Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders

Anna Matveeva1 Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin2, Ireland;2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, IrelandView further author information

Orla Watters2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, Ireland;3 SFI FutureNeuro Research Centre, Dublin2, IrelandView further author information

Ani Rukhadze4 German Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyView further author information

Niraj Khemka1 Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin2, Ireland;2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, IrelandView further author information

Debora Gentile4 German Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyView further author information

Ivan Fernandez Perez1 Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin2, Ireland;2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, IrelandView further author information

Irene Llorente-Folch1 Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin2, Ireland;2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, IrelandView further author information

Cliona Farrell1 Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin2, Ireland;2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, IrelandView further author information

Elide Lo Cacciato4 German Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyView further author information

Joshua Jackson4 German Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyView further author information

Antonia Piazzesi4 German Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyView further author information

Lena Wischhof4 German Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyView further author information

Ina Woods1 Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin2, Ireland;2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, IrelandView further author information

Luise Halang1 Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin2, Ireland;2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, IrelandView further author information

Marion Hogg2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, Ireland;3 SFI FutureNeuro Research Centre, Dublin2, Ireland;5 Department of Biosciences, Nottingham Trent University, Clifton Campus, Nottingham, UKView further author information

Amaya Garcia Muñoz6 Systems Biology Ireland, School of Medicine, University College Dublin, Dublin 4, Belfield, IrelandView further author information

Eugène T. Dillon7 Mass Spectrometry Resource, Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin 4, IrelandView further author information

David Matallanas6 Systems Biology Ireland, School of Medicine, University College Dublin, Dublin 4, Belfield, IrelandView further author information

Ingrid Arijs8 Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, and;9 VIB Center for Cancer Biology, Leuven, BelgiumView further author information

Diether Lambrechts8 Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, and;9 VIB Center for Cancer Biology, Leuven, BelgiumView further author information

Daniele Bano4 German Center for Neurodegenerative Diseases (DZNE), Bonn, GermanyView further author information

Niamh M. C. Connolly1 Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin2, Ireland;2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, IrelandView further author information

Jochen H. M. Prehn1 Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin2, Ireland;2 Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin2, Ireland;3 SFI FutureNeuro Research Centre, Dublin2, IrelandCorrespondence[email protected]