140
Views
0
CrossRef citations to date
0
Altmetric
Research Article

The effect of acute and chronic formaldehyde exposure on learning and memory in male and female rats

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Received 15 Jul 2023, Accepted 26 Dec 2023, Published online: 08 Jan 2024

References

  • Bolt H. Experimental toxicology of formaldehyde. J Cancer Res Clin Oncol. 1987;113(4):305–309. doi:10.1007/BF00397713.
  • Kiernan JA. Formaldehyde, formalin, paraformaldehyde and glutaraldehyde: what they are and what they do. Microscopy Today. 2000;8(1):8–13. doi:10.1017/S1551929500057060.
  • Altinoz MA, Ozpinar A, Ozpinar A, et al. Methenamine’s journey of 160 years: repurposal of an old urinary antiseptic for treatment and hypoxic radiosensitization of cancers and glioblastoma. Clin Exp Pharmacol Physiol. 2019;46(5):407–412. doi:10.1111/1440-1681.13070.
  • Perkins JL, Kimbrough JD. Formaldehyde exposure in a gross anatomy laboratory. J Occup Med. 1985;27(11):813–815. doi:10.1097/00043764-198511000-00013.
  • Beane Freeman LE, Blair A, Lubin JH, et al. Mortality from solid tumors among workers in formaldehyde industries: an update of the NCI cohort. Am J Ind Med. 2013;56(9):1015–1026. doi:10.1002/ajim.22214.
  • Kilburn KH. Neurobehavioral impairment and seizures from formaldehyde. Arch Environ Health. 1994;49(1):37–44. doi:10.1080/00039896.1994.9934412.
  • Lu Z, Li CM, Qiao Y, et al. Effect of inhaled formaldehyde on learning and memory of mice. Indoor Air. 2008;18(2):77–83. doi:10.1111/j.1600-0668.2008.00524.x.
  • Tang X-Q, Zhuang Y-Y, Zhang P, et al. Formaldehyde impairs learning and memory involving the disturbance of hydrogen sulfide generation in the hippocampus of rats. J Mol Neurosci. 2013;49(1):140–149. doi:10.1007/s12031-012-9912-4.
  • Jones DG, Smith BJ. The hippocampus and its response to differential environments. p. Prog Neurobiol. 1980;15(1):19–69. doi:10.1016/0301-0082(80)90015-5.
  • Gurel A, Coskun O, Armutcu F, et al. Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies. J Chem Neuroanat. 2005;29(3):173–178. doi:10.1016/j.jchemneu.2005.01.001.
  • Zararsiz I, Meydan S, Sarsilmaz M, et al. Protective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in rats. Toxicol Ind Health. 2011;27(6):489–495. doi:10.1177/0748233710389852.
  • Zararsiz I, Kus I, Ogeturk M, et al. Melatonin prevents formaldehyde-induced neurotoxicity in prefrontal cortex of rats: an immunohistochemical and biochemical study. Cell Biochem Funct. 2007;25(4):413–418. doi:10.1002/cbf.1315.
  • Paxinos G, Watson C. The rat brain in stereotaxic coordinates: hard cover edition. Elsevier; Academic Press; 2006.
  • Vorhees CV, Williams MT. Assessing spatial learning and memory in rodents. Ilar J. 2014;55(2):310–332. doi:10.1093/ilar/ilu013.
  • D’Hooge R, De Deyn PP. Applications of the morris water maze in the study of learning and memory. Brain Res Brain Res Rev. 2001;36(1):60–90. doi:10.1016/s0165-0173(01)00067-4.
  • Rogers J, Churilov L, Hannan AJ, et al. Search strategy selection in the morris water maze indicates allocentric map formation during learning that underpins spatial memory formation. Neurobiol Learn Mem. 2017;139:37–49. doi:10.1016/j.nlm.2016.12.007.
  • Ahmadi M, Rajaei Z, Hadjzadeh MA, et al. Crocin improves spatial learning and memory deficits in the morris water maze via attenuating cortical oxidative damage in diabetic rats. Neurosci Lett. 2017;642:1–6. doi:10.1016/j.neulet.2017.01.049.
  • Jeong DU, Lee J, Chang WS, et al. Identifying the appropriate time for deep brain stimulation to achieve spatial memory improvement on the morris water maze. BMC Neurosci. 2017;18(1):29. doi:10.1186/s12868-017-0345-4.
  • Ning H, Cao D, Wang H, et al. Effects of haloperidol, olanzapine, ziprasidone, and PHA-543613 on spatial learning and memory in the morris water maze test in naïve and MK-801-treated mice. Brain Behav. 2017;7(8):e00764. doi:10.1002/brb3.764.
  • Kupferschmid BJ, Therrien B, Rowsey PJ. Effects of low-dose lipopolysaccharide and age on spatial learning in different morris water maze protocols. SAGE Open Med. 2017;5:2050312117729112. doi:10.1177/2050312117729112.
  • Barrientos RM, Kitt MM, D’Angelo HM, et al. Stable, long-term, spatial memory in young and aged rats achieved with a one day morris water maze training protocol. Learn Mem. 2016;23(12):699–702. doi:10.1101/lm.043489.116.
  • Wang W, Liu L, Jiang P, et al. Levodopa improves learning and memory ability on global cerebral ischemia-reperfusion injured rats in the morris water maze test. Neurosci Lett. 2017;636:233–240. doi:10.1016/j.neulet.2016.11.026.
  • Tong Z, Han C, Luo W, et al. Accumulated hippocampal formaldehyde induces age-dependent memory decline. Age (Dordr). 2013;35(3):583–596. doi:10.1007/s11357-012-9388-8.
  • Mei Y, Jiang C, Wan Y, et al. Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline. Aging Cell. 2015;14(4):659–668. doi:10.1111/acel.12345.
  • Kilburn KH, Warshaw R, Thornton JC. Formaldehyde impairs memory, equilibrium, and dexterity in histology technicians: effects which persist for days after exposure. Arch Environ Health. 1987;42(2):117–120. doi:10.1080/00039896.1987.9935806.
  • Poucet B, Save E, Lenck-Santini PP. Sensory and memory properties of hippocampal place cells. Rev Neurosci. 2000;11(2-3):95–111.
  • Blum KI, Abbott LF. A model of spatial map formation in the hippocampus of the rat. Neural Comput. 1996;8(1):85–93. doi:10.1162/neco.1996.8.1.85.
  • Lee I, Yoganarasimha D, Rao G, et al. Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3. Nature. 2004;430(6998):456–459. doi:10.1038/nature02739.
  • Riedel G, Micheau J, Lam AG, et al. Reversible neural inactivation reveals hippocampal participation in several memory processes. Nat Neurosci. 1999;2(10):898–905. doi:10.1038/13202.
  • Barker GR, Warburton EC. When is the hippocampus involved in recognition memory? J Neurosci. 2011;31(29):10721–10731. doi:10.1523/JNEUROSCI.6413-10.2011.
  • Burgess N, Maguire EA, O’Keefe J. The human hippocampus and spatial and episodic memory. Neuron. 2002;35(4):625–641. doi:10.1016/s0896-6273(02)00830-9.
  • Kessels RP, de Haan EH, Kappelle LJ, et al. Varieties of human spatial memory: a meta-analysis on the effects of hippocampal lesions. Brain Res Brain Res Rev. 2001;35(3):295–303. doi:10.1016/s0165-0173(01)00058-3.
  • de Hoz L, Moser EI, Morris RG. Spatial learning with unilateral and bilateral hippocampal networks. Eur J Neurosci. 2005;22(3):745–754. doi:10.1111/j.1460-9568.2005.04255.x.
  • Eric Kandel JS. Thomas jessell, principles of neural science. In: Principles of neural science. Vol. 4. McGraw-Hill Companies; 2000.
  • Ozdemir D, Baykara B, Aksu I, et al. Relationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats. Neurosci Lett. 2012;507(1):84–89. doi:10.1016/j.neulet.2011.11.059.
  • Liu Y, Ye Z, Yang H, et al. Disturbances of soluble N-ethylmaleimide-sensitive factor attachment proteins in hippocampal synaptosomes contribute to cognitive impairment after repetitive formaldehyde inhalation in male rats. Neuroscience. 2010;169(3):1248–1254. doi:10.1016/j.neuroscience.2010.05.061.
  • Öztürk F. Apopitoz. İnönü Üniversitesi Tıp Fakültesi Dergisi. 2002;9(2):6.
  • Pitten FA, Kramer A, Herrmann K, et al. Formaldehyde neurotoxicity in animal experiments. Pathol Res Pract. 2000;196(3):193–198. doi:10.1016/S0344-0338(00)80100-4.
  • Ozdem Turkoglu A, et al. Beneficial effects of caffeic acid phenethyl ester on formaldehyde-induced learning and memory disabilities: a labyrinth test performance study. Erciyes Medical Journal. 2008;30:211–217.
  • Sorg BA, Swindell S, Tschirgi ML. Repeated low level formaldehyde exposure produces enhanced fear conditioning to odor in male, but not female, rats. Brain Res. 2004;1008(1):11–19. doi:10.1016/j.brainres.2004.02.015.
  • Li Y, Song Z, Ding Y, et al. Effects of formaldehyde exposure on anxiety-like and depression-like behavior, cognition, Central levels of glucocorticoid receptor and tyrosine hydroxylase in mice. Chemosphere. 2016;144:2004–2012. doi:10.1016/j.chemosphere.2015.10.102.
  • Boja JW, Nielsen JA, Foldvary E, et al. Acute low-level formaldehyde behavioural and neurochemical toxicity in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):671–674. doi:10.1016/0278-5846(85)90038-7.
  • Usanmaz SE, Akarsu ES, Vural N. Neurotoxic effects of acute and subacute formaldehyde exposures in mice. Environ Toxicol Pharmacol. 2002;11(2):93–100. doi:10.1016/s1382-6689(01)00109-0.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.