Iron, copper, zinc and magnesium on rheumatoid arthritis: a two-sample Mendelian randomization study

References

• Ahmadzadeh N, Shingu M, Nobunaga M. 1989. Iron-binding proteins and free iron in synovial fluids of rheumatoid arthritis patients. Clin Rheumatol. 8(3):345–351. doi:10.1007/BF02030347.
   PubMed Web of Science ®Google Scholar
• Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo A, Paolisso G. 2003. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med. 24(1–3):39–52. doi:10.1016/s0098-2997(02)00090-0.
   PubMedGoogle Scholar
• Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gogele M, Anderson D, Broer L, Podmore C, et al. 2014 Oct 29. Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun. 5:4926. doi:10.1038/ncomms5926.
   PubMed Web of Science ®Google Scholar
• Bowden J, Davey Smith G, Haycock PC, Burgess S. 2016. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median Estimator. Genet Epidemiol. 40(4):304–314. May. doi:10.1002/gepi.21965.
   PubMed Web of Science ®Google Scholar
• Brenner M, Laragione T, Gulko PS. Short-term low-magnesium diet reduces autoimmune arthritis severity and synovial tissue gene expression. Physiol Genomics. 2017 Apr 1 49(4):238–242. doi:10.1152/physiolgenomics.00003.2017.
   PubMed Web of Science ®Google Scholar
• Brewer GJ. 2003. Copper in medicine. Curr Opin Chem Biol. 7(2):207–212. Apr. doi:10.1016/s1367-5931(03)00018-8.
   PubMed Web of Science ®Google Scholar
• Cai Y, Zhang G, Liang J, Jing Z, Zhang R, Lv L, Dang X. 2021. Causal relationships between osteoarthritis and senile central nerve System dysfunction: a bidirectional two-sample Mendelian randomization study. Front Aging Neurosci. 13:793023. doi: 10.3389/fnagi.2021.793023.
   PubMed Web of Science ®Google Scholar
• Cao Z, Wu Y, Li Q, Li Y, Wu J. 2022. A causal relationship between childhood obesity and risk of osteoarthritis: results from a two-sample Mendelian randomization analysis. Ann Med. 54(1):1636–1645. Dec. doi:10.1080/07853890.2022.2085883.
   PubMed Web of Science ®Google Scholar
• Chakraborty M, Chutia H, Changkakati R. 2015. Serum copper as a marker of disease activity in rheumatoid arthritis. J Clin Diagn Res. Dec 9(12):BC09–11. doi:10.7860/JCDR/2015/14851.7001.
   PubMedGoogle Scholar
• Chavan VU, Ramavataram D, Patel PA, Rupani MP. 2015. Evaluation of serum magnesium, lipid profile and various biochemical parameters as risk factors of cardiovascular diseases in patients with rheumatoid arthritis. J Clin Diagn Res. Apr 9(4):BC01–05. doi:10.7860/JCDR/2015/12206.5740.
   PubMed Web of Science ®Google Scholar
• Chen Y, Shen J, Wu Y, Ni M, Deng Y, Sun X, Wang X, Zhang T, Pan F, Tang Z. 2022. Tea consumption and risk of lower respiratory tract infections: a two‑sample Mendelian randomization study. Eur J Nutr. 62(1):1–9. doi:10.1007/s00394-022-02994-w.
   PubMed Web of Science ®Google Scholar
• Collins JF, Klevay LM. 2011. Copper. Adv Nutr. Nov 2(6):520–522. doi:10.3945/an.111.001222.
   PubMed Web of Science ®Google Scholar
• Dan YL, Wang P, Cheng Z, Wu Q, Wang XR, Wang DG, Pan HF. Circulating adiponectin levels and systemic lupus erythematosus: a two-sample Mendelian randomization study. Rheumatology (Oxford). 2021 Feb 1 60(2):940–946. doi:10.1093/rheumatology/keaa506.
   PubMed Web of Science ®Google Scholar
• Evans DM, Zhu G, Dy V, Heath AC, Madden PA, Kemp JP, McMahon G, St Pourcain B, Timpson NJ, Golding J, et al. 2013 Oct 1. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. Hum Mol Genet. 22(19):3998–4006. doi:10.1093/hmg/ddt239.
   PubMed Web of Science ®Google Scholar
• Ganz T, Nemeth E. 2012. Hepcidin and iron homeostasis. Biochim Biophys Acta. 1823(9):1434–1443. Sep. doi:10.1016/j.bbamcr.2012.01.014.
   PubMed Web of Science ®Google Scholar
• Gao H, Dai W, Zhao L, Min J, Wang F. 2018. The role of zinc and zinc homeostasis in macrophage function. J Immunol Res. 2018:1–11. doi: 10.1155/2018/6872621.
   Web of Science ®Google Scholar
• Geiger H, Wanner C. 2012. Magnesium in disease. Clin Kidney J. 5(Suppl 1):i25–i38. Feb. doi:10.1093/ndtplus/sfr165.
   PubMedGoogle Scholar
• Gill D, Karhunen V, Malik R, Dichgans M, Sofat N. 2021. Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study. Osteoarthr Cartil. Mar 29(3):365–371. doi:10.1016/j.joca.2020.12.015.
   PubMed Web of Science ®Google Scholar
• Harada S, Sugiyama E, Taki H, Shinoda K, Fujita T, Maruyama M, Kobayashi M. 2002 Dec. D-penicillamine cooperates with copper sulfate to enhance the surface expression of functional fas antigen in rheumatoid synovial fibroblasts via the generation of hydrogen peroxide. Clin Exp Rheumatol. 20(4):469–476.
   PubMed Web of Science ®Google Scholar
• Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, et al. 2018. The MR-Base platform supports systematic causal inference across the human phenome. Elife. 7. May 30. doi:10.7554/eLife.34408.
   PubMed Web of Science ®Google Scholar
• Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell. 2004 Apr 30 117(3):285–297. doi:10.1016/s0092-8674(04)00343-5.
   PubMed Web of Science ®Google Scholar
• Hentze MW, Muckenthaler MU, Galy B, Camaschella C. Two to tango: regulation of mammalian iron metabolism. Cell. 2010 Jul 9 142(1):24–38. doi:10.1016/j.cell.2010.06.028.
   PubMed Web of Science ®Google Scholar
• Huang T, Yan G, Guan M. 2020. Zinc homeostasis in bone: zinc transporters and bone diseases. Int J Mol Sci. 21(4):1236. Feb 12. doi: 10.3390/ijms21041236.
   PubMed Web of Science ®Google Scholar
• Huang G, Zhong Y, Li W, Liao W, Wu P. 2021. Causal relationship between parathyroid hormone and the risk of osteoarthritis: a Mendelian randomization study. Front Genet. 12:686939. doi:10.3389/fgene.2021.686939.
   PubMed Web of Science ®Google Scholar
• Hu C, Zhu F, Liu L, Zhang M, Chen G. Relationship between dietary magnesium intake and rheumatoid arthritis in US women: a cross-sectional study. BMJ Open. 2020. Nov 9 10(11):e039640. doi:10.1136/bmjopen-2020-039640.
   PubMed Web of Science ®Google Scholar
• Khalaf W, Al-Rubaie HA, Shihab S. Studying anemia of chronic disease and iron deficiency in patients with rheumatoid arthritis by iron status and circulating hepcidin. Hematol Rep. 2019 Feb 19 11(1):7708. doi:10.4081/hr.2019.7708.
   PubMed Web of Science ®Google Scholar
• Kumar LD, Karthik R, Gayathri N, Sivasudha T. 2016. Advancement in contemporary diagnostic and therapeutic approaches for rheumatoid arthritis. Biomed Pharmacother. 79:52–61. Apr. doi:10.1016/j.biopha.2016.02.001.
   PubMed Web of Science ®Google Scholar
• Lee DM, Weinblatt ME. 2001. Rheumatoid arthritis. Lancet. 358(9285):903–911. doi:10.1016/s0140-6736(01)06075-5.
   PubMed Web of Science ®Google Scholar
• Li J, Liang Y, Mao H, Deng W, Zhang J. 2014. Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients. Pak J Med Sci. 30(5):1064–1067. Sep. doi:10.12669/pjms.305.5214.
   PubMed Web of Science ®Google Scholar
• Ling H, Li M, Yang C, Sun S, Zhang W, Zhao L, Xu N, Zhang J, Shen Y, Zhang X, et al. 2022. Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis. Rheumatology (Oxford). 61(11):4521–4534. doi:10.1093/rheumatology/keac069.
   PubMed Web of Science ®Google Scholar
• Li C, Niu M, Guo Z, Liu P, Zheng Y, Liu D, Yang S, Wang W, Li Y, Hou H. 2022. A mild causal relationship between tea consumption and obesity in general population: a two-sample Mendelian randomization study. Front Genet. 13:795049. doi:10.3389/fgene.2022.795049.
   PubMed Web of Science ®Google Scholar
• Lin S, Yang H. 2021. Ovarian cancer risk according to circulating zinc and copper concentrations: a meta-analysis and Mendelian randomization study. Clin Nutr. Apr 40(4):2464–2468. doi:10.1016/j.clnu.2020.10.011.
   PubMed Web of Science ®Google Scholar
• Long L, Guo H, Chen X, Liu Y, Wang R, Zheng X, Huang X, Zhou Q, Wang Y. 2022. Advancement in understanding the role of ferroptosis in rheumatoid arthritis. Front Physiol. 13:1036515. doi:10.3389/fphys.2022.1036515.
   PubMed Web of Science ®Google Scholar
• Luo H, Zhang R. 2021. Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the xc-/GPX4 axis. Exp Ther Med. Jan 21(1):72. 10.3892/etm.2020.9504.
   PubMed Web of Science ®Google Scholar
• Ma Y, Zhang X, Fan D, Xia Q, Wang M, Pan F. 2019. Common trace metals in rheumatoid arthritis: a systematic review and meta-analysis. J Trace Elements Med Biol. 56:81–89. doi:10.1016/j.jtemb.2019.07.007.
   PubMed Web of Science ®Google Scholar
• McDermid JM, Lonnerdal B. 2012. Iron. Adv Nutr. 3(4):532–533. Jul 1. doi: 10.3945/an.112.002261.
   PubMed Web of Science ®Google Scholar
• Meisinger C, Linseisen J, Leitzmann M, Baurecht H, Baumeister SE. 2020. Association of physical activity and sedentary behavior with type 2 diabetes and glycemic traits: a two-sample Mendelian randomization study. BMJ Open Diabetes Res Care. Dec 8(2):e001896. doi:10.1136/bmjdrc-2020-001896.
   PubMed Web of Science ®Google Scholar
• Meng H, Jiang L, Song Z, Wang F. 2022. Causal associations of circulating lipids with osteoarthritis: a bidirectional Mendelian randomization study. Nutrients. 14(7):1327. Mar 22. doi: 10.3390/nu14071327.
   PubMed Web of Science ®Google Scholar
• Mierzecki A, Strecker D, Radomska K. 2011. A pilot study on zinc levels in patients with rheumatoid arthritis. Biol Trace Elem Res. 143(2):854–862. Nov. doi:10.1007/s12011-010-8952-2.
   PubMed Web of Science ®Google Scholar
• Murakami M, Hirano T. 2008. Intracellular zinc homeostasis and zinc signaling. Cancer Sci. 99(8):1515–1522. Aug. doi:10.1111/j.1349-7006.2008.00854.x.
   PubMed Web of Science ®Google Scholar
• Nieves JW. 2014. Bone. Maximizing bone health–magnesium, BMD and fractures. Nat Rev Endocrinol. May 10(5):255–256. doi:10.1038/nrendo.2014.39.
   PubMed Web of Science ®Google Scholar
• Ni JJ, Xu Q, Yan SS, Han BX, Zhang H, Wei XT, Feng GJ, Zhao M, Pei YF, Zhang L. 2021. Gut microbiota and psychiatric disorders: a two-sample Mendelian randomization study. Front Microbiol. 12:737197. doi: 10.3389/fmicb.2021.737197.
   PubMed Web of Science ®Google Scholar
• Norouzi M, Rezvankhah B, Haeri MR, Heydari H, Tafaroji J, Shafigh N, Avval JO, Dahmardeh AR, Masoumzadeh N, Gharehbeglou M. 2022. Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis. Eur J Transl Myol. 32(3): Jul 5. doi:10.4081/ejtm.2022.10622.
   PubMed Web of Science ®Google Scholar
• Onal S, Naziroglu M, Colak M, Bulut V, Flores-Arce MF. 2011. Effects of different medical treatments on serum copper, selenium and zinc levels in patients with rheumatoid arthritis. Biol Trace Elem Res. 142(3):447–455. Sep. doi:10.1007/s12011-010-8826-7.
   PubMed Web of Science ®Google Scholar
• Petrovska N, Prajzlerova K, Vencovsky J, Senolt L, Filkova M. 2021. The pre-clinical phase of rheumatoid arthritis: from risk factors to prevention of arthritis. Autoimmun Rev. 20(5):102797. May. doi:10.1016/j.autrev.2021.102797.
   PubMed Web of Science ®Google Scholar
• Qu Z, Yang F, Hong J, Wang W, Li S, Jiang G, Yan S. Causal relationship of serum nutritional factors with osteoarthritis: a Mendelian randomization study. Rheumatology (Oxford). 2021 May 14 60(5):2383–2390. doi:10.1093/rheumatology/keaa622.
   PubMed Web of Science ®Google Scholar
• Rondanelli M, Faliva MA, Tartara A, Gasparri C, Perna S, Infantino V, Riva A, Petrangolini G, Peroni G. 2021. An update on magnesium and bone health. Biometals. 34(4):715–736. Aug. doi:10.1007/s10534-021-00305-0.
   PubMed Web of Science ®Google Scholar
• Sahebari M, Ayati R, Mirzaei H, Sahebkar A, Hejazi S, Saghafi M, Saadati N, Ferns GA, Ghayour-Mobarhan M. 2016. Serum Trace element concentrations in rheumatoid arthritis. Biol Trace Elem Res. 171(2):237–245. Jun. doi:10.1007/s12011-015-0501-6.
   PubMed Web of Science ®Google Scholar
• Sato H, Takai C, Kazama JJ, Wakamatsu A, Hasegawa E, Kobayashi D, Kondo N, Nakatsue T, Abe A, Ito S, et al. 2020. Jun 18. Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis. Sci Rep. 10(1):9882. doi:10.1038/s41598-020-66945-3.
   PubMedGoogle Scholar
• Shao Y-R, Xu D-Y, Lin J. 2023. Nutrients and rheumatoid arthritis: from the perspective of neutrophils. Front Immunol. 14. doi:10.3389/fimmu.2023.1113607.
   Web of Science ®Google Scholar
• Sparks JA. Rheumatoid arthritis. Ann Intern Med. 2019. Jan 1 170(1):ITC1–ITC16. doi:10.7326/AITC201901010.
   PubMed Web of Science ®Google Scholar
• Sugimoto J, Romani AM, Valentin-Torres AM, Luciano AA, Ramirez Kitchen CM, Funderburg N, Mesiano S, Bernstein HB. Magnesium decreases inflammatory cytokine production: a novel innate immunomodulatory mechanism. J Immunol. 2012 Jun 15 188(12):6338–6346. doi:10.4049/jimmunol.1101765.
   PubMed Web of Science ®Google Scholar
• Tański W, Chabowski M, Jankowska-Polańska B, Jankowska EA. 2021. Iron metabolism in patients with rheumatoid arthritis. Eur Rev Med Pharmacol Sci. 25(12):4325–4335. doi:10.26355/eurrev_202106_26140.
   PubMed Web of Science ®Google Scholar
• Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, et al. 2022. Copper induces cell death by targeting lipoylated TCA cycle proteins. Sci. 375(6586):1254–1261. doi:10.1126/science.abf0529.
   PubMed Web of Science ®Google Scholar
• Ullah Z, Ullah MI, Hussain S, Kaul H, Lone KP. 2016. Determination of serum Trace elements (Zn, Cu, and Fe) in Pakistani patients with rheumatoid arthritis. Biol Trace Elem Res. 175(1):10–16. doi:10.1007/s12011-016-0746-8.
   PubMed Web of Science ®Google Scholar
• Wang H, Zhang R, Shen J, Jin Y, Chang C, Hong M, Guo S, He D. 2023. Circulating level of blood iron and copper associated with inflammation and disease activity of rheumatoid arthritis. Biol Trace Elem Res. 201(1):90–97. Jan. doi:10.1007/s12011-022-03148-z.
   PubMed Web of Science ®Google Scholar
• Yang M, Wan X, Zheng H, Xu K, Xie J, Yu H, Wang J, Xu P. 2023. No Evidence of a genetic causal relationship between ankylosing spondylitis and gut microbiota: A two-sample Mendelian randomization study. Nutrients. 15(4):1057. Feb 20. doi: 10.3390/nu15041057.
   PubMed Web of Science ®Google Scholar
• Yang M, Xu J, Zhang F, Luo P, Xu K, Feng R, Xu P. 2023. Large-scale genetic correlation analysis between spondyloarthritis and human blood metabolites. J Clin Med. 12(3):1201. Feb 2. doi: 10.3390/jcm12031201.
   PubMed Web of Science ®Google Scholar
• Zhang J. 2022. Mendelian randomization study implies causal linkage between telomere length and juvenile idiopathic arthritis in a European population. J Inflamm Res. 15:977–986. doi:10.2147/JIR.S354619.
   PubMed Web of Science ®Google Scholar
• Zhao J, Guo S, Schrodi SJ, He D. 2022. Cuproptosis and cuproptosis-related genes in rheumatoid arthritis: implication, prospects, and perspectives. Front Immunol. 13:930278. doi: 10.3389/fimmu.2022.930278.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Li X, Ng L, Zhao Q, Guo W, Hu J, Zhong J, Su W, Liu C, Su S. 2023. Identification of copper death-associated molecular clusters and immunological profiles in rheumatoid arthritis. Front Immunol. 14:1103509. doi:10.3389/fimmu.2023.1103509.
   PubMed Web of Science ®Google Scholar
• Zhou J, Liu C, Francis M, Sun Y, Ryu MS, Grider A, Ye K. 2020. The causal effects of blood iron and copper on lipid metabolism diseases: evidence from phenome-wide Mendelian randomization study. Nutrients. 12(10):3174. Oct 17. doi: 10.3390/nu12103174.
   PubMed Web of Science ®Google Scholar
• Zhuo C, Zhao J, Chen M, Lu Y. 2021. Physical activity and risks of cardiovascular diseases: a Mendelian randomization study. Front Cardiovasc Med. 8:722154. doi: 10.3389/fcvm.2021.722154.
   PubMed Web of Science ®Google Scholar