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Virulence Volume 13, 2022 - Issue 1
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Research Paper

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

Jia Luoa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Jiajia Zhanga College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Jinghua Nia College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Sen Jianga College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Nengwen Xiaa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Yiwen Guoa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Qi Shaoa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Qi Caoa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Wanglong Zhenga College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Nanhua Chena College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Quan Zhanga College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information
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Hongjun Chene Shanghai Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Shanghai, ChinaView further author information
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Qing Chenf College of Bioscience and Resource Environment, Beijing University of Agriculture, Beijing, ChinaView further author information
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Hongfei Zhug Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, ChinaView further author information
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François Meurensh BIOEPAR, INRAE, Oniris, Nantes, France;i Department of Veterinary Microbiology and Immunology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, CanadaView further author information
&
Jianzhong Zhua College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7082-1993View further author information
ORCID Icon show all
Pages 740-756 | Received 09 Dec 2021, Accepted 11 Apr 2022, Published online: 01 May 2022

Citations (8)

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Read on this site (1)

Boli Hu, Guifang Zhong, Shuxiang Ding, Kang Xu, Xiran Peng, Weiren Dong & Jiyong Zhou. (2023) African swine fever virus protein p17 promotes mitophagy by facilitating the interaction of SQSTM1 with TOMM70. Virulence 14:1.
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Articles from other publishers (7)

Mingyang Cheng, Makoye Mhozya Kanyema, Yu Sun, Wenhui Zhao, Yiyuan Lu, Junhong Wang, Xiaoxu Li, Chunwei Shi, Jianzhong Wang, Nan Wang, Wentao Yang, Yanlong Jiang, Haibin Huang, Guilian Yang, Yan Zeng, Chunfeng Wang & Xin Cao. (2023) African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation. Journal of Virology 97:2.
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Liangzheng Yu, Zhenbang Zhu, Junhua Deng, Kegong Tian & Xiangdong Li. (2023) Antagonisms of ASFV towards Host Defense Mechanisms: Knowledge Gaps in Viral Immune Evasion and Pathogenesis. Viruses 15:2, pages 574.
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Elena Riera, Raquel García-Belmonte, Ricardo Madrid, Daniel Pérez-Núñez & Yolanda Revilla. (2023) African swine fever virus ubiquitin-conjugating enzyme pI215L inhibits IFN-I signaling pathway through STAT2 degradation. Frontiers in Microbiology 13.
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Gen Lu, Kang Ou, Yihan Zhang, Huan Zhang, Shouhua Feng, Zuofeng Yang, Guo Sun, Jinling Liu, Shu Wei, Shude Pan & Zeliang Chen. (2023) Structural Analysis, Multi-Conformation Virtual Screening and Molecular Simulation to Identify Potential Inhibitors Targeting pS273R Proteases of African Swine Fever Virus. Molecules 28:2, pages 570.
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Wen-Rui He, Jin Yuan, Yu-He Ma, Cheng-Yan Zhao, Zhong-Yuan Yang, Yuhang Zhang, Shichong Han, Bo Wan & Gai-Ping Zhang. (2022) Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A Review. Animals 12:21, pages 2935.
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Yang Yu, Jingyang Liu, Cun Liu, Ruijuan Liu, Lijuan Liu, Zhenhai Yu, Jing Zhuang & Changgang Sun. (2022) Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation. Cells 11:19, pages 3043.
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Wanglong Zheng, Nengwen Xia, Jiajia Zhang, Qi Cao, Sen Jiang, Jia Luo, Hui Wang, Nanhua Chen, Quan Zhang, François Meurens & Jianzhong Zhu. (2022) African Swine Fever Virus Structural Protein p17 Inhibits cGAS-STING Signaling Pathway Through Interacting With STING. Frontiers in Immunology 13.
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