Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 27, 2024 - Issue 2
360
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Effects of omega-3 supplementation on anxiety-like behaviors and neuroinflammation in Wistar rats following cafeteria diet-induced obesity

, , , , , , , , , & show all

References

  • Hersey M, Woodruff JL, Maxwell N, Sadek AT, Bykalo MK, Bain I, et al. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain Behav Immun. 2021;96:63–72.
  • de Oliveira S, Feijó GDS, Neto J, Jantsch J, Braga MF, Castro LFDS, et al. Zinc supplementation decreases obesity-related neuroinflammation and improves metabolic function and memory in rats. Obesity. 2021;29(1):116–24.
  • Johnson PM, Kenny PJ. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci. 2010;13(5):635–41.
  • Stein DJ, Scott KM, de Jonge P, Kessler RC. Epidemiology of anxiety disorders: from surveys to nosology and back. Dialogues Clin Neurosci. 2017;19(2):127–36.
  • de Macedo IC, de Freitas JS, da Silva Torres IL. The influence of palatable diets in reward system activation: a mini review. Adv Pharmacol Sci. 2016;2016:1–7.
  • Castro H, Pomar CA, Picó C, Sánchez J, Palou A. Cafeteria diet overfeeding in young male rats impairs the adaptive response to fed/fasted conditions and increases adiposity independent of body weight. Int J Obes. 2015;39(3):430–7.
  • Khan SU, Lone AN, Khan MS, Virani SS, Blumenthal RS, Nasir K, et al. Effect of omega-3 fatty acids on cardiovascular outcomes: a systematic review and meta-analysis. EClinicalMedicine. 2021;38:100997.
  • Skulas-Ray AC, Wilson PWF, Harris WS, Brinton EA, Kris-Etherton PM, Richter CK, et al. Omega-3 fatty acids for the management of hypertriglyceridemia: a science advisory from the American Heart Association. Circulation. 2019;140(12):e673–e691.
  • Calder PC. Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochim Biophys Acta. 2015;1851(4):469–84.
  • Neto J, Jantsch J, de Oliveira S, Braga MF, Castro LFDS, Diniz BF, et al. DHA/EPA supplementation decreases anxiety-like behaviour, but it does not ameliorate metabolic profile in obese male rats. Br J Nutr. 2021;128(5):964–974.
  • Su K-P, Tseng P-T, Lin P-Y, Okubo R, Chen T-Y, Chen Y-W, Matsuoka YJ. Association of use of omega-3 polyunsaturated fatty acids with changes in severity of anxiety symptoms: a systematic review and meta-analysis. JAMA Network Open. 2018;1(5):e182327.
  • Chewcharat A, Chewcharat P, Rutirapong A, Papatheodorou S. The effects of omega-3 fatty acids on diabetic nephropathy: a meta-analysis of randomized controlled trials. PLoS One. 2020;15(2):e0228315.
  • Seibenhener ML, Wooten MC. Use of the open field maze to measure locomotor and anxiety-like behavior in mice. J Visualized Exp. 2015;(96). doi:10.3791/52434
  • Bourin M, Hascoët M. The mouse light/dark box test. Eur J Pharmacol. 2003;463(1-3):55–65. doi:10.1016/s0014-2999(03)01274-3
  • Shoji H, Takao K, Hattori S, Miyakawa T. Contextual and cued fear conditioning test using a video analyzing system in mice. J Visualized Exp. 2014;(85). doi:10.3791/50871
  • Lalanza JF, Snoeren EMS. The cafeteria diet: a standardized protocol and its effects on behavior. Neurosci Biobehav Rev. 2021;122:92–119.
  • Buyukdere Y, Gulec A, Akyol A. Cafeteria diet increased adiposity in comparison to high fat diet in young male rats. PeerJ. 2019;7:e6656.
  • Stella AB, Cappellari GG, Barazzoni R, Zanetti M. Update on the impact of omega 3 fatty acids on inflammation, insulin resistance and sarcopenia: a review. Int J Mol Sci. 2018;19(1):218.
  • Chacińska M, Zabielski P, Książek M, Szałaj P, Jarząbek K, Kojta I, et al. The impact of OMEGA-3 fatty acids supplementation on insulin resistance and content of adipocytokines and biologically active lipids in adipose tissue of high-fat diet fed rats. Nutrients. 2019;11(4):835.
  • Dutheil S, Ota KT, Wohleb ES, Rasmussen K, Duman RS. High-fat diet induced anxiety and anhedonia: impact on brain homeostasis and inflammation. Neuropsychopharmacology. 2016;41(7):1874–87.
  • Sangouni AA, Orang Z, Mozaffari-Khosravi H. Effect of omega-3 supplementation on fatty liver and visceral adiposity indices in diabetic patients with non-alcoholic fatty liver disease: a randomized controlled trial. Clin Nutr ESPEN. 2021;44:130–5.
  • Itsiopoulos C, Marx W, Mayr HL, Tatucu-Babet OA, Dash SR, George ES, et al. The role of omega-3 polyunsaturated fatty acid supplementation in the management of type 2 diabetes mellitus: a narrative review. J Nutr Intermed Metab. 2018;14:42–51.
  • Madruga C, Xavier LL, Achaval M, Sanvitto GL, Lucion AB. Early handling, but not maternal separation, decreases emotional responses in two paradigms of fear without changes in mesolimbic dopamine. Behav Brain Res. 2006;166(2):241–6.
  • Benetti F, Andrade de Araujo P, Luiz Sanvitto G, Lucion AB. Effects of neonatal novelty exposure on sexual behavior, fear, and stress-response in adult rats. Dev Psychobiol. 2007;49(3):258–64.
  • Warneke W, Klaus S, Fink H, Langley-Evans SC, Voigt J-P. The impact of cafeteria diet feeding on physiology and anxiety-related behaviour in male and female Sprague-Dawley rats of different ages. Pharmacol Biochem Behav. 2014;116:45–54.
  • Larrieu T, Layé S. Food for mood: relevance of nutritional omega-3 fatty acids for depression and anxiety. Front Physiol. 2018;9:1047.
  • Deane KHO, Jimoh OF, Biswas P, O’Brien A, Hanson S, Abdelhamid AS, et al. Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials. Br J Psychiatry. 2021;218(3):135–42.
  • Ramos A, Pereira E, Martins GC, Wehrmeister TD, Izídio GS. Integrating the open field, elevated plus maze and light/dark box to assess different types of emotional behaviors in one single trial. Behav Brain Res. 2008;193(2):277–88.
  • Vendruscolo LF, Takahashi RN, Brüske GR, Ramos A. Evaluation of the anxiolytic-like effect of NKP608, a NK1-receptor antagonist, in two rat strains that differ in anxiety-related behaviors. Psychopharmacology. 2003;170(3):287–93.
  • Padurariu M, Antioch I, Balmus I, Ciobica A, El-Lethey HS, Kamel MM. Describing some behavioural animal models of anxiety and their mechanistics with special reference to oxidative stress and oxytocin relevance. Int J Vet Sci Med. 2017;5(2):98–104.
  • Solanki N, Alkadhi I, Atrooz F, Patki G, Salim S. Grape powder prevents cognitive, behavioral, and biochemical impairments in a rat model of posttraumatic stress disorder. Nutr Res. 2015;35(1):65–75.
  • Guillemot-Legris O, Muccioli GG. Obesity-induced neuroinflammation: beyond the hypothalamus. Trends Neurosci. 2017;40(4):237–53.
  • Greene C, Hanley N, Campbell M. Claudin-5: gatekeeper of neurological function. Fluids Barriers CNS. 2019;16(1):3.
  • Van Dyken P, Lacoste B. Impact of metabolic syndrome on neuroinflammation and the blood-brain barrier. Front Neurosci. 2018;12:930.
  • de Fraga LS, Tassinari ID, Jantsch J, Guedes RP, Bambini-Junior V. ‘A picture is worth a thousand words’: the use of microscopy for imaging neuroinflammation. Clin Exp Immunol. 2021;206(3):325–45.
  • Xie B, Tao C, Li J, Hilsabeck RC, Aguirre A. Artificial intelligence for caregivers of persons with Alzheimer’s disease and related dementias: systematic literature review. JMIR Med Inform. 2020;8(8):e18189. doi:10.2196/18189
  • Rom S, Zuluaga-Ramirez V, Gajghate S, Seliga A, Winfield M, Heldt NA, et al. Hyperglycemia-driven neuroinflammation compromises BBB leading to memory loss in both diabetes mellitus (DM) type 1 and type 2 mouse models. Mol Neurobiol. 2019;56(3):1883–96.
  • de Paula GC, Brunetta HS, Engel DF, Gaspar JM, Velloso LA, Engblom D, et al. Hippocampal function is impaired by a short-term high-fat diet in mice: increased blood-brain barrier permeability and neuroinflammation as triggering events. Front Neurosci. 2021;15:734158.
  • Zhang W, Zhang H, Mu H, Zhu W, Jiang X, Hu X, et al. Omega-3 polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury. Neurobiol Dis. 2016;91:37–46.
  • Liu Y, Chen F, Li Q, Odle J, Lin X, Zhu H, et al. Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge. J Nutr. 2013;143(11):1799–807.
  • Kassubek R, Gorges M, Schocke M, Hagenston VAM, Huss A, Ludolph AC, et al. GFAP in early multiple sclerosis: a biomarker for inflammation. Neurosci Lett. 2017;657:166–70.
  • Lau JKY, Tian M, Shen Y, Lau S-F, Fu W-Y, Fu AKY, Ip NY. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Sci Rep. 2021;11(1):4359.
  • Bondan EF, Cardoso CV, Martins MFM, Otton R. Memory impairments and increased GFAP expression in hippocampal astrocytes following hypercaloric diet in rats. Arq Neuropsiquiatr. 2019;77(9):601–8.
  • de Andrade AM, Fernandes MC, de Fraga LS, Porawski M, Giovenardi M, Guedes RP. Omega-3 fatty acids revert high-fat diet-induced neuroinflammation but not recognition memory impairment in rats. Metab Brain Dis. 2017;32(6):1871–81.
  • Mori MA, Delattre AM, Carabelli B, Pudell C, Bortolanza M, Staziaki PV, et al. Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson’s disease is mediated by a reduction of inducible nitric oxide synthase. Nutr Neurosci. 2018;21(5):341–51.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.