74
Views
0
CrossRef citations to date
0
Altmetric
Research Article

The neuroprotective effects of Piracetam on cisplatin-induced cognitive decline

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all
Received 03 Aug 2023, Accepted 26 Dec 2023, Published online: 09 Jan 2024

References

  • Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014;740:364–378. doi: 10.1016/j.ejphar.2014.07.025.
  • Turrina S, Gibelli F, De Leo D. Chemotherapy-induced cognitive impairment from the forensic medicine perspective: a review of the updated literature. J Forensic Leg Med. 2020;76:102070. doi: 10.1016/j.jflm.2020.102070.
  • He Z, Liao Y, Zheng M, et al. Piracetam improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Cell Mol Neurobiol. 2008;28(4):613–627. doi: 10.1007/s10571-007-9165-x.
  • Giurgea C. The “nootropic” approach to the pharmacology of the integrative activity of the brain. Cond Reflex. 1973;8(2):108–115. doi: 10.1007/BF03000311.
  • Malykh AG, Sadaie MR. Piracetam and Piracetam-Like drugs. Drugs [Internet]. 2010;70(3):287–312. doi: 10.2165/11319230-000000000-00000.
  • Waegemans T, Wilsher CR, Danniau A, et al. Clinical efficacy of piracetam in cognitive impairment: a meta-analysis. Dement Geriatr Cogn Disord. 2002;13(4):217–224. doi: 10.1159/000057700.
  • Genton P, Van Vleymen B. Piracetam and levetiracetam: close structural similarities but different pharmacological and clinical profiles. Epileptic Disord. 2000;2(2):99–105.
  • Marisco PC, Carvalho FB, Rosa MM, et al. Piracetam prevents scopolamine-induced memory impairment and decrease of NTPDase, 5’-nucleotidase and adenosine deaminase activities. Neurochem Res. 2013;38(8):1704–1714. doi: 10.1007/s11064-013-1072-6.
  • ELBeltagy M, Mustafa S, Umka J, et al. Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil. Behav Brain Res. 2010;208(1):112–117. doi: 10.1016/j.bbr.2009.11.017.
  • Lyons L, ElBeltagy M, Umka J, et al. Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy. Psychopharmacology (Berl). 2011;215(1):105–115. doi: 10.1007/s00213-010-2122-2.
  • Elbeltagy M, A Atieh D, H Abdin B, et al. Memantine improves memory and hippocampal proliferation in adult male rats. Folia Neuropathol. 2021;59(2):143–151. doi: 10.5114/fn.2021.107607.
  • Yang M, Kim JS, Song MS, et al. Cyclophosphamide impairs hippocampus-dependent learning and memory in adult mice: possible involvement of hippocampal neurogenesis in chemotherapy-induced memory deficits. Neurobiol Learn Mem. 2010;93(4):487–494. doi: 10.1016/j.nlm.2010.01.006.
  • Egeland M, Guinaudie C, Du Preez A, et al. Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression. Transl Psychiatry. 2017;7(4):e1101–e1101. doi: 10.1038/tp.2017.68.
  • Bustamante-Barrientos FA, Méndez-Ruette M, Ortloff A, et al. The impact of estrogen and estrogen-like molecules in neurogenesis and neurodegeneration: beneficial or harmful? Front Cell Neurosci. 2021;15:636176. doi: 10.3389/fncel.2021.636176.
  • Moran TH, Capone GT, Knipp S, et al. The effects of piracetam on cognitive performance in a mouse model of down’s syndrome. Physiol Behav. 2002;77(2–3):403–409. doi: 10.1016/s0031-9384(02)00873-9.
  • Johnsson A, Wennerberg J. Amifostine as a protector against cisplatin-induced toxicity in nude mice. Acta Oncol. 1999;38(2):247–253. doi: 10.1080/028418699431681.
  • Tang JJ, Huang LF, Deng JL, et al. Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD alzheimer’s disease mice model. Redox Biol. 2022;50:102229. doi: 10.1016/j.redox.2022.102229.
  • Shen SY, Yu R, Li W, et al. The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice. Neurobiol Dis. 2022;169:105743. doi: 10.1016/j.nbd.2022.105743.
  • Dix SL, Aggleton JP. Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition. Behav Brain Res. 1999;99(2):191–200. doi: 10.1016/s0166-4328(98)00079-5.
  • Mustafa S, Walker A, Bennett G, et al. 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. Eur J Neurosci. 2008;28(2):323–330. doi: 10.1111/j.1460-9568.2008.06325.x.
  • Bruel-Jungerman E, Laroche S, Rampon C. New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur J Neurosci. 2005;21(2):513–521. doi: 10.1111/j.1460-9568.2005.03875.x.
  • Elbeltagy M, Salman A, Shatarat A, et al. Atomoxetine enhances memory and proliferation in adult male rat hippocampus. Eur J Anat. 2019;23(4):243–251.
  • Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Phys. 2000;182(3):311–322. doi: 10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9.
  • Zhao Y, Wang H, Zhou J, et al. Glutathione peroxidase GPX1 and its dichotomous roles in cancer. Cancers (Basel). 2022;14(10):2560. doi: 10.3390/cancers14102560.
  • Mumby DG, Gaskin S, Glenn MJ, et al. Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learn Mem. 2002;9(2):49–57. doi: 10.1101/lm.41302.
  • Lee I, Hunsaker MR, Kesner RP. The role of hippocampal subregions in detecting spatial novelty. Behav Neurosci. 2005;119(1):145–153. doi: 10.1037/0735-7044.119.1.145.
  • Kee N, Teixeira CM, Wang AH, et al. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat Neurosci. 2007;10(3):355–362. doi: 10.1038/nn1847.
  • Imayoshi I, Sakamoto M, Ohtsuka T, et al. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci. 2008;11(10):1153–1161. doi: 10.1038/nn.2185.
  • Dietrich J, Han R, Yang Y, et al. CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol. 2006;5(7):22. doi: 10.1186/jbiol50.
  • Eichenbaum H, Yonelinas AP, Ranganath C. The medial temporal lobe and recognition memory. Annu Rev Neurosci. 2007;30(1):123–152. doi: 10.1146/annurev.neuro.30.051606.094328.
  • Malík M, Tlustoš P. Nootropics as cognitive enhancers: types, dosage and side effects of smart drugs. Nutrients. 2022;14(16):3367. doi: 10.3390/nu14163367.
  • Winblad B. Piracetam: a review of pharmacological properties and clinical uses. CNS Drug Rev. 2005;11(2):169–182. doi: 10.1111/j.1527-3458.2005.tb00268.x.
  • Taupin P. Nootropic agents stimulate neurogenesis. Brain cells, Inc.: WO2007104035. Expert Opin Ther Pat. 2009;19(5):727–730. doi: 10.1517/13543770902721303.
  • Ennaceur A, Delacour J. Effect of combined or separate administration of piracetam and choline on learning and memory in the rat. Psychopharmacology (Berl). 1987;92(1):58–67. doi: 10.1007/BF00215480.
  • Jessberger S, Clark RE, Broadbent NJ, et al. Dentate gyrus-specific knockdown of adult neurogenesis ­impairs spatial and object recognition memory in adult rats. Learn Mem. 2009;16(2):147–154. doi: 10.1101/lm.1172609.
  • Oliveros A, Yoo KH, Rashid MA, et al. Adenosine A2A receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function. Proc Natl Acad Sci U S A. 2022;119(28):e2206415119.
  • Rashid MA, Oliveros A, Kim YS, et al. Nicotinamide mononucleotide prevents Cisplatin-Induced mitochondrial defects in cortical neurons derived from human induced pluripotent stem cells. Brain Plast. 2022;8(2):143–152. doi: 10.3233/BPL-220143.
  • Tuan BT, Visacri MB, Amaral LS, et al. Effects of High-Dose cisplatin chemotherapy and conventional radiotherapy on urinary oxidative and nitrosative stress biomarkers in patients with head and neck cancer. Basic Clin Pharmacol Toxicol. 2016;118(1):83–86. doi: 10.1111/bcpt.12443.
  • Turan MI, Cayir A, Cetin N, et al. An investigation of the effect of thiamine pyrophosphate on cisplatin-induced oxidative stress and DNA damage in rat brain tissue compared with thiamine: thiamine and thiamine pyrophosphate effects on cisplatin neurotoxicity. Hum Exp Toxicol. 2014;33(1):14–21. doi: 10.1177/0960327113485251.
  • Gunturk EE, Yucel B, Gunturk I, et al. The effects of N-acetylcysteine on cisplatin induced cardiotoxicity. Bratisl Lek Listy. 2019;120(6):423–428. doi: 10.4149/BLL_2019_068.
  • Chirino YI, Sánchez-González DJ, Martínez-Martínez CM, et al. Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity. Toxicology. 2008;245(1–2):18–23. doi: 10.1016/j.tox.2007.12.007.
  • Conte E, Bresciani E, Rizzi L, et al. Cisplatin-Induced skeletal muscle dysfunction: mechanisms and counteracting therapeutic strategies. Int J Mol Sci. 2020;21(4):1242
  • Garcia JM, Scherer T, Chen J A, et al. Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice. Endocrinology. 2013;154(9):3118–3129. doi: 10.1210/en.2013-1179.
  • Hussain Y, Krishnamurthy S. Piracetam attenuates binge eating disorder related symptoms in rats. Pharmacol Biochem Behav. 2018;169:35–47. doi: 10.1016/j.pbb.2018.04.003.
  • Gelisse P, Juntas-Morales R, Genton P, et al. Dramatic weight loss with levetiracetam. Epilepsia. 2008;49(2):308–315. doi: 10.1111/j.1528-1167.2007.01273.x.
  • Hadjikoutis S, Pickersgill TP, Smith PEM. Drug points: Weight loss associated with levetiracetam. BMJ. 2003;327(7420):905–905. doi: 10.1136/bmj.327.7420.905.
  • Tripathi PN, Srivastava P, Sharma P, et al. Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory. Bioorg Chem. 2019;85:82–96. doi: 10.1016/j.bioorg.2018.12.017.
  • Srivastava P, Tripathi PN, Sharma P, et al. Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory. Eur J Med Chem. 2019;163:116–135. doi: 10.1016/j.ejmech.2018.11.049.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.