Effects and mechanisms of resveratrol for prevention and management of cancers: An updated review

Abstract

Cancer is a severe public health problem. Resveratrol is a famous natural compound that has various bioactivities, such as antioxidant, anti-inflammatory, antidiabetic and antiaging activities. Especially, resveratrol could prevent and treat various cancers, such as oral, thyroid, breast, lung, liver, pancreatic, gastric, colorectal, bladder, prostate and ovarian cancers. The underlying mechanisms have been widely studied, such as inhibiting cell proliferation, suppressing metastasis, inducing apoptosis, stimulating autophagy, modulating immune system, attenuating inflammation, regulating gut microbiota and enhancing effects of other anticancer drugs. In this review, we summarize effects and mechanisms of resveratrol on different cancers. This paper is helpful to develop resveratrol, crude extract containing resveratrol, or foods containing resveratrol into functional food, dietary supplements or auxiliary agents for prevention and management of cancers.

Keywords:

• Resveratrol
• anticancer
• mechanism
• proliferation
• apoptosis
• metastasis

Author contributions

Conceptualization, S.-X.W., Y.-J.Z., R.-Y.G., and H.-B.L.; Writing—original draft preparation, S.-X.W., R.-G.X., S.-Y.H., D.-D.Z., A.S. (Adila Saimaiti), C.-N.Z., and A.S. (Ao Shang); Writing—review and editing, Y.-J.Z., R.-Y.G. and H.-B.L.; Supervision, Y.-J.Z., R.-Y.G. and H.-B.L.; Funding acquisition, R.-Y.G. and H.-B.L.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This research was funded by Local Financial Funds of National Agricultural Science and Technology Center, Chengdu (No. NASC2021KR01), and the Key Project of Guangdong Provincial Science and Technology Program (No. 2014B020205002).