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Research Articles

The structure of apathy symptoms

ORCID Icon, ORCID Icon &
Pages 377-388 | Received 05 Jan 2023, Accepted 27 Jul 2023, Published online: 12 Aug 2023

References

  • Akaike, H. (1987). Factor analysis and AIC. Psychometrika, 52, 317–332.
  • Ang, Y. S., Lockwood, P., Apps, M. A., Muhammed, K., Husain, M., & Gulinello, M. (2017). Distinct subtypes of apathy revealed by the apathy motivation index. PloS one, 12(1), e0169938. https://doi.org/10.1371/journal.pone.0169938
  • Asparouhov, T., & Muthén, B. (2006). Robust chi square difference testing with mean and variance adjusted test statistics ( Mplus Web Notes: No. 10). https://www.statmodel.com/download/webnotes/webnote10.pdf
  • Barrash, J., Asp, E., Markon, K., Manzel, K., Anderson, S. W., & Tranel, D. (2011). Dimensions of personality disturbance after focal brain damage: Investigation with the Iowa scales of personality change. Journal of Clinical and Experimental Neuropsychology, 33(8), 833–852. https://doi.org/10.1080/13803395.2011.561300
  • Barrash, J., Bruss, J., Anderson, S. W., Kuceyeski, A., Manzel, K., Tranel, D., & Boes, A. D. (2022). Lesions in different prefrontal sectors are associated with different types of acquired personality disturbances. Cortex, 147, 169–184. https://doi.org/10.1016/j.cortex.2021.12.004
  • Barrash, J., Stillman, A., Anderson, S. W., Uc, E. Y., Dawson, J., & Rizzo, M. (2010). Prediction of driving ability with neuropsychological tests: Demographic adjustments diminish accuracy. Journal of the International Neuropsychological Society, 16(4), 679–686. https://doi.org/10.1017/S1355617710000470
  • Benton, A. L., Hamsher, K., & Sivan, A. (1989). Multilingual Aphasia Examination. AJA Associates.
  • Benton, A. L., & Van Allen, M. W. (1968). Impairment in facial recognition in patients with cerebral disease. Cortex, 4(4), 344–358. https://doi.org/10.1016/S0010-94526880018-8
  • Benton, A. L., Varney, N. R., & Hamsher, K. D. (1978). Visuospatial judgment: A clinical test. Archives of Neurology, 35(6), 364–367. https://doi.org/10.1001/archneur.1978.00500300038006
  • Blanchard, J. J., & Cohen, A. S. (2006). The structure of negative symptoms within schizophrenia: Implications for assessment. Schizophrenia Bulletin, 32(2), 238–245. https://doi.org/10.1093/schbul/sbj013
  • Bock, M. A., Bahorik, A., Brenowitz, W. D., & Yaffe, K. (2020). Apathy and risk of probable incident dementia among community-dwelling older adults. Neurology, 95(24), e3280–e3287. https://doi.org/10.1212/WNL.0000000000010951
  • Boyle, P. A., Malloy, P. F., Salloway, S., Cahn-Weiner, D. A., Cohen, R., & Cummings, J. L. (2003). Executive dysfunction and apathy predict functional impairment in Alzheimer disease. American Journal of Geriatric Psychiatry, 11(2), 214–221. https://doi.org/10.1176/appi.ajgp.11.2.214
  • Browne, M. W., & Cudeck, R. (1993). Alternative ways of assessing model fit. In Testing Structural Equation Models. K.A. & Long J.S. Sage Publications, 136–162. Thousand Oaks, CA.
  • Bucks, R., Ashworth, D., Wilcock, G., & Siegfried, K. (1996). Assessment of activities of daily living in dementia: Development of the bristol activities of daily living scale. Age and Ageing, 25(2), 113–120. https://doi.org/10.1093/ageing/25.2.113
  • Butterfield, L. C., Cimino, C. R., Oelke, L. E., Hauser, R. A., & Sanchez-Ramos, J. (2010). The independent influence of apathy and depression on cognitive functioning in Parkinson’s disease. Neuropsychology, 24(6), 721–730. https://doi.org/10.1037/a0019650
  • Clarke, D. E., Ko, J. Y., Kuhl, E. A., van Reekum, R., Salvador, R., & Marin, R. S. (2011). Are the available apathy measures reliable and valid? A review of the psychometric evidence. Journal of Psychosomatic Research, 70(1), 73–97. https://doi.org/10.1016/j.jpsychores.2010.01.012
  • Clarke, D., Reekum, R., Simard, M., Streiner, D., Freedman, M., & Conn, D. (2007). Apathy in dementia: An examination of the psychometric properties of the apathy evaluation scale. The Journal of Neuropsychiatry and Clinical Neurosciences, 19(1), 57–64. https://doi.org/10.1176/appi.neuropsych.19.1.57
  • Clark, L. A., & Watson, D. (2019). Constructing validity: New developments in creating objective measuring instruments. Psychological Assessment, 31, 1412–1427. https://doi.org/10.1037/pas0000626
  • Cohen, A. S., Kim, Y., & Najolia, G. M. (2013). Psychiatric symptom versus neurocognitive correlates of diminished expressivity in schizophrenia and mood disorders. Schizophrenia Research, 146(1–3), 249–253. https://doi.org/10.1016/j.schres.2013.02.002
  • Dickson, S. S., & Husain, M. (2022). Are there distinct dimensions of apathy? The argument for reappraisal. Cortex, 149, 246–256. https://doi.org/10.1016/j.cortex.2022.01.001
  • Eisenberg, D. P., Aniskin, D. B., White, L., Stein, J. A., Harvey, P. D., & Galynker, I. I. (2009). Structural differences within negative and depressive syndrome dimensions in schizophrenia, organic brain disease, and major depression: A confirmatory factor analysis of the positive and negative syndrome scale. Psychopathology, 42(4), 242–248. https://doi.org/10.1159/000218522
  • Esposito, F., Rochat, L., Van der Linden, A. C. J., Lekeu, F., Charnallet, A., & Van der Linden, M. (2014). Apathy in aging: Are lack of interest and lack of initiative dissociable?. Archives of Gerontology & Geriatrics, 58, 43–50. https://doi.org/10.1016/j.archger.2013.09.002
  • Faerden, A., Nesvåg, R., Barrett, E. A., Agartz, I., Finset, A., Friis, S., Rossberg, J. I., & Melle, I. (2008). Assessing apathy: The use of the Apathy evaluation scale in first episode psychosis. European Psychiatry, 23(1), 33–39. https://doi.org/10.1016/j.eurpsy.2007.09.002
  • Foussias, G., & Remington, G. (2010). Negative symptoms in schizophrenia: Avolition and Occam’s razor. Schizophrenia Bulletin, 36(2), 359–369. https://doi.org/10.1093/schbul/sbn094
  • Hama, S., Yamashita, H., Shigenobu, M., Watanabe, A., Hiramoto, K., Kurisu, K., Yamawaki, S., & Kitaoka, T. (2007). Depression or apathy and functional recovery after stroke. International Journal of Geriatric Psychiatry, 22(10), 1046–1051. https://doi.org/10.1002/gps.1866
  • Hayton, J. C., Allen, D. G., & Scarpello, V. (2004). Factor retention decisions in exploratory factor analysis: A tutorial on parallel analysis. Organizational Research Methods, 7(2), 191–205. https://doi.org/10.1177/1094428104263675
  • Hu, L. T., & Bentler, P. M. (1999). Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Structural Equation Modeling, 6(1), 1–55. https://doi.org/10.1080/10705519909540118
  • Kaplan, E. F., Goodglass, H., & Weintraub, S. (1983). The Boston Naming Test (2nd ed). Lea & Febiger.
  • Kumfor, F., Zhen, A., Hodges, J. R., Piguet, O., & Irish, M. (2018). Apathy in Alzheimer’s disease and frontotemporal dementia: Distinct clinical profiles and neural correlates. Cortex, 103, 350–359. https://doi.org/10.1016/j.cortex.2018.03.019
  • Lampe, I. K., & Heeren, T. J. (2004). Is apathy in late-life depressive illness related to age-at-onset, cognitive function or vascular risk? International Psychogeriatrics, 16(4), 481–486. https://doi.org/10.1017/S1041610204000766
  • Landes, A. M., Sperry, S. D., & Strauss, M. E. (2005). Prevalence of apathy, dysphoria, and depression in relation to dementia severity in Alzheimer’s disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 17(3), 342–349. https://doi.org/10.1176/appi.neuropsych.17.3.342
  • Leontjevas, R., Teerenstra, S., Smalbrugge, M., Vernooij-Dassen, M., Bohlmeijer, E. T., Gerritsen, D. L., & Koopman, R. (2013). More insight into the concept of apathy: A multidisciplinary depression program has a different effects on depressive symptoms and apathy in nursing homes. International Psychogeriatrics, 25(12), 1941–1952. https://doi.org/10.1017/S1041610213001440
  • Lopez, F. V., Eglit, G. M., Schiehser, D. M., Pirogovsky‐Turk, E., Litvan, I., Lessig, S., & Filoteo, J. V. (2019). Factor analysis of the apathy scale in Parkinson’s disease. Movement Disorders Clinical Practice, 6(5), 379–386. https://doi.org/10.1002/mdc3.12767
  • Marin, R. (1996). Apathy: Concept, syndrome, neural mechanisms, and treatment. Seminars in Clinical Neuropsychiatry, 1(4), 304–314. https://doi.org/10.1053/SCNP00100304
  • Marin, R. S. (1991). Apathy: A neuropsychiatric syndrome. The Journal of Neuropsychiatry and Clinical Neurosciences, 3, 243–254. https://doi.org/10.1176/jnp.3.3.243
  • Marin, R. S., Biedrzycki, R. C., & Firinciogullari, S. (1991). Reliability and validity of the Apathy evaluation scale. Psychiatry Research, 38(2), 143–162. https://doi.org/10.1016/0165-1781(91)90040-V
  • Messinger, J. W., Trémeau, F., Antonius, D., Mendelsohn, E., Prudent, V., Stanford, A. D., & Malaspina, D. (2011). Avolition and expressive deficits capture negative symptom phenomenology: Implications for DSM-5 and schizophrenia research. Clinical Psychology Review, 31(1), 161–168. https://doi.org/10.1016/j.cpr.2010.09.002
  • Miller, D. S., Robert, P., Ereshefsky, L., Adler, L., Bateman, D., Cummings, J., DeKosky, S. T., Fischer, C. E., Husain, M., Ismail, Z., Jaeger, J., Lerner, A. J., Li, A., Lyketsos, C. G., Manera, V., Mintzer, J., Moebius, H. J., Mortby, M., Meulien, D., … Lanctôt, K. L. (2021). Diagnostic criteria for apathy in neurocognitive disorders. Alzheimer’s & Dementia, 17(12), 1892–1904. https://doi.org/10.1002/alz.12358
  • Milner, B. (1963). Effects of different brain lesions on card sorting: The role of the frontal lobes. Archives of Neurology, 100–110. https://doi.org/10.1001/archneur.1963.00460070100010
  • Mograbi, D. C., & Morris, R. G. (2014). On the relation among mood, apathy, and anosognosia in Alzheimer’s disease. Journal of the International Neuropsychological Society, 20(1), 2–7. https://doi.org/10.1017/S1355617713001276
  • Mohammad, D., Ellis, C., Rau, A., Rosenberg, P. B., Mintzer, J., Ruthirakuhan, M., Lanctôt, K. L., & Herrmann, N. (2018). Psychometric properties of apathy scales in dementia: A systematic review. Journal of Alzheimer’s Disease, 66(3), 1065–1082. https://doi.org/10.3233/JAD-180485
  • Montoya‐Murillo, G., Ibarretxe‐Bilbao, N., Peña, J., & Ojeda, N. (2019). The impact of apathy on cognitive performance in the elderly. International Journal of Geriatric Psychiatry, 34(5), 657–665. https://doi.org/10.1002/gps.5062
  • Mortby, M. E., Adler, L., Agüera-Ortiz, L., Bateman, D. R., Brodaty, H., Cantillon, M., Geda, Y. E., Ismail, Z., Lanctôt, K. L., Marshall, G. A., Padala, P. R., Politis, A., Rosenberg, P. B., Siarkos, K., Sultzer, D. L., & Theleritis, C. (2022). Apathy as a treatment target in Alzheimer’s disease: Implications for clinical trials. The American Journal of Geriatric Psychiatry, 30(2), 119–147. https://doi.org/10.1016/j.jagp.2021.06.016
  • Muthén, L. K., & Muthén, B. O. (2012). Mplus user’s guide (7th) ed.). Muthén & Muthén.
  • Norton, L. E., Malloy, P. F., & Salloway, S. (2001). The impact of behavioral symptoms on activities of daily living in patients with dementia. American Journal of Geriatric Psychiatry, 9(1), 41–48. https://doi.org/10.1176/appi.ajgp.9.1.41
  • Petitet, P., Scholl, J., Attaallah, B., Drew, D., Manohar, S., & Husain, M. (2021). The relationship between apathy and impulsivity in large population samples. Scientific Reports, 11(1), 1–11. https://doi.org/10.1038/s41598-021-84364-w
  • PsychCorp. (2008). Wechsler adult intelligence scale–fourth edition. technical and interpretive manual. Pearson.
  • Quaranta, D., Marra, C., Rossi, C., Gainotti, G., & Masullo, C. (2012). Different apathy profile in behavioral variant of frontotemporal dementia and Alzheimer’s disease: A preliminary investigation. Current Gerontology and Geriatrics Research, 2012, 1–8. https://doi.org/10.1155/2012/719250
  • Radakovic, R., & Abrahams, S. (2014). Developing a new apathy measurement scale: Dimensional Apathy Scale. Psychiatry Research, 219(3), 658–663. https://doi.org/10.1016/j.psychres.2014.06.010
  • Radakovic, R., & Abrahams, S. (2018). Multidimensional apathy: Evidence from neurodegenerative disease. Current Opinion in Behavioral Sciences, 22, 42–49. https://doi.org/10.1016/j.cobeha.2017.12.022
  • Ready, R. E., Mather, M. A., Santorelli, G. D., & Santospago, B. P. (2016). Apathy, alexithymia, and depressive symptoms: Points of convergence and divergence. Psychiatry Research, 244, 306–311. https://doi.org/10.1016/j.psychres.2016.07.046
  • Ready, R., Ott, B., & Grace, J. (2004). Validity of informant reports about AD and MCI patients‘memory. Alzheimer’s Disease and Associated Disorders, 18(1), 11–16. https://doi.org/10.1097/00002093-200401000-00003
  • Reise, S. P. (2012). The rediscovery of bifactor measurement models. Multivariate Behavioral Research, 47, 667–696. https://doi.org/10.1080/00273171.2012.715555
  • Reitan, R. (1958). Validity of the trail making test as an indicator of organic brain damage. Perceptual and Motor Skills, 8(3), 271–276. https://doi.org/10.2466/pms.1958.8.3.271
  • Rey, A. (1941). L’examen psychologique dans les cas d’encéphalopathie traumatique.(Les problems.). Archives De Psychologie, 215–285.
  • Rey, A. (1964). L’examen clinique en psychologie. Presses Universitaires De France.
  • Rhemtulla, M., Brosseau-Liard, P. E., & Savalei, V. (2012). When can categorical variables be treated as continuous? A comparison of robust continuous and categorical SEM estimation methods under suboptimal conditions. Psychological Methods, 17(3), 354–373. https://doi.org/10.1037/a0029315
  • Robert, P., Lanctôt, K. L., Agüera-Ortiz, L., Aalten, P., Bremond, F., Defrancesco, M., Hanon, C., David, R., Dubois, B., Dujardin, K., Husain, M., König, A., Levy, R., Mantua, V., Meulien, D., Miller, D., Moebius, H. J., Rasmussen, J., Robert, G., … Manera, V. (2018). Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group. European Psychiatry, 54, 71–76. https://doi.org/10.1016/j.eurpsy.2018.07.008
  • Robert, P., Onyike, C., Leentjens, A., Dujardin, K., Aalten, P., Starkstein, S., Drapier, D., Clement, J. P., Drapier, D., Bayle, F., Benoit, M., Boyer, P., Lorca, P. M., Thibaut, F., Gauthier, S., Grossberg, G., Vellas, B., Byrne, J., & Verhey, F. R. J. (2009). Proposed diagnostic criteria for apathy in Alzheimer’s disease and other neuropsychiatric disorders. European Psychiatry, 24(2), 98–104. https://doi.org/10.1016/j.eurpsy.2008.09.001
  • Sagen, U., Faerden, A., Haug, T., Melle, I., Finset, A., & Dammen, T. (2010). Are there common core features of apathy in different neuropsychiatric samples as assessed by the Apathy evaluation scale? Nordic Journal of Psychiatry, 64(1), 49–57. https://doi.org/10.3109/08039480903274415
  • Silverberg, N. H., & Millis, S. R. (2009). Impairment versus deficiency in neuropsychological assessment: Implications for ecological validity. Journal of the International Neuropsychological Society, 15(1), 94–102. https://doi.org/10.1017/S1355617708090139
  • Sockeel, P., Dujardin, K., Devos, D., Deneve, C., Destée, A., & Defebvre, L. (2006). The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: Validation in Parkinson’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 77(5), 579–584. https://doi.org/10.1136/jnnp.2005.075929
  • Starkstein, S. E., Ingram, L., Garau, M. L., & Mizrahi, R. (2005). On the overlap between apathy and depression in dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 76(8), 1070–1074. https://doi.org/10.1136/jnnp.2004.052795
  • Umucu, E., Wyman, M., Lee, B., Zuelsdorff, M., Benton, S. F., Nystrom, N., … Gleason, C. E. (2019). Apathy in preclinical Alzheimer’s disease: Psychometric validation of the Apathy Evaluation Scale. American Journal of Alzheimer’s Disease & Other Dementias, 34(1), 16–22. https://doi.org/10.1177/1533317518794020
  • van Dalen, J., van Charante, E., Nederkoorn, P., van Gool, W., & Richard, E. (2013). Postroke Apathy. Stroke, 44(3), 851–860. https://doi.org/10.1161/STROKEAHA.112.674614
  • van Dalen, J. W., van Wanrooij, L. L., van Charante, E. P. M., Brayne, C., van Gool, W. A., & Richard, E. (2018). Association of apathy with risk of incident dementia: A systematic review and meta-analysis. JAMA psychiatry, 75(10), 1012–1021. https://doi.org/10.1001/jamapsychiatry.2018.1877
  • van Reekum, R., Stuss, D. T., & Ostrander, L. (2005). Apathy: Why care? The Journal of Neuropsychiatry and Clinical Neurosciences, 17(1), 7–19. https://doi.org/10.1176/appi.neuropsych.17.1.7
  • Watson, D., O’Hara, M. W., Simms, L. J., Kotov, R., Chmielewski, M., McDade-Montez, E. A., Gamez, W., & Stuart, S. (2007). Development and validation of the Inventory of Depression and Anxiety Symptoms (IDAS). Psychological Assessment, 19(3), 253–268. https://doi.org/10.1037/1040-3590.19.3.253
  • Wechsler, D. (1997). The WMS–III Administration and Scoring Manual. San Antonio, TX: The Psychological Corporation.
  • Weitzner, M. A., Kanfer, S., & Booth-Jones, M. (2005). Apathy and pituitary disease: It has nothing to do with depression. The Journal of Neuropsychiatry and Clinical Neurosciences, 17(2), 159–166. https://doi.org/10.1176/appi.neuropsych.17.2.159

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