The anticancer properties of phytochemical extracts from Salvia plants

Figures & data

Figure 1 Salvia miltiorrhiza (A); the roots of S. miltiorrhiza (Danshen) (B); and Salvia officinalis (C).

Table 1 Phytochemicals with potential anticancer properties in Salvia genus

Phytochemical	Structure	Phytochemical category	Plant name	Plant part	Refs
Cryptotanshinone		Diterpene	S. bulleyana	Root	29, 30
			S. bowleyana	Root
			S. campanulata	Root
			S. castanea	Root
			S. cavaleriei var. simplicifolia	Root
			S. digitaloides	Root
			S. dabieshanensis	Root
			S. evansiana	Root
			S. flava	Root
			S. maximowicziana	Root
			S. meiliensis	Root
			S. miltiorrhiza	Root
			S. officinalis	Root
			S. przewalskii	Root
			S. pauciflora	Root
			S. prattii	Root
			S. prionitis	Root
			S. paramiltiorrhiza	Root
			S. plectranthoides	Root
			S. roborowskii	Root
			S. sinica	Root
			S. trijuga	Root
			S. umbratica	Root
			S. vasta	Root
			S. yunnanensis	Root
Castanol C		Diterpene	S. castanea	Whole plant	31, 32
			S. yunnanensis	Root
Camphor		Monoterpene	S. libanotica	Leaf	24,
			S. officinalis	Leaf	^Citation33–Citation35
			S. sclarea	Leaf
Dihydrotanshinone		Diterpene	S. bowleyana	Root	29, 30
			S. campanulata	Root
			S. castanea	Root
			S. cavaleriei var. simplicifolia	Root
			S. digitaloides	Root
			S. dabieshanensis	Root
			S. evansiana	Root
			S. flava	Root
			S. maximowicziana	Root
			S. meiliensis	Root
			S. miltiorrhiza	Root
			S. omeiana	Root
			S. officinalis	Root
			S. przewalskii	Root
			S. pauciflora	Root
			S. prattii	Root
			S. prionitis	Root
			S. paramiltiorrhiza	Root
			S. plectranthoides	Root
			S. roborowskii	Root
			S. sinica	Root
			S. trijuga	Root
			S. umbratica	Root
			S. vasta	Root
			S. yunnanensis	Root
Danshensu		Phenolic acid	S. miltiorrhiza	Whole plant	^Citation36–Citation39
			S. yunnanensis	Whole plant
			S. campanulata	Whole plant
			S. bulleyana	Root
			S. castanea	Whole plant
			S. digitaloides	Whole plant
			S. evansiana	Whole plant
			S. flava	Root
			S. maximowicziana	Whole plant
			S. pauciflora	Whole plant
			S. omeiana	Root
			S. pauciflora	Whole plant
			S. prattii	Root
			S. przewalskii	Whole plant
			S. roborowskii	Whole plant
			S. sonchifolia	Whole plant
			S. officinalis	Leaf
			S. plebeia	Whole plant
			S. bowleyana	Whole plant
			S. cavaleriei var. simplicifolia	Whole plant
			S. dabieshanensis	Whole plant
			S. meiliensis	Whole plant
			S. prionitis	Whole plant
			S. paramiltiorrhiza	Whole plant
			S. plectranthoides	Whole plant
			S. yunnanensis	Whole plant
			S. sinica	Whole plant
			S. trijuga	Whole plant
			S. vasta	Whole plant
			S. deserta	Whole plant
			S. baimaensis	Whole plant
			S. chinensis	Whole plant
			S. japonica	Whole plant
			S. kiangsiensis	Whole plant
			S. scapiformis	Whole plant
Demethylcryptojaponol		Diterpene	S. hypargeia	Root	40
			S. montbretii	Root
Danshenol A		Diterpene	S. yunnanensis	Root	32
Dihydroneotanshinlactone		Alkaloid	S. digitaloides	Root	32, 41
			S. yunnanensis	Root
Deacetylnemorone		Diterpene	S. leriifolia	Whole plant	42
Daucosterol		Steroid	S. sahendica	Leaf	43
Ferruginol		Monoterpene	S. chorassanica	Root	32,
			S. hypargeia	Root	^Citation44–Citation47
			S. miltiorrhiza	Root
			S. Przewalskii	Root
			S. yunnanensis	Root
6a-Hydroxysalvinolone		Diterpene	S. hypargeia	Root	45
6a-hydroxysugiol		Diterpene	S. przewalskii	Root	32, 47
			S. yunnanensis	Root
6-Hydroxysalvinolone		Diterpene	S. chorassanica	Root	40, 42,
			S. hypargeia	Root	44
			S. leriifolia	Whole plant
			S. montbretii	Root
Lupine-2,3-diol		Triterpenes	S. leriifolia	Whole plant	42
Linalyl acetate		Monoterpene	S. libanotica	Leaf	^Citation33–Citation35
			S. sclarea	Leaf
Neo-tanshinlactone		Diterpene	S. miltiorrhiza	Root	48
Protocatechualdehyde		Phenolic acid	S. miltiorrhiza	Whole plant	48
			S. przewalskii	Whole plant
Rosmarinic acid		Phenolic acid	S. bulleyana	Whole plant	36, 50
			S. bowleyana	Whole plant
			S. baimaensis	Whole plant
			S. chienii	Whole plant
			S. chinensis	Whole plant
			S. campanulata	Whole plant
			S. castanea	Whole plant
			S. difitaloides	Whole plant
			S. deserta	Whole plant
			S. dabieshanensis	Whole plant
			S. evansiana	Whole plant
			S. flava	Root
			S. farinacea	Whole plant
			S. japonica	Whole plant
			S. kiangsiensis	Whole plant
			S. maximowicziana	Root
			S. meiliensis	Whole plant
			S. miltiorrhiza	Whole plant
			S. officinalis	Whole plant
			S. paramiltiorrhiza	Whole plant
			S. plectranthoides	Whole plant
			S. prionitis	Whole plant
			S. plebeian	Whole plant
			S. pauciflora	Root
			S. prattii	Whole plant
			S. przewalskii	Whole plant
			S. roborowskii	Whole plant
			Scavaleriei var. simplcifolia	Whole plant
			S. sinica	Whole plant
			S. splendens	Whole plant
			S. scapiformis	Whole plant
			S. staminea	Whole plant
			S. trijuga	Whole plant
			S. umbratica	Whole plant
			S. virgata	Whole plant
			S. verbenaca	Whole plant
			S. vasta	Whole plant
			S. yunnanensis	Whole plant
Salvinal		Neolignan	S. miltiorrhiza	Root	51
Salvianolic acid A		Phenolic acid	S. cavaleriei	Whole plant	30, 52,
			S. flava	Whole plant	53
			S. miltiorrhiza	Whole plant
			S. prionitis	Whole plant
Salvianolic acid B		Phenolic acid	S. baimaensis	Whole plant	^Citation36–Citation38
			S. bowleyana	Whole plant
			S. bulleyana	Root
			S. castanea	Whole plant
			S. chinensis	Whole plant
			S. campanulata	Root
			S. digitaloides	Root
			S. dabieshanensis	Whole plant
			S. evansiana	Whole plant
			S. flava	Root
			S. kiangsiensis	Whole plant
			S. maximowicziana	Root
			S. meiliensis	Whole plant
			S. miltiorrhiza	Whole plant
			S. paramiltiorrhiza	Whole plant
			S. plectranthoides	Root
			S. prionitis	Whole plant
			S. przewalskii	Whole plant
			S. plebeia	Whole plant
			S. pauciflora	Root
			S. sinica	Whole plant
			S. trijuga	Root
			S. vasta	Root
			S. yunnanensis	Root
Saprorthoquinone		Diterpene	S. hypargeia	Root	45
Salyunnanin D		Diterpene	S. yunnanensis	Root	32
Salyunnanin E		Diterpene	S. yunnanensis	Root	32
Tanshinone IIA		Diterpene	S. bowleyana	Root	30, 54
			S. bulleyana	Root
			S. campanulata	Root
			S. castanea	Root
			S. cavaleriei var. simplicifolia	Root
			S. dabieshanensis	Root
			S. digitaloides	Root
			S. evansiana	Root
			S. flava	Root
			S. maximowicziana	Root
			S. meiliensis	Root
			S. miltiorrhiza	Root
			S. officinalis	Root
			S. przewalskii	Root
			S. pauciflora	Root
			S. prattii	Root
			S. prionitis	Root
			S. paramiltiorrhiza	Root
			S. plectranthoides	Root
			S. roborowskii	Root
			S. sinica	Root
			S. trijuga	Root
			S. umbratica	Root
			S. vasta	Root
			S. yunnanensis	Root
Tanshinone I		Diterpene	S. bowleyana	Root	30, 55
			S. bulleyana	Root
			S. campanulata	Root
			S. castanea	Root
			S. cavaleriei var. simplicifolia	Root
			S. dabieshanensis	Root
			S. digitaloides	Root
			S. evansiana	Root
			S. flava	Root
			S. meiliensis	Root
			S. maximowicziana	Root
			S. miltiorrhiza	Root
			S. officinalis	Root
			S. prionitis	Root
			S. paramiltiorrhiza	Root
			S. plectranthoides	Root
			S. przewalskii	Root
			S. pauciflora	Root
			S. prattii	Root
			S. roborowskii	Root
			S. sinica	Root
			S. trijuga	Root
			S. umbratica	Root
			S. vasta	Root
			S. yunnanensis	Root
α-Terpineol		Monoterpene	S. eremophila	Leaf	^Citation33–Citation35,
			S. libanotica	Leaf	56
			S. nemorosa	Leaf
			S. sclarea	Leaf
Taxodione		Diterpene	S. chorassanica	Root	40, 44,
			S. hypargeia	Root	45
			S. montbretii	Root

Note: Properties of phytochemical extracts from Salvia plants. Data from Erstad and Cusack.¹³

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