Figures & data
Figure 1. Dysregulated autophagy by triglyceride-derived FAs contributes to the energy failure of photoreceptors and drives neovascular retinal diseases. Fasting activates TFEB and SIRT3, increasing autophagy and mitochondrial efficiency to meet photoreceptors’ energy demands. Conversely, excess lipids in the murine vldlr−/− RAP model suppresses TFEB activity, and SIRT3 expression, contributing to the energy failure of photoreceptors and VEGF secretion driving RAP-like neovascular disease.
