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Expert Opinion on Biological Therapy Volume 23, 2023 - Issue 9
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Editorial

Reduced doses of biological therapies in psoriasis: a new potentially “sustainable” frontier of psoriasis treatment

Simone RiberoDepartment of Medical Sciences, Dermatology Clinic, University of Turin, Turin, ItalyCorrespondence[email protected]
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,
Michela OrtoncelliDepartment of Medical Sciences, Dermatology Clinic, University of Turin, Turin, ItalyView further author information
,
Luca MastorinoDepartment of Medical Sciences, Dermatology Clinic, University of Turin, Turin, ItalyView further author information
,
Pietro QuaglinoDepartment of Medical Sciences, Dermatology Clinic, University of Turin, Turin, ItalyView further author information
&
Paolo DapavoDepartment of Medical Sciences, Dermatology Clinic, University of Turin, Turin, ItalyView further author information
Pages 867-868 | Received 24 May 2023, Accepted 02 Aug 2023, Published online: 08 Aug 2023

References

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  • Huang JX, Lee YH, Wei JC. Patient-tailored dose reduction of tumor necrosis factor inhibitors in axial spondyloarthritis. Int Immunopharmacol. 2023 Feb 8;116:109804. Online ahead of print. doi: 10.1016/j.intimp.2023.109804
  • Llamas-Velasco M, Daudén E. Reduced doses of biological therapies in psoriasis may increase efficiency without decreasing drug survival. Dermatol Ther. 2020;33(6):e14134. doi: 10.1111/dth.14134
  • Braverman G, Bridges SL, Moreland LW. Tapering biologic DMARDs in rheumatoid arthritis. Curr Opin Pharmacol. 2022;67:102308. doi: 10.1016/j.coph.2022.102308
  • Bagel J, Glick B, Wu JJ, et al. Dose escalation and associated costs in biologic treatment of psoriasis based on real-world data. J Med Econ. 2021;24(1):782–791. doi: 10.1080/13696998.2021.1937187
  • Dapavo P, Siliquini N, Mastorino L, et al. Efficacy, safety, and drug survival of IL-23, IL-17, and TNF-alpha inhibitors for psoriasis treatment: a retrospective study. J DermatolTreat. 2022 Jun;33(4):2352–2357. doi: 10.1080/09546634.2021.1961998
  • Mastorino L, Susca S, Cariti C, et al. “Superresponders” at biologic treatment for psoriasis: A comparative study among IL17 and IL23 inhibitors. Exp Dermatol. 2022 Dec 21. doi: 10.1111/exd.14731
  • Eyerich K, Weisenseel P, Pinter A, et al. IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants with moderate-to-severe plaque-type psoriasis (GUIDE). BMJ Open. 2021;11(9):e049822. doi: 10.1136/bmjopen-2021-049822
  • Mehta H, Mashiko S, Angsana J. Differential changes in inflammatory mononuclear phagocyte and T cell profiles within psoriatic skin during treatment with Guselkumab versus Secukinumab. J Invest Dermatol. 2021;141(7):1707–1718.e9. doi: 10.1016/j.jid.2021.01.005
  • Schots L, Soenen R, Blanquart B, et al. Blocking interleukin-17 in psoriasis: Real-world experience from the PsoPlus cohort. J Eur Acad Dermatol Venereol. 2023 Apr;37(4):698–710. Epub 2023 Jan 13. PMID: 36562700. doi: 10.1111/jdv.18827

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