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Reviews

Polyphenols in edible herbal medicine: targeting gut-brain interactions in depression-associated neuroinflammation

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Pages 12207-12223 | Published online: 15 Jul 2022

References

  • Akao, T., K. Kawabata, E. Yanagisawa, K. Ishihara, Y. Mizuhara, Y. Wakui, Y. Sakashita, and K. Kobashi. 2000. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. The Journal of Pharmacy and Pharmacology 52 (12):1563–8. doi: 10.1211/0022357001777621.
  • Alam, M., S. Ali, G. M. Ashraf, A. L. Bilgrami, D. K. Yadav, and M. I. Hassan. 2022. Epigallocatechin 3-gallate: From green tea to cancer therapeutics. Food Chemistry 379 (379):132135. doi: 10.1016/j.foodchem.2022.132135.
  • Almudhi, A, and S. A. Gabr. 2022. Green tea consumption and the management of adrenal stress hormones in adolescents who stutter. Biomedical Reports 16 (4):32. doi: 10.3892/br.2022.1515.
  • Amaretti, A., S. Raimondi, A. Leonardi, A. Quartieri, and M. Rossi. 2015. Hydrolysis of the rutinose-conjugates flavonoids rutin and hesperidin by the gut microbiota and bifidobacteria. Nutrients 7 (4):2788–800. doi: 10.3390/nu7042788.
  • Baune, B. T. 2017. Are non-steroidal anti-inflammatory drugs clinically suitable for the treatment of symptoms in depression-associated inflammation? Current Topics in Behavioral Neurosciences 31:303–19. doi: 10.1007/7854_2016_19.
  • Bedel, H. A., C. Kencebay Manas, G. Özbey, and C. Usta. 2018. The antidepressant-like activity of ellagic acid and its effect on hippocampal brain derived neurotrophic factor levels in mouse depression models. Natural Product Research 32 (24):2932–5. doi: 10.1080/14786419.2017.1385021.
  • Bharti, R., B. S. Chopra, S. Raut, and N. Khatri. 2020. Pueraria tuberosa: A review on traditional uses, pharmacology, and phytochemistry. Frontiers in Pharmacology 11:582506. doi: 10.3389/fphar.2020.582506.
  • Blake, C., K. M. Fabick, K. D. Setchell, T. D. Lund, and E. D. Lephart. 2011. Neuromodulation by soy diets or equol: Anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects. BMC Neuroscience 12 (12):28. doi: 10.1186/1471-2202-12-28.
  • Bohn, T. 2014. Dietary factors affecting polyphenol bioavailability. Nutrition Reviews 72 (7):429–52. doi: 10.1111/nure.12114.
  • Braune, A., M. Gütschow, W. Engst, and M. Blaut. 2001. Degradation of quercetin and luteolin by Eubacterium ramulus. Applied and Environmental Microbiology 67 (12):5558–67. doi: 10.1128/AEM.67.12.5558-5567.2001.
  • Brites, D, and A. Fernandes. 2015. Neuroinflammation and depression: Microglia activation, extracellular microvesicles and microRNA dysregulation. Frontiers in Cellular Neuroscience 9 (9):476. doi: 10.3389/fncel.2015.00476.
  • Caviedes, A., C. Lafourcade, C. Soto, and U. Wyneken. 2017. BDNF/NF-κB signaling in the neurobiology of depression. Current Pharmaceutical Design 23 (21):3154–63. doi: 10.2174/1381612823666170111141915.
  • Chaudhary, A., V. S. Jaswal, S. Choudhary, Sonika, A. Sharma, V. Beniwal, H. S. Tuli, and S. Sharma. 2019. Ferulic acid: A promising therapeutic phytochemical and recent patents advances. Recent Patents on Inflammation & Allergy Drug Discovery 13 (2):115–23. doi: 10.2174/1872213X13666190621125048.
  • Chen, C., T. Li, Z. Chen, L. Wang, and X. Luo. 2020. Absorption Rates and mechanisms of avenanthramides in a Caco-2 Cell model and their antioxidant activity during absorption. Journal of Agricultural and Food Chemistry 68 (8):2347–56. doi: 10.1021/acs.jafc.9b06576.
  • Chen, L., X. Wang, Y. Zhang, H. Zhong, C. Wang, P. Gao, and B. Li. 2021. Daidzein alleviates hypothalamic-pituitary-adrenal axis hyperactivity, ameliorates depression-like behavior, and partly rectifies circulating cytokine imbalance in two rodent models of depression. Frontiers in Behavioral Neuroscience 15:671864. doi: 10.3389/fnbeh.2021.671864.
  • Chen, C., Q. Yin, J. Tian, X. Gao, X. Qin, G. Du, and Y. Zhou. 2020. Studies on the potential link between antidepressant effect of Xiaoyao San and its pharmacological activity of hepatoprotection based on multi-platform metabolomics. Journal of Ethnopharmacology 249 (249):112432. doi: 10.1016/j.jep.2019.112432.
  • Chen, Z., C. Zhang, F. Gao, Q. Fu, C. Fu, Y. He, and J. Zhang. 2018. A systematic review on the rhizome of Ligusticum chuanxiong Hort. (Chuanxiong). Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 119 (119):309–25. doi: 10.1016/j.fct.2018.02.050.
  • Cho, J. 2006. Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin. Archives of Pharmacal Research 29 (8):699–706. doi: 10.1007/BF02968255.
  • Ciesarová, Z., M. Murkovic, K. Cejpek, F. Kreps, B. Tobolková, R. Koplík, E. Belajová, K. Kukurová, Ľ. Daško, Z. Panovská, et al. 2020. Why is sea buckthorn (Hippophae rhamnoides L.) so exceptional? A review. Food Research International (Ottawa, Ont.) 133 (133):109170. doi: 10.1016/j.foodres.2020.109170.
  • Dai, J. Y., J. L. Yang, and C. Li. 2008. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers. Acta Pharmacologica Sinica 29 (9):1086–93. doi: 10.1111/j.1745-7254.2008.00850.x.
  • D’Amelio, M., V. Cavallucci, S. Middei, C. Marchetti, S. Pacioni, A. Ferri, A. Diamantini, D. De Zio, P. Carrara, L. Battistini, et al. 2011. Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer’s disease. Nature Neuroscience 14 (1):69–76. doi: 10.1038/nn.2709.
  • DaSilva, N. A., P. P. Nahar, H. Ma, A. Eid, Z. Wei, S. Meschwitz, N. H. Zawia, A. L. Slitt, and N. P. Seeram. 2019. Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro. Nutritional Neuroscience 22 (3):185–95. doi: 10.1080/1028415X.2017.1360558.
  • De Munter, J., D. Pavlov, A. Gorlova, M. Sicker, A. Proshin, A. V. Kalueff, A. Svistunov, D. Kiselev, A. Nedorubov, S. Morozov, et al. 2021. Increased Oxidative stress in the prefrontal cortex as a shared feature of depressive- and PTSD-like syndromes: Effects of a standardized herbal antioxidant. Frontiers in Nutrition 8 (8):661455. doi: 10.3389/fnut.2021.661455.
  • Dionisie, V., G. A. Filip, M. C. Manea, M. Manea, and S. Riga. 2021. The anti-inflammatory role of SSRI and SNRI in the treatment of depression: A review of human and rodent research studies. Inflammopharmacology 29 (1):75–90. doi: 10.1007/s10787-020-00777-5.
  • Dong, X., Y. Gu, S. Rayamajhi, A. Thapa, G. Meng, Q. Zhang, L. Liu, H. Wu, S. Zhang, T. Zhang, et al. 2022. Green tea consumption and risk of depressive symptoms: Results from the TCLSIH Cohort Study. Journal of Affective Disorders 310 (310):183–8. doi: 10.1016/j.jad.2022.04.112.
  • Donoso, F., S. Egerton, T. F. S. Bastiaanssen, P. Fitzgerald, S. Gite, F. Fouhy, R. P. Ross, C. Stanton, T. G. Dinan, and J. F. Cryan. 2020. Polyphenols selectively reverse early-life stress-induced behavioural, neurochemical and microbiota changes in the rat. Psychoneuroendocrinology 116:104673. doi: 10.1016/j.psyneuen.2020.104673.
  • Du, H. X., X. G. Chen, L. Zhang, Y. Liu, C. S. Zhan, J. Chen, Y. Zhang, Z. Q. Yu, J. Zhang, H. Y. Yang, et al. 2019. Microglial activation and neurobiological alterations in experimental autoimmune prostatitis-induced depressive-like behavior in mice. Neuropsychiatric Disease and Treatment 15 (15):2231–45. doi: 10.2147/NDT.S211288.
  • Eghbali, S., S. F. Askari, R. Avan, and A. Sahebkar. 2021. Therapeutic effects of Punica granatum (pomegranate): An updated review of clinical trials. Journal of Nutrition and Metabolism 2021 (2021):5297162. doi: 10.1155/2021/5297162.
  • Elumalai, P, and S. Lakshmi. 2016. Role of quercetin benefits in neurodegeneration. Advances in Neurobiology 12:229–45. doi: 10.1007/978-3-319-28383-8_12.
  • Enayati, M., B. Mosaferi, J. R. Homberg, D. M. Diniz, and A. A. Salari. 2020. Prenatal maternal stress alters depression-related symptoms in a strain- and sex-dependent manner in rodent offspring. Life Sciences 251:117597. doi: 10.1016/j.lfs.2020.117597.
  • Espín, J. C., M. Larrosa, M. T. García-Conesa, and F. Tomás-Barberán. 2013. Biological significance of urolithins, the gut microbial ellagic acid-derived metabolites: The evidence so far. Evidence-Based Complementary and Alternative Medicine: eCAM 2013:270418. doi: 10.1155/2013/270418.
  • Fang, K., H. R. Li, X. X. Chen, X. R. Gao, L. L. Huang, A. Q. Du, C. Jiang, H. Li, and J. F. Ge. 2020. Corrigendum: quercetin alleviates LPS-induced depression-like behavior in rats via regulating BDNF-related imbalance of Copine 6 and TREM1/2 in the hippocampus and PFC. Frontiers in Pharmacology 11 (11):518. doi: 10.3389/fphar.2020.00518.
  • Fan, C., Y. Li, T. Lan, W. Wang, X. Mao, and S. Y. Yu. 2021. Prophylactic treatment of curcumin in a rat model of depression by attenuating hippocampal synaptic loss. Food & Function 12 (22):11202–13. doi: 10.1039/d1fo02676c.
  • Fan, C., Q. Song, P. Wang, Y. Li, M. Yang, and S. Y. Yu. 2018. Neuroprotective effects of curcumin on IL-1β-induced neuronal apoptosis and depression-like behaviors caused by chronic stress in rats. Frontiers in Cellular Neuroscience 12 (12):516. doi: 10.3389/fncel.2018.00516.
  • Fraga, C. G., K. D. Croft, D. O. Kennedy, and F. A. Tomás-Barberán. 2019. The effects of polyphenols and other bioactives on human health. Food & Function 10 (2):514–28. doi: 10.1039/c8fo01997e.
  • Francis, H. M., R. J. Stevenson, J. R. Chambers, D. Gupta, B. Newey, and C. K. Lim. 2019. A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial. Plos One 14 (10):e222768. doi: 10.1371/journal.pone.0222768.
  • Frost, J. L, and D. P. Schafer. 2016. Microglia: Architects of the developing nervous system. Trends in Cell Biology 26 (8):587–97. doi: 10.1016/j.tcb.2016.02.006.
  • Fu, X., J. Jiao, T. Qin, J. Yu, Q. Fu, X. Deng, S. Ma, and Z. Ma. 2021. A new perspective on ameliorating depression-like behaviors: Suppressing neuroinflammation by upregulating PGC-1α. Neurotoxicity Research 39 (3):872–85. doi: 10.1007/s12640-020-00292-z.
  • Fu, H., L. Liu, Y. Tong, Y. Li, X. Zhang, X. Gao, J. Yong, J. Zhao, D. Xiao, K. Wen, et al. 2019. The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice. European Journal of Pharmacology 853 (15):236–46. 853:doi: 10.1016/j.ejphar.2019.03.035.
  • Fusar-Poli, L., L. Vozza, A. Gabbiadini, A. Vanella, I. Concas, S. Tinacci, A. Petralia, M. S. Signorelli, and E. Aguglia. 2020. Curcumin for depression: A meta-analysis. Critical Reviews in Food Science and Nutrition 60 (15):2643–53. doi: 10.1080/10408398.2019.1653260.
  • Gao, L., J. Li, Y. Zhou, X. Huang, X. Qin, and G. Du. 2018. Effects of baicalein on cortical proinflammatory cytokines and the intestinal microbiome in senescence accelerated mouse prone 8. ACS Chemical Neuroscience 9 (7):1714–24. doi: 10.1021/acschemneuro.8b00074.
  • Gaya, P., Á. Peirotén, M. Medina, I. Álvarez, and J. M. Landete. 2018. Bifidobacterium pseudocatenulatum INIA P815: The first bacterium able to produce urolithins A and B from ellagic acid. Journal of Functional Foods 45:95–9. doi: 10.1016/j.jff.2018.03.040.
  • Ge, S., L. Duo, J. Wang, J. Yang, Z. Li, and Y. Tu. 2021. A unique understanding of traditional medicine of pomegranate, Punica granatum L. and its current research status. Journal of Ethnopharmacology 271 (271):113877. doi: 10.1016/j.jep.2021.113877.
  • Gerhard, D. M., E. S. Wohleb, and R. S. Duman. 2016. Emerging treatment mechanisms for depression: Focus on glutamate and synaptic plasticity. Drug Discovery Today 21 (3):454–64. doi: 10.1016/j.drudis.2016.01.016.
  • Giménez-Bastida, J. A., P. Truchado, M. Larrosa, J. C. Espín, F. A. Tomás-Barberán, A. Allende, and M. T. García-Conesa. 2012. Urolithins, ellagitannin metabolites produced by colon microbiota, inhibit quorum sensing in Yersinia enterocolitica: Phenotypic response and associated molecular changes. Food Chemistry 132 (3):1465–74. doi: 10.1016/j.foodchem.2011.12.003.
  • Gu, Z., L. Chu, and Y. Han. 2019. Therapeutic effect of resveratrol on mice with depression. Experimental and Therapeutic Medicine 17 (4):3061–4. doi: 10.3892/etm.2019.7311.
  • Guan, T., C. Cao, Y. Hou, Y. Li, X. Wei, S. Li, S. Jia, and X. Zhao. 2021. Effects of quercetin on the alterations of serum elements in chronic unpredictable mild stress-induced depressed rats. Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine 34 (3):589–602. doi: 10.1007/s10534-021-00298-w.
  • Guo, L. T., S. Q. Wang, J. Su, L. X. Xu, Z. Y. Ji, R. Y. Zhang, Q. W. Zhao, Z. Q. Ma, X. Y. Deng, and S. P. Ma. 2019. Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway. Journal of Neuroinflammation 16 (1):95. doi: 10.1186/s12974-019-1474-8.
  • Gupta, A., A. K. Singh, R. Kumar, S. Jamieson, A. K. Pandey, and A. Bishayee. 2021. Neuroprotective potential of ellagic acid: A critical review. Advances in Nutrition (Bethesda, Md.) 12 (4):1211–38. doi: 10.1093/advances/nmab007.
  • Habtemariam, S. 2017. Protective effects of caffeic acid and the Alzheimer’s brain: An update. Mini Reviews in Medicinal Chemistry 17 (8):667–74. doi: 10.2174/1389557516666161130100947.
  • Hao, W. Z., Q. Chen, L. Wang, G. Tao, H. Gan, L. J. Deng, J. Q. Huang, and J. X. Chen. 2022. Emerging roles of long non-coding RNA in depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry 115 (115):110515. doi: 10.1016/j.pnpbp.2022.110515.
  • Hao, W. Z., X. J. Li, P. W. Zhang, and J. X. Chen. 2020. A review of antibiotics, depression, and the gut microbiome. Psychiatry Research 284:112691. doi: 10.1016/j.psychres.2019.112691.
  • Hao, W. Z., Q. Y. Ma, G. Tao, J. Q. Huang, and J. X. Chen. 2021. Oral coniferyl ferulate attenuated depression symptoms in mice via reshaping gut microbiota and microbial metabolism. Food & Function 12 (24):12550–64. doi: 10.1039/d1fo02655k.
  • Hao, W., J. Wu, N. Yuan, L. Gong, J. Huang, Q. Ma, H. Zhu, H. Gan, X. Da, L. Deng, et al. 2021. Xiaoyaosan improves antibiotic-induced depressive-like and anxiety-like behavior in mice through modulating the gut microbiota and regulating the NLRP3 inflammasome in the colon. Frontiers in Pharmacology 12:619103. doi: 10.3389/fphar.2021.619103.
  • Hassaninasab, A., Y. Hashimoto, K. Tomita-Yokotani, and M. Kobayashi. 2011. Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proceedings of the National Academy of Sciences of the United States of America 108 (16):6615–20. doi: 10.1073/pnas.1016217108.
  • He, H., S. Peng, X. Song, R. Jia, Y. Zou, L. Li, and Z. Yin. 2022. Protective effect of isoflavones and triterpenoid saponins from pueraria lobata on liver diseases: A review. Food Science & Nutrition 10 (1):272–85. doi: 10.1002/fsn3.2668.
  • Hook, I. L. 2014. Danggui to Angelica sinensis root: Are potential benefits to European women lost in translation? A review. Journal of Ethnopharmacology 152 (1):1–13. doi: 10.1016/j.jep.2013.12.018.
  • Hoshino, Y., S. Machmudah, S. Hirayama, H. Kanda, M. Hoshino, and M. Goto. 2022. Extraction of Functional components from freeze-dried Angelica furcijuga leaves using supercritical carbon dioxide. ACS Omega 7 (6):5104–11. doi: 10.1021/acsomega.1c06105.
  • Huang, T., Y. Liu, and C. Zhang. 2019. Pharmacokinetics and bioavailability enhancement of baicalin: A review. European Journal of Drug Metabolism and Pharmacokinetics 44 (2):159–68. doi: 10.1007/s13318-018-0509-3.
  • Jang, H. M., H. J. Lee, S. E. Jang, M. J. Han, and D. H. Kim. 2018. Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice. Mucosal Immunology 11 (5):1386–97. doi: 10.1038/s41385-018-0042-3.
  • Jarosova, V., O. Vesely, I. Doskocil, K. Tomisova, P. Marsik, J. D. Jaimes, K. Smejkal, P. Kloucek, and J. Havlik. 2020. Metabolism of cis- and trans-resveratrol and dihydroresveratrol in an intestinal epithelial model. Nutrients 12 (3):595. doi: 10.3390/nu12030595.
  • Ji, Y., X. Lang, W. Wang, S. Li, C. Zhao, X. Shen, T. Zhang, and H. Ye. 2021. Lactobacillus paracasei ameliorates cognitive impairment in high-fat induced obese mice via insulin signaling and neuroinflammation pathways. Food & Function 12 (18):8728–37. doi: 10.1039/D1FO01320C.
  • Jia, X., Z. Gao, and H. Hu. 2021. Microglia in depression: Current perspectives. Science China. Life Sciences 64 (6):911–25. doi: 10.1007/s11427-020-1815-6.
  • Jiang, M., Z. Li, and G. Zhu. 2020. Immunological regulatory effect of flavonoid baicalin on innate immune toll-like receptors. Pharmacological Research 158:104890. doi: 10.1016/j.phrs.2020.104890.
  • Johnson, S. L., R. D. Kirk, N. A. DaSilva, H. Ma, N. P. Seeram, and M. J. Bertin. 2019. Polyphenol microbial metabolites exhibit gut and blood-brain barrier permeability and protect murine microglia against LPS-induced inflammation. Metabolites 9 (4):78. doi: 10.3390/metabo9040078.
  • Jones, B. D., Z. J. Daskalakis, A. F. Carvalho, R. Strawbridge, A. H. Young, B. H. Mulsant, and M. I. Husain. 2020. Inflammation as a treatment target in mood disorders. BJPsych Open 6 (4):60. doi: 10.1192/bjo.2020.43.
  • Kang, S. H., T. H. Kim, K. C. Shin, Y. J. Ko, and D. K. Oh. 2019. Biotransformation of food-derived saponins, platycosides, into deglucosylated saponins including deglucosylated platycodin D and their anti-inflammatory activities. Journal of Agricultural and Food Chemistry 67 (5):1470–7. doi: 10.1021/acs.jafc.8b06399.
  • Kim, M., E. N. Marsh, S. U. Kim, and J. Han. 2010. Conversion of (3S,4R)-tetrahydrodaidzein to (3S)-equol by THD reductase: Proposed mechanism involving a radical intermediate. Biochemistry 49 (26):5582–7. doi: 10.1021/bi100465y.
  • Kocaadam, B, and N. Şanlier. 2017. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical Reviews in Food Science and Nutrition 57 (13):2889–95. doi: 10.1080/10408398.2015.1077195.
  • Köhler-Forsberg, O. N. C. Lydholm, C. Hjorthøj, M. Nordentoft, O. Mors, and M. E. Benros. 2019. Efficacy of anti‐inflammatory treatment on major depressive disorder or depressive symptoms: Meta‐analysis of clinical trials. Acta Psychiatrica Scandinavica 139 (5):404–19. doi: 10.1111/acps.13016.
  • Kosari-Nasab, M., G. Shokouhi, A. Ghorbanihaghjo, M. M. Abbasi, and A. A. Salari. 2018. Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury. Life Sciences 213 (15)213::198–205. doi: 10.1016/j.lfs.2018.10.040.
  • Kwatra, M., S. Ahmed, B. Gawali, S. R. Panda, and V. Naidu. 2020. Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: Role of TLR4/NF-κB, p38 MAPK/JNK, Nrf2/ARE signaling. Neurochemistry International 140 (140):104835. doi: 10.1016/j.neuint.2020.104835.
  • Kwon, C. Y., H. W. Suh, J. W. Kim, and S. Y. Chung. 2022. Anti-anger effects of herbal medicine: A mini-review of rat studies. Chinese Journal of Integrative Medicine 28 (3):263–71. doi: 10.1007/s11655-022-3506-3.
  • Lavefve, L., L. R. Howard, and F. Carbonero. 2020. Berry polyphenols metabolism and impact on human gut microbiota and health. Food & Function 11 (1):45–65. 29doi: 10.1039/c9fo01634a.
  • Lee, B., I. Shim, H. Lee, and D. H. Hahm. 2018. Effects of Epigallocatechin Gallate on behavioral and cognitive impairments, hypothalamic-pituitary-adrenal axis dysfunction, and alternations in Hippocampal BDNF expression under single prolonged stress. Journal of Medicinal Food 21 (10):979–89. doi: 10.1089/jmf.2017.4161.
  • Leulier, F., L. T. MacNeil, W.-J. Lee, J. F. Rawls, P. D. Cani, M. Schwarzer, L. Zhao, and S. J. Simpson. 2017. Integrative physiology: At the crossroads of nutrition, microbiota, animal physiology, and human health. Cell Metabolism 25 (3):522–34. doi: 10.1016/j.cmet.2017.02.001.
  • Li, M., X. Cui, L. Jin, M. Li, and J. Wei. 2022. Bolting reduces ferulic acid and flavonoid biosynthesis and induces root lignification in Angelica sinensis. Plant Physiology and Biochemistry : PPB 170:171–9. doi: 10.1016/j.plaphy.2021.12.005.
  • Li, C., B. Huang, and Y. W. Zhang. 2021. Chinese herbal medicine for the treatment of depression: effects on the neuroendocrine-immune network. Pharmaceuticals 14 (1):65. doi: 10.3390/ph14010065.
  • Li, F., S. Qasim, D. Li, and Q. P. Dou. 2022. Updated review on green tea polyphenol epigallocatechin-3-gallate as a cancer epigenetic regulator. Seminars in Cancer Biology 83:335–52. doi: 10.1016/j.semcancer.2020.11.018.
  • Li, M., H. Shao, X. Zhang, and B. Qin. 2016. Hesperidin alleviates lipopolysaccharide-induced neuroinflammation in mice by promoting the miRNA-132 pathway. Inflammation 39 (5):1681–9. doi: 10.1007/s10753-016-0402-7.
  • Liu, X., X. Li, S. Ji, X. Cui, and M. Li. 2016. Screening of bioactive ingredients in Ligusticum Chuanxiong Hort for protection against Myocardial Ischemia. Cellular Physiology and Biochemistry : international Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 40 (3-4):770–80. doi: 10.1159/000453137.
  • Liu, X, and C. Liu. 2017. Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex. International Immunopharmacology 48 (48):30–4. doi: 10.1016/j.intimp.2017.04.019.
  • Liu, X., C. Liu, J. Tian, X. Gao, K. Li, G. Du, and X. Qin. 2020. Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique. Journal of Ethnopharmacology 246:112219. doi: 10.1016/j.jep.2019.112219.
  • Liu, T., Y. Ma, R. Zhang, H. Zhong, L. Wang, J. Zhao, L. Yang, and X. Fan. 2019. Resveratrol ameliorates estrogen deficiency-induced depression- and anxiety-like behaviors and hippocampal inflammation in mice. Psychopharmacology 236 (4):1385–99. doi: 10.1007/s00213-018-5148-5.
  • Liu, Y. M., J. D. Shen, L. P. Xu, H. B. Li, Y. C. Li, and L. T. Yi. 2017. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress. International Immunopharmacology 45:128–34. doi: 10.1016/j.intimp.2017.02.007.
  • Liu, J. J., Y. B. Wei, R. Strawbridge, Y. Bao, S. Chang, L. Shi, J. Que, B. S. Gadad, M. H. Trivedi, J. R. Kelsoe, et al. 2020. Peripheral cytokine levels and response to antidepressant treatment in depression: A systematic review and meta-analysis. Molecular Psychiatry 25 (2):339–50. doi: 10.1038/s41380-019-0474-5.
  • Li, F., K. Zhang, M. Yu, T. Chen, L. Ma, H. Zhang, H. Jia, and Z. Zou. 2021. Antidepressant-like effect and phytochemical profile of supercritical CO2 extract from Citri reticulatae pericarpium. Die Pharmazie 76 (6):249–55. doi: 10.1691/ph.2021.1408.
  • Lu, C., R. Gao, Y. Zhang, N. Jiang, Y. Chen, J. Sun, Q. Wang, B. Fan, X. Liu, and F. Wang. 2021. S-equol, a metabolite of dietary soy isoflavones, alleviates lipopolysaccharide-induced depressive-like behavior in mice by inhibiting neuroinflammation and enhancing synaptic plasticity. Food & Function 12 (13):5770–8. doi: 10.1039/d1fo00547b.
  • Ma, B. N, and X. J. Li. 2020. Resveratrol extracted from Chinese herbal medicines: A novel therapeutic strategy for lung diseases. Chinese Herbal Medicines 12 (4):349–58. doi: 10.1016/j.edible. herbal medicineed.2020.07.003.
  • Maiti, P., J. Manna, J. Thammathong, B. Evans, K. D. Dubey, S. Banerjee, and G. L. Dunbar. 2021. Tetrahydrocurcumin has similar anti-amyloid properties as curcumin: in vitro comparative structure-activity studies. Antioxidants (Basel) 10 (10):1592. doi: 10.3390/antiox10101592.
  • Makris, A. P., M. Karianaki, K. I. Tsamis, and S. A. Paschou. 2021. The role of the gut-brain axis in depression: Endocrine, neural, and immune pathways. Hormones (Athens, Greece) 20 (1):1–12. doi: 10.1007/s42000-020-00236-4.
  • Mantzorou, M., E. Pavlidou, G. Vasios, E. Tsagalioti, and C. Giaginis. 2018. Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data. Phytotherapy Research: PTR 32 (6):957–75. doi: 10.1002/ptr.6037.
  • Mao, Q., Z. Huang, S. Ip, and C. Che. 2008. Antidepressant‐like effect of ethanol extract from Paeonia lactiflora in mice. Phytotherapy Research : PTR 22 (11):1496–9. doi: 10.1002/ptr.2519.
  • Mehta, V., A. Parashar, and M. Udayabanu. 2017. Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress. Physiology & Behavior 171:69–78. doi: 10.1016/j.physbeh.2017.01.006.
  • Meng, X., J. Zhou, C. N. Zhao, R. Y. Gan, and H. B. Li. 2020. Health benefits and molecular mechanisms of resveratrol: A narrative review. Foods 9 (3):340. doi: 10.3390/foods9030340.
  • Milenkovic, V. M., E. H. Stanton, C. Nothdurfter, R. Rupprecht, and C. H. Wetzel. 2019. The role of chemokines in the pathophysiology of major depressive disorder. International Journal of Molecular Sciences 20 (9):2283. doi: 10.3390/ijms20092283.
  • Moore, A., J. Beidler, and M. Y. Hong. 2018. Resveratrol and depression in animal models: A systematic review of the biological mechanisms. Molecules 23 (9):2197. doi: 10.3390/molecules23092197.
  • Olcha, P., A. Winiarska-Mieczan, M. Kwiecień, Ł. Nowakowski, A. Miturski, A. Semczuk, B. Kiczorowska, and K. Gałczyński. 2022. Antioxidative, anti-inflammatory, anti-obesogenic, and antidiabetic properties of tea polyphenols-the positive impact of regular tea consumption as an element of prophylaxis and pharmacotherapy support in endometrial cancer. International Journal of Molecular Sciences 23 (12):6703. doi: 10.3390/ijms23126703.
  • Parhiz, H., A. Roohbakhsh, F. Soltani, R. Rezaee, and M. Iranshahi. 2015. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models. Phytotherapy Research : PTR 29 (3):323–31. doi: 10.1002/ptr.5256.
  • Park, H. Y., M. Kim, and J. Han. 2011. Stereospecific microbial production of isoflavanones from isoflavones and isoflavone glucosides. Applied Microbiology and Biotechnology 91 (4):1173–81. doi: 10.1007/s00253-011-3310-7.
  • Park, H. J., H. S. Shim, K. An, A. Starkweather, K. S. Kim, and I. Shim. 2015. IL-4 inhibits IL-1β-induced depressive-like behavior and central neurotransmitter alterations. Mediators of Inflammation 2015:941413. doi: 10.1155/2015/941413.
  • Pervin, M., K. Unno, A. Nakagawa, Y. Takahashi, K. Iguchi, H. Yamamoto, M. Hoshino, A. Hara, A. Takagaki, F. Nanjo, et al. 2017. Blood brain barrier permeability of (-)-epigallocatechin gallate, its proliferation-enhancing activity of human neuroblastoma SH-SY5Y cells, and its preventive effect on age-related cognitive dysfunction in mice. Biochemistry and Biophysics Reports 9:180–6. doi: 10.1016/j.bbrep.2016.12.012.
  • Petralia, M. C., E. Mazzon, P. Fagone, M. S. Basile, V. Lenzo, M. C. Quattropani, S. Di Nuovo, K. Bendtzen, and F. Nicoletti. 2020. The cytokine network in the pathogenesis of major depressive disorder. Close to translation? Autoimmunity Reviews 19 (5):102504. doi: 10.1016/j.autrev.2020.102504.
  • Pitsillou, E., S. M. Bresnehan, E. A. Kagarakis, S. J. Wijoyo, J. Liang, A. Hung, and T. C. Karagiannis. 2020. The cellular and molecular basis of major depressive disorder: Towards a unified model for understanding clinical depression. Molecular Biology Reports 47 (1):753–70. doi: 10.1007/s11033-019-05129-3.
  • Prasad, S., S. Gupta, A. Tyagi, and B. Aggarwal. 2014. Curcumin, a component of golden spice: From bedside to bench and back. Biotechnology Advances 32 (6):1053–64. doi: 10.1016/j.biotechadv.2014.04.004.
  • Pundir, S., P. Garg, A. Dviwedi, A. Ali, V. K. Kapoor, D. Kapoor, S. Kulshrestha, U. R. Lal, and P. Negi. 2021. Ethnomedicinal uses, phytochemistry and dermatological effects of Hippophae rhamnoides L.: A review. Journal of Ethnopharmacology 266:113434. doi: 10.1016/j.jep.2020.113434.
  • Rai, S. N., H. Dilnashin, H. Birla, S. S. Singh, W. Zahra, A. S. Rathore, B. K. Singh, and S. P. Singh. 2019. The role of PI3K/Akt and ERK in neurodegenerative disorders. Neurotoxicity Research 35 (3):775–95. doi: 10.1007/s12640-019-0003-y.
  • Raimundo, A. F., S. Ferreira, F. A. Tomás-Barberán, C. N. Santos, and R. Menezes. 2021. Urolithins: Diet-derived bioavailable metabolites to tackle diabetes. Nutrients 13 (12):4285. doi: 10.3390/nu13124285.
  • Ramaholimihaso, T., F. Bouazzaoui, and A. Kaladjian. 2020. Curcumin in depression: Potential mechanisms of action and current evidence-a narrative review. Frontiers in Psychiatry 11:572533. doi: 10.3389/fpsyt.2020.572533.
  • Ren, L, and G. Chen. 2017. Rapid antidepressant effects of Yueju: A new look at the function and mechanism of an old herbal medicine. Journal of Ethnopharmacology 203:226–32. doi: 10.1016/j.jep.2017.03.042.
  • Rinwa, P, and A. Kumar. 2013. Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats. Neuroscience 255:86–98. doi: 10.1016/j.neuroscience.2013.09.044.
  • Rommel, A, and R. E. Wrolstad. 1993. Ellagic acid content of red raspberry juice as influenced by cultivar, processing, and environmental factors. Journal of Agricultural and Food Chemistry 41 (11):1951–60. doi: 10.1021/jf00035a026.
  • Rudzki, L, and M. Maes. 2020. The microbiota-gut-immune-glia (MGIG) axis in major depression. Molecular Neurobiology 57 (10):4269–95. doi: 10.1007/s12035-020-01961-y.
  • Sakamoto, S., X. Zhu, Y. Hasegawa, S. Karma, M. Obayashi, E. Alway, and A. Kamiya. 2021. Inflamed brain: Targeting immune changes and inflammation for treatment of depression. Psychiatry and Clinical Neurosciences 75 (10):304–11. doi: 10.1111/pcn.13286.
  • Selma, M. V., D. Beltrán, R. García-Villalba, J. C. Espín, and F. A. Tomás-Barberán. 2014. Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species. Food & Function 5 (8):1779–84. doi: 10.1039/c4fo00092g.
  • Selma, M. V., J. C. Espin, and F. A. Tomas-Barberan. 2009. Interaction between phenolics and gut microbiota: Role in human health. Journal of Agricultural and Food Chemistry 57 (15):6485–501. doi: 10.1021/jf902107d.
  • Serra, H., T. Mendes, M. R. Bronze, and A. L. Simplício. 2008. Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones. Bioorganic & Medicinal Chemistry 16 (7):4009–18. doi: 10.1016/j.bmc.2008.01.028.
  • Shen, L, and H. F. Ji. 2018. Reciprocal interactions between resveratrol and gut microbiota deepen our understanding of molecular mechanisms underlying its health benefits. Trends in Food Science & Technology 81:232–6. doi: 10.1016/j.tifs.2018.09.026.
  • Shen, J., C. Qu, L. Xu, H. Sun, and J. Zhang. 2019. Resveratrol exerts a protective effect in chronic unpredictable mild stress-induced depressive-like behavior: Involvement of the AKT/GSK3β signaling pathway in hippocampus. Psychopharmacology 236 (2):591–602. doi: 10.1007/s00213-018-5087-1.
  • Singh, T., T. Kaur, and R. K. Goel. 2017. Ferulic acid supplementation for management of depression in epilepsy. Neurochemical Research 42 (10):2940–8. doi: 10.1007/s11064-017-2325-6.
  • Sowndhararajan, K., P. Deepa, M. Kim, S. J. Park, and S. Kim. 2018. Neuroprotective and cognitive enhancement potentials of baicalin: A review. Brain Sciences 8 (6):104. doi: 10.3390/brainsci8060104.
  • Su, W.-J., Y. Zhang, Y. Chen, H. Gong, Y.-J. Lian, W. Peng, Y.-Z. Liu, Y.-X. Wang, Z.-L. You, S.-J. Feng, et al. 2017. NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model. Behavioural Brain Research 322 (Pt A):1–8. doi: 10.1016/j.bbr.2017.01.018.
  • Swann, O. G., M. Kilpatrick, M. Breslin, and W. H. Oddy. 2020. Dietary fiber and its associations with depression and inflammation. Nutrition Reviews 78 (5):394–411. doi: 10.1093/nutrit/nuz072.
  • Swanson, K. V., M. Deng, and J. P. Ting. 2019. The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nature Reviews. Immunology 19 (8):477–89. doi: 10.1038/s41577-019-0165-0.
  • Takagaki, A, and F. Nanjo. 2010. Metabolism of (−)-epigallocatechin gallate by rat intestinal flora. Journal of Agricultural and Food Chemistry 58 (2):1313–21. doi: 10.1021/jf903375s.
  • Taram, F., A. N. Winter, and D. A. Linseman. 2016. Neuroprotection comparison of chlorogenic acid and its metabolites against mechanistically distinct cell death-inducing agents in cultured cerebellar granule neurons. Brain Research 1648 (Pt A):69–80. doi: 10.1016/j.brainres.2016.07.028.
  • Thapliyal, S., T. Singh, S. Handu, M. Bisht, P. Kumari, P. Arya, P. Srivastava, and R. Gandham. 2021. A review on potential footprints of ferulic acid for treatment of neurological disorders. Neurochemical Research 46 (5):1043–57. doi: 10.1007/s11064-021-03257-6.
  • Tian, J. S., C. C. Liu, H. Xiang, X. F. Zheng, G. J. Peng, X. Zhang, G. H. Du, and X. Qin. 2015. M.Investigation on the antidepressant effect of sea buckthorn seed oil through the GC-MS-based metabolomics approach coupled with multivariate analysis. Food & Function 6 (11):3585–92. doi: 10.1039/c5fo00695c.
  • Tomas-Barberan, F. A., M. V. Selma, and J. C. Espín. 2018. Polyphenols’ gut microbiota metabolites: Bioactives or biomarkers? Journal of Agricultural and Food Chemistry 66 (14):3593–4. doi: 10.1021/acs.jafc.8b00827.
  • Troubat, R., P. Barone, S. Leman, T. Desmidt, A. Cressant, B. Atanasova, B. Brizard, W. El Hage, A. Surget, C. Belzung, et al. 2021. Neuroinflammation and depression: A review. The European Journal of Neuroscience 53 (1):151–71. doi: 10.1111/ejn.14720.
  • Vissiennon, C., K. Nieber, O. Kelber, and V. Butterweck. 2012. Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin–are they prodrugs? The Journal of Nutritional Biochemistry 23 (7):733–40. doi: 10.1016/j.jnutbio.2011.03.017.
  • Walsh, K. R, and M. L. Failla. 2009. Transport and metabolism of equol by Caco-2 human intestinal cells. Journal of Agricultural and Food Chemistry 57 (18):8297–302. doi: 10.1021/jf9011906.
  • Wang, T. Y, and J. X. Chen. 2019. Effects of curcumin on vessel formation insight into the pro- and antiangiogenesis of curcumin. Evidence-Based Complementary and Alternative Medicine : eCAM 2019 (2019):1390795. doi: 10.1155/2019/1390795.
  • Wang, Y., F. Chen, Y. Ma, T. Zhang, P. Sun, M. Lan, F. Li, and W. Fang. 2021. An ancient whole-genome duplication event and its contribution to flavor compounds in the tea plant (Camellia sinensis). Horticulture Research 8 (1):176. doi: 10.1038/s41438-021-00613-z.
  • Wang, Z., K. L. Lam, J. Hu, S. Ge, A. Zhou, B. Zheng, S. Zeng, and S. Lin. 2019. Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice. Food Science & Nutrition 7 (2):579–88. doi: 10.1002/fsn3.868.
  • Wang, W., P. Lin, L. Ma, K. Xu, and X. Lin. 2016. Separation and determination of flavonoids in three traditional chinese medicines by capillary electrophoresis with amperometric detection. Journal of Separation Science 39 (7):1357–62. doi: 10.1002/jssc.201501287.
  • Wang, C., H. Lin, N. Yang, H. Wang, Y. Zhao, P. Li, J. Liu, and F. Wang. 2019. Effects of platycodins folium on depression in mice based on a UPLC-Q/TOF-MS serum assay and hippocampus metabolomics. Molecules 24 (9):1712. doi: 10.3390/molecules24091712.
  • Wang, J., P. Li, T. Qin, D. Sun, X. Zhao, and B. Zhang. 2020. Protective effect of epigallocatechin-3-gallate against neuroinflammation and anxiety-like behavior in a rat model of myocardial infarction. Brain and Behavior 10 (6):e01633. doi: 10.1002/brb3.1633.
  • Wang, T., K. Niu, A. Fan, N. Bi, H. Tao, X. T. Chen, and H. L. Wang. 2020. Dietary intake of polyunsaturated fatty acids alleviates cognition deficits and depression-like behaviour via cannabinoid system in sleep deprivation rats. Behavioural Brain Research 384:112545. doi: 10.1016/j.bbr.2020.112545.
  • Wang, H., Y. Zhang, H. Li, W. Zeng, and M. Qiao. 2017. Shuyu capsules relieve liver-qi depression by regulating ERK-CREB-BDNF signal pathway in central nervous system of rat. Experimental and Therapeutic Medicine 14 (5):4831–8. doi: 10.3892/etm.2017.5125.
  • Wang, Z., Q. Zhang, L. Yuan, S. Wang, L. Liu, X. Yang, G. Li, and D. Liu. 2014. The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration. Behavioural Brain Research 274 (274):282–90. doi: 10.1016/j.bbr.2014.08.018.
  • Wei, W. L., R. Zeng, C. M. Gu, Y. Qu, and L. F. Huang. 2016. Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis. Journal of Ethnopharmacology 190:116–41. doi: 10.1016/j.jep.2016.05.023.
  • Wen, L., L. Tang, M. Zhang, C. Wang, S. Li, Y. Wen, H. Tu, H. Tian, J. Wei, P. Liang, et al. 2022. Gallic acid alleviates visceral pain and depression via inhibition of P2X7 receptor. International Journal of Molecular Sciences 23 (11):6159. doi: 10.3390/ijms23116159.
  • Wu, H., M. Chen, Y. Fan, F. Elsebaei, and Y. Zhu. 2012. Determination of rutin and quercetin in Chinese herbal medicine by ionic liquid-based pressurized liquid extraction-liquid chromatography-chemiluminescence detection. Talanta 88 (88):222–9. doi: 10.1016/j.talanta.2011.10.036.
  • Xiao, Y., Y. Dai, L. Li, F. Geng, Y. Xu, J. Wang, S. Wang, and J. Zhao. 2021. Tetrahydrocurcumin ameliorates Alzheimer’s pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 139 (139):111651. doi: 10.1016/j.biopha.2021.111651.
  • Xie, L., Z. Gu, H. Liu, B. Jia, Y. Wang, M. Cao, R. Song, Z. Zhang, and Y. Bian. 2020. The Anti-depressive effects of hesperidin and the relative mechanisms based on the NLRP3 inflammatory signaling pathway. Frontiers in Pharmacology 11 (11):1251. doi: 10.3389/fphar.2020.01251.
  • Xu, J., C. Yuan, G. Wang, J. Luo, H. Ma, L. Xu, Y. Mu, Y. Li, N. P. Seeram, X. Huang, et al. 2018. Urolithins attenuate LPS-induced neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB signaling pathways. Journal of Agricultural and Food Chemistry 66 (3):571–80. doi: 10.1021/acs.jafc.7b03285.
  • Yu, X., S. Sun, Y. Guo, Y. Liu, D. Yang, G. Li, and S. Lü. 2018. Citri reticulatae pericarpium (Chenpi): Botany, ethnopharmacology, phytochemistry, and pharmacology of a frequently used traditional Chinese medicine. Journal of Ethnopharmacology 220 (220):265–82. doi: 10.1016/j.jep.2018.03.031.
  • Yu, H., F. Zhang, and X. Guan. 2019. Baicalin reverse depressive-like behaviors through regulation SIRT1-NF-kB signaling pathway in olfactory bulbectomized rats. Phytotherapy Research : PTR 33 (5):1480–9. doi: 10.1002/ptr.6340.
  • Zhang, W. Y., Y. J. Guo, W. X. Han, M. Q. Yang, L. P. Wen, K. Y. Wang, and P. Jiang. 2019. Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress. International Immunopharmacology 67 (67):138–44. doi: 10.1016/j.intimp.2018.12.012.
  • Zhang, R., L. Guo, Z. Ji, X. Li, C. Zhang, Z. Ma, Q. Fu, R. Qu, and S. Ma. 2018. Radix scutellariae attenuates CUMS-induced depressive-like behavior by promoting neurogenesis via cAMP/PKA pathway. Neurochemical Research 43 (11):2111–20. doi: 10.1007/s11064-018-2635-3.
  • Zhang, Z., X. Peng, S. Li, N. Zhang, Y. Wang, and H. Wei. 2014. Isolation and identification of quercetin degrading bacteria from human fecal microbes. PloS One 9 (3):e90531. doi: 10.1371/journal.pone.0090531.
  • Zhang, L., Y. Wang, D. Yang, C. Zhang, N. Zhang, M. Li, and Y. Liu. 2015. Platycodon grandiflorus–An ethnopharmacological, phytochemical and pharmacological review. Journal of Ethnopharmacology 164 (164):147–61. doi: 10.1016/j.jep.2015.01.052.
  • Zhang, G., M. Zhu, Y. Liao, D. Gong, and X. Hu. 2022. Action mechanisms of two key xanthine oxidase inhibitors in tea polyphenols and their combined effect with allopurinol. Journal of the Science of Food and Agriculture 2022. doi: 10.1002/jsfa.12085.
  • Zhao, T., C. Li, S. Wang, and X. Song. 2022. Green tea (Camellia sinensis): A review of its phytochemistry, pharmacology, and toxicology. Molecules 27 (12):3909. doi: 10.3390/molecules27123909.
  • Zhao, F., C. Zhang, D. Xiao, W. Zhang, L. Zhou, S. Gu, and R. Qu. 2020. Radix scutellariae ameliorates stress-induced depressive-like behaviors via protecting neurons through the TGFβ3-Smad2/3-Nedd9 signaling pathway. Neural Plasticity 2020 (2):8886715–3. doi: 10.1155/2020/8886715.
  • Zheng, X., Y. Cheng, Y. Chen, Y. Yue, Y. Li, S. Xia, Y. Li, H. Deng, J. Zhang, and Y. Cao. 2019. Ferulic acid improves depressive-like behavior in prenatally-stressed offspring rats via anti-inflammatory activity and HPA axis. International Journal of Molecular Sciences 20 (3):493. doi: 10.3390/ijms20030493.
  • Zhi, H., H. D. L. Liang, L. Xiao, C. Fang, and Z. Jing. 2010. Effect of 3(‘)-daidzein sulfonic sodium on the anti-oxidation of retinal ischemia/reperfusion injury in rats. Adv Exp Med Biol 664:585–91. doi: 10.1007/978-1-4419-1399-9_67.
  • Zhou, N., X. Gu, T. Zhuang, Y. Xu, L. Yang, and M. Zhou. 2020. Gut microbiota: a pivotal hub for polyphenols as antidepressants. Journal of Agricultural and Food Chemistry 68 (22):6007–20. doi: 10.1021/acs.jafc.0c01461.

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