150
Views
0
CrossRef citations to date
0
Altmetric
Review article

Prenatal phthalate exposure and birth size: a systematic review and meta-analysis

, , , , , , , , , & show all
Pages 2813-2829 | Received 31 Mar 2023, Accepted 22 Oct 2023, Published online: 18 Nov 2023

References

  • Adibi JJ, Layden AJ, Birru RL, Miragaia A, Xun X, Smith MC, Yin Q, Millenson ME, O’Connor TG, Barrett ES, et al. 2021. First trimester mechanisms of gestational sac placental and foetal teratogenicity: a framework for birth cohort studies. Hum Reprod Update. 27(4):747–770. doi: 10.1093/humupd/dmaa063.
  • Bellavia A, Hauser R, Seely EW, Meeker JD, Ferguson KK, McElrath TF, James-Todd T. 2017. Urinary phthalate metabolite concentrations and maternal weight during early pregnancy. Int J Hyg Environ Health. 220(8):1347–1355. doi: 10.1016/j.ijheh.2017.09.005.
  • Benjamin S, Masai E, Kamimura N, Takahashi K, Anderson RC, Faisal PA. 2017. Phthalates impact human health: epidemiological evidences and plausible mechanism of action. J Hazard Mater. 340:360–383. doi: 10.1016/j.jhazmat.2017.06.036.
  • Bloom MS, Valachovic EL, Begum TF, Kucklick JR, Brock JW, Wenzel AG, Wineland RJ, Cruze L, Unal ER, Newman RB. 2021. Association between gestational phthalate exposure and newborn head circumference; impacts by race and sex. Environ Res. 195:110763. doi: 10.1016/j.envres.2021.110763.
  • Borenstein M, Hedges LV, Higgins J, Rothstein HR. 2009. Introduction to meta-analysis. 10(1002/9780470743386):1–7.
  • Botton J, Philippat C, Calafat AM, Caries S, Charles M-A, Slama R, Gro EM-C-CS. 2016. Phthalate pregnancy exposure and male offspring growth from the intra-uterine period to five years of age [article]. Environ Res. 151:601–609. doi: 10.1016/j.envres.2016.08.033.
  • Bräuner EV, Uldbjerg CS, Beck AL, Lim YH, Boye H, Frederiksen H, Andersson AM, Jensen TK. 2023. Prenatal paraben exposures and birth size: sex-specific associations in a healthy population - a study from the odense child cohort. Sci Total Environ. 869:161748. doi: 10.1016/j.scitotenv.2023.161748.
  • Casas M, Valvi D, Ballesteros-Gomez A, Gascon M, Fernández MF, Garcia-Esteban R, Iñiguez C, Martínez D, Murcia M, Monfort N, et al. 2016. Exposure to bisphenol a and phthalates during pregnancy and ultrasound measures of fetal growth in the INMA-Sabadell Cohort. Environ Health Perspect. 124(4):521–528. doi: 10.1289/ehp.1409190.
  • Chang CH, Tsai YA, Huang YF, Tsai MS, Hou JW, Lin CL, Wang PW, Huang LW, Chen CY, Wu CF, et al. 2022. The sex-specific association of prenatal phthalate exposure with low birth weight and small for gestational age: a nationwide survey by the Taiwan Maternal and infant cohort study (TMICS). Sci Total Environ. 806(Pt 3):151261. doi: 10.1016/j.scitotenv.2021.151261.
  • Chiu, Y. H., Bellavia, A., James-Todd, T., Correia, K. F., Valeri, L., Messerlian, C., Ford, J. B., Mínguez-Alarcón, L., Calafat, A. M., Hauser, R., Williams, P. L., & EARTH Study Team (2018). Evaluating effects of prenatal exposure to phthalate mixtures on birth weight: A comparison of three statistical approaches. Environment international, 113, 231–239. doi: 10.1016/j.envint.2018.02.005.
  • Darvishmotevalli M, Moradnia M, Hosseini R, Bina B, Feizi A, Ebrahimpour K, Pourzamani H, Feizabadi GK, Kelishadi R. 2021. Association between prenatal phthalate exposure and anthropometric measures of newborns in a sample of Iranian population. Environ Sci Pollut Res Int. 28(36):50696–50706. doi: 10.1007/s11356-021-14182-0.
  • Draper NR. 1998. Applied regression analysis. Technometrics. 9(1):182–183. doi: 10.1080/00401706.1967.10490452.
  • Dutta S, Haggerty DK, Rappolee DA, Ruden DM. 2020. Phthalate exposure and long-term epigenomic consequences: a review. Front Genet. 11:405. doi: 10.3389/fgene.2020.00405.
  • Egger M, Smith GD, Schneider M, Minder C. 1997. Bias in meta-analysis detected by a simple, graphical test. Bmj. 315(7109):629–634. doi: 10.1136/bmj.315.7109.629.
  • Ferguson KK, Cantonwine DE, Rivera-González LO, Loch-Caruso R, Mukherjee B, Anzalota Del Toro LV, Jiménez-Vélez B, Calafat AM, Ye X, Alshawabkeh AN, et al. 2014. Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in puerto rico. Environ Sci Technol. 48(12):7018–7025. doi: 10.1021/es502076j.
  • Ferguson KK, Rosen EM, Barrett ES, Nguyen RHN, Bush N, McElrath TF, Swan SH, Sathyanarayana S. 2019. Joint impact of phthalate exposure and stressful life events in pregnancy on preterm birth. Environ Int. 133:105254. doi: 10.1016/j.envint.2019.105254.
  • Gao H, Xu YY, Huang K, Ge X, Zhang YW, Yao HY, Xu YQ, Yan SQ, Jin ZX, Sheng J, et al. 2017. Cumulative risk assessment of phthalates associated with birth outcomes in pregnant Chinese women: a prospective cohort study [article]. Environ Pollut. 222:549–556. doi: 10.1016/j.envpol.2016.11.026.
  • Golestanzadeh M, Goodarzi-Khoigani M, Shahrbanoo Daniali S, Ebrahimpour K, Zarean E, Yazdi M, Basirat Z, Kelishadi R. 2022. Association between phthalate metabolites in human amniotic fluid and offspring birth size: a sub-study of the PERSIAN birth cohort. Environ Sci Pollut Res Int. 29(51):76970–76982. doi: 10.1007/s11356-022-20839-1.
  • González-Mariño I, Ares L, Montes R, Rodil R, Cela R, López-García E, Postigo C, López de Alda M, Pocurull E, Marcé RM, et al. 2021. Assessing population exposure to phthalate plasticizers in thirteen Spanish cities through the analysis of wastewater. J Hazard Mater. 401:123272. doi: 10.1016/j.jhazmat.2020.123272.
  • Goodrich JM, Ingle ME, Domino SE, Treadwell MC, Dolinoy DC, Burant C, Meeker JD, Padmanabhan V. 2019. First trimester maternal exposures to endocrine disrupting chemicals and metals and fetal size in the Michigan mother-infant pairs study. J Dev Orig Health Dis. 10(4):447–458. doi: 10.1017/S204017441800106X.
  • Gray LE Jr., Laskey J, Ostby J. 2006. Chronic di-n-butyl phthalate exposure in rats reduces fertility and alters ovarian function during pregnancy in female long evans hooded rats. Toxicol Sci. 93(1):189–195. doi: 10.1093/toxsci/kfl035.
  • Grindler NM, Vanderlinden L, Karthikraj R, Kannan K, Teal S, Polotsky AJ, Powell TL, Yang IV, Jansson T. 2018. Exposure to phthalate, an endocrine disrupting chemical, alters the First trimester placental methylome and transcriptome in women. Sci Rep. 8(1):6086. doi: 10.1038/s41598-018-24505-w.
  • Heidari T, Batavani RA, Malekinejad H, Hobbenaghi R. 2022. Evaluation of di-n-butyl phthalate reproductive toxicity in pregnant rats and their offspring and assessment of vitamin E administration in reducing toxicity. Vet Res Forum. 13(2):201–208. doi: 10.30466/vrf.2020.118147.2806.
  • Higgins JP, Thompson SG. 2002. Quantifying heterogeneity in a meta-analysis. Stat Med. 21(11):1539–1558. doi: 10.1002/sim.1186.
  • Hsieh CJ, Chang YH, Hu A, Chen ML, Sun CW, Situmorang RF, Wu MT, Wang SL. 2019. Personal care products use and phthalate exposure levels among pregnant women. Sci Total Environ. 648:135–143. doi: 10.1016/j.scitotenv.2018.08.149.
  • Huang Y, Li J, Garcia JM, Lin H, Wang Y, Yan P, Wang L, Tan Y, Luo J, Qiu Z, et al. 2014. Phthalate levels in cord blood are associated with preterm delivery and fetal growth parameters in Chinese women. PloS One. 9(2):e87430. doi:10.1371/journal.pone.0087430.
  • Huang YF, Pan WC, Tsai YA, Chang CH, Chen PJ, Shao YS, Tsai MS, Hou JW, Lu CA, Chen ML. 2017. Concurrent exposures to nonylphenol, bisphenol A, phthalates, and organophosphate pesticides on birth outcomes: a cohort study in Taipei, Taiwan. Sci Total Environ. 607-608:1126–1135. doi: 10.1016/j.scitotenv.2017.07.092.
  • Katsikantami I, Tzatzarakis MN, Alegakis AK, Karzi V, Hatzidaki E, Stavroulaki A, Vakonaki E, Xezonaki P, Sifakis S, Rizos AK, et al. 2020. Phthalate metabolites concentrations in amniotic fluid and maternal urine: Cumulative exposure and risk assessment. Toxicol Rep. 7:529–538. doi: 10.1016/j.toxrep.2020.04.008.
  • Kayentao K, Garner P, van Eijk AM, Naidoo I, Roper C, Mulokozi A, MacArthur JR, Luntamo M, Ashorn P, Doumbo OK, et al. 2013. Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis. Jama. 309(6):594–604. doi: 10.1001/jama.2012.216231.
  • Kim Y, Ha EH, Kim EJ, Park H, Ha M, Kim JH, Hong YC, Chang N, Kim BN. 2011. Prenatal exposure to phthalates and infant development at 6 months: prospective mothers and children’s environmental health (MOCEH) study. Environ Health Perspect. 119(10):1495–1500. doi: 10.1289/ehp.1003178.
  • Kim JH, Park H, Lee J, Cho G, Choi S, Choi G, Kim SY, Eun SH, Suh E, Kim SK, et al. 2016. Association of diethylhexyl phthalate with obesity-related markers and body mass change from birth to 3 months of age. J Epidemiol Commun H. 70(5):466–472. doi: 10.1136/jech-2015-206315.
  • Lee HR, Jeung EB, Cho MH, Kim TH, Leung PC, Choi KC. 2013. Molecular mechanism(s) of endocrine-disrupting chemicals and their potent oestrogenicity in diverse cells and tissues that express oestrogen receptors. J Cell Mol Med. 17(1):1–11. doi: 10.1111/j.1582-4934.2012.01649.x.
  • Lipsey MW, Wilson DB. 2001. Practical meta-analysis. Sage Publications, Inc.
  • Lovekamp-Swan T, Davis BJ. 2003. Mechanisms of phthalate ester toxicity in the female reproductive system. Environ Health Perspect. 111(2):139–145. doi: 10.1289/ehp.5658.
  • Marie C, Vendittelli F, Sauvant-Rochat MP. 2015. Obstetrical outcomes and biomarkers to assess exposure to phthalates: a review. Environ Int. 83:116–136. doi: 10.1016/j.envint.2015.06.003.
  • McLachlan JA, Simpson E, Martin M. 2006. Endocrine disrupters and female reproductive health. Best Pract Res Clin Endocrinol Metab. 20(1):63–75. doi: 10.1016/j.beem.2005.09.009.
  • Messerlian C, Braun JM, Mínguez-Alarcón L, Williams PL, Ford JB, Mustieles V, Calafat AM, Souter I, Toth T, Hauser R, et al. 2017. Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples. Environ Int. 107:55–64. doi: 10.1016/j.envint.2017.06.015.
  • Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 6(7):e1000097. doi: 10.1371/journal.pmed.1000097.
  • Moore NP. 2000. The oestrogenic potential of the phthalate esters. Reprod Toxicol. 14(3):183–192. doi: 10.1016/s0890-6238(00)00068-x.
  • Nidens N, Krönke A, Jurkutat A, Schlingmann M, Poulain T, Nüchter M, Kiviranta H, Körner A, Vogel M, Lindh C, et al. 2021. Associations of prenatal exposure to phthalates and one phthalate substitute with anthropometric measures in early life: results from the German LIFE child cohort study. Best Pract Res Clin Endocrinol Metab. 35(5):101532. doi: 10.1016/j.beem.2021.101532.
  • Nieminen P, Lehtiniemi H, Vähäkangas K, Huusko A, Rautio A. 2013. Standardised regression coefficient as an effect size index in summarising findings in epidemiological studies. Epidemiology, Biostatistics And Public Health. 10(4). doi: 10.2427/8854.
  • Nkwabong E, Kamgnia Nounemi N, Sando Z, Mbu RE, Mbede J. 2015. Risk factors and placental histopathological findings of term born low birth weight neonates. Placenta. 36(2):138–141. doi: 10.1016/j.placenta.2014.12.005.
  • Petersen JH, Jensen LK. 2010. Phthalates and food-contact materials: enforcing the 2008 European Union plastics legislation. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 27(11):1608–1616. doi: 10.1080/19440049.2010.501825.
  • Philippat C, Mortamais M, Chevrier C, Petit C, Calafat AM, Ye X, Silva MJ, Brambilla C, Pin I, Charles M-A, et al. 2012. Exposure to phthalates and phenols during pregnancy and offspring size at birth. Environ Health Perspect. 120(3):464–470. doi: 10.1289/ehp.1103634.
  • Polańska K, Ligocka D, Sobala W, Hanke W. 2016. Effect of environmental phthalate exposure on pregnancy duration and birth outcomes. Int J Occup Med Environ Health. 29(4):683–697. doi: 10.13075/ijomeh.1896.00691.
  • Qian B, Zheng ZX, Yang L, Wang CQ, Lin YC, Lin ZN. 2023. Prenatal exposure to phthalates and polybrominated diphenyl ethers on neonatal health: a birth cohort study in guangxi, China. Environ Res. 216(Pt 2):114571. doi: 10.1016/j.envres.2022.114571.
  • Qureshi MS, Yusoff AR, Wirzal MD, Sirajuddin B, Afridi J, I H, Üstündag Z. 2016. Methods for the Determination of Endocrine-Disrupting Phthalate Esters. Crit Rev Anal Chem. 46(2):146–159. doi: 10.1080/10408347.2015.1004157.
  • Santos S, Sol CM, van Zwol-Janssens C, Philips EM, Asimakopoulos AG, Martinez-Moral MP, Kannan K, Jaddoe VWV, Trasande L. 2021. Maternal phthalate urine concentrations, fetal growth and adverse birth outcomes. A population-based prospective cohort study. Environ Int. 151:106443. doi: 10.1016/j.envint.2021.106443.
  • Shoaff JR, Romano ME, Yolton K, Lanphear BP, Calafat AM, Braun JM. 2016. Prenatal phthalate exposure and infant size at birth and gestational duration. Environ Res. 150:52–58. doi: 10.1016/j.envres.2016.05.033.
  • Smarr MM, Grantz KL, Sundaram R, Maisog JM, Kannan K, Louis GMB. 2015. Parental urinary biomarkers of preconception exposure to bisphenol a and phthalates in relation to birth outcomes [article]. Environ Health: A Glob Access Sci Source. 14(1). doi:10.1186/s12940-015-0060-5
  • Song Q, Li R, Zhao Y, Zhu Q, Xia B, Chen S, Zhang Y. 2018. Evaluating effects of prenatal exposure to phthalates on neonatal birth weight: structural equation model approaches. Chemosphere. 205:674–681. doi: 10.1016/j.chemosphere.2018.04.063.
  • Suzuki Y, Niwa M, Yoshinaga J, Watanabe C, Mizumoto Y, Serizawa S, Shiraishi H. 2009. Exposure assessment of phthalate esters in Japanese pregnant women by using urinary metabolite analysis. Environ Health Prev Med. 14(3):180–187. doi: 10.1007/s12199-009-0078-9.
  • Szychowski KA, Wójtowicz AK. 2013. Components of plastic disrupt the function of the nervous system. Postepy Hig Med Dosw (Online). 67:499–506. Składniki tworzyw sztucznych zaburzające funkcje układu nerwowego. doi: 10.5604/17322693.1051001.
  • Tang Z, Chai M, Wang Y, Cheng J. 2020. Phthalates in preschool children’s clothing manufactured in seven Asian countries: occurrence, profiles and potential health risks. J Hazard Mater. 387:121681. doi: 10.1016/j.jhazmat.2019.121681.
  • Tetz LM, Cheng AA, Korte CS, Giese RW, Wang P, Harris C, Meeker JD, Loch-Caruso R. 2013. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro. Toxicol Appl Pharmacol. 268(1):47–54. doi: 10.1016/j.taap.2013.01.020.
  • Tran TM, Le HT, Minh TB, Kannan K. 2017. Occurrence of phthalate diesters in indoor air from several northern cities in Vietnam, and its implication for human exposure. Sci Total Environ. 601-602:1695–1701. doi: 10.1016/j.scitotenv.2017.06.016.
  • Tsai YA, Tsai MS, Hou JW, Lin CL, Chen CY, Chang CH, Liao KW, Wang SL, Chen BH, Wu MT, et al. 2018. Evidence of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake in Taiwanese pregnant women and the health effects on birth outcomes [article]. Sci Total Environ. 618:635–644. doi: 10.1016/j.scitotenv.2017.07.175.
  • Uldbjerg CS, Lim YH, Krause M, Frederiksen H, Andersson AM, Bräuner EV. 2022. Sex-specific associations between maternal exposure to parabens, phenols and phthalates during pregnancy and birth size outcomes in offspring. Sci Total Environ. 836:155565. doi: 10.1016/j.scitotenv.2022.155565.
  • van den Dries MA, Keil AP, Tiemeier H, Pronk A, Spaan S, Santos S, Asimakopoulos AG, Kannan K, Gaillard R, Guxens M, et al. 2021. Prenatal exposure to nonpersistent chemical mixtures and fetal growth: a population-based study. Environ Health Perspect. 129(11):117008. doi: 10.1289/ehp9178.
  • Vrijheid M, Casas M, Gascon M, Valvi D, Nieuwenhuijsen M. 2016. Environmental pollutants and child health-A review of recent concerns. Int J Hyg Environ Health. 219(4–5):331–342. doi: 10.1016/j.ijheh.2016.05.001.
  • Wells G (2014). The Newcastle-Ottawa scale (NOS) for assessing the quality of non-randomised studies in meta-analyses. Symposium on Systematic Reviews: Beyond the Basics; Canada.
  • Wilson MP, Schwarzman MR. 2009. Toward a new U.S. chemicals policy: rebuilding the foundation to advance new science, green chemistry, and environmental health. Environ Health Perspect. 117(8):1202–1209. doi: 10.1289/ehp.0800404.
  • Wittassek M, Angerer J, Kolossa-Gehring M, Schäfer SD, Klockenbusch W, Dobler L, Günsel AK, Müller A, Wiesmüller GA. 2009. Fetal exposure to phthalates–a pilot study. Int J Hyg Environ Health. 212(5):492–498. doi: 10.1016/j.ijheh.2009.04.001.
  • Wolff MS, Engel SM, Berkowitz GS, Ye X, Silva MJ, Zhu C, Wetmur J, Calafat AM. 2008. Prenatal phenol and phthalate exposures and birth outcomes. Environ Health Perspect. 116(8):1092–1097. doi: 10.1289/ehp.11007.
  • Yaghjyan L, Ghita GL, Dumont-Driscoll M, Yost RA, Chang SH. 2016. Maternal exposure to di-2-ethylhexylphthalate and adverse delivery outcomes: a systematic review. Reprod Toxicol. 65:76–86. doi: 10.1016/j.reprotox.2016.07.002.
  • Yang C, Lim W, Bazer FW, Song G. 2017. Oleic acid stimulation of motility of human extravillous trophoblast cells is mediated by stearoyl-CoA desaturase-1 activity. Mol Hum Reprod. 23(11):755–770. doi: 10.1093/molehr/gax051.
  • Yu Z, Han Y, Shen R, Huang K, Xu YY, Wang QN, Zhou SS, Xu DX, Tao FB. 2018. Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling. Toxicol Lett. 294:1–10. doi: 10.1016/j.toxlet.2018.05.013.
  • Zhang YW, Gao H, Mao LJ, Tao XY, Ge X, Huang K, Zhu P, Hao JH, Wang QN, Xu YY, et al. 2018. Effects of the phthalate exposure during three gestation periods on birth weight and their gender differences: a birth cohort study in China [article]. Sci Total Environ. 613-614:1573–1578. doi: 10.1016/j.scitotenv.2017.08.319.
  • Zhang Y, Lin L, Cao Y, Chen B, Zheng L, Ge RS. 2009. Phthalate levels and low birth weight: a nested case-control study of Chinese newborns. J Pediatr. 155(4):500–504. doi: 10.1016/j.jpeds.2009.04.007.
  • Zhao Y, Chen J, Wang X, Song Q, Xu HH, Zhang YH. 2016. Third trimester phthalate exposure is associated with DNA methylation of growth-related genes in human placenta. Sci Rep. 6(1):33449. doi: 10.1038/srep33449.
  • Zhao Y, Shi HJ, Xie CM, Chen J, Laue H, Zhang YH. 2015. Prenatal phthalate exposure, infant growth, and global DNA methylation of human placenta. Environ And Mol Mutagen. 56(3):286–292. doi: 10.1002/em.21916.
  • Zhong Q, Liu HL, Fu H, Niu QS, Wu HB, Huang F. 2021. Prenatal exposure to phthalates with preterm birth and gestational age: a systematic review and meta-analysis. Chemosphere. 282:130991. doi: 10.1016/j.chemosphere.2021.130991.
  • Zhu Y, Wan Y, Zhang B, Zhou A, Huo W, Wu C, Liu H, Jiang Y, Chen Z, Jiang M, et al. 2018. Relationship between maternal phthalate exposure and offspring size at birth. Sci Total Environ. 612:1072–1078. doi: 10.1016/j.scitotenv.2017.08.207.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.