120
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Liposomal formulations of Oleae europaea L.: analyzing the antioxidant and antidiabetic activities along with toxicity profile in pancreatic beta TC6 cell line

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Received 16 Oct 2023, Accepted 06 Feb 2024, Published online: 12 Feb 2024

References

  • Ahmadvand H, Noori A, Dehnoo MG, Bagheri S, Cheraghi RA. 2014. Hypoglycemic, hypolipidemic and antiatherogenic effects of oleuropein in alloxan-induced type 1 diabetic rats. Asian Pac J Trop Dis. 4(1):421–425. doi: 10.1016/S2222-1808(14)60481-3.
  • Al-Azzawie HF, Alhamdani MSS. 2006. Hypoglycemic and antioxidant effect of oleuropein in alloxan- diabetic rabbits. Life Sci. 78(12):1371–1377. doi: 10.1016/j.lfs.2005.07.029.
  • Ali H, Houghton P, Soumyanath A. 2006. α-amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. J Ethnopharmacol. 107(3):449–455. doi: 10.1016/j.jep.2006.04.004.
  • Alnusaire TS. 2021. Olive leaves (Olea europaea L) extract loaded lipid nanoparticles: optimization of processing parameters by box-behnken statistical design, in-vitro characterization, and evaluation of antioxidant and antimicrobial activity. J Oleo Sci. 70(10):1403–1416. doi: 10.5650/jos.ess21149.
  • Alnusaire TS, Sayed AM, Elmaidomy AH, Al-Sanea MM, Albogami S, Albqmi M, Alowaiesh BF, Mostafa EM, Musa A, Youssif KA, et al. 2021. An in vitro and in silico study of the enhanced antiproliferative and pro-oxidant potential of Olea europaea L. cv. Arbosana leaf extract via elastic nanovesicles (Spanlastics). Antioxid (Basel). 10(12):1860. doi:10.3390/antiox10121860.
  • Alshraim MO, Sangi S, Harisa GI, Alomrani AH, Yusuf O, Badran MM. 2019. Chitosan-coated flexible liposomes magnify the anticancer activity and bioavailability of docetaxel: impact on composition. Molecules. 24(2):250. doi: 10.3390/molecules24020250.
  • Altınyay Ç, Güvenç A, Altun LM. 2011. Antioxidant activıties of oleuropein and the aqueous extracts of Olea europaea L. varieties growing in Turkey. Turk J Pharm Sci. 8(1):23–30.
  • Ansari M, Kazemipour M, Fathi S. 2011. Development of a simple green extraction procedure and HPLC method for determination of oleuropein in olive leaf extract applied to a multi-source comparative study. J Iranian Chem Soc. 8(1):38–47. doi: 10.1007/BF03246200.
  • Benavente-Garcia O, Castillo J, Lorente J, Ortuno A, Del Rio JA. 2000. Antioxidant activity of phenolics extracted from Olea europaea L. leaves. Food Chem. 68(4):457–462. doi: 10.1016/S0308-8146(99)00221-6.
  • Cumaoğlu A, Ari N, Kartal M, Karasu Ç. 2011. Polyphenolic extracts from Olea europea L. protect against cytokine-induced β-cell damage through maintenance of redox homeostasis. Rejuvenation Res. 14(3):325–34. doi: 10.1089/rej.2010.1111.
  • Elgin Cebe G, Konyalıoğlu S, Zeybek U. 2012. Olea europaea var. europaea (Zeytin) yaprak infüzyonunun antioksidan etkisi. Ege Üniv Ziraat Fak Derg. 49(3):209–212.
  • Erdoğan S, Küpeli Akkol E, Avcı G. 2020. Research on the antioxidant efficiacy of olive (Olea europaea L.) leaf using by in vitro methods. Kocatepe Vet J. 13(3):319–326. doi: 10.30607/kvj.698776.
  • Feng S, Zhang C, Liu L, Xu Z, Chen T, Zhou L, Yuan M, Li T, Ding C. 2021. Comparison of phenolic compounds in olive leaves by different drying and storage methods. Separations. 8(9):156. doi: 10.3390/separations8090156.
  • Ghasemi S, Koohi DE, Emmamzadehhashemi MSB, Khamas SS, Moazen M, Hashemi AK, Amin G, Golfakhrabadi F, Yousefi Z, Yousefbeyk F. 2018. Investigation of phenolic compounds and antioxidant activity of leaves extracts from seventeen cultivars of Iranian olive (Olea europaea L.). J Food Sci Technol. 55(11):4600–4607. doi: 10.1007/s13197-018-3398-1.
  • Gonzalez M, Zarzuelo A, Gamez MJ, Utrilla MP, Jimenez J, Osuna I. 1992. Hypoglycemic activity of olive leaf. Planta Med. 58(6):513–515. doi: 10.1055/s-2006-961538.
  • Gopinath D, Ravi D, Rao BR, Apte SS, Renuka D, Rambhau D. 2004. Ascorbyl palmitate vesicles (Aspasomes): formation, characterization and applications. Int J Pharm. 271(1–2):95–113. doi: 10.1016/j.ijpharm.2003.10.032.
  • Gyamfi MA, Yonamine M, Aniya Y. 1999. Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally induced liver injuries. Gen Pharmacol. 32(6):661–667. doi: 10.1016/S0306-3623(98)00238-9.
  • Hassen I, Casabianca H, Hosni K. 2015. Biological activities of the natural antioxidant oleuropein: exceeding the expectation – a mini-review. J Funct Foods. 18:926–940. doi: 10.1016/j.jff.2014.09.001.
  • Immordino ML, Dosio F, Cattel L. 2006. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomedicine. 1:297–315.
  • Karaboğa Arslan AK, Öztürk E, Yerer MB, Koşar M. 2017. Oleuropein in olive leaf and its pharmacological effects. J Health Sci. 26:89–93.
  • Karatoprak G Ş, Başkal G, Yücel Ç. 2022. Melissa officinalis L. nanoethosomal formulation: evaluation of antioxidant, enzyme inhibitory activities and in vitro toxicity. Int J Environ Health Res May. 23:1–10.
  • Kosar M, Goger F, Baser KHC. 2008. In vitro antioxidant properties and phenolic composition of Salvia virgata jacq. From Turkey. J Agric Food Chem. 56(7):2369–2374. doi: 10.1021/jf073516b.
  • Lee-Huang S, Zhang L, Lin Huang P, Chang YT, Huang PL. 2003. Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment. Biochem Biophys Res Commun. 307(4):1029–1037. doi: 10.1016/S0006-291X(03)01292-0.
  • Le Tutour B, Guedon D. 1992. Antioxidative activities of Olea europaea leaves and related phenolic compounds. Phytochemistry. 31(4):1173–1178. doi: 10.1016/0031-9422(92)80255-D.
  • Lins PG, Marina Piccoli Pugine S, Scatolini AM, de Melo MP. 2018. In vitro antioxidant activity of olive leaf extract (Olea europaea L.) and its protective effect on oxidative damage in human erythrocytes. Heliyon. 4(9):e00805. doi: 10.1016/j.heliyon.2018.e00805.
  • Liu S, Li D, Huang B, Chen Y, Lu X, Wang Y. 2003. Inhibition of pancreatic lipase, α-glucosidase, α-amylase, and hypolipidemic effects of the total flavonoids from Nelumbo nucifera leaves. J Ethnopharmacol. 149(1):263–269. doi: 10.1016/j.jep.2013.06.034.
  • Maeda H, Bharate GY, Daruwalla J. 2009. Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. Eur J Pharm Biopharm. 71(3):409–419. doi: 10.1016/j.ejpb.2008.11.010.
  • Muzzalupo I, Badolati G, Chiappetta A, Picci N, Muzzalupo R. 2020. In vitro antifungal activity of olive (Olea europaea) leaf extracts loaded in chitosan nanoparticles. Front Bioeng Biotechnol. 8:151. doi: 10.3389/fbioe.2020.00151.
  • Re R, Pellegrini N, Proteggente A, Pannalaa A, Yanga M, Rice-Evans C. 1999. Antioxidant activity applying an improved ABTS radical cation decolorisation assay. Free Radic Biol Med. 26(9–10):1231–1237. doi: 10.1016/S0891-5849(98)00315-3.
  • Savournin C, Baghdikian B, Elias R, Dargouth-Kesraoui F, Boukef K, Balansard G. 2001. Rapid high-performance liquid chromatography analysis for the quantitative determination of oleuropein in Olea europaea leaves. J Agric Food Chem. 49:618–621.
  • Singleton VL, Orthofer R, Lamuela-Raventos RM. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Methods Enzymol. 299:152–178.
  • Visioli F, Poli A, Galli C. 2002. Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev. 22(1):65–75. doi: 10.1002/med.1028.
  • Yücel Ç, Şeker Karatoprak G. 2017. Development and evaluation of the antioxidant activity of liposomes and nanospheres containing rosmarinic acid. Farmacia. 65(1):40–45.
  • Yücel Ç, Şeker Karatoprak G, İlbasmış Tamer S, Değim İT. 2023. Ferulic acid-loaded aspasomes: a new approach to enhance the skin permeation, anti-aging and antioxidant effects. J Drug Deliv Sci Technol. 86:104748. doi: 10.1016/j.jddst.2023.104748.
  • Zhishen J, Mengcheng T, Jianming W. 1999. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 64(4):555–559. doi: 10.1016/S0308-8146(98)00102-2.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.