Role of Long Non-coding RNA in Nerve Regeneration

Abstract

Nerve injury can be caused by a variety of factors. It often takes a long time to repair a nerve injury and severe nerve injury is even difficult to heal. Therefore, increasing attention has focused on nerve injury and repair. Long non-coding RNA (lncRNA) is a newly discovered non-coding RNA with a wide range of biological activities. Numerous studies have shown that a variety of lncRNAs undergo changes in expression after nerve injury, indicating that lncRNAs may be involved in various biological processes of nerve repair and regeneration. Herein, we summarize the biological roles of lncRNAs in neurons, glial cells and other cells during nerve injury and regeneration, which will help lncRNAs to be better applied in nerve injury and regeneration in the future.

Keywords:

• LncRNA
• central nerve injury
• peripheral nerve injury
• nerve repair and regeneration
• neurons
• glial cells

Author contributions

J. Q., M. J. and D. Y. designed and conceptualized the data. J. Q., M. J., D. G. and D. Y. contributed in writing the manuscript. M. J. and D. Y. edited and formatted the manuscript. Z. D., M. C. and D. Y. revised, supervised and corrected the manuscript. J. Q., M. J. and M. C. created the figures and figure legends. All authors read and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The study was supported by the National Natural Science Foundation of China [Grant No. 31971277; 31950410551]; the Scientific Research Foundation for Returned Scholars, Ministry of Education of China; A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).