55
Views
0
CrossRef citations to date
0
Altmetric
Research Article

CircFKBP3 absence alleviates oxygen glucose deprivation-induced function loss of human brain microvascular endothelial cells in vitro via governing the miR-766-3p/TRAF3 axis

, , , &
Received 21 Sep 2023, Accepted 31 Oct 2023, Published online: 29 Dec 2023

References

  • Marin MA, Carmichael ST. Stroke in CNS white matter: models and mechanisms. Neurosci Lett. 2018;684:193–199. doi: 10.1016/j.neulet.2018.07.039.
  • Khoshnam SE, Winlow W, Farzaneh M, et al. Pathogenic mechanisms following ischemic stroke. Neurol Sci. 2017;38(7):1167–1186. doi: 10.1007/s10072-017-2938-1.
  • Feng Z, Sun Q, Chen W, et al. The neuroprotective mechanisms of ginkgolides and bilobalide in cerebral ischemic injury: a literature review. Mol Med. 2019;25(1):57. doi: 10.1186/s10020-019-0125-y.
  • Yasmeen S, Akram BH, Hainsworth AH, et al. Cyclic nucleotide phosphodiesterases (PDEs) and endothelial function in ischaemic stroke. A review. Cell Signal. 2019;61:108–119. doi: 10.1016/j.cellsig.2019.05.011.
  • Zhang Z, Yang T, Xiao J. Circular RNAs: promising biomarkers for human diseases. EBioMedicine. 2018;34:267–274. doi: 10.1016/j.ebiom.2018.07.036.
  • Su M, Xiao Y, Ma J, et al. Circular RNAs in cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers. Mol Cancer. 2019;18(1):90. doi: 10.1186/s12943-019-1002-6.
  • Jiao K, Walsh LJ, Ivanovski S, et al. The emerging regulatory role of circular RNAs in periodontal tissues and cells. Int J Mol Sci. 2021;22(9):22.
  • Altesha MA, Ni T, Khan A, et al. Circular RNA in cardiovascular disease. J Cell Physiol. 2019;234(5):5588–5600. doi: 10.1002/jcp.27384.
  • Dong Z, Deng L, Peng Q, et al. CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke. J Cell Physiol. 2020;235(3):2609–2618. doi: 10.1002/jcp.29165.
  • Dai Q, Ma Y, Xu Z, et al. Downregulation of circular RNA HECTD1 induces neuroprotection against ischemic stroke through the microRNA-133b/TRAF3 pathway. Life Sci. 2021;264:118626. doi: 10.1016/j.lfs.2020.118626.
  • Xu X, Wu Z, Qiu H, et al. Circular RNA circPHC3 promotes cell death and apoptosis in human BMECs after oxygen glucose deprivation via miR-455-5p/TRAF3 axis in vitro. Neuropsychiatr Dis Treat. 2021;17:147–156. doi: 10.2147/NDT.S288669.
  • Pei L, Xu X, Yuan T. Circ_0101874 overexpression strengthens PDE4D expression by targeting miR-335-5p to promote neuronal injury in ischemic stroke. J Stroke Cerebrovasc Dis. 2022;31(12):106817. doi: 10.1016/j.jstrokecerebrovasdis.2022.106817.
  • Panda AC. Circular RNAs act as miRNA sponges. Adv Exp Med Biol. 2018;1087:67–79. doi: 10.1007/978-981-13-1426-1_6.
  • Su Q, Lv X. Revealing new landscape of cardiovascular disease through circular RNA-miRNA-mRNA axis. Genomics. 2020;112(2):1680–1685. doi: 10.1016/j.ygeno.2019.10.006.
  • Cai J, Shangguan S, Li G, et al. Knockdown of lncRNA Gm11974 protect against cerebral ischemic reperfusion through miR-766-3p/NR3C2 axis. Artif Cells Nanomed Biotechnol. 2019;47(1):3847–3853. doi: 10.1080/21691401.2019.1666859.
  • Pan Q, Liao X, Liu H, et al. MicroRNA-125a-5p alleviates the deleterious effects of ox-LDL on multiple functions of human brain microvessel endothelial cells. Am J Physiol Cell Physiol. 2017;312(2):C119–C130. doi: 10.1152/ajpcell.00296.2016.
  • Kimura T, Horikoshi Y, Kuriyagawa C, et al. Rho/ROCK pathway and noncoding RNAs: implications in ischemic stroke and spinal cord injury. Int J Mol Sci. 2021;22(21):22. doi: 10.3390/ijms222111573.
  • Xu D, Li F, Xue G, et al. Effect of wnt signalling pathway on neurogenesis after cerebral ischemia and its therapeutic potential. Brain Res Bull. 2020;164:1–13. doi: 10.1016/j.brainresbull.2020.07.005.
  • Wang SW, Liu Z, Shi ZS. Non-Coding RNA in acute ischemic stroke: mechanisms, biomarkers and therapeutic targets. Cell Transplant. 2018;27(12):1763–1777. doi: 10.1177/0963689718806818.
  • Zhou D, Huang Z, Zhu X, et al. Circular RNA 0025984 ameliorates ischemic stroke injury and protects astrocytes through miR-143-3p/TET1/ORP150 pathway. Mol Neurobiol. 2021;58(11):5937–5953. doi: 10.1007/s12035-021-02486-8.
  • Peng J, He F, Zhang C, et al. Protein kinase C-alpha signals P115RhoGEF phosphorylation and RhoA activation in TNF-alpha-induced mouse brain microvascular endothelial cell barrier dysfunction. J Neuro­inflammation. 2011;8(1):28. doi: 10.1186/1742-2094-8-28.
  • Zhang M, Tang M, Wu Q, et al. LncRNA DANCR attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through regulating of miR-33a-5p/XBP1s. Aging (Albany NY). 2020;12(2):1778–1791. doi: 10.18632/aging.102712.
  • Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature. 2011;473(7347):298–307. doi: 10.1038/nature10144.
  • Zhang Z, Chopp M. Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia. Trends Cardiovasc Med. 2002;12(2):62–66. doi: 10.1016/s1050-1738(01)00149-9.
  • Liu J, Wang Y, Akamatsu Y, et al. Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Prog Neurobiol. 2014;115:138–156. doi: 10.1016/j.pneurobio.2013.11.004.
  • Li Z, Xu J, Guan H, et al. Circ_0059354 aggravates the progression of papillary thyroid carcinoma by elevating ARFGEF1 through sponging miR-766-3p. J Endocrinol Invest. 2022;45(4):825–836. doi: 10.1007/s40618-021-01713-2.
  • He XX, Luo SS, Qin HQ, et al. MicroRNA-766-3p-mediated downregulation of HNF4G inhibits proliferation in colorectal cancer cells through the PI3K/AKT pathway. Cancer Gene Ther. 2022;29(6):803–813. doi: 10.1038/s41417-021-00362-0.
  • Dalmay T. Mechanism of miRNA-mediated repression of mRNA translation. Essays Biochem. 2013;54:29–38. doi: 10.1042/bse0540029.
  • Gong J, Li ZZ, Guo S, et al. Neuron-Specific tumour necrosis factor Receptor-Associated factor 3 is a Central regulator of neuronal death in acute ischemic stroke. Hypertension. 2015;66(3):604–616. doi: 10.1161/HYPERTENSIONAHA.115.05430.
  • Wu G, McBride DW, Zhang JH. Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-kappaB pathway after MCAO in rats. Neurobiol Dis. 2018;110:59–67. doi: 10.1016/j.nbd.2017.11.009.
  • Yao S, Tang B, Li G, et al. miR-455 inhibits neuronal cell death by targeting TRAF3 in cerebral ischemic stroke. Neuropsychiatr Dis Treat. 2016;12:3083–3092. doi: 10.2147/NDT.S121183.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.