The oral microbial odyssey influencing chronic metabolic disease

Abstract

Introduction

Since the oral cavity is the gateway to the gut, oral microbes likely hold the potential to influence metabolic disease by affecting the gut microbiota.

Method

A thorough review of literature has been performed to link the alterations in oral microbiota with chronic metabolic disease by influencing the gut microbiota.

Result

A strong correlation exists between abnormalities in oral microbiota and several systemic disorders, such as cardiovascular disease, diabetes, and obesity, which likely initially manifest as oral diseases. Ensuring adequate oral hygiene practices and cultivating diverse oral microflora are crucial for the preservation of general well-being. Oral bacteria have the ability to establish and endure in the gastrointestinal tract, leading to the development of prolonged inflammation and activation of the immune system. Oral microbe-associated prophylactic strategies could be beneficial in mitigating metabolic diseases.

Conclusion

Oral microbiota can have a profound impact on the gut microbiota and influence the pathogenesis of metabolic diseases.

Keywords:

• Oral microbiota
• gut microbiota
• inflammation
• metabolic disease
• diabetes
• obesity

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

No experimental data are available for this review article.

Additional information

Funding

The authors received funding from the Science and Engineering Research Board (SRG/2021/000082).