Advanced search
Publication Cover
International Journal of Neuroscience Latest Articles
Submit an article Journal homepage
68
Views
0
CrossRef citations to date
0
Altmetric
Original Article

Mechanistic study of electroacupuncture preconditioning in alleviating myocardial ischemia-reperfusion injury in rats: involvement of mTOR/ROS signaling pathway to inhibit ferroptosis

Yan Xiaoa Department of Acupuncture and Moxibustion, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, ChinaView further author information
&
Liang Dingb Department of Gastroenterology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, ChinaCorrespondence[email protected]
View further author information
Received 21 Nov 2023, Accepted 20 Dec 2023, Published online: 06 Feb 2024

References

  • Davidson SM, Ferdinandy P, Andreadou I, et al. Multitarget strategies to reduce myocardial ischemia/reperfusion injury: JACC review topic of the week. J Am Coll Cardiol. 2019;73(1):89–99. doi: 10.1016/j.jacc.2018.09.086
  • Virani SS, Alonso A, Benjamin EJ, et al. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139–e596. doi: 10.1161/CIR.0000000000000757.
  • Algoet M, Janssens S, Himmelreich U, et al. Myocardial ischemia-reperfusion injury and the influence of inflammation. Trends Cardiovasc Med. 2023;33(6):357–366. doi: 10.1016/j.tcm.2022.02.005.
  • Mokhtari-Zaer A, Marefati N, Atkin SL, et al. The protective role of curcumin in myocardial ischemia-reperfusion injury. J Cell Physiol. 2018;234(1):214–222. doi: 10.1002/jcp.26848.
  • Xiao Y, Chen W-Y, Zhong Z-H, et al. Electroacupuncture preconditioning attenuates myocardial ischemiareperfusion injury by inhibiting mitophagy mediated by the mTORC1-ULK1-FUNDC1 pathway. Biomed Pharmacother. 2020;127:110148. doi: 10.1016/j.biopha.2020.110148.
  • Li S, Lei Z, Yang X, et al. Propofol protects myocardium from ischemia/reperfusion injury by inhibiting ferroptosis through the AKT/p53 signaling pathway. Front Pharmacol. 2022;13:841410. doi: 10.3389/fphar.2022.841410.
  • Baba Y, Shimada BK, Horiuchi KM, et al. Protective effects of mTOR against ferroptosis, a form of iron-dependent regulated cell death, in cardiomyocytes. FASEB J. 2023;31(S1):11–16. doi: 10.1096/fasebj.31.1_supplement.846.20.
  • Chen W, Zhong Z, Bai H, et al. An autophagic mechanism study on effect of electroacupuncture at different times pretreating myocardial ischemiareperfusion injury. Zhongguo Zhen Jiu. 2018;38(10):1087–1092.
  • Chen J, Shi YP, Zhou T, et al. Study on the mechanism of “shuanggu yitong” electroacupuncture preconditioning on cell apoptosis in a rat model of myocardial ischemia reperfusion injury. Chin J Basic Med Tradit Chin Med. 2023;29(9):1468–1473.
  • Yin HJ, Zhang Y, Jiang YR. Effect of folium panaxquinquefolium saponins on apoptpsis of cardiac muscle cells and apoptosis related gene expression in rats with acute myocardial infarction. Chin J Integr Tradit West Med. 2005;25(3):232–235.
  • Hioki A, Asanuma T, Masuda K, et al. Detection of abnormal myocardial deformation during acute myocardial ischemia using three-dimensional speckle tracking echocardiography. J Echocardiogr. 2020;18(1):57–66. doi: 10.1007/s12574-019-00449-6.
  • Tsou MT, Huang CH, Chiu JH. Electroacupuncture on PC6 (neiguan) attenuates ischemia/reperfusion injury in rat hearts. Am J Chin Med. 2004;32(6):951–965. doi: 10.1142/S0192415X04002557.
  • Zhao L, Li D, Zheng H, et al. Acupuncture as adjunctive therapy for chronic stable angina: a randomized clinical trial. JAMA Intern Med. 2019;179(10):1388–1397. doi: 10.1001/jamainternmed.2019.2407.
  • Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. doi: 10.1016/j.cell.2012.03.042.
  • Adedoyin O, Boddu R, Traylor A, et al. Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells. Am J Physiol Renal Physiol. 2018;314(5):F702–F714. doi: 10.1152/ajprenal.00044.2017.
  • Fang X, Wang H, Han D, et al. Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci USA. 2019;116(7):2672–2680. doi: 10.1073/pnas.1821022116.
  • Li JH, Zhang LJ, Peng JC, et al. Inhibition of mTOR enhances sorafenib-induced activated HSC ferroptosis. J Hainan Med Univ. 2023;29(5):331–339346.
  • Chen Y, Zeng Y, He P, et al. Protective mechanism of regulating ferroptosis by conggan zhixin recipe in myocardial ischemia-reperfusion injury based on the theory of heartache governing liver. Acta Lab Anim Sci Sin. 2023;31(8):999–1006.
  • Tu LY, Yong L, Tian F, et al. Ferrostatin 1 inhibits BMSC iron death induced by high glucose in mice and prevents diabetic osteoporosis. Chin J Osteopor. 2023;29(10):1425–1430.
  • Fang Y, Chen X, Tan Q, et al. Inhibiting ferroptosis through disrupting the NCOA4 − FTH1 interaction: a new mechanism of action. ACS Cent Sci. 2021;7(6):980–989. doi: 10.1021/acscentsci.0c01592.
  • Gryzik M, Asperti M, Denardo A, et al. NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells. Biochim Biophys Acta Mol Cell Res. 2021;1868(2):118913. doi: 10.1016/j.bbamcr.2020.118913.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.