The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

Jia Luoa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Jiajia Zhanga College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Jinghua Nia College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Sen Jianga College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Nengwen Xiaa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Yiwen Guoa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Qi Shaoa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Qi Caoa College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Wanglong Zhenga College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Nanhua Chena College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Quan Zhanga College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaView further author information

Hongjun Chene Shanghai Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Shanghai, ChinaView further author information

Qing Chenf College of Bioscience and Resource Environment, Beijing University of Agriculture, Beijing, ChinaView further author information

Hongfei Zhug Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, ChinaView further author information

François Meurensh BIOEPAR, INRAE, Oniris, Nantes, France;i Department of Veterinary Microbiology and Immunology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, CanadaView further author information

Jianzhong Zhua College Veterinary Medicine, Yangzhou University, Yangzhou, China;b Safety, Yangzhou UniversityJoint International Research Laboratory of Agriculture and Agri-Product, Yangzhou, China;c Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China;d Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, ChinaCorrespondence[email protected]