Effects and mechanisms of resveratrol for prevention and management of cancers: An updated review

References

• Al Aameri, R. F. H., S. Sheth, E. M. A. Alanisi, V. Borse, D. Mukherjea, L. P. Rybak, and V. Ramkumar. 2017. Tonic suppression of PCAT29 by the IL-6 signaling pathway in prostate cancer: Reversal by resveratrol. Plos One 12 (5):e0177198. doi: 10.1371/journal.pone.0177198.
   PubMed Web of Science ®Google Scholar
• Alayev, A., R. S. Salamon, N. S. Schwartz, A. Y. Berman, S. L. Wiener, and M. K. Holz. 2017. Combination of rapamycin and resveratrol for treatment of bladder cancer. Journal of Cellular Physiology 232 (2):436–46. doi: 10.1002/jcp.25443.
   PubMed Web of Science ®Google Scholar
• Almeida, T. C., G. N. da Silva, D. V. de Souza, A. C. de Moraes Malinverni, O. Aguiar, Jr, D. Estadella, and D. A. Ribeiro. 2021. Resveratrol effects in oral cancer cells: A comprehensive review. Medical Oncology 38 (8):97. doi: 10.1007/s12032-021-01548-0.
   PubMed Web of Science ®Google Scholar
• Almeida, T. C., C. C. C. Guerra, B. L. G. De Assis, R. Soares, C. C. M. Garcia, A. A. Lima, and G. N. da Silva. 2019. Antiproliferative and toxicogenomic effects of resveratrol in bladder cancer cells with different TP53 status. Environmental and Molecular Mutagenesis 60 (8):740–51. doi: 10.1002/em.22297.
   PubMed Web of Science ®Google Scholar
• Alrafas, H. R., P. B. Busbee, K. N. Chitrala, M. Nagarkatti, and P. Nagarkatti. 2020. Alterations in the gut microbiome and suppression of histone deacetylases by resveratrol are associated with attenuation of colonic inflammation and protection against colorectal cancer. Journal of Clinical Medicine 9 (6):1796. doi: 10.3390/jcm9061796.
   PubMed Web of Science ®Google Scholar
• da Costa Araldi, I. C., F. P. R. Bordin, F. C. Cadoná, F. Barbisan, V. F. Azzolin, C. F. Teixeira, T. Baumhardt, I. B. M. da Cruz, M. M. M. F. Duarte, L. d F. Bauermann, et al. 2018. The in vitro radiosensitizer potential of resveratrol on MCF-7 breast cancer cells. Chemico-Biological Interactions 282:85–92. doi: 10.1016/j.cbi.2018.01.013.
   PubMed Web of Science ®Google Scholar
• Bai, Y., H. Yang, G. Zhang, L. Hu, Y. Lei, Y. Qin, Y. Yang, Q. Wang, R. Li, Q. Mao, et al. 2017. Inhibitory effects of resveratrol on the adhesion, migration and invasion of human bladder cancer cells. Molecular Medicine Reports 15 (2):885–9. doi: 10.3892/mmr.2016.6051.
   PubMed Web of Science ®Google Scholar
• Barata, P. C, and A. O. Sartor. 2019. Metastatic castration-sensitive prostate cancer: Abiraterone, docetaxel, or. Cancer 125 (11):1777–88. doi: 10.1002/cncr.32039.
   PubMed Web of Science ®Google Scholar
• Bian, P., W. Hu, C. Liu, and L. Li. 2020. Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved. Archives of Biochemistry and Biophysics 689:108461. doi: 10.1016/j.abb.2020.108461.
   PubMed Web of Science ®Google Scholar
• Blanquer-Rossello, M. D., R. Hernandez-Lopez, P. Roca, J. Oliver, and A. Valle. 2017. Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells. Biochimica et Biophysica Acta. General Subjects 1861 (2):431–40. doi: 10.1016/j.bbagen.2016.10.009.
   PubMed Web of Science ®Google Scholar
• Bostan, M., M. Mihaila, G. G. Petrica-Matei, N. Radu, R. Hainarosie, C. D. Stefanescu, V. Roman, and C. C. Diaconu. 2021. Resveratrol modulation of apoptosis and cell cycle response to cisplatin in head and neck cancer cell lines. International Journal of Molecular Sciences 22 (12):6322. doi: 10.3390/ijms22126322.
   PubMed Web of Science ®Google Scholar
• Bray, F., J. Ferlay, I. Soerjomataram, R. L. Siegel, L. A. Torre, and A. Jemal. 2018. Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 68 (6):394–13. doi: 10.3322/caac.21609.
   PubMed Web of Science ®Google Scholar
• Buhrmann, C., M. Yazdi, B. Popper, A. B. Kunnumakkara, B. B. Aggarwal, and M. Shakibaei. 2019a. Induction of the epithelial-to-mesenchymal transition of human colorectal cancer by human TNF-beta (lymphotoxin) and its reversal by resveratrol. Nutrients 11 (3):704. doi: 10.3390/nu11030704.
   PubMed Web of Science ®Google Scholar
• Buhrmann, C., M. Yazdi, B. Popper, P. Shayan, A. Goel, B. B. Aggarwal, and M. Shakibaei. 2019b. Evidence that TNF-beta induces proliferation in colorectal cancer cells and resveratrol can down-modulate it. Experimental Biology and Medicine (Maywood, N.J.) 244 (1):1–12. doi: 10.1177/1535370218824538.
   PubMed Web of Science ®Google Scholar
• Cao, S.-Y., Y. Li, X. Meng, C.-N. Zhao, S. Li, R.-Y. Gan, and H.-B. Li. 2019a. Dietary natural products and lung cancer: Effects and mechanisms of action. Journal of Functional Foods 52:316–31. doi: 10.1016/j.jff.2018.11.004.
   Web of Science ®Google Scholar
• Cao, S.-Y., C.-N. Zhao, R.-Y. Gan, X.-Y. Xu, X.-L. Wei, H. Corke, A. G. Atanasov, and H.-B. Li. 2019b. Effects and mechanisms of tea and its bioactive compounds for the prevention and treatment of cardiovascular diseases: An updated review. Antioxidants 8 (6):166. doi: 10.3390/antiox8060166.
   Web of Science ®Google Scholar
• Chang, C.-H., C.-Y. Lee, C.-C. Lu, F.-J. Tsai, Y.-M. Hsu, J.-W. Tsao, Y.-N. Juan, H.-Y. Chiu, J.-S. Yang, C.-C. Wang, et al. 2017. Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer car cells: A key role of AMPK and AKT/mTOR signaling. International Journal of Oncology 50 (3):873–82. doi: 10.3892/ijo.2017.3866.
   PubMed Web of Science ®Google Scholar
• Chauhan, S. S., A. B. Shetty, E. Hatami, P. Chowdhury, and M. M. Yallapu. 2020. Pectin-tannic acid nano-complexes promote the delivery and bioactivity of drugs in pancreatic cancer cells. Pharmaceutics 12 (3):285. doi: 10.3390/pharmaceutics12030285.
   PubMed Web of Science ®Google Scholar
• Chen, Y.-A., H.-M. Lien, M.-C. Kao, U.-G. Lo, L.-C. Lin, C.-J. Lin, S.-J. Chang, C.-C. Chen, J.-T. Hsieh, H. Lin, et al. 2017. Sensitization of radioresistant prostate cancer cells by resveratrol isolated from arachis hypogaea stems. Plos One 12 (1):e0169204. doi: 10.1371/journal.pone.0169204.
   PubMed Web of Science ®Google Scholar
• Chen, Y.-R., Y.-S. Chen, Y.-T. Chin, Z.-L. Li, Y.-J. Shih, Y.-C S. H. Yang, C. A. ChangOu, P.-Y. Su, S.-H. Wang, Y.-H. Wu, et al. 2019. Thyroid hormone-induced expression of inflammatory cytokines interfere with resveratrol-induced anti-proliferation of oral cancer cells. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 132:110693. doi: 10.1016/j.fct.2019.110693.
   PubMed Web of Science ®Google Scholar
• Cheng, L., B. Yan, K. Chen, Z. Jiang, C. Zhou, J. Cao, W. Qian, J. Li, L. Sun, J. Ma, et al. 2018a. Resveratrol-induced downregulation of NAF-1 enhances the sensitivity of pancreatic cancer cells to gemcitabine via the ROS/Nrf2 signaling pathways. Oxidative Medicine and Cellular Longevity 2018:9482018. doi: 10.1155/2018/9482018.
   PubMed Web of Science ®Google Scholar
• Cheng, T.-M., Y.-T. Chin, Y. Ho, Y.-R. Chen, Y.-N. Yang, Y.-C. Yang, Y.-J. Shih, T.-I. Lin, H.-Y. Lin, P. J. Davis, et al. 2018b. Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 112:67–75. doi: 10.1016/j.fct.2017.12.011.
   PubMed Web of Science ®Google Scholar
• Cho, C. J., C. W. Yang, C. L. Wu, J. Y. Ho, C. P. Yu, S. T. Wu, and D. S. Yu. 2019. The modulation study of multiple drug resistance in bladder cancer by curcumin and resveratrol. Oncology Letters 18 (6):6869–76. doi: 10.3892/ol.2019.11023.
   PubMed Web of Science ®Google Scholar
• Dai, H., H. B. Deng, Y. H. Wang, and J. J. Guo. 2018. Resveratrol inhibits the growth of gastric cancer via the Wnt/-catenin pathway. Oncology Letters 16 (2):1579–83. doi: 10.3892/ol.2018.8772.
   PubMed Web of Science ®Google Scholar
• Dariya, B., S. K. Behera, G. Srivani, S. Aliya, A. Alam, and G. P. Nagaraju. 2020. Resveratrol binds and activates RKIP protein in colorectal cancer. Amino Acids 52 (9):1299–306. doi: 10.1007/s00726-020-02889-2.
   PubMed Web of Science ®Google Scholar
• Davidson, K. W., M. J. Barry, C. M. Mangione, M. Cabana, A. B. Caughey, E. M. Davis, K. E. Donahue, C. A. Doubeni, A. H. Krist, M. Kubik, et al. 2021. Screening for colorectal cancer: Us preventive services task force recommendation statement. Jama 325 (19):1965–77. doi: 10.1001/jama.2021.6238.
   PubMed Web of Science ®Google Scholar
• Dermani, F. K., M. Saidijam, R. Amini, A. Mahdavinezhad, K. Heydari, and R. Najafi. 2017. Resveratrol inhibits proliferation, invasion, and epithelial-mesenchymal transition by increasing miR-200c expression in HCT-116 colorectal cancer cells. Journal of Cellular Biochemistry 118 (6):1547–55. doi: 10.1002/jcb.25816.
   PubMed Web of Science ®Google Scholar
• El-kott, A. F., A. A. Shati, M. A. Al-Kahtani, and S. A. Alharbi. 2019. The apoptotic effect of resveratrol in ovarian cancer cells is associated with downregulation of galectin-3 and stimulating Mir-424-3p transcription. Journal of Food Biochemistry 43 (12):e13072. doi: 10.1111/jfbc.13072.
   PubMed Web of Science ®Google Scholar
• Elshaer, M., Y. R. Chen, X. J. Wang, and X. W. Tang. 2018. Resveratrol: An overview of its anti-cancer mechanisms. Life Sciences 207:340–9. doi: 10.1016/j.lfs.2018.06.028.
   PubMed Web of Science ®Google Scholar
• Farha, A. K., R.-Y. Gan, H.-B. Li, D.-T. Wu, A. G. Atanasov, K. Gul, J.-R. Zhang, Q.-Q. Yang, and H. Corke. 2022. The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives. Critical Reviews in Food Science and Nutrition 62 (3):832–59. doi: 10.1080/10408398.2020.1829541.
   PubMed Web of Science ®Google Scholar
• Ferraresi, A., S. Phadngam, F. Morani, A. Galetto, O. Alabiso, G. Chiorino, and C. Isidoro. 2017. Resveratrol inhibits IL-6-induced ovarian cancer cell migration through epigenetic up-regulation of autophagy. Molecular Carcinogenesis 56 (3):1164–81. doi: 10.1002/mc.22582.
   PubMed Web of Science ®Google Scholar
• Fonseca, J., F. Moradi, L. A. Maddalena, B. Ferreira-Tollstadius, S. Selim, and J. A. Stuart. 2019. Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1. Oncology Letters 17 (1):697–705. doi: 10.3892/ol.2018.9526.
   PubMed Web of Science ®Google Scholar
• Fu, Y., Y. Ye, G. Zhu, Y. Xu, J. Sun, H. Wu, F. Feng, Z. Wen, S. Jiang, Y. Li, et al. 2020. Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species. Molecular Medicine Reports 23 (3):170. doi: 10.3892/mmr.2020.11809.
   Web of Science ®Google Scholar
• Fudhaili, A., N. A. Yoon, S. Kang, J. Ryu, J. Y. Jeong, D. H. Lee, and S. S. Kang. 2019. Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non-small cell lung cancer cell lines. Oncology Reports 41 (2):1377–86. doi: 10.3892/or.2018.6898.
   PubMed Web of Science ®Google Scholar
• Gao, P, and G. H. Ren. 2021. Identification of potential target genes of non-small cell lung cancer in response to resveratrol treatment by bioinformatics analysis. Aging 13 (19):23245–61. doi: 10.18632/aging.203616.
   PubMedGoogle Scholar
• Gao, Y. F, and T. O. Tollefsbol. 2018. Combinational proanthocyanidins and resveratrol synergistically inhibit human breast cancer cells and impact epigenetic-mediating machinery. International Journal of Molecular Sciences 19 (8):2204. doi: 10.3390/ijms19082204.
   PubMed Web of Science ®Google Scholar
• He, M., L. Xia, and J. Li. 2021. Potential mechanisms of plant-derived natural products in the treatment of cervical cancer. Biomolecules 11 (10):1539. doi: 10.3390/biom11101539.
   PubMed Web of Science ®Google Scholar
• Ho, Y., C.-Y. Wu, Y.-T. Chin, Z.-L. Li, Y.-S. Pan, T.-Y. Huang, P.-Y. Su, S.-Y. Lee, D. R. Crawford, K.-W. Su, et al. 2020. Ndat suppresses pro-inflammatory gene expression to enhance resveratrol-induced anti-proliferation in oral cancer cells. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 136:111092. doi: 10.1016/j.fct.2019.111092.
   PubMed Web of Science ®Google Scholar
• Hoca, M., E. Becer, H. Kabadayi, S. Yucecan, and H. S. Vatansever. 2020. The effect of resveratrol and quercetin on epithelial-mesenchymal transition in pancreatic cancer stem cell. Nutrition and Cancer 72 (7):1231–42. doi: 10.1080/01635581.2019.1670853.
   PubMed Web of Science ®Google Scholar
• Hsieh, T. C, and J. M. Wu. 2020. Resveratrol suppresses prostate cancer epithelial cell scatter/invasion by targeting inhibition of hepatocyte growth factor (HGF) secretion by prostate stromal cells and upregulation of e-cadherin by prostate cancer epithelial cells. International Journal of Molecular Sciences 21 (5):1760. doi: 10.3390/ijms21051760.
   PubMed Web of Science ®Google Scholar
• Hu, C. Y., Y. Liu, M. Y. Teng, K. L. Jiao, J. Zhen, M. X. Wu, and Z. Li. 2019. Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling. Cell Biology and Toxicology 35 (5):445–56. doi: 10.1007/s10565-019-09471-x.
   PubMed Web of Science ®Google Scholar
• Jang, M., L. Cai, G. O. Udeani, K. V. Slowing, C. F. Thomas, C. W. Beecher, H. H. Fong, N. R. Farnsworth, A. D. Kinghorn, R. G. Mehta, et al. 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (New York, N.Y.) 275 (5297):218–20. doi: 10.1126/science.275.5297.218.
   PubMed Web of Science ®Google Scholar
• Jang, Y. G., R. E. Go, K. A. Hwang, and K. C. Choi. 2019. Resveratrol inhibits DHT-induced progression of prostate cancer cell line through interfering with the AR and CXCR4 pathway. The Journal of Steroid Biochemistry and Molecular Biology 192:105406. doi: 10.1016/j.jsbmb.2019.105406.
   PubMed Web of Science ®Google Scholar
• Jiang, H., G. T. Wang, J. T. Gu, Y. Xiao, P. L. Wang, X. Huang, H. C. Sha, Z. Wang, and Q. Y. Ma. 2022. Resveratrol inhibits the expression of RYR2 and is a potential treatment for pancreatic cancer. Naunyn-Schmiedeberg’s Archives of Pharmacology 395 (3):315–24. doi: 10.1007/s00210-022-02203-9.
   PubMed Web of Science ®Google Scholar
• Jiang, Q., M. Y. Yang, Z. Qu, J. X. Zhou, and Q. Zhang. 2017. Resveratrol enhances anticancer effects of paclitaxel in HEPG2 human liver cancer cells. BMC Complementary and Alternative Medicine 17 (1):477. doi: 10.1186/s12906-017-1956-0.
   PubMedGoogle Scholar
• Khusbu, F. Y., X. Zhou, M. Roy, F. Z. Chen, Q. Cao, and H. C. Chen. 2020. Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proliferation and migration. The International Journal of Biochemistry & Cell Biology 118:105644. doi: 10.1016/j.biocel.2019.105644.
   PubMed Web of Science ®Google Scholar
• Kim, J. Y., K. H. Cho, B. Y. Jeong, C. G. Park, and H. Y. Lee. 2020a. Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol. Experimental & Molecular Medicine 52 (7):1152–63. doi: 10.1038/s12276-020-0474-1.
   PubMed Web of Science ®Google Scholar
• Kim, S., W. Kim, D.-H. Kim, J.-H. Jang, S.-J. Kim, S.-A. Park, H. Hahn, B. W. Han, H.-K. Na, K.-S. Chun, et al. 2020b. Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity. Archives of Biochemistry and Biophysics 689:108413. doi: 10.1016/j.abb.2020.108413.
   PubMed Web of Science ®Google Scholar
• Kim, T. H., J. H. Park, and J. S. Woo. 2019. Resveratrol induces cell death through ros-dependent downregulation of Notch1/PTEN/Akt signaling in ovarian cancer cells. Molecular Medicine Reports 19 (4):3353–60. doi: 10.3892/mmr.2019.9962.
   PubMed Web of Science ®Google Scholar
• Lacerda-Abreu, M. A., T. Russo-Abrahao, and J. R. Meyer-Fernandes. 2021. Resveratrol is an inhibitor of sodium-dependent inorganic phosphate transport in triple-negative MDA-MB-231 breast cancer cells. Cell Biology International 45 (8):1768–75. doi: 10.1002/cbin.11616.
   PubMed Web of Science ®Google Scholar
• Leon-Galicia, I., J. Diaz-Chavez, M. E. Albino-Sanchez, E. Garcia-Villa, R. Bermudez-Cruz, J. Garcia-Mena, L. A. Herrera, A. Garcia-Carranca, and P. Gariglio. 2018. Resveratrol decreases Rad51 expression and sensitizes cisplatin-resistant MCF-7 breast cancer cells. Oncology Reports 39 (6):3025–33. doi: 10.3892/or.2018.6336.
   PubMed Web of Science ®Google Scholar
• Li, D., G. Wang, G. Jin, K. Yao, Z. Zhao, L. Bie, Y. Guo, N. Li, W. Deng, X. Chen, et al. 2019a. Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. International Journal of Molecular Medicine 43 (1):630–40. doi: 10.3892/ijmm.2018.3969.
   PubMed Web of Science ®Google Scholar
• Li, L. J., D. K. Chen, J. L. Zhu, J. Ouyang, B. L. Song, S. L. Zhao, K. S. Luo, W. Li, and Y. Liu. 2019b. Inhibition of resveratrol on bladder cancer and its molecular mechanism. Acta Medica Mediterranea 35 (2):797–802. doi: 10.19193/0393-6384_2019_2_120.
   Web of Science ®Google Scholar
• Li, R., M. Liang, X. Liang, L. Yang, M. Su, and K. P. Lai. 2020a. Chemotherapeutic effectiveness of combining cetuximab for metastatic colorectal cancer treatment: A system review and meta-analysis. Frontiers in Oncology 10:868. doi: 10.3389/fonc.2020.00868.
   PubMed Web of Science ®Google Scholar
• Li, W. P., C. M. Li, L. J. Ma, and F. G. Jin. 2020b. Resveratrol inhibits viability and induces apoptosis in the small-cell lung cancer H446 cell line via the PI3K/Akt/c-Myc pathway. Oncology Reports 44 (5):1821–30. doi: 10.3892/or.2020.7747.
   PubMed Web of Science ®Google Scholar
• Li, W. P., Y. Shi, R. X. Wang, L. Pan, L. J. Ma, and F. G. Jin. 2018. Resveratrol promotes the sensitivity of small-cell lung cancer H446 cells to cisplatin by regulating intrinsic apoptosis. International Journal of Oncology 53 (5):2123–30. doi: 10.3892/ijo.2018.4533.
   PubMed Web of Science ®Google Scholar
• Li, Y., S. Li, X. Meng, R.-Y. Gan, J.-J. Zhang, and H.-B. Li. 2017. Dietary natural products for prevention and treatment of breast cancer. Nutrients 9 (7):728. doi: 10.3390/nu9070728.
   PubMed Web of Science ®Google Scholar
• Li, Y., Y. X. Yang, X. P. Liu, Y. W. Long, and Y. H. Zheng. 2019c. Prmt5 promotes human lung cancer cell apoptosis via AKT/GSK3 beta signaling induced by resveratrol. Cell Transplantation 28 (12):1664–73. doi: 10.1177/0963689719885083.
   PubMed Web of Science ®Google Scholar
• Liang, Z.-J., Y. Wan, D.-D. Zhu, M.-X. Wang, H.-M. Jiang, D.-L. Huang, L.-F. Luo, M.-J. Chen, W.-P. Yang, H.-M. Li, et al. 2021. Resveratrol mediates the apoptosis of triple negative breast cancer cells by reducing pold1 expression. Frontiers in Oncology 11:569295. doi: 10.3389/fonc.2021.569295.
   PubMed Web of Science ®Google Scholar
• Lin, C.-C., Y.-T. Chin, Y.-J. Shih, Y.-R. Chen, Y.-Y. Chung, C.-Y. Lin, C.-N. Hsiung, J. Whang-Peng, S.-Y. Lee, H.-Y. Lin, et al. 2019. Resveratrol antagonizes thyroid hormone-induced expression of checkpoint and proliferative genes in oral cancer cells. Journal of Dental Sciences 14 (3):255–62. doi: 10.1016/j.jds.2019.01.013.
   PubMed Web of Science ®Google Scholar
• Lin, Y.-H., L.-Y. Zhu, Y.-Q. Yang, Z.-H. Zhang, Q.-G. Chen, Y.-P. Sun, J.-J. Bi, X.-M. Luo, Z.-H. Ni, X.-B. Wang, et al. 2021. Resveratrol inhibits MUC5AC expression by regulating SPDEF in lung cancer cells. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 89:153601. doi: 10.1016/j.phymed.2021.153601.
   PubMed Web of Science ®Google Scholar
• Liu, X., H. Li, M. L. Wu, J. Wu, Y. Sun, K. L. Zhang, and J. Liu. 2019. Resveratrol reverses retinoic acid resistance of anaplastic thyroid cancer cells via demethylating CRABP2 gene. Frontiers in Endocrinology 10:734. doi: 10.3389/fendo.2019.00734.
   PubMed Web of Science ®Google Scholar
• Liu, Y., L. Tong, Y. Luo, X. Li, G. W. Chen, and Y. F. Wang. 2018. Resveratrol inhibits the proliferation and induces the apoptosis in ovarian cancer cells via inhibiting glycolysis and targeting AMPK/mTOR signaling pathway. Journal of Cellular Biochemistry 119 (7):6162–72. doi: 10.1002/jcb.26822.
   PubMed Web of Science ®Google Scholar
• Liu, Z. L., X. H. Wu, J. J. Lv, H. Sun, and F. Q. Zhou. 2019. Resveratrol induces p53 in colorectal cancer through SET7/9. Oncology Letters 17 (4):3783–9. doi: 10.3892/ol.2019.10034.
   PubMed Web of Science ®Google Scholar
• Liu, Z. X., Y. J. Li, G. H. She, X. F. Zheng, L. Y. Shao, P. Y. Wang, M. Pang, S. Y. Xie, and Y. X. Sun. 2020. Resveratrol induces cervical cancer hela cell apoptosis through the activation and nuclear translocation promotion of foxo3a. Die Pharmazie 75 (6):250–4. doi: 10.1691/ph.2020.0386.
   PubMed Web of Science ®Google Scholar
• Lucas, J., T. C. Hsieh, H. D. Halicka, Z. Darzynkiewicz, and J. M. Wu. 2018. Upregulation of PD-l1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300-mediated NF-kappa B signaling. International Journal of Oncology 53 (4):1469–80. doi: 10.3892/ijo.2018.4512.
   PubMed Web of Science ®Google Scholar
• Luo, Y. Y., D. Liu, X. Q. Wang, X. P. Ye, N. Li, Y. Zhang, J. J. Song, and Q. Wang. 2021. Resveratrol exerts an antiproliferative effect in pancreatic cancer cells by inducing mitochondrial-mediated apoptosis. Acta Poloniae Pharmaceutica - Drug Research 77 (6):871–9. doi: 10.32383/appdr/130296.
   Web of Science ®Google Scholar
• Madencioglu, S., E. Becer, H. Kabadayi, H. S. Vatansever, and S. Yucecan. 2021. Resveratrol triggers apoptosis in colon cancer cells rather than senescence. Progress in Nutrition 23 (1):e2021018. doi: 10.23751/pn.v23i1.9571.
   Web of Science ®Google Scholar
• Mao, Q.-Q., X.-Y. Xu, A. Shang, R.-Y. Gan, D.-T. Wu, A. G. Atanasov, and H.-B. Li. 2020. Phytochemicals for the prevention and treatment of gastric cancer: Effects and mechanisms. International Journal of Molecular Sciences 21 (2):570. doi: 10.3390/ijms21020570.
   PubMed Web of Science ®Google Scholar
• Martinez-Martinez, D., A. Soto, B. Gil-Araujo, B. Gallego, A. Chiloeches, and M. Lasa. 2019. Resveratrol promotes apoptosis through the induction of dual specificity phosphatase 1 and sensitizes prostate cancer cells to cisplatin. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 124:273–9. doi: 10.1016/j.fct.2018.12.014.
   PubMed Web of Science ®Google Scholar
• Meng, X., J. Zhou, C.-N. Zhao, R.-Y. Gan, and H.-B. Li. 2020. Health benefits and molecular mechanisms of resveratrol: A narrative review. Foods 9 (3):340. doi: 10.3390/foods9030340.
   PubMed Web of Science ®Google Scholar
• Mieszala, K., M. Rudewicz, A. Gomulkiewicz, K. Ratajczak-Wielgomas, J. Grzegrzolka, P. Dziegiel, and S. Borska. 2018. Expression of genes and proteins of multidrug resistance in gastric cancer cells treated with resveratrol. Oncology Letters 15 (4):5825–32. doi: 10.3892/ol.2018.8022.
   PubMed Web of Science ®Google Scholar
• Mikami, S., I. Ota, T. Masui, T. Uchiyama, H. Okamoto, T. Kimura, S. Takasawa, and T. Kitahara. 2019. Resveratrol-induced REG iii expression enhances chemo- and radiosensitivity in head and neck cancer in xenograft mice. Oncology Reports 42 (1):436–42. doi: 10.3892/or.2019.7137.
   PubMed Web of Science ®Google Scholar
• Mukherjee, S., J. I. Dudley, and D. K. Das. 2010. Dose-dependency of resveratrol in providing health benefits. Dose-Response 8 (4):dose-response.0. doi: 10.2203/dose-response.09-015.Mukherjee.
   Web of Science ®Google Scholar
• Qian, W., Q. Xiao, L. Wang, T. Qin, Y. Xiao, J. Li, Y. Yue, C. Zhou, W. Duan, Q. Ma, et al. 2020. Resveratrol slows the tumourigenesis of pancreatic cancer by inhibiting NF kappa B activation. Biomedicine & Pharmacotherapy 127:110116. doi: 10.1016/j.biopha.2020.110116.
   PubMed Web of Science ®Google Scholar
• Rasheduzzaman, M., J. K. Jeong, and S. Y. Park. 2018. Resveratrol sensitizes lung cancer cell to TRAIL by p53 independent and suppression of Akt/NF-kappa B signaling. Life Sciences 208:208–20. doi: 10.1016/j.lfs.2018.07.035.
   PubMed Web of Science ®Google Scholar
• Ratajczak, K., N. Glatzel-Plucińska, K. Ratajczak-Wielgomas, K. Nowińska, and S. Borska. 2021. Effect of resveratrol treatment on human pancreatic cancer cells through alterations of Bcl-2 family members. Molecules 26 (21):6560. doi: 10.3390/molecules26216560.
   PubMed Web of Science ®Google Scholar
• Rauf, A., M. Imran, M. S. Butt, M. Nadeem, D. G. Peters, and M. S. Mubarak. 2018. Resveratrol as an anti-cancer agent: A review. Critical Reviews in Food Science and Nutrition 58 (9):1428–47. doi: 10.1080/10408398.2016.1263597.
   PubMed Web of Science ®Google Scholar
• Ren, B., M. X.-Y. Kwah, C. Liu, Z. Ma, M. K. Shanmugam, L. Ding, X. Xiang, P. C.-L. Ho, L. Wang, P. S. Ong, et al. 2021. Resveratrol for cancer therapy: Challenges and future perspectives. Cancer Letters 515:63–72. doi: 10.1016/j.canlet.2021.05.001.
   PubMed Web of Science ®Google Scholar
• Ren, M. T., X. X. Zhou, M. L. Gu, W. R. Jiao, M. S. Yu, Y. M. Wang, S. Liu, J. P. Yang, and F. Ji. 2020. Resveratrol synergizes with cisplatin in antineoplastic effects against AGS gastric cancer cells by inducing endoplasmic reticulum stress-mediated apoptosis and G2/M phase arrest. Oncology Reports 44 (4):1605–15. doi: 10.3892/or.2020.7708.
   PubMed Web of Science ®Google Scholar
• Roncoroni, L., L. Elli, P. Braidotti, D. Tosi, V. Vaira, L. Tacchini, V. Lombardo, F. Branchi, A. Scricciolo, L. Doneda, et al. 2018. Transglutaminase 2 mediates the cytotoxicity of resveratrol in a human cholangiocarcinoma and gallbladder cancer cell lines. Nutrition and Cancer 70 (5):761–9. doi: 10.1080/01635581.2018.1470648.
   PubMed Web of Science ®Google Scholar
• Shang, A., J. Li, D.-D. Zhou, R.-Y. Gan, and H.-B. Li. 2021. Molecular mechanisms underlying health benefits of tea compounds. Free Radical Biology & Medicine 172:181–200. doi: 10.1016/j.freeradbiomed.2021.06.006.
   PubMed Web of Science ®Google Scholar
• Sharifi-Rad, J., S. Rajabi, M. Martorell, M. D. López, M. T. Toro, S. Barollo, D. Armanini, P. V. T. Fokou, G. Zagotto, G. Ribaudo, et al. 2020. Plant natural products with anti-thyroid cancer activity. Fitoterapia 146:104640. doi: 10.1016/j.fitote.2020.104640.
   PubMed Web of Science ®Google Scholar
• Singh, S. K., S. Banerjee, E. P. Acosta, J. W. Lillard, and R. Singh. 2017. Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/p21(WAF1/CIP1) and p27(KIP1) pathway. Oncotarget 8 (10):17216–28. doi: 10.18632/oncotarget.15303.
   PubMedGoogle Scholar
• Singh, V., R. Singh, P. K. Kujur, and R. P. Singh. 2020. Combination of resveratrol and quercetin causes cell growth inhibition, DNA damage, cell cycle arrest, and apoptosis in oral cancer cells. Assay and Drug Development Technologies 18 (5):226–38. doi: 10.1089/adt.2020.972.
   PubMed Web of Science ®Google Scholar
• Sun, H., T. Zhang, R. Liu, W. Cao, Z. Zhang, Z. Liu, W. Qian, D. Wang, D. Yu, C. Zhong, et al. 2021a. Resveratrol inhibition of renal cancer stem cell characteristics and modulation of the sonic hedgehog pathway. Nutrition and Cancer 73 (7):1157–67. doi: 10.1080/01635581.2020.1784966.
   PubMed Web of Science ®Google Scholar
• Sun, X. D., P. Fu, L. X. Xie, S. M. Chai, Q. Q. Xu, L. Zeng, X. B. Wang, N. Jiang, and M. Sang. 2021b. Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes. International Journal of Molecular Medicine 47 (1):335–45. doi: 10.3892/ijmm.2020.4789.
   PubMed Web of Science ®Google Scholar
• Sun, X., Q. Xu, L. Zeng, L. Xie, Q. Zhao, H. Xu, X. Wang, N. Jiang, P. Fu, M. Sang, et al. 2020. Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3(Tyr705)phosphorylation. Cancer Medicine 9 (22):8685–700. doi: 10.1002/cam4.3510.
   PubMed Web of Science ®Google Scholar
• Sun, Y., Q. M. Zhou, Y. Y. Lu, H. Zhang, Q. L. Chen, M. Zhao, and S. B. Su. 2019. Resveratrol inhibits the migration and metastasis of MDA-MB-231 human breast cancer by reversing TGF-beta 1-induced epithelial-mesenchymal transition. Molecules 24 (6):1131. doi: 10.3390/molecules24061131.
   PubMed Web of Science ®Google Scholar
• Sung, H., J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray. 2021. Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 71 (3):209–49. doi: 10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Tao, J., S. Li, R.-Y. Gan, C.-N. Zhao, X. Meng, and H.-B. Li. 2020. Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action. Critical Reviews in Food Science and Nutrition 60 (6):1025–37. doi: 10.1080/10408398.2018.1555789.
   PubMed Web of Science ®Google Scholar
• Tao, J., Y. Li, S. Li, and H.-B. Li. 2018. Plant foods for the prevention and management of colon cancer. Journal of Functional Foods 42:95–110. doi: 10.1016/j.jff.2017.12.064.
   Web of Science ®Google Scholar
• Vargas, J. E., R. Puga, G. Lenz, C. Trindade, and E. Filippi-Chiela. 2020. Cellular mechanisms triggered by the cotreatment of resveratrol and doxorubicin in breast cancer: A translational in vitro-in silico model. Oxidative Medicine and Cellular Longevity 2020:5432651. doi: 10.1155/2020/5432651.
   PubMed Web of Science ®Google Scholar
• Vendrely, V., E. Peuchant, E. Buscail, I. Moranvillier, B. Rousseau, A. Bedel, A. Brillac, H. de Verneuil, F. Moreau-Gaudry, S. Dabernat, et al. 2017. Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model. Cancer Letters 390:91–102. doi: 10.1016/j.canlet.2017.01.002.
   PubMed Web of Science ®Google Scholar
• Wang, D. L., Z. F. Gao, and X. Zhang. 2018. Resveratrol induces apoptosis in murine prostate cancer cells via hypoxia-inducible factor 1-alpha (HIF-1 alpha)/reactive oxygen species (ROS)/P53 signaling. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 24:8970–6. doi: 10.12659/msm.913290.
   PubMed Web of Science ®Google Scholar
• Wang, H. X., R. Z. Jia, T. L. Lv, M. Wang, S. W. He, and X. Zhang. 2020a. Resveratrol suppresses tumor progression via inhibiting STAT3/HIF-1 alpha/VEGF pathway in an orthotopic rat model of non-small-cell lung cancer (NSCLC). OncoTargets and Therapy ume 13:7057–63. doi: 10.2147/OTT.S259016.
   Web of Science ®Google Scholar
• Wang, S. S., Q. Meng, Q. Xie, and M. Zhang. 2017. Effect and mechanism of resveratrol on drug resistance in human bladder cancer cells. Molecular Medicine Reports 15 (3):1179–87. doi: 10.3892/mmr.2017.6111.
   PubMed Web of Science ®Google Scholar
• Wang, Y. J., W. H. Wang, X. J. Wu, C. J. Li, Y. P. Huang, H. Y. Zhou, and Y. Cui. 2020b. Resveratrol sensitizes colorectal cancer cells to cetuximab by connexin 43 upregulation-induced Akt inhibition. Frontiers in Oncology 10:383. doi: 10.3389/fonc.2020.00383.
   PubMed Web of Science ®Google Scholar
• Wu, H., L. Chen, F. F. Zhu, X. Han, L. D. Sun, and K. P. Chen. 2019. The cytotoxicity effect of resveratrol: Cell cycle arrest and induced apoptosis of breast cancer 4T1 cells. Toxins 11 (12):731. doi: 10.3390/toxins11120731.
   PubMed Web of Science ®Google Scholar
• Wu, J., Y. T. Li, X. T. Tian, Y. S. Liu, M. L. Wu, P. N. Li, and J. Liu. 2020. STAT3 signaling statuses determine the fate of resveratrol-treated anaplastic thyroid cancer cells. Cancer Biomarkers 27 (4):461–9. doi: 10.3233/CBM-191010.
   PubMed Web of Science ®Google Scholar
• Wu, J., T. Zhou, Y. Wang, Y. Jiang, and Y. Wang. 2021. Mechanisms and advances in anti-ovarian cancer with natural plants component. Molecules 26 (19):5949. doi: 10.3390/molecules26195949.
   PubMed Web of Science ®Google Scholar
• Wu, Q., J. P. C. Wong, and H. F. Kwok. 2020. Putting the brakes on tumorigenesis with natural products of plant origin: Insights into the molecular mechanisms of actions and immune targets for bladder cancer treatment. Cells 9 (5):1213. doi: 10.3390/cells9051213.
   PubMed Web of Science ®Google Scholar
• Wu, X. X., Y. D. Xu, B. R. Zhu, Q. Liu, Q. F. Yao, and G. Zhao. 2018. Resveratrol induces apoptosis in SGC-7901 gastric cancer cells. Oncology Letters 16 (3):2949–56. doi: 10.3892/ol.2018.9045.
   PubMed Web of Science ®Google Scholar
• Xiao, Y., T. Qin, L. Sun, W. Qian, J. Li, W. Duan, J. Lei, Z. Wang, J. Ma, X. Li, et al. 2020. Resveratrol ameliorates the malignant progression of pancreatic cancer by inhibiting hypoxia-induced pancreatic stellate cell activation. Cell Transplantation 29:963689720929987. doi: 10.1177/0963689720929987.
   PubMed Web of Science ®Google Scholar
• Xiong, L., J. H. Nie, X. M. Lin, J. B. Wu, Z. Chen, B. Xu, and J. Liu. 2020. Biological implications of PTEN upregulation and altered sodium/iodide symporter intracellular distribution in resveratrol-suppressed anaplastic thyroid cancer cells. Journal of Cancer 11 (23):6883–91. doi: 10.7150/jca.48180.
   PubMed Web of Science ®Google Scholar
• Xu, G. R., J. Z. Chen, G. R. Wang, J. H. Xiao, N. Zhang, Y. Y. Chen, H. R. Yu, G. Z. Wang, and Y. F. Zhao. 2020a. Resveratrol inhibits the tumorigenesis of follicular thyroid cancer via ST6GAL2-regulated activation of the hippo signaling pathway. Molecular Therapy Oncolytics 16:124–33. doi: 10.1016/j.omto.2019.12.010.
   PubMed Web of Science ®Google Scholar
• Xu, J. H., D. Y. Liu, H. L. Niu, G. F. Zhu, Y. W. Xu, D. L. Ye, J. Li, and Q. L. Zhang. 2017. Resveratrol reverses doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer. Journal of Experimental & Clinical Cancer Research 36 (1):19. doi: 10.1186/s13046-016-0487-8.
   PubMed Web of Science ®Google Scholar
• Xu, Q. H., Y. Xiao, X. Q. Li, L. Fan, C. C. Zhou, L. Cheng, Z. D. Jiang, and G. H. Wang. 2020b. Resveratrol counteracts hypoxia-induced gastric cancer invasion and EMT through hedgehog pathway suppression. Anti-Cancer Agents in Medicinal Chemistry 20 (9):1105–14. doi: 10.2174/1871520620666200402080034.
   PubMed Web of Science ®Google Scholar
• Xu, X.-Y., C.-N. Zhao, S.-Y. Cao, G.-Y. Tang, R.-Y. Gan, and H.-B. Li. 2020c. Effects and mechanisms of tea for the prevention and management of cancers: An updated review. Critical Reviews in Food Science and Nutrition 60 (10):1693–705. doi: 10.1080/10408398.2019.1588223.
   PubMed Web of Science ®Google Scholar
• Yang, M. D., Y. Sun, W. J. Zhou, X. Z. Xie, Q. M. Zhou, Y. Y. Lu, and S. B. Su. 2021a. Resveratrol enhances inhibition effects of cisplatin on cell migration and invasion and tumor growth in breast cancer MDA-MB-231 cell models in vivo and in vitro. Molecules 26 (8):2204. doi: 10.3390/molecules26082204.
   PubMed Web of Science ®Google Scholar
• Yang, M., Z. Li, J. Tao, H. Hu, Z. Li, Z. Zhang, F. Cheng, Y. Sun, Y. Zhang, J. Yang, et al. 2021b. Resveratrol induces PD-L1 expression through snail-driven activation of wnt pathway in lung cancer cells. Journal of Cancer Research and Clinical Oncology 147 (4):1101–13. doi: 10.1007/s00432-021-03510-z.
   PubMed Web of Science ®Google Scholar
• Yang, T. T., J. M. Zhang, J. T. Zhou, M. X. Zhu, L. Wang, and L. H. Yan. 2018. Resveratrol inhibits interleukin-6 induced invasion of human gastric cancer cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 99:766–73. doi: 10.1016/j.biopha.2018.01.153.
   PubMed Web of Science ®Google Scholar
• Yang, Z. Y., Q. G. Xie, Z. L. Chen, H. B. Ni, L. Xia, Q. F. Zhao, Z. Y. Chen, and P. F. Chen. 2019. Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of malat1-mediated epithelial-to-mesenchymal transition. Experimental and Therapeutic Medicine 17 (3):1569–78. doi: 10.3892/etm.2018.7142.
   PubMed Web of Science ®Google Scholar
• Yao, S. L., M. Gao, Z. J. Wang, W. Y. Wang, L. Zhan, and B. Wei. 2021. Upregulation of microRNA-34a sensitizes ovarian cancer cells to resveratrol by targeting Bcl-2. Yonsei Medical Journal 62 (8):691–701. doi: 10.3349/ymj.2021.62.8.691.
   PubMed Web of Science ®Google Scholar
• Ye, M., H. S. Tian, S. H. Lin, J. R. Mo, Z. Li, X. J. Chen, and J. J. Liu. 2020. Resveratrol inhibits proliferation and promotes apoptosis via the androgen receptor splicing variant 7 and PI3K/AKT signaling pathway in LNCaP prostate cancer cells. Oncology Letters 20 (5):1– doi: 10.3892/ol.2020.12032.
   PubMed Web of Science ®Google Scholar
• Yeung, A. W. K., B. B. Aggarwal, I. E. Orhan, D. Barreca, M. Battino, T. Belwal, A. Bishayee, M. Daglia, H. P. Devkota, et al. 2019. Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis – A review. Animal Science Papers and Reports 37 (2):103–18.
   Web of Science ®Google Scholar
• Yin, L., R. Zhang, Y. Hu, W. Li, M. Wang, Z. Liang, Z. Sun, R. Ji, W. Xu, H. Qian, et al. 2020. Gastric-cancer-derived mesenchymal stem cells: A promising target for resveratrol in the suppression of gastric cancer metastasis. Human Cell 33 (3):652–62. doi: 10.1007/s13577-020-00339-5.
   PubMed Web of Science ®Google Scholar
• Yuan, L., M. Zhou, D. Huang, H. S. Wasan, K. Zhang, L. Sun, H. Huang, S. Ma, M. Shen, S. Ruan, et al. 2019. Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial-mesenchymal transition via the AKT/GSK-3 beta/snail signaling pathway. Molecular Medicine Reports 20 (3):2783–95. doi: 10.3892/mmr.2019.10528.
   PubMed Web of Science ®Google Scholar
• Zaffaroni, N, and G. L. Beretta. 2021. Resveratrol and prostate cancer: The power of phytochemicals. Current Medicinal Chemistry 28 (24):4845–62. doi: 10.2174/0929867328666201228124038.
   PubMed Web of Science ®Google Scholar
• Zhang, S., D. Wang, J. Huang, Y. Hu, and Y. Xu. 2020. Application of capsaicin as a potential new therapeutic drug in human cancers. Journal of Clinical Pharmacy and Therapeutics 45 (1):16–28. doi: 10.1111/jcpt.13039.
   PubMed Web of Science ®Google Scholar
• Zhang, Y. T., Y. Li, C. C. Sun, X. Chen, L. Y. Han, T. Q. Wang, J. F. Liu, X. J. Chen, and D. Zhao. 2021. Effect of pterostilbene, a natural derivative of resveratrol, in the treatment of colorectal cancer through Top1/Tdp1-mediated DNA repair pathway. Cancers 13 (16):4002. doi: 10.3390/cancers13164002.
   PubMed Web of Science ®Google Scholar
• Zhao, Y. H., X. Y. Yuan, X. Li, and Y. Zhang. 2019. Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1. Journal of Cellular Biochemistry 120 (2):1527–31. doi: 10.1002/jcb.27335.
   PubMed Web of Science ®Google Scholar
• Zhou, C., W. Qian, J. Ma, L. Cheng, Z. Jiang, B. Yan, J. Li, W. Duan, L. Sun, J. Cao, et al. 2019. Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting srebp1. Cell Proliferation 52 (1):e12514. doi: 10.1111/cpr.12514.
   PubMed Web of Science ®Google Scholar
• Zhou, D.-D., M. Luo, S.-Y. Huang, A. Saimaiti, A. Shang, R.-Y. Gan, and H.-B. Li. 2021. Effects and mechanisms of resveratrol on aging and age-related diseases. Oxidative Medicine and Cellular Longevity 2021:9932218. doi: 10.1155/2021/9932218.
   PubMed Web of Science ®Google Scholar
• Zhu, Z. W., J. G. Wu, L. Y. Xu, Y. Wan, H. C. Chao, and T. Sun. 2021. Chinese herb resveratrol inhibits renal pelvic cancer cell proliferation via regulating miR-30a-5p. Journal of Biobased Materials and Bioenergy 15 (2):253–9. doi: 10.1166/jbmb.2021.2063.
   Web of Science ®Google Scholar