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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 27, 2024 - Issue 7
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Research Article

Neonatal overnutritional programming impairs the hypophagia and neuron activation induced by acute lipopolysaccharide in adult male rats

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References

  • Plagemann A, Harder T, Schellong K, et al. Early postnatal life as a critical time window for determination of long-term metabolic health. Best Pract Res Clin Endocrinol Metab. 2012;26:641–53. doi:10.1016/j.beem.2012.03.008.
  • Sánchez-Garrido MA, Garciá-Galiano D, Tena-Sempere M. Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine. Hum Reprod Update. 2022;28:346–75. doi:10.1093/humupd/dmac005.
  • Clarke MA, Stefanidis A, Spencer SJ. Postnatal overfeeding leads to obesity and exacerbated febrile responses to lipopolysaccharide throughout life. J Neuroendocrinol. 2012;24:511–24. doi:10.1111/j.1365-2826.2011.02269.x.
  • de Souza CF, Stopa LRS, Martins AB, et al. Lactation overnutrition-induced obesity impairs effects of exogenous corticosterone on energy homeostasis and hypothalamic-pituitary-adrenal axis in male rats. Life Sci. 2022: 304.
  • Wunderlich ALM, Martins AB, de Souza CF, et al. Neonatal overnutrition, but not neonatal undernutrition, disrupts CCK-induced hypophagia and neuron activation of the nucleus of the solitary tract and paraventricular nucleus of hypothalamus of male Wistar rats. Brain Res Bull. 2023;195:109–19. doi:10.1016/j.brainresbull.2023.02.012.
  • Plagemann A, Harder T, Rake A, et al. Observations on the orexigenic hypothalamic neuropeptide Y-system in neonatally overfed weanling rats. J Neuroendocrinol. 1999;11:541–6. doi:10.1046/j.1365-2826.1999.00357.x.
  • Remmers F, Fodor M, Delemarre-van de Waal HA. Neonatal food restriction permanently alters rat body dimensions and energy intake. Physiol Behav. 2008;95:208–15. doi:10.1016/j.physbeh.2008.05.021.
  • Velkoska E, Cole TJ, Dean RG, et al. Early undernutrition leads to long-lasting reductions in body weight and adiposity whereas increased intake increases cardiac fibrosis in male Rats. J Nutr. 2008;138:1622–7. doi:10.1093/jn/138.9.1622.
  • Radler ME, Hale MW, Kent S. Calorie restriction attenuates lipopolysaccharide (LPS)-induced microglial activation in discrete regions of the hypothalamus and the subfornical organ. Brain Behav Immun. 2014;38:13–24. doi:10.1016/j.bbi.2013.11.014.
  • Plagemann A, Rake A, Harder T, et al. Reduction of cholecystokinin-8S-neurons in the paraventricular hypothalamic nucleus of neonatally overfed weanling rats. Neurosci Lett. 1998;258:13–6. doi:10.1016/S0304-3940(98)00823-4.
  • Debarba LK, Marangon PB, Borges BC, et al. Neonatal nutritional programming induces gliosis and alters the expression of T-cell protein tyrosine phosphatase and connexins in male rats. Horm Behav. 2020;120:104690), doi:10.1016/j.yhbeh.2020.104690.
  • Kristensen P, Judge ME, Thim L, et al. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998;393:72–6. doi:10.1038/29993.
  • Chandra RK. Nutrition and the immune system from birth to old age. Eur J Clin Nutr. 2002;56(Suppl 3):S73–S76. doi:10.1038/sj.ejcn.1601492.
  • Rorato R, Menezes AM, Giusti-Paiva A, et al. Prostaglandin mediates endotoxaemia-induced hypophagia by activation of pro-opiomelanocortin and corticotrophin-releasing factor neurons in rats. Exp Physiol. 2009;94:371–9. doi:10.1113/expphysiol.2008.045435.
  • Sachot C, Poole S, Luheshi GN. Circulating leptin mediates lipopolysaccharide-induced anorexia and fever in rats. Journal of Physiology. 2004;561:263–72. doi:10.1113/jphysiol.2004.074351.
  • Gavrilov Yv, Perekrest Sv, Novikova NS. Intracellular expression of c-Fos protein in various structures of the hypothalamus in electrical pain stimulation and administration of antigens. Neurosci Behav Physiol. 2008;38:87–92. doi:10.1007/s11055-008-0012-4.
  • Borges BC, Rorato R, Avraham Y, et al. Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge. Am J Physiol Endocrinol Metab. 2011;300:E858–E869. doi:10.1152/ajpendo.00558.2010.
  • Gautron L, Mingam R, Moranis A, et al. Influence of feeding status on neuronal activity in the hypothalamus during lipopolysaccharide-induced anorexia in rats. Neuroscience. 2005;134:933–46. doi:10.1016/j.neuroscience.2005.03.063.
  • Borges BdC, Rorato R, Torres Uchoa E, et al. High-fat diet induces site-specific unresponsiveness to LPS-stimulated STAT3 activation in the hypothalamus. Am J Physiol Regul Integr Comp Physiol. 2014;306:34–44. doi:10.1152/ajpregu.00147.2013.
  • Kloss CUA, Bohatschek M, Kreutzberg GW, et al. Effect of lipopolysaccharide on the morphology and integrin immunoreactivity of ramified microglia in the mouse brain and in cell culture. Exp Neurol. 2001;168:32–46. doi:10.1006/exnr.2000.7575.
  • Heidel E, Plagemann A, Davidowa H. Increased response to NPY of hypothalamic VMN neurons in postnatally overfed juvenile rats. Neuroreport. 1999;10:1827–31. doi:10.1097/00001756-199906230-00005.
  • Rorato R, Reis WL, Antunes-Rodrigues J, et al. Cholecystokinin and hypothalamic corticotrophin-releasing factor participate in endotoxin-induced hypophagia. Exp Physiol. 2011;96:439–50. doi:10.1113/expphysiol.2010.056465.
  • Bernardis LL, Patterson BD. Correlation between “Lee index” and carcass fat content in wealing and adult female rats with hypothamic lesion. J Endocrinol. 1968;40:527–8. doi:10.1677/joe.0.0400527.
  • Iwasa T, Matsuzaki T, Tungalagsuvd A, et al. Prenatal undernutrition results in greater lipopolysaccharide-induced changes in hypothalamic TNF-α expression, but does not affect the equivalent changes in the serum levels of luteinizing hormone and testosterone, in adult male rats. Intern J Develop Neurosci. 2016;48:80–3. doi:10.1016/j.ijdevneu.2015.12.001.
  • Reis L, Oliveira MK, Rojas VCT, et al. Curcumin attenuates LPS-induced sickness behavior and fever in rats by modulating Nrf2 activity. Neurosci Lett. 2022;781:136680), doi:10.1016/j.neulet.2022.136680.
  • Paxinos G, Watson C. The Rat Brain in stereotaxic coordinates. 6th ed San Diego: Academic Press; 2006.
  • Engelbregt MJT, van Weissenbruch MM, Lips P, et al. Body composition and bone measurements in intra-uterine growth retarded and early postnatally undernourished male and female rats at the age of 6 months: Comparison with puberty. Bone. 2004;34:180–6. doi:10.1016/j.bone.2003.04.001.
  • Iwasa T, Matsuzaki T, Tungalagsuvd A, et al. Prenatal undernutrition increases the febrile response to lipopolysaccharides in adulthood in male rats. Intern J Develop Neurosci. 2015;44:1–5. doi:10.1016/j.ijdevneu.2015.04.004.
  • Gayle DA, Beloosesky R, Desai M, et al. Maternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain. Am J Physiol Regul Integr Comp Physiol. 2004;286:R1024–R1029. doi:10.1152/ajpregu.00664.2003.
  • Layé S, Gheusi G, Cremona S, et al. Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression. Am J Physiol Regul Integr Comp Physiol. 2000;279:R93–R98. doi:10.1152/ajpregu.2000.279.1.R93.
  • Chisari AN, Giovambattista A, Perelló M, et al. Maternal undernutrition induces neuroendocrine immune dysfunction in male pups at weaning. Neuroimmunomodulation. 2001;9:41–8. doi:10.1159/000049006.
  • Desai M, Gayle DA, Casillas E, et al. Early undernutrition attenuates the inflammatory response in adult rat offspring. J Matern Fetal Neonatal Med. 2009;22:571–5. doi:10.1080/14767050902874105.
  • Romanovsky AA, Kulchitsky VA, Akulich Nv, et al. First and second phases of biphasic fever: two sequential stages of the sickness syndrome? Am J Physiol. 1996;271:R244–R253.
  • Davidowa H, Li Y, Plagemann A. Altered responses to orexigenic (AGRP, MCH) and anorexigenic (α-MSH, CART) neuropeptides of paraventricular hypothalamic neurons in early postnatally overfed rats. Eur J Neurosci. 2003;18:613–21. doi:10.1046/j.1460-9568.2003.02789.x.
  • Liu Y, Huang Y, Liu T, et al. Lipopolysacharide rapidly and completely suppresses AgRP neuron-mediated food intake in male mice. Endocrinology. 2016;157:2380–92. doi:10.1210/en.2015-2081.
  • Bellinger LL, Bernardis LL. The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: Lessons learned from lesioning studies. Physiol Behav. 2002;76:431–42. doi:10.1016/S0031-9384(02)00756-4.
  • Jeong JH, Lee DK, Jo YH. Cholinergic neurons in the dorsomedial hypothalamus regulate food intake. Mol Metab. 2017;6:306–12. doi:10.1016/j.molmet.2017.01.001.
  • Paxinos G, Watson C. The rat brain, in stereotaxic coordinates. Academic Press; 1997.

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