Gender variations in the impact of hyperuricemia on thyroid disorders

ABSTRACT

This study aimed to examine the impact of hyperuricemia on various thyroid disorders with emphasized focus on differences resulting from different genders. 16094 adults aged ≥18 years were enrolled in this cross-sectional study using a randomized stratified sampling strategy. Clinical data including thyroid function and antibodies, uric acid, and anthropometric measurements were measured. Multivariable logistic regression was used to determine the association between hyperuricemia and thyroid disorders. Women who have hyperuricemia are at a significantly increased risk of developing hyperthyroidism. Women’s risk of overt hyperthyroidism and Graves’ disease may be markedly increased by hyperuricemia. Men with hyperuricemia did not differ significantly in their chance of acquiring any thyroid disorders.

KEYWORDS:

• Grave’s disease
• hyperthyroidism
• hyperuricemia
• risk factors
• thyroid disorders

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions https://pan.baidu.com/s/1XAwPKatb9QspN8mLmwBNdw?pwd=695j.

Additional information

Funding

This work was supported by Natural Science Foundation of Ningxia Province [grant number 2020AAC03424] and Ningxia Medical University Special Talent Fund [grant number XT2019023].