The role of fungi in the diagnosis of colorectal cancer

Figures & data

Figure 1. Diseases that require differential diagnosis. (a) Laboratory fungal infections should be considered during biopsy of tumour tissue. (b) Tumor patients are often immunosuppressed after chemotherapy and radiotherapy and are prone to invasive mycosis. Therefore, fungi and fungal antibodies can also be found in the blood. (c) If a change in faecal fungal flora abundance is found, in addition to considering CRC, intestinal flora disorders, fungal intestinal infections, and perianal skin infections should also be considered.

Table 1. Evaluation of some colorectal markers associated with microorganisms.

Biomarker panel	AUC (%)	Country
14 fungi (Coker et al. 2019)	93 82 74	Multicounty China Europe
12 bacteria plus FOBT (Yuan et al. 2021)	92	China
5 bacteriophages (Shen et al. 2021)	86 78	China, Austria, and Japan China and Italy
4 bacteria plus FIT (Liang et al. 2020)	90	Asia
6 bacteria and 11 metabolites (Coker et al. 2022)	94	China
11 bacteria, 4 fungi, and 1 archaea (Liu et al. 2022)	83	Multicounty
5 fungi and 9 bacteria 12 bacteria (Lin et al. 2022)	90 83	Multicounty Multicounty

Figure 2. Different samples used for the diagnosis of colorectal cancer.

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