Figures & data
Figure 1. Mannosylated nanotrinity synthesis and macrophage remodelling. Mannose was covalently conjugated with chitosan oligosaccharides and then the product was incubated with imatinib-laden nanoparticles obtaining the chitosan-coated nanoparticles. The mannosylated nanotrinity developed in this study could significantly induce macrophage remodelling in situ by the two-pronged process, “turning on” M1 phenotype polarisation meanwhile “shutting off” M2 phenotype polarisation, and thus allowed to eradicate C. albicans infection (Gao et al. Citation2020).
Figure 2. The functional assessment of the econazole-triamcinolone loaded silica nanoparticles. Maheen et al. mixed MSNs with econazole nitrate (EN) and triamcinolone acetonide (TA) to accelerate healing. In the C. albicans-infected animal models, the EN-TA-loaded MSNs exhibited superiority in anti-fungal activity and wound healing, compared with EN/TA alone. (A) SEM analysis of EN-TA-MSNs. (B) Skin irritation studies and in vivo antifungal studies in control group (a), group treated with pure EN-TA suspension (b), and group treated with EN-TA loaded MSNs (c) (Maheen et al. Citation2022).
