The role of dietary polyphenols in alternating DNA methylation in cancer

References

• Abbaszadeh, S., M. Rashidipour, P. Khosravi, S. Shahryarhesami, B. Ashrafi, M. Kaviani, and M. Moradi Sarabi. 2020. Biocompatibility, cytotoxicity, antimicrobial and epigenetic effects of novel chitosan-based quercetin nanohydrogel in human cancer cells. International Journal of Nanomedicine 15:5963–75. doi: 10.2147/IJN.S263013.
   PubMed Web of Science ®Google Scholar
• Aggarwal, B. B., A. Kumar, and A. C. Bharti. 2003. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Research 23 (1a):363–98.
   PubMed Web of Science ®Google Scholar
• Ali Hosseini, S., R. C. Sobti, K. Malekzadeh, S. K. Singh, and K. Joshi. 2010. Frequency of P16INK4a and P14ARF genes methylation and its impact on bladder cancer cases in north Indian population. Disease Markers 28 (6):361–8. doi: 10.3233/dma-2010-0716.
   PubMed Web of Science ®Google Scholar
• Alizadeh, M., A. Nafari, A. Safarzadeh, S. Veiskarami, M. Almasian, and A. Asghar Kiani. 2021. The impact of EGCG and RG108 on SOCS1 promoter DNA methylation and expression in U937 leukemia cells. Reports of Biochemistry & Molecular Biology 10 (3):455–61. doi: 10.52547/rbmb.10.3.455.
   PubMed Web of Science ®Google Scholar
• Alvarez, M. C., V. Maso, C. O. Torello, K. P. Ferro, and S. T. O. Saad. 2018. The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes. Clinical Epigenetics 10 (1):139. doi: 10.1186/s13148-018-0563-3.
   PubMedGoogle Scholar
• Al-Yousef, N., Z. Shinwari, B. Al-Shahrani, M. Al-Showimi, and N. Al-Moghrabi. 2020. Curcumin induces re‑expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines. Oncology Reports 43 (3):827–38. doi: 10.3892/or.2020.7473.
   PubMed Web of Science ®Google Scholar
• Arai, T., Y. Miyoshi, S. J. Kim, T. Taguchi, Y. Tamaki, and S. Noguchi. 2006. Association of GSTP1 CpG islands hypermethylation with poor prognosis in human breast cancers. Breast Cancer Research and Treatment 100 (2):169–76. doi: 10.1007/s10549-006-9241-9.
   PubMed Web of Science ®Google Scholar
• Bai, Y., C. Wei, Y. Zhong, Y. Zhang, J. Long, S. Huang, F. Xie, Y. Tian, X. Wang, and H. Zhao. 2020. Development and validation of a prognostic nomogram for gastric cancer based on DNA methylation-driven differentially expressed genes. International Journal of Biological Sciences 16 (7):1153–65. doi: 10.7150/ijbs.41587.
   PubMed Web of Science ®Google Scholar
• Beetch, M., C. Boycott, S. Harandi-Zadeh, T. Yang, B. J. E. Martin, T. Dixon-McDougall, K. Ren, A. Gacad, J. H. Dupuis, M. Ullmer, et al. 2021. Pterostilbene leads to DNMT3B-mediated DNA methylation and silencing of OCT1-targeted oncogenes in breast cancer cells. The Journal of Nutritional Biochemistry 98:108815. doi: 10.1016/j.jnutbio.2021.108815.
   PubMed Web of Science ®Google Scholar
• Berman, A. Y., R. A. Motechin, M. Y. Wiesenfeld, and M. K. Holz. 2017. The therapeutic potential of resveratrol: A review of clinical trials. NPJ Precision Oncology. 1. doi: 10.1038/s41698-017-0038-6.
   PubMed Web of Science ®Google Scholar
• Bishop, K. S., and L. R. Ferguson. 2015. The interaction between epigenetics, nutrition and the development of cancer. Nutrients 7 (2):922–47. doi: 10.3390/nu7020922.
   PubMed Web of Science ®Google Scholar
• Brovarets’, O. h. O., and D. M. Hovorun. 2019. Intramolecular tautomerization of the quercetin molecule due to the proton transfer: QM computational study. Plos ONE 14 (11):e0224762. doi: 10.1371/journal.pone.0224762.
   PubMed Web of Science ®Google Scholar
• Brueckner, B., R. Garcia Boy, P. Siedlecki, T. Musch, H. C. Kliem, P. Zielenkiewicz, S. Suhai, M. Wiessler, and F. Lyko. 2005. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Research 65 (14):6305–11. doi: 10.1158/0008-5472.can-04-2957.
   PubMed Web of Science ®Google Scholar
• Calderón-Montaño, J. M., E. Burgos-Morón, C. Pérez-Guerrero, and M. López-Lázaro. 2011. A review on the dietary flavonoid kaempferol. Mini Reviews in Medicinal Chemistry 11 (4):298–344. doi: 10.2174/138955711795305335.
   PubMed Web of Science ®Google Scholar
• Celik, S., D. Akcora, T. Ozkan, N. Varol, S. Aydos, and A. Sunguroglu. 2015. Methylation analysis of the DAPK1 gene in imatinib-resistant chronic myeloid leukemia patients. Oncology Letters 9 (1):399–404. doi: 10.3892/ol.2014.2677.
   PubMed Web of Science ®Google Scholar
• Chatterjee, B., K. Ghosh, and S. R. Kanade. 2019. Curcumin-mediated demethylation of the proximal promoter CpG island enhances the KLF4 recruitment that leads to increased expression of p21Cip1 in vitro. Journal of Cellular Biochemistry 120 (1):809–20. doi: 10.1002/jcb.27442.
   PubMed Web of Science ®Google Scholar
• Chen, T., C. Yang, Z. Xi, F. Chen, and H. Li. 2020. Reduced caudal type homeobox 2 (CDX2) promoter methylation is associated with curcumin’s suppressive effects on epithelial-mesenchymal transition in colorectal cancer cells. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 26:e926443. doi: 10.12659/msm.926443.
   PubMed Web of Science ®Google Scholar
• Chen, X., J. Zhang, W. Ruan, M. Huang, C. Wang, H. Wang, Z. Jiang, S. Wang, Z. Liu, C. Liu, et al. 2020. Urine DNA methylation assay enables early detection and recurrence monitoring for bladder cancer. The Journal of Clinical Investigation 130 (12):6278–89. doi: 10.1172/jci139597.
   PubMed Web of Science ®Google Scholar
• Christman, J. K. 2002. 5-Azacytidine and 5-aza-2’-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 21 (35):5483–95. doi:10.1038/sj.onc.1205699. 12154409
   PubMed Web of Science ®Google Scholar
• Constâncio, V., S. P. Nunes, R. Henrique, and C. Jerónimo. 2020. DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types. Cells 9 (3):624. doi: 10.3390/cells9030624.
   PubMed Web of Science ®Google Scholar
• Cooper, D. N, and H. Youssoufian. 1988. The CpG dinucleotide and human genetic disease. Human Genetics 78 (2):151–5. doi: 10.1007/bf00278187.
   PubMed Web of Science ®Google Scholar
• Dawson, M. A., and T. Kouzarides. 2012. Cancer epigenetics: From mechanism to therapy. Cell 150 (1):12–27. doi: 10.1016/j.cell.2012.06.013.
   PubMed Web of Science ®Google Scholar
• Ding, W., G. Chen, and T. Shi. 2019. Integrative analysis identifies potential DNA methylation biomarkers for pan-cancer diagnosis and prognosis. Epigenetics 14 (1):67–80. doi: 10.1080/15592294.2019.1568178.
   PubMed Web of Science ®Google Scholar
• Dong, X., J. Zhang, F. Yang, J. Wu, R. Cai, T. Wang, and J. Zhang. 2018. Effect of luteolin on the methylation status of the OPCML gene and cell growth in breast cancer cells. Experimental and Therapeutic Medicine 16 (4):3186–94. doi: 10.3892/etm.2018.6526.
   PubMed Web of Science ®Google Scholar
• Du, L., Z. Xie, L-c Wu, M. Chiu, J. Lin, K. K. Chan, S. Liu, and Z. Liu. 2012. Reactivation of RASSF1A in breast cancer cells by curcumin. Nutrition and Cancer 64 (8):1228–35. doi: 10.1080/01635581.2012.717682.
   PubMed Web of Science ®Google Scholar
• Fang, M. Z., D. Chen, Y. Sun, Z. Jin, J. K. Christman, and C. S. Yang. 2005. Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 11 (19 Pt 1):7033–41. doi: 10.1158/1078-0432.ccr-05-0406.
   PubMed Web of Science ®Google Scholar
• Fang, M. Z., Y. Wang, N. Ai, Z. Hou, Y. Sun, H. Lu, W. Welsh, and C. S. Yang. 2003. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Research 63 (22):7563–70.
   PubMed Web of Science ®Google Scholar
• Fernández-Bedmar, Z., J. Anter, A. Alonso-Moraga, J. Martín de Las Mulas, Y. Millán-Ruiz, and S. Guil-Luna. 2017. Demethylating and anti-hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices. Molecular Carcinogenesis 56 (6):1653–62. doi: 10.1002/mc.22621.
   PubMed Web of Science ®Google Scholar
• Filion, G. J., S. Zhenilo, S. Salozhin, D. Yamada, E. Prokhortchouk, and P.-A. Defossez. 2006. A family of human zinc finger proteins that bind methylated DNA and repress transcription. Molecular and Cellular Biology 26 (1):169–81.
   PubMed Web of Science ®Google Scholar
• Fudhaili, A., N. A. Yoon, S. Kang, J. Ryu, J. Y. Jeong, D. H. Lee, and S. S. Kang. 2019. Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines. Oncology Reports 41 (2):1377–86. doi: 10.3892/or.2018.6898.
   PubMed Web of Science ®Google Scholar
• Galiniak, S., D. Aebisher, and D. Bartusik-Aebisher. 2019. Health benefits of resveratrol administration. Acta Biochimica Polonica 66 (1):13–21. doi: 10.18388/abp.2018_2749.
   PubMed Web of Science ®Google Scholar
• Gao, T., S. Wang, B. He, Y. Pan, G. Song, L. Gu, L. Chen, Z. Nie, Y. Xu, and R. Li. 2012. The association of RAS association domain family Protein1A (RASSF1A) methylation states and bladder cancer risk: A systematic review and meta-analysis. PloS One 7 (11):e48300. doi: 10.1371/journal.pone.0048300.
   PubMed Web of Science ®Google Scholar
• Gao, Z., Z. Xu, M.-S. Hung, Y.-C. Lin, T. Wang, M. Gong, X. Zhi, D. M. Jablon, and L. You. 2009. Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells. Anticancer Research 29 (6):2025–30.
   PubMed Web of Science ®Google Scholar
• Gupta, S. C., S. Patchva, and B. B. Aggarwal. 2013. Therapeutic roles of curcumin: Lessons learned from clinical trials. The AAPS Journal 15 (1):195–218. doi: 10.1208/s12248-012-9432-8.
   PubMed Web of Science ®Google Scholar
• Hanoun, N., Y. Delpu, A. A. Suriawinata, B. Bournet, C. Bureau, J. Selves, G. J. Tsongalis, M. Dufresne, L. Buscail, P. Cordelier, et al. 2010. The silencing of microRNA 148a production by DNA hypermethylation is an early event in pancreatic carcinogenesis. Clinical Chemistry 56 (7):1107–18. doi: 10.1373/clinchem.2010.144709.
   PubMed Web of Science ®Google Scholar
• He, H., H. Zhang, Z. Li, R. Wang, N. Li, and L. Zhu. 2015. miRNA-214: Expression, therapeutic and diagnostic potential in cancer. Tumori 101 (4):375–83. doi: 10.5301/tj.5000318.
   PubMed Web of Science ®Google Scholar
• Hewlings, S. J., and D. S. Kalman. 2017. Curcumin: A review of its effects on human health. Foods 6 (10):92. doi: 10.3390/foods6100092.
   PubMed Web of Science ®Google Scholar
• Hou, Z., L. Sun, F. Xu, F. Hu, J. Lan, D. Song, Y. Feng, J. Wang, X. Luo, J. Hu, et al. 2020. Blocking histone methyltransferase SETDB1 inhibits tumorigenesis and enhances cetuximab sensitivity in colorectal cancer. Cancer Letters 487:63–73. doi: 10.1016/j.canlet.2020.05.029.
   PubMed Web of Science ®Google Scholar
• Izquierdo-Torres, E., A. Hernández-Oliveras, I. Meneses-Morales, G. Rodríguez, G. Fuentes-García, and Á. Zarain-Herzberg. 2019. Resveratrol up-regulates ATP2A3 gene expression in breast cancer cell lines through epigenetic mechanisms. The International Journal of Biochemistry & Cell Biology 113:37–47. doi: 10.1016/j.biocel.2019.05.020.
   PubMed Web of Science ®Google Scholar
• Jia, W., F. Deng, W. Fu, J. Hu, G. Chen, X. Gao, X. Tan, G. Li, G. Liu, and S. Zhu. 2019. Curcumin suppresses wilms’ tumor metastasis by inhibiting RECK methylation. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 111:1204–12. doi: 10.1016/j.biopha.2018.12.111.
   PubMed Web of Science ®Google Scholar
• Jiang, A., X. Wang, X. Shan, Y. Li, P. Wang, P. Jiang, and Q. Feng. 2015. Curcumin reactivates silenced tumor suppressor gene RARβ by reducing DNA methylation. Phytotherapy Research: PTR 29 (8):1237–45. doi: 10.1002/ptr.5373.
   PubMed Web of Science ®Google Scholar
• Kahkeshani, N., F. Farzaei, M. Fotouhi, S. S. Alavi, R. Bahramsoltani, R. Naseri, S. Momtaz, Z. Abbasabadi, R. Rahimi, M. H. Farzaei, et al. 2019. Pharmacological effects of gallic acid in health and diseases: A mechanistic review. Iranian Journal of Basic Medical Sciences 22 (3):225–37. doi: 10.22038/ijbms.2019.32806.7897.
   PubMed Web of Science ®Google Scholar
• Kang, K. A., M. J. Piao, Y. J. Hyun, A. X. Zhen, S. J. Cho, M. J. Ahn, J. M. Yi, and J. W. Hyun. 2019. Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells. Experimental & Molecular Medicine 51 (4):1–14. doi: 10.1038/s12276-019-0238-y.
   Google Scholar
• Kato, K., N. K. Long, H. Makita, M. Toida, T. Yamashita, D. Hatakeyama, A. Hara, H. Mori, and T. Shibata. 2008. Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells. British Journal of Cancer 99 (4):647–54. doi: 10.1038/sj.bjc.6604521.
   PubMed Web of Science ®Google Scholar
• Kawamoto, K., H. Enokida, T. Gotanda, H. Kubo, K. Nishiyama, M. Kawahara, and M. Nakagawa. 2006. p16INK4a and p14ARF methylation as a potential biomarker for human bladder cancer. Biochemical and Biophysical Research Communications 339 (3):790–6. doi: 10.1016/j.bbrc.2005.11.072.
   PubMed Web of Science ®Google Scholar
• Kedhari Sundaram, M., A. Hussain, S. Haque, R. Raina, and N. Afroze. 2019. Quercetin modifies 5’CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells. Journal of Cellular Biochemistry 120 (10):18357–69. doi: 10.1002/jcb.29147.
   PubMed Web of Science ®Google Scholar
• Khan, N., F. Afaq, M. Saleem, N. Ahmad, and H. Mukhtar. 2006. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Research 66 (5):2500–5. doi: 10.1158/0008-5472.can-05-3636.
   PubMed Web of Science ®Google Scholar
• Khor, T. O., Y. Huang, T. Y. Wu, L. Shu, J. Lee, and A. N. Kong. 2011. Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation. Biochemical Pharmacology 82 (9):1073–8. doi: 10.1016/j.bcp.2011.07.065.
   PubMed Web of Science ®Google Scholar
• Klutstein, M., D. Nejman, R. Greenfield, and H. Cedar. 2016. DNA methylation in cancer and aging. Cancer Research 76 (12):3446–50. doi: 10.1158/0008-5472.can-15-3278.
   PubMed Web of Science ®Google Scholar
• Kulis, M, and M. Esteller. 2010. DNA methylation and cancer. Advances in Genetics 70:27–56. doi: 10.1016/b978-0-12-380866-0.60002-2.
   PubMed Web of Science ®Google Scholar
• Kumar, U., U. Sharma, and G. Rathi. 2017. Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 39 (2):1010428317692258. doi: 10.1177/1010428317692258.
   Google Scholar
• Kuo, H. D., R. Wu, S. Li, A. Y. Yang, and A. N. Kong. 2019. Anthocyanin delphinidin prevents neoplastic transformation of mouse skin JB6 P + Cells: Epigenetic Re-activation of Nrf2-ARE pathway. The AAPS Journal 21 (5):83. doi: 10.1208/s12248-019-0355-5.
   PubMed Web of Science ®Google Scholar
• Lakhanpal, P., and D. K. Rai. 2007. Quercetin: A versatile flavonoid. Internet Journal of Medical Update 2 (2):22–37.
   Google Scholar
• Lao, V. V., and W. M. Grady. 2011. Epigenetics and colorectal cancer. Nature Reviews. Gastroenterology & Hepatology 8 (12):686–700. doi: 10.1038/nrgastro.2011.173.
   PubMed Web of Science ®Google Scholar
• LaPak, K. M., and C. E. Burd. 2014. The molecular balancing act of p16(INK4a) in cancer and aging. Molecular Cancer Research: MCR 12 (2):167–83. doi: 10.1158/1541-7786.mcr-13-0350.
   PubMed Web of Science ®Google Scholar
• Lasabova, Z., P. Tilandyova, K. Kajo, P. Zubor, T. Burjanivova, J. Danko, and L. Plank. 2010. Hypermethylation of the GSTP1 promoter region in breast cancer is associated with prognostic clinicopathological parameters. Neoplasma 57 (1):35–40. doi: 10.4149/neo_2010_01_035.
   PubMed Web of Science ®Google Scholar
• Lee, W. J., and B. T. Zhu. 2006. Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. Carcinogenesis 27 (2):269–77. doi: 10.1093/carcin/bgi206.
   PubMed Web of Science ®Google Scholar
• Liang, W., Z. Chen, C. Li, J. Liu, J. Tao, X. Liu, … J. He. 2021. Accurate diagnosis of pulmonary nodules using a noninvasive DNA methylation test. Journal of Clinical Investigation 131 (10). doi: 10.1172/jci145973.
   Web of Science ®Google Scholar
• Li, E., T. H. Bestor, and R. Jaenisch. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69 (6):915–26.
   PubMed Web of Science ®Google Scholar
• Li, Y., F. Jiang, L. Chen, Y. Yang, S. Cao, Y. Ye, X. Wang, J. Mu, Z. Li, and L. Li. 2015. Blockage of TGFβ-SMAD2 by demethylation-activated miR-148a is involved in caffeic acid-induced inhibition of cancer stem cell-like properties in vitro and in vivo. FEBS Open Bio 5:466–75. doi: 10.1016/j.fob.2015.05.009.
   PubMed Web of Science ®Google Scholar
• Li, S., W. Li, C. Wang, R. Wu, R. Yin, H.-C. Kuo, L. Wang, and A.-N. Kong. 2019. Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation. Chemico-Biological Interactions 309:108701. doi: 10.1016/j.cbi.2019.06.014.
   PubMed Web of Science ®Google Scholar
• Li, C.-L., H. Nie, M. Wang, L.-P. Su, J.-F. Li, Y.-Y. Yu, M. Yan, Q.-L. Qu, Z.-G. Zhu, and B.-Y. Liu. 2012. microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis. Oncology Reports 27 (6):1960–6. doi: 10.3892/or.2012.1719.
   PubMed Web of Science ®Google Scholar
• Link, A., F. Balaguer, Y. Shen, J. J. Lozano, H. C. Leung, C. R. Boland, and A. Goel. 2013. Curcumin modulates DNA methylation in colorectal cancer cells. PloS One 8 (2):e57709. doi: 10.1371/journal.pone.0057709.
   PubMed Web of Science ®Google Scholar
• Liu, X., H. Li, M. L. Wu, J. Wu, Y. Sun, K. L. Zhang, and J. Liu. 2019. Resveratrol reverses retinoic acid resistance of anaplastic thyroid cancer cells via demethylating CRABP2 gene. Frontiers in Endocrinology 10:734. doi: 10.3389/fendo.2019.00734.
   PubMed Web of Science ®Google Scholar
• Liu, Y., J. Zhou, Y. Hu, J. Wang, and C. Yuan. 2017. Curcumin inhibits growth of human breast cancer cells through demethylation of DLC1 promoter. Molecular and Cellular Biochemistry 425 (1–2):47–58. doi: 10.1007/s11010-016-2861-4.
   PubMed Web of Science ®Google Scholar
• Li, K., Z. Wu, J. Yao, J. Fan, and Q. Wei. 2021. DNA methylation patterns-based subtype distinction and identification of soft tissue sarcoma prognosis. Medicine, 100 (5):e23787. doi: 10.1097/md.0000000000023787.
   PubMed Web of Science ®Google Scholar
• Li, D., L. Zhang, Y. Liu, H. Sun, J. U. Onwuka, Z. Zhao, W. Tian, J. Xu, Y. Zhao, and H. Xu. 2019. Specific DNA methylation markers in the diagnosis and prognosis of esophageal cancer. Aging 11 (23):11640–58. doi: 10.18632/aging.102569.
   PubMedGoogle Scholar
• Luger, K. 2003. Structure and dynamic behavior of nucleosomes. Current Opinion in Genetics & Development 13 (2):127–35. doi: 10.1016/S0959-437X(03)00026-1.
   PubMed Web of Science ®Google Scholar
• Luo, H., Q. Zhao, W. Wei, L. Zheng, S. Yi, G. Li, … R. H. Xu. 2020. Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer. Science Translational Medicine 12 (524). doi: 10.1126/scitranslmed.aax7533.
   Web of Science ®Google Scholar
• Ma, L., J. M. Feugang, P. Konarski, J. Wang, J. Lu, S. Fu, B. Ma, B. Tian, C. Zou, and Z. Wang. 2006. Growth inhibitory effects of quercetin on bladder cancer cell. Frontiers in Bioscience: A Journal and Virtual Library 11:2275–85. doi: 10.2741/1970.
   PubMed Web of Science ®Google Scholar
• Medina-Aguilar, R., C. Pérez-Plasencia, L. A. Marchat, P. Gariglio, J. García Mena, S. Rodríguez Cuevas, E. Ruíz-García, H. Astudillo-de la Vega, J. Hernández Juárez, A. Flores-Pérez, et al. 2016. Methylation landscape of human breast cancer cells in response to dietary compound resveratrol. Plos ONE 11 (6):e0157866. doi: 10.1371/journal.pone.0157866.
   PubMed Web of Science ®Google Scholar
• Morgan, A. E., T. J. Davies, and M. T. Mc Auley. 2018. The role of DNA methylation in ageing and cancer. The Proceedings of the Nutrition Society 77 (4):412–22. doi: 10.1017/s0029665118000150.
   PubMed Web of Science ®Google Scholar
• Morris, J., V. R. Moseley, A. B. Cabang, K. Coleman, W. Wei, E. Garrett-Mayer, and M. J. Wargovich. 2016. Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells. Oncotarget 7 (23):35313–26. doi: 10.18632/oncotarget.9204.
   PubMedGoogle Scholar
• Moseley, V. R., J. Morris, R. W. Knackstedt, and M. J. Wargovich. 2013. Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells. Anticancer Research 33 (12):5325–33.
   PubMed Web of Science ®Google Scholar
• Nandakumar, V., M. Vaid, and S. K. Katiyar. 2011. (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis 32 (4):537–44. doi: 10.1093/carcin/bgq285.
   PubMed Web of Science ®Google Scholar
• Okano, M., D. W. Bell, D. A. Haber, and E. Li. 1999. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 (3):247–57. doi: 10.1016/S0092-8674(00)81656-6.
   PubMed Web of Science ®Google Scholar
• Pan, Y., G. Liu, F. Zhou, B. Su, and Y. Li. 2018. DNA methylation profiles in cancer diagnosis and therapeutics. Clinical and Experimental Medicine 18 (1):1–14. doi: 10.1007/s10238-017-0467-0.
   PubMed Web of Science ®Google Scholar
• Panni, S., R. C. Lovering, P. Porras, and S. Orchard. 2020. Non-coding RNA regulatory networks. Biochimica et Biophysica Acta. Gene Regulatory Mechanisms 1863 (6):194417. doi: 10.1016/j.bbagrm.2019.194417.
   PubMed Web of Science ®Google Scholar
• Paredes-Gonzalez, X., F. Fuentes, Z. Y. Su, and A. N. Kong. 2014. Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications. The AAPS Journal 16 (4):727–35. doi: 10.1208/s12248-014-9613-8.
   PubMed Web of Science ®Google Scholar
• Prasher, D., S. C. Greenway, and R. B. Singh. 2020. The impact of epigenetics on cardiovascular disease. Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire 98 (1):12–22. doi: 10.1139/bcb-2019-0045.
   PubMedGoogle Scholar
• Qiao, G., W. Zhuang, B. Dong, C. Li, J. Xu, G. Wang, L. Xie, Z. Zhou, D. Tian, G. Chen, et al. 2021. Discovery and validation of methylation signatures in circulating cell-free DNA for early detection of esophageal cancer: A case-control study. BMC Medicine 19 (1):243. doi: 10.1186/s12916-021-02109-y.
   PubMed Web of Science ®Google Scholar
• Qiu, W., J. Lin, Y. Zhu, J. Zhang, L. Zeng, M. Su, and Y. Tian. 2017. Kaempferol modulates DNA methylation and downregulates DNMT3B in bladder cancer. Cellular Physiology and Biochemistry: international Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 41 (4):1325–35. doi: 10.1159/000464435.
   PubMedGoogle Scholar
• Remely, M., F. Ferk, S. Sterneder, T. Setayesh, S. Roth, T. Kepcija, R. Noorizadeh, I. Rebhan, M. Greunz, J. Beckmann, et al. 2017. EGCG prevents high fat diet-induced changes in gut microbiota, decreases of DNA strand breaks, and changes in expression and DNA methylation of Dnmt1 and MLH1 in C57BL/6J male mice. Oxidative Medicine and Cellular Longevity 2017:3079148. doi: 10.1155/2017/3079148.
   PubMed Web of Science ®Google Scholar
• Sadoughi, F., P. Maleki Dana, Z. Asemi, and B. Yousefi. 2021. Targeting microRNAs by curcumin: Implication for cancer therapy. Critical Reviews in Food Science and Nutrition:1–12. doi: 10.1080/10408398.2021.1916876.
   Web of Science ®Google Scholar
• Sharma, V., A. K. Jha, A. Kumar, A. Bhatnagar, G. Narayan, and J. Kaur. 2015. Curcumin-mediated reversal of p15 gene promoter methylation: Implication in anti-neoplastic action against acute lymphoid leukaemia cell line. Folia Biologica (Praha) 61 (2):81–9.
   PubMed Web of Science ®Google Scholar
• Sharma, V., L. Kumar, S. K. Mohanty, J. P. Maikhuri, S. Rajender, and G. Gupta. 2016. Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin. Molecular and Cellular Endocrinology 431:12–23. doi: 10.1016/j.mce.2016.04.024.
   PubMed Web of Science ®Google Scholar
• Sheng, J., W. Shi, H. Guo, W. Long, Y. Wang, J. Qi, J. Liu, and Y. Xu. 2019. The inhibitory effect of (-)-epigallocatechin-3-gallate on breast cancer progression via reducing SCUBE2 methylation and DNMT activity. Molecules 24 (16):2899. doi: 10.3390/molecules24162899.
   Web of Science ®Google Scholar
• Shi, X., H. Y. Gao, W. Yan, X. W. He, and W. Yang. 2018. [Effects of EGCG on proliferation, cell cycle and DAPK1 gene methylation of acute promyelocytic leukemia NB4 cell line]. Zhongguo Shi Yan Xue ye Xue za Zhi 26 (5):1288–93. doi: 10.7534/j.issn.1009-2137.2018.05.006.
   PubMedGoogle Scholar
• Shu, L., T. O. Khor, J.-H. Lee, S. S. S. Boyanapalli, Y. Huang, T.-Y. Wu, C. L.-L. Saw, K.-L. Cheung, and A.-N T. Kong. 2011. Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells. The AAPS Journal 13 (4):606–14. doi: 10.1208/s12248-011-9300-y.
   PubMed Web of Science ®Google Scholar
• Siddiqui, I. A., M. Asim, B. B. Hafeez, V. M. Adhami, R. S. Tarapore, and H. Mukhtar. 2011. Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 25 (4):1198–207. doi: 10.1096/fj.10-167924.
   PubMed Web of Science ®Google Scholar
• Singh, B. N., S. Shankar, and R. K. Srivastava. 2011. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochemical Pharmacology 82 (12):1807–21. doi: 10.1016/j.bcp.2011.07.093.
   PubMed Web of Science ®Google Scholar
• Tamaru, H, and E. U. Selker. 2001. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414 (6861):277–83.
   PubMed Web of Science ®Google Scholar
• Tan, S., C. Wang, C. Lu, B. Zhao, Y. Cui, X. Shi, and X. Ma. 2009. Quercetin is able to demethylate the p16INK4a gene promoter. Chemotherapy 55 (1):6–10. doi: 10.1159/000166383.
   PubMed Web of Science ®Google Scholar
• Tong, R., X. Wu, Y. Liu, Y. Liu, J. Zhou, X. Jiang, L. Zhang, X. He, and L. Ma. 2020. Curcumin-induced DNA demethylation in human gastric cancer cells is mediated by the DNA-damage response pathway. Oxidative Medicine and Cellular Longevity 2020:2543504. doi: 10.1155/2020/2543504.
   PubMed Web of Science ®Google Scholar
• Wang, K., Z. Chen, J. Shi, Y. Feng, M. Yu, Y. Sun, Q. Zhuang, B. Liang, G. Luo, X. Xu, et al. 2020. Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells. The Prostate 80 (12):977–85. doi: 10.1002/pros.24029.
   PubMed Web of Science ®Google Scholar
• Weng, Y.-P., P.-F. Hung, W.-Y. Ku, C.-Y. Chang, B.-H. Wu, M.-H. Wu, J.-Y. Yao, J.-R. Yang, and C.-H. Lee. 2018. The inhibitory activity of gallic acid against DNA methylation: Application of gallic acid on epigenetic therapy of human cancers. Oncotarget 9 (1):361–74. doi: 10.18632/oncotarget.23015.
   PubMedGoogle Scholar
• Wu, M., M. Jiang, M. Xue, Q. Li, B. Cheng, M. Huang, … Y. Zhang. 2020. [ Epigallocatechin gallate induces CHD5 gene demethylation to promote acute myeloid leukemia cell apoptosis in vitro by regulating p19(Arf)-p53-p21(Cip1) signaling pathway. ]. Nan Fang Yi Ke Da Xue Xue Bao 40 (9):1230–8. doi: 10.12122/j.issn.1673-4254.2020.09.02.
   PubMedGoogle Scholar
• Wu, Y., M. Sarkissyan, and J. V. Vadgama. 2015. Epigenetics in breast and prostate cancer. Methods in Molecular Biology (Clifton, NJ) 1238:425–66. doi: 10.1007/978-1-4939-1804-1_23.
   PubMedGoogle Scholar
• Xu, Q., Y. Jiang, Y. Yin, Q. Li, J. He, Y. Jing, Y.-T. Qi, Q. Xu, W. Li, B. Lu, et al. 2013. A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. Journal of Molecular Cell Biology 5 (1):3–13. doi: 10.1093/jmcb/mjs049.
   PubMed Web of Science ®Google Scholar
• Yin, L., N. Zhang, and Q. Yang. 2021. DNA methylation subtypes for ovarian cancer prognosis. FEBS Open Bio 11 (3):851–65. doi: 10.1002/2211-5463.13056.
   PubMed Web of Science ®Google Scholar
• Yu, J., Y. Peng, L.-C. Wu, Z. Xie, Y. Deng, T. Hughes, S. He, X. Mo, M. Chiu, Q.-E. Wang, et al. 2013. Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PloS One 8 (2):e55934. doi: 10.1371/journal.pone.0055934.
   PubMed Web of Science ®Google Scholar
• Zhan, L., B. Zhang, Y. Tan, C. Yang, C. Huang, Q. Wu, Y. Zhang, X. Chen, M. Zhou, and A. Shu. 2017. Quantitative assessment of the relationship between RASSF1A gene promoter methylation and bladder cancer (PRISMA). Medicine 96 (7):e6097. doi: 10.1097/md.0000000000006097.
   PubMed Web of Science ®Google Scholar
• Zhang, S., Y. Wang, Y. Gu, J. Zhu, C. Ci, Z. Guo, C. Chen, Y. Wei, W. Lv, H. Liu, et al. 2018. Specific breast cancer prognosis-subtype distinctions based on DNA methylation patterns. Molecular Oncology 12 (7):1047–60. doi: 10.1002/1878-0261.12309.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., X. Wang, L. Han, Y. Zhou, and S. Sun. 2015. Green tea polyphenol EGCG reverse cisplatin resistance of A549/DDP cell line through candidate genes demethylation. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 69:285–90. doi: 10.1016/j.biopha.2014.12.016.
   PubMed Web of Science ®Google Scholar
• Zhao, R., F. Meng, N. Wang, W. Ma, and Q. Yan. 2014. Silencing of CHD5 gene by promoter methylation in leukemia. PloS One 9 (1):e85172. doi: 10.1371/journal.pone.0085172.
   PubMed Web of Science ®Google Scholar
• Zheng, N. G., J. L. Wang, S. L. Yang, and J. L. Wu. 2014. Aberrant epigenetic alteration in Eca9706 cells modulated by nanoliposomal quercetin combined with butyrate mediated via epigenetic-NF-κB signaling. Asian Pacific Journal of Cancer Prevention: APJCP 15 (11):4539–43. doi: 10.7314/apjcp.2014.15.11.4539.
   PubMedGoogle Scholar
• Zhou, X. Q., X. N. Xu, L. Li, J. J. Ma, E. M. Zhen, and C. B. Han. 2015. Epigallocatechin‑3‑gallate inhibits the invasion of salivary adenoid cystic carcinoma cells by reversing the hypermethylation status of the RECK gene. Molecular Medicine Reports 12 (4):6031–6. doi: 10.3892/mmr.2015.4213.
   PubMed Web of Science ®Google Scholar
• Zhu, W., W. Qin, K. Zhang, G. E. Rottinghaus, Y. C. Chen, B. Kliethermes, and E. R. Sauter. 2012. Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutrition and Cancer 64 (3):393–400. doi: 10.1080/01635581.2012.654926.
   PubMed Web of Science ®Google Scholar