Tomatidine ameliorates high-fat-diet/streptozocin (HFD/STZ)-induced type 2 diabetes mellitus in mice

References

• Brus, L., et al., 2022. Circulating tumor cells in metastatic breast cancer: ready for clinical practice? European journal of gynaecological oncology, 43 (3), 4–8.
   Web of Science ®Google Scholar
• Chiu, F.L., and Lin, J.K., 2008. Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages. FEBS letters, 582 (16), 2407–2412. doi: 10.1016/j.febslet.2008.05.049.
   PubMed Web of Science ®Google Scholar
• Chu, X., et al., 2022. Correction for: Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats. Aging, 14 (3), 1590–1591. doi: 10.18632/aging.203892.
   Google Scholar
• Fang, E.F., et al., 2017. Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Scientific reports, 7 (1), 46208. doi: 10.1038/srep46208.
   Google Scholar
• Fujimaki, J., et al., 2022. The steroidal alkaloid tomatidine and tomatidine-rich tomato leaf extract suppress the human gastric cancer-derived 85As2 cells in vitro and in vivo via modulation of interferon-stimulated genes. Nutrients, 14 (5), 1023. doi: 10.3390/nu14051023.
   Web of Science ®Google Scholar
• Fujiwara, Y., et al., 2012. Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT). Journal of agricultural and food chemistry, 60 (10), 2472–2479. doi: 10.1021/jf204197r.
   Web of Science ®Google Scholar
• Guo, Y., et al., 2021. Suppressive role of E3 ubiquitin ligase FBW7 in type I diabetes in non-obese diabetic mice through mediation of ubiquitination of EZH2. Cell death discovery, 7 (1), 361. doi: 10.1038/s41420-021-00605-x.
   Web of Science ®Google Scholar
• Harmel, E., et al., 2014. AMPK in the small intestine in normal and pathophysiological conditions. Endocrinology, 155 (3), 873–888. doi: 10.1210/en.2013-1750.
   Web of Science ®Google Scholar
• Harreiter, J., et al., 2017. Switch to combined GLP1 receptor agonist lixisenatide with basal insulin glargine in poorly controlled T2DM patients with premixed insulin therapy: a clinical observation and pilot study in nine patients. Diabetes : therapy: research, treatment and education of diabetes and related disorders, 8 (3), 683–692. doi: 10.1007/s13300-017-0249-4.
   PubMed Web of Science ®Google Scholar
• Huang, W.C., et al., 2021. Tomatidine improves pulmonary inflammation in mice with acute lung injury. Mediators of inflammation, 2021, 4544294–11. doi: 10.1155/2021/4544294.
   Web of Science ®Google Scholar
• Hui, C.W., et al., 2023. alpha-Tomatine degradation to tomatidine by food-related Aspergillus species belonging to the section Nigri. Bioscience, biotechnology, and biochemistry, 87 (6), 663–671. doi: 10.1093/bbb/zbad031.
   Web of Science ®Google Scholar
• Kim, Y.S., et al., 2022. Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction. Experimental & molecular medicine, 54 (4), 493–502. doi: 10.1038/s12276-022-00746-8.
   Web of Science ®Google Scholar
• Li, J., et al., 2023. Tectorigenin inhibits inflammation in keratinocytes by inhibition of NLRP3 inflammasome regulated by the TLR4/NF-kappaB pathway. Allergologia et immunopathologia, 51 (2), 82–89. doi: 10.15586/aei.v51i2.780.
   Web of Science ®Google Scholar
• Li, Y.Y., et al., 2013. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. Toxicology and applied pharmacology, 273 (2), 325–334. doi: 10.1016/j.taap.2013.09.006.
   Web of Science ®Google Scholar
• Luo, D., et al., 2023. Tianhuang formula regulates adipocyte mitochondrial function by AMPK/MICU1 pathway in HFD/STZ-induced T2DM mice. BMC complementary medicine and therapies, 23 (1), 202. doi: 10.1186/s12906-023-04009-5.
   Google Scholar
• Medina, J.M., et al., 2012. Tomatidine promotes the inhibition of 24-alkylated sterol biosynthesis and mitochondrial dysfunction in Leishmania amazonensis promastigotes. Parasitology, 139 (10), 1253–1265. doi: 10.1017/S0031182012000522.
   Web of Science ®Google Scholar
• Sanchez-Bao, A.M., et al., 2023. Identifying advanced MAFLD in a cohort of T2DM and clinical features. Frontiers in endocrinology, 14, 1058995. doi: 10.3389/fendo.2023.1058995.
   Web of Science ®Google Scholar
• Troost-Kind, B., et al., 2021. Tomatidine reduces chikungunya virus progeny release by controlling viral protein expression. PLoS neglected tropical diseases, 15 (11), e0009916. doi: 10.1371/journal.pntd.0009916.
   Web of Science ®Google Scholar
• Wu, S.J., et al., 2021a. Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice. The journal of nutritional biochemistry, 91, 108602. doi: 10.1016/j.jnutbio.2021.108602.
   Web of Science ®Google Scholar
• Wu, S.Y., et al., 2023. Protective effects of statins on the incidence of NAFLD-related decompensated cirrhosis in T2DM. Liver international, 43 (10), 2232–2244. doi: 10.1111/liv.15656.
   Web of Science ®Google Scholar
• Wu, T., et al., 2021b. Serum bile acid profiles improve clinical prediction of nonalcoholic fatty liver in T2DM patients. Journal of proteome research, 20 (8), 3814–3825. doi: 10.1021/acs.jproteome.1c00104.
   Web of Science ®Google Scholar
• Yang, Y., et al., 2021. Epigenetics and beyond: targeting histone methylation to treat type 2 diabetes mellitus. Frontiers in pharmacology, 12, 807413. doi: 10.3389/fphar.2021.807413.
   PubMed Web of Science ®Google Scholar