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Research ArticlesIssue

Association between ethylene oxide exposure and sex steroid hormone levels in male adults in the United States

Pages 164-179 | Received 07 Jun 2023, Accepted 17 Dec 2023, Published online: 15 Feb 2024

References

  • Agency for Toxic Substances and Disease Registry. 2022. Toxicological profile for ethylene oxide. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. https://www.atsdr.cdc.gov/toxprofiles/tp137.pdf.
  • Calabrese EJ, Baldwin LA. 2001. U-shaped dose-responses in biology, toxicology, and public health. Annu Rev Public Health. 22(1):15–33. doi: 10.1146/annurev.publhealth.22.1.15.
  • Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, Zoeller RT, Gore AC. 2009. Endocrine-disrupting chemicals: an endocrine society scientific statement. Endocr Rev. 30(4):293–342. doi: 10.1210/er.2009-0002.
  • ECHA (European Chemicals Agency). Ethylene oxide. https://echa.europa.eu/brief-profile/-/briefprofile/100.000.773.
  • Farmer PB, Sepai O, Lawrence R, Autrup H, Sabro Nielsen P, Vestergård AB, Waters R, Leuratti C, Jones NJ, Stone J, et al. 1996. Biomonitoring human exposure to environmental carcinogenic chemicals. Mutagenesis. 11(4):363–381. doi: 10.1093/mutage/11.4.363.
  • Filser JG, Kessler W, Artati A, Erbach E, Faller T, Kreuzer PE, Li Q, Lichtmannegger J, Numtip W, Klein D, et al. 2013. Ethylene oxide in blood of ethylene-exposed B6C3F1 mice, Fischer 344 rats, and humans. Toxicol Sci. 136(2):344–358. doi: 10.1093/toxsci/kft218.
  • Guo J, Wan Z, Cui G, Pan A, Liu G. 2021. Association of exposure to ethylene oxide with risk of diabetes mellitus: results from NHANES 2013–2016. Environ Sci Pollut Res Int. 28(48):68551–68559. doi: 10.1007/s11356-021-15444-7.
  • Hagmar L, Welinder H, Lindén K, Attewell R, Osterman-Golkar S, Törnqvist M. 1991. An Epidemiological study of cancer risk among workers exposed to ethylene oxide using hemoglobin adducts to validate environmental exposure assessments. Int Arch Occup Environ Health. 63(4):271–277. doi: 10.1007/BF00386377.
  • Holyoak GR, Wang S, Liu Y, Bunch TD. 1996. Toxic effects of ethylene oxide residues on bovine embryos in vitro. Toxicology. 108(1-2):33–38. doi: 10.1016/S0300-483X(95)03268-K.
  • IARC. 2012. Chemical agents and related occupations: ethylene Oxide Vol. 100F.
  • Jones RR, Fisher JA, Medgyesi DN, Buller ID, Liao LM, Gierach G, Ward MH, Silverman DT. 2023. Ethylene oxide emissions and incident breast cancer and non-Hodgkin lymphoma in a US cohort. J Natl Cancer Inst. 115(4):405–412. doi: 10.1093/jnci/djad004.
  • Kagawa T, Ohgami N, He T, Tazaki A, Ohnuma S, Naito H, Yajima I, Chen D, Deng Y, Tamura T, et al. 2023. Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice. Eur Hear J Open. 3(5):1–12. doi: 10.1093/ehjopen/oead074.
  • Kaido M, Mori K, Koide O. 1992. Testicular damage caused by inhalation of ethylene oxide in rats: light and electron microscopic studies. Toxicol Pathol. 20(1):32–43. doi: 10.1177/019262339202000105.
  • Kirman CR, Hays SM. 2017. Derivation of endogenous equivalent values to support risk assessment and risk management decisions. Regul Toxicol Pharmacol. 91(September):165–172. doi: 10.1016/j.yrtph.2017.10.032.
  • Kirman CR, Li AA, Sheehan PJ, Bus JS, Lewis RC, Hays SM. 2021. Ethylene oxide review: characterization of total exposure via endogenous and exogenous pathways and their implications to risk assessment and risk management. J Toxicol Environ Health B Crit Rev. 24(1):1–29. doi: 10.1080/10937404.2020.1852988.
  • Kresovich JK, Argos M, Turyk ME. 2015. Associations of lead and cadmium with sex hormones in adult males. Environ Res. 142:25–33. doi: 10.1016/j.envres.2015.05.026.
  • Li Q, Csanády GA, Kessler W, Klein D, Pankratz H, Pütz C, Richter N, Filser JG. 2011. Kinetics of ethylene and ethylene oxide in subcellular fractions of lungs and livers of male B6C3F1 mice and male Fischer 344 rats and of human livers. Toxicol Sci. 123(2):384–398. doi: 10.1093/toxsci/kfr194.
  • Mauras N, Lima J, Patel D, Rini A, Di Salle E, Kwok A, Lippe B. 2003. Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males. J Clin Endocrinol Metab. 88(12):5951–5956. doi: 10.1210/jc.2003-031279.
  • More S, Benford D, Hougaard Bennekou S, Bampidis V, Bragard C, Halldorsson T, Hernandez-Jerez A, Koutsoumanis K, Lambré C, Machera K, et al. 2021. Opinion on the impact of non-monotonic dose responses on EFSA′s human health risk assessments. EFSA J. 19(10):6877. doi: 10.2903/j.efsa.2021.6877.
  • Mori K, Kaido M, Fujishiro K, Inoue N, Ide Y, Koide O. 1991. Preventive effects of methylcobalamin on the testicular damage induced by ethylene oxide. Arch Toxicol. 65(5):396–401. doi: 10.1007/BF02284263.
  • Mori K, Kaido M, Fujishiro K, Inoue N, Koide O, Hori H, Tanaka I. 1991. Dose dependent effects of inhaled ethylene oxide on spermatogenesis in rats. Br J Ind Med. 48(4):270–274. doi: 10.1136/oem.48.4.270.
  • National Center for Health Statistics Center for Disease Control and Prevention. 2006. Analytic and reporting guidelines the national health and nutrition examination survey (NHANES). Prevention. :1–14. https://www.cdc.gov/nchs/data/nhanes/nhanes_03_04/nhanes_analytic_guidelines_dec_2005.pdf
  • Nguyen HD, Oh H, Kim MS. 2022. The effects of chemical mixtures on lipid profiles in the Korean adult population: threshold and molecular mechanisms for dyslipidemia involved. Environ Sci Pollut Res Int. 29(26):39182–39208. doi: 10.1007/s11356-022-18871-2.
  • Pirkle JL. 2019. Laboratory procedure manual. https://wwwn.cdc.gov/nchs/data/nhanes/2015-2016/labmethods/AMDGYD_ETHOX_I_MET.pdf.
  • Rinaldi S, Peeters PHM, Bezemer ID, Dossus L, Biessy C, Sacerdote C, Berrino F, Panico S, Palli D, Tumino R, et al. 2006. Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: the European prospective investigation into cancer and nutrition. Cancer Causes Control. 17(8):1033–1043. doi: 10.1007/s10552-006-0041-7.
  • Rowland AS, Baird DD, Shore DL, Darden B, Wilcox AJ. 1996. Ethylene oxide exposure may increase the risk of spontaneous abortion, preterm birth, and postterm birth. Epidemiology. 7(4):363–368. doi: 10.1097/00001648-199607000-00005.
  • Schettgen T, Broding HC, Angerer J, Drexler H. 2002. Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide–biomarkers in occupational and environmental medicine. Toxicol Lett. 134(1-3):65–70. doi: 10.1016/S0378-4274(02)00164-9.
  • Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH. 2019. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review. J Steroid Biochem Mol Biol. 194(July):105439. doi: 10.1016/j.jsbmb.2019.105439.
  • Shea JL, Wong PY, Chen Y. 2014. Free testosterone. Clinical utility and important analytical aspects of measurement. Adv Clin Chem. 63:59–84. doi: 10.1016/B978-0-12-800094-6.00002-9.
  • Shen X, Meng X, Wang C, Chen X, Chen Q, Cai J, Zhang J, Zhang Q, Fan L. 2023. Prenatal exposure to fine particulate matter and newborn anogenital distance: a prospective cohort study. Environ Health. 22(1):16. doi: 10.1186/s12940-023-00969-w.
  • Shobana N, Kumar MK, Navin AK, Akbarsha MA, Aruldhas MM. 2020. Prenatal exposure to excess chromium attenuates transcription factors regulating expression of androgen and follicle stimulating hormone receptors in sertoli cells of prepuberal rats. Chem Biol Interact. 328(July):109188. doi: 10.1016/j.cbi.2020.109188.
  • Steenland K, Whelan E, Deddens J, Stayner L, Ward E. 2003. Ethylene oxide and breast cancer incidence in a cohort study of 7576 women (United States). Cancer Causes Control. 14(6):531–539. doi: 10.1023/A:1024891529592.
  • Tian M, Wu S, Wang YX, Liu L, Zhang J, Shen H, Lu Y, Bao H, Huang Q. 2022. Associations of environmental phthalate exposure with male steroid hormone synthesis and metabolism: an integrated epidemiology and toxicology study. J Hazard Mater. 436(May):129213. doi: 10.1016/j.jhazmat.2022.129213.
  • Timothy OT, Ts’o MBCBKJL. 1974. Testicular atrophy from inhalation of ethylene oxide cyclic tetramer. Toxycology Appl. Pharmacol. 27:342–354.
  • U.S. Department of Health and Human Services. 2022. Vital and Health Statistics National Health and Nutrition Examination Survey, 2015–2018: Sample Design and Estimation Procedures Data Evaluation and Methods Research. Vol. 2.
  • U.S. Environmental Protection Agency. 2016. Evaluation of the inhalation carcinogenicity of ethylene oxide.
  • Walker WH, Cooke PS. 2023. Functions of steroid hormones in the male reproductive tract as revealed by mouse models. Int J Mol Sci. 24(3):2748. doi: 10.3390/ijms24032748.
  • Walker WH. 2011. Testosterone signaling and the regulation of spermatogenesis. Spermatogenesis. 1(2):116–120. doi: 10.4161/spmg.1.2.16956.
  • Wang Y, Aimuzi R, Nian M, Zhang Y, Luo K, Zhang J. 2021. Perfluoroalkyl substances and sex hormones in postmenopausal women: NHANES 2013–2016. Environ Int. 149:106408. doi: 10.1016/j.envint.2021.106408.
  • Welshons WV, Nagel SC, Vom Saal FS. 2006. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology. 147(6 Suppl):S56–S69. doi: 10.1210/en.2005-1159.
  • Wierman ME. 2007. Sex steroid effects at target tissues: mechanisms of action. Adv Physiol Educ. 31(1):26–33. doi: 10.1152/advan.00086.2006.
  • Wirbisky SE, Freeman JL. 2015. Atrazine exposure and reproductive dysfunction through the hypothalamus-pituitary-gonadal (HPG) axis. Toxics. 3(4):414–450. doi: 10.3390/toxics3040414.
  • Woodward MJ, Obsekov V, Jacobson MH, Kahn LG, Trasande L. 2020. Phthalates and sex steroid hormones among men from Nhanes, 2013–2016. J Clin Endocrinol Metab. 105(4):E1225–E1234. doi: 10.1210/clinem/dgaa039.
  • Xiao L, Yang C, Gu W, Liu R, Chen D. 2022. Associations between Serum copper, zinc, selenium level and sex hormones among 6–19 years old children and adolescents in NHANES 2013–2016. Front Endocrinol (Lausanne). 13:924338. doi: 10.3389/fendo.2022.924338.
  • Xu C, Liu Q, Liu H, Héroux P, Zhang Q, Jiang ZY, Gu A. 2015. Low serum testosterone levels are associated with elevated urinary mandelic acid, and strontium levels in adult men ACCORDING to the US 2011-2012 National Health and Nutrition Examination Survey. PLoS One. 10(5):e0127451. doi: 10.1371/journal.pone.0127451.
  • Xu H, Mao Y, Xu B. 2020. Association between pyrethroid pesticide exposure and hearing loss in adolescents. Environ Res. 187(May):109640. doi: 10.1016/j.envres.2020.109640.
  • Zeng G, Zhang Q, Wang X, Wu KH. 2021. Association between blood ethylene oxide levels and the risk of cardiovascular diseases in the general population. Environ Sci Pollut Res Int. 28(45):64921–64928. doi: 10.1007/s11356-021-15572-0.
  • Zhao J, Leung JYY, Lin SL, Mary Schooling C. 2016. Cigarette smoking and testosterone in men and women: a systematic review and meta-analysis of observational studies. Prev Med. 85:1–10. doi: 10.1016/j.ypmed.2015.12.021.
  • Zhou H, Wang Y, Gatcombe M, Farris J, Botelho JC, Caudill SP, Vesper HW. 2017. Simultaneous measurement of total estradiol and testosterone in human serum by isotope dilution liquid chromatography tandem mass spectrometry. Anal Bioanal Chem. 409(25):5943–5954. doi: 10.1007/s00216-017-0529-x.
  • Zhu X, Kong X, Chen M, Shi S, Cheang I, Zhu Q, Lu X, Yue X, Tang Y, Liao S, et al. 2022. Blood ethylene oxide, systemic inflammation, and serum lipid profiles: results from NHANES 2013–2016. Chemosphere. 299:134336. doi: 10.1016/j.chemosphere.2022.134336.

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