fabricating dry ECG electrodes because it exhibits robust mechanical flexibility, good environmental stability and excellent carrier mobility. This review paper presents the progress of various fabrication methods to make graphene-based ECG electrodes and provides the researcher’s clarification on recent advancements and direction in this domain. This paper focuses on a systematic review and comparative study of various fabrication methods of graphene-based ECG electrodes, such as screen printing, dip coating, drop casting, wet transfer, electrospinning, wet transfer and dry patterning, spin coating, spray coating, ink-jet printing etc.

Abbreviations

BLG=

Bi-Layer Graphene

CG=

Chemically modified Graphene

CRGO=

Chemically Reduced Graphene Oxide

CVD=

Chemical Vapor Deposition

ECG=

Electrocardiogram

EEG=

Electroencephalogram

EMG=

Electromyography

EOG=

Electrooculogram

GES=

Graphene Electronic

GET=

Graphene Electronic Tattoo

GNR=

Graphene Nano-Ribbons

GO=

Graphene Oxide

GS=

Graphene Sponge

GT=

Graphene-Based Textiles

LIG=

Laser Induced Graphene

LINA=

Laser Induced Nanographene Aggregates

PDMS=

Polydimethylsiloxane

PEDOT=

Poly(3,4-Ethylenedio-xythiophene)

PEG=

Polyethylene Glycol

PEP=

Polyaziridine-Encapsulated Phosphorene

PET=

Polyethylene Terephthalate

PHA=

Polyhydroxyalkanoate

PMMA=

Polymethyl Methacrylate

PSS=

Poly(Styrenesulfonate)

PVA=

Polyvinyl Alcohol

PVDF=

Polyvinylidene Fluoride

rGO=

Reduced Graphene Oxide

RMS=

Root Mean Square

SEM=

Scanning Electron Microscopy

SNR=

Signal To Noise Ratio

TEM=

Transmission Electron Microscopy

Author contributions

Conceptualisation, RD and RPC; methodology, PS; software, BA and BPD; validation, PS.; formal analysis, PS, and BA; investigation, AGS, MO and NB; resources, BA, BPD, and RPC; data curation, RD and RPC; writing—original draft preparation, RD, RPC, and PS; supervision, AS, and PN.; project administration, BA; funding acquisition, AS, and PN writing—review and editing: PS, BA, RD and BPD; coordination, PN; All authors have read and agreed to the published version of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).