Promoter of lncRNA MORT is aberrantly methylated in colorectal cancer

References

• Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, R. L.; Torre, L. A.; Jemal, A. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and MORTality Worldwide for 36 Cancers in 185 Countries. CA. Cancer J. Clin. 2018, 68, 394–424. DOI: 10.3322/caac.21492.
   PubMed Web of Science ®Google Scholar
• Ostovarpour, M.; Khalaj-Kondori, M.; Ghasemi, T. Correlation between Expression Levels of lncRNA FER1L4 and RB1 in Patients with Colorectal Cancer. Mol. Biol. Rep. 2021, 48, 4581–4589. DOI: 10.1007/s11033-021-06488-6.
   PubMed Web of Science ®Google Scholar
• Ghasemi, T.; Khalaj-Kondori, M.; Hosseinpour Feizi, M. A.; Asadi, P. Aberrant Expression of lncRNAs SNHG6, TRPM2-AS1, MIR4435-2HG, and Hypomethylation of TRPM2-AS1 Promoter in Colorectal Cancer. Cell Biol. Int. 2021, 45, 2464–2478. DOI: 10.1002/cbin.11692.
   PubMed Web of Science ®Google Scholar
• Yang, Y.; Zhao, Y.; Hu, N.; Zhao, J.; Bai, Y. lncRNA KIAA0125 Functions as a Tumor Suppressor Modulating Growth and Metastasis of Colorectal Cancer via Wnt/β-Catenin Pathway. Cell Biol. Int. 2019, 43, 1463–1470. DOI: 10.1002/cbin.11196.
   PubMed Web of Science ®Google Scholar
• Fearon, E. F.; Vogelstein, B. A Genetic Model for Colorectal Tumorigenesis. Cell 1989, 61, 759–767. DOI: 10.1016/0092-8674(90)90186-i.
   Web of Science ®Google Scholar
• Sanchez Calle, A.; Kawamura, Y.; Yamamoto, Y.; Takeshita, F.; Ochiya, T. Emerging Roles of Long Non-Coding RNA in Cancer. Cancer Sci. 2018, 109, 2093–2100. DOI: 10.1111/cas.13642.
   PubMed Web of Science ®Google Scholar
• Khajehdehi, M.; Khalaj-Kondori, M.; Ghasemi, T.; Jahanghiri, B.; Damaghi, M. Long Noncoding RNAs in Gastrointestinal Cancer: Tumor Suppression versus Tumor Promotion. Dig. Dis. Sci. 2021, 66, 381–397. DOI: 10.1007/s10620-020-06200-x.
   PubMed Web of Science ®Google Scholar
• Pellino, G.; Gallo, G.; Pallante, P.; Capasso, R.; De Stefano, A.; Maretto, I.; Malapelle, U.; Qiu, S.; Nikolaou, S.; Barina, A.; et al. Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives. Gastroenterol. Res. Pract. 2018, 2018, 2397863–2397821. DOI: 10.1155/2018/2397863.
   PubMed Web of Science ®Google Scholar
• He, M.; Lin, Y.; Xu, Y. Identification of Prognostic Biomarkers in Colorectal Cancer Using a Long Non-Coding RNA-Mediated Competitive Endogenous RNA Network. Oncol. Lett. 2019, 17, 2687–2694. DOI: 10.3892/ol.2019.9936.
   PubMed Web of Science ®Google Scholar
• Jahangiri, B.; Khalaj-Kondori, M.; Asadollahi, E.; Sadeghizadeh, M. Cancer-Associated Fibroblasts Enhance Cell Proliferation and Metastasis of Colorectal Cancer SW480 Cells by Provoking Long Noncoding RNA UCA1. J. Cell Commun. Signal. 2019, 13, 53–64. DOI: 10.1007/s12079-018-0471-5.
   PubMed Web of Science ®Google Scholar
• Cai, J.; Zuo, X.; Chen, Z.; Zhang, Y.; Wang, J.; Wang, J.; Ye, X.; Zhao, W. Long Noncoding RNAs Serve as Potential Diagnostic Biomarkers for Colorectal Cancer. J. Cancer 2019, 10, 611–619. DOI: 10.7150/jca.28780.
   PubMed Web of Science ®Google Scholar
• Hu, D.; Zhan, Y.; Zhu, K.; Bai, M.; Han, J.; Si, Y.; Zhang, H.; Kong, D. Plasma Exosomal Long Non-Coding RNAs Serve as Biomarkers for Early Detection of Colorectal Cancer. Cell. Physiol. Biochem. 2018, 51, 2704–2715. DOI: 10.1159/000495961.
   PubMedGoogle Scholar
• Mori, Y.; Olaru, A. V.; Cheng, Y.; Agarwal, R.; Yang, J.; Luvsanjav, D.; Yu, W.; Selaru, F. M.; Hutfless, S.; Lazarev, M.; et al. Novel Candidate Colorectal Cancer Biomarkers Identified by Methylation Microarray-Based Scanning. Endocr. Relat. Cancer. 2011, 18, 465–478. DOI: 10.1530/ERC-11-0083.
   PubMed Web of Science ®Google Scholar
• Moarii, M.; Boeva, V.; Vert, J. P.; Reyal, F. Changes in Correlation between Promoter Methylation and Gene Expression in Cancer. BMC Genomics. 2015, 16, 873. DOI: 10.1186/s12864-015-1994-2.
   PubMed Web of Science ®Google Scholar
• Di Fiore, R.; Suleiman, S.; Drago-Ferrante, R.; Felix, A.; O’Toole, S. A.; O’Leary, J. J.; Ward, M. P.; Beirne, J.; Yordanov, A.; Vasileva-Slaveva, M.; et al. LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies? Int. J. Mol. Sci. 2021, 22, 7829. DOI: 10.3390/ijms22157829.
   PubMed Web of Science ®Google Scholar
• Zhou, T.; Wu, L.; Zong, Z.; Ma, N.; Li, Y.; Jiang, Z.; Wang, Q.; Chen, S. Long Non‑Coding RNA MORTal Obligate RNA Transcript Inhibits the Migration and Invasion of Colon Cancer Cells by Inactivating Transforming Growth Factor β1. Oncol. Lett. 2020, 19, 1131–1136. DOI: 10.3892/ol.2019.11189.
   PubMed Web of Science ®Google Scholar
• Zhuang, L.; Ding, W.; Ding, W.; Zhang, Q.; Xu, X.; Xi, D. lncRNA ZNF667-AS1 (NR_036521.1) Inhibits the Progression of Colorectal Cancer via Regulating ANK2/JAK2 Expression. J. Cell. Physiol. 2021, 236, 2178–2193. DOI: 10.1002/jcp.30004.
   PubMed Web of Science ®Google Scholar
• Lu, X.; Ge, G.; Ji, F.; Wang, J. LncRNA MORT Overexpression Inhibits Cancer Cell Migration and Invasion in Hepatocellular Carcinoma by Downregulating NOTCH1. Cancer Biother. Radiopharm. 2021, 37, 537–543. DOI: 10.1089/cbr.2020.4020.
   PubMed Web of Science ®Google Scholar
• Huang, Y.; Zhuang, Q.; Zhuang, W. MORTal Obligate RNA Transcript Inhibits Cancer Cell Invasion and Migration in Lung Adenocarcinoma by Downregulating miRNA-223. Cancer Biother. Radiopharm. 2020, 35, 345–350. DOI: 10.1089/cbr.2019.3244.
   PubMed Web of Science ®Google Scholar
• Vrba, L.; Futscher, B. W. Epigenetic Silencing of MORT is an Early Event in Cancer and is Associated with Luminal, Receptor Positive Breast Tumor Subtypes. J. Breast Cancer. 2017, 20, 198–202. DOI: 10.4048/jbc.2017.20.2.198.
   PubMed Web of Science ®Google Scholar
• Wang, Y.; Sun, Q.; Ji, L.; Wang, G.; Niu, X.; Sun, S. LncRNA MORT Regulates Bladder Cancer Behaviors by Downregulating MicroRNA-146a-5p. Nephron 2020, 144, 351–357. DOI: 10.1159/000506291.
   PubMed Web of Science ®Google Scholar
• Meng, W.; Cui, W.; Zhao, L.; Chi, W.; Cao, H.; Wang, B. Aberrant Methylation and Downregulation of ZNF667-AS1 and ZNF667 Promote the Malignant Progression of Laryngeal Squamous Cell Carcinoma. J. Biomed. Sci. 2019, 26, 13. DOI: 10.1186/s12929-019-0506-0.
   PubMed Web of Science ®Google Scholar
• Jin, Z.; Jiang, S.; Jian, S.; Shang, Z. Long Noncoding RNA MORT Overexpression Inhibits Cancer Cell Proliferation in Oral Squamous Cell Carcinoma by Downregulating ROCK1. J. Cell. Biochem. 2019, 120, 11702–11707. DOI: 10.1002/jcb.28449.
   PubMed Web of Science ®Google Scholar
• Chen, X.; Huang, Y.; Shi, D.; Nie, C.; Luo, Y.; Guo, L.; Zou, Y.; Xie, C. LncRNA ZNF667-as1 Promotes ablim1 Expression by Adsorbing Microrna-1290 to Suppress Nasopharyngeal Carcinoma Cell Progression. Onco. Targets Ther. 2020, 13, 4397–4409. DOI: 10.2147/OTT.S245554.
   PubMed Web of Science ®Google Scholar
• Dong, Z.; Li, S.; Wu, X.; Niu, Y.; Liang, X.; Yang, L.; Guo, Y.; Shen, S.; Liang, J.; Guo, W. Aberrant Hypermethylation-Mediated Downregulation of Antisense lncRNA ZNF667-AS1 and Its Sense Gene ZNF667 Correlate with Progression and Prognosis of Esophageal Squamous Cell Carcinoma. Cell Death Dis. 2019, 10, 930. DOI: 10.1038/s41419-019-2171-3.
   PubMed Web of Science ®Google Scholar
• Zhao, L.; Li, R.; Han, D.; Zhang, X.; Nian, G.; Wu, M. Independent Prognostic Factor of Low-Expressed LncRNA ZNF667-AS1 for Cervical Cancer and Inhibitory Function on the Proliferation of Cervical Cancer. Eur. Rev. Med. Pharmacol. Sci 2017, 21, 5353–5360.
   PubMed Web of Science ®Google Scholar
• Vrba, L.; Garbe, J. C.; Stampfer, M. R.; Futscher, B. W. A lincRNA Connected to Cell MORTality and Epigenetically-Silenced in Most Common Human Cancers. Epigenetics 2015, 10, 1074–1083. DOI: 10.1080/15592294.2015.1106673.
   PubMed Web of Science ®Google Scholar
• Vrba, L.; Futscher, B. W. Epigenetic Silencing of lncRNA MORT in 16 TCGA Cancer Types. F1000Res. 2018, 7, 211. DOI: 10.12688/f1000research.13944.1.
   PubMedGoogle Scholar
• Barker. Phenol-Chloroform Isoamyl Alcohol (PCI) DNA Extraction. 1998.
   Google Scholar
• Herman, J. G.; Graff, J. R.; Myöhänen, S.; Nelkin, B. D.; Baylin, S. B. Methylation-Specific PCR: A Novel PCR Assay for Methylation Status of CpG Islands. Proc. Natl. Acad. Sci. U S A. 1996, 93, 9821–9826. DOI: 10.1111/j.1442-200X.2011.03428.x.
   Google Scholar
• Ng, E. K. O.; Leung, C. P. H.; Shin, V. Y.; Wong, C. L. P.; Ma, E. S. K.; Jin, H. C.; Chu, K. M.; Kwong, A. Quantitative Analysis and Diagnostic Significance of Methylated SLC19A3 DNA in the Plasma of Breast and Gastric Cancer Patients. PLoS One. 2011, 6, e22233. DOI: 10.1371/journal.pone.0022233.
   PubMed Web of Science ®Google Scholar
• Paraskevopoulou, M. D.; Georgakilas, G.; Kostoulas, N.; Reczko, M.; Maragkakis, M.; Dalamagas, T. M.; Hatzigeorgiou, A. G. DIANA-LncBase: Experimentally Verified and Computationally Predicted microRNA Targets on Long Non-Coding RNAs. Nucleic Acids Res. 2013, 41, D239–245. DOI: 10.1093/nar/gks1246.
   PubMed Web of Science ®Google Scholar
• Xie, B.; Ding, Q.; Han, H.; Wu, D. MiRCancer: A microRNA-Cancer Association Database Constructed by Text Mining on Literature. Bioinformatics 2013, 29, 638–644. DOI: 10.1093/bioinformatics/btt014.
   PubMed Web of Science ®Google Scholar
• Sticht, C.; Torre, C. D.; La; Parveen, A.; Gretz, N. miRWalk : An Online Resource for Prediction of microRNA Binding Sites. PLoS One 2018, 13, 1–6. DOI: 10.1371/journal.pone.0206239.
   Web of Science ®Google Scholar
• Ghasemi, T.; Khalaj-Kondori, M.; Hosseinpour Feizi, M. A.; Asadi, P. lncRNA-miRNA-mRNA Interaction Network for Colorectal Cancer; an In Silico Analysis. Comput. Biol. Chem. 2020, 89, 107370. DOI: 10.1016/j.compbiolchem.2020.107370.
   PubMed Web of Science ®Google Scholar
• Huang, D. W.; Sherman, B. T.; Tan, Q.; Collins, J. R.; Alvord, W. G.; Roayaei, J.; Stephens, R.; Baseler, M. W.; Lane, H. C.; Lempicki, R. A. The DAVID Gene Functional Classification Tool : A Novel Biological Module-Centric Algorithm to Functionally Analyze Large Gene Lists. Genome Biol. 2007, 8, R183. DOI: 10.1186/gb-2007-8-9-r183.
   PubMed Web of Science ®Google Scholar
• Shannon, P.; Markiel, A.; Ozier, O.; Baliga, N. S.; Wang, J. T.; Ramage, D.; Amin, N.; Schwikowski, B.; Ideker, T. Cytoscape : A Software Environment for Integrated Models of Biomolecular Interaction Networks. Genome Res. 2003, 13, 2498–2504. DOI: 10.1101/gr.1239303.metabolite.
   PubMed Web of Science ®Google Scholar
• Sung, H.; Ferlay, J.; Siegel, R. L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and MORTality Worldwide for 36 Cancers in 185 Countries. CA. Cancer J. Clin. 2021, 71, 209–249. DOI: 10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Han, D.; Wang, M.; Ma, N.; Xu, Y.; Jiang, Y.; Gao, X. Long Noncoding RNAs: Novel Players in Colorectal Cancer. Cancer Lett. 2015, 361, 13–21. DOI: 10.1016/j.canlet.2015.03.002.
   PubMed Web of Science ®Google Scholar
• Fang, Z.; Rajewsky, N. The Impact of miRNA Target Sites in Coding Sequences and in 3’UTRs. PLoS One. 2011, 6, e18067. DOI: 10.1371/journal.pone.0018067.
   PubMed Web of Science ®Google Scholar
• Poliseno, L.; Salmena, L.; Zhang, J.; Carver, B.; William, J.; Pandolfi, P. P.; Program, G.; Israel, B.; Cancer, D.; Israel, B. A Coding-Independent Function of Gene and Pseudogene mRNAs Regulates Tumour Biology. Nature 2011, 465, 1033–1038. DOI: 10.1038/nature09144.A.
   Web of Science ®Google Scholar
• Zhao, Q.; Liu, C.; Cui, Q.; Luan, X.; Wang, Q.; Zhou, C. miR-190b Promotes Colorectal Cancer Progression through Targeting Forkhead Box Protein P2. Exp. Ther. Med. 2020, 19, 79–84. DOI: 10.3892/etm.2019.8175.
   PubMed Web of Science ®Google Scholar
• Wang, H.; Deng, Z.; Chen, X.; Cai, J.; Ma, T.; Zhong, Q.; Li, R.; Li, L.; Li, T. Downregulation of miR-222-3p Reverses Doxorubicin-Resistance in Lovo Cells through Upregulating Forkhead Box Protein P2 (FOXP2) Protein. Med. Sci. Monit. 2019, 25, 2169–2178. DOI: 10.12659/MSM.913325.
   PubMed Web of Science ®Google Scholar
• Nishida, K.; Kuwano, Y.; Rokutan, K. The MicroRNA-23b/27b/24 Cluster Facilitates Colon Cancer Cell Migration by Targeting FOXP2. Cancers. 2020, 12, 174. DOI: 10.3390/cancers12010174.
   PubMed Web of Science ®Google Scholar
• Cuiffo, B. G.; Campagne, A.; Bell, G. W.; Lembo, A.; Orso, F.; Lien, E. C.; Bhasin, M. K.; Raimo, M.; Hanson, S. E.; Marusyk, A.; et al. MSC-Regulated microRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis. Cell Stem Cell 2014, 15, 762–774. DOI: 10.1016/j.stem.2014.10.001.
   PubMed Web of Science ®Google Scholar
• Hsu, H. H.; Kuo, W. W.; Shih, H. N.; Cheng, S. F.; Yang, C. K.; Chen, M. C.; Tu, C. C.; Viswanadha, V. P.; Liao, P. H.; Huang, C. Y. FOXC1 Regulation of miR-31-5p Confers Oxaliplatin Resistance by Targeting LATS2 in Colorectal Cancer. Cancers. 2019, 11, 1576. DOI: 10.3390/cancers11101576.
   PubMed Web of Science ®Google Scholar
• Zhang, X.; Wang, W.; Zhu, W.; Dong, J.; Cheng, Y.; Yin, Z.; Shen, F. Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels. Int. J. Mol. Sci. 2019, 20, 5573. DOI: 10.3390/ijms20225573.
   PubMed Web of Science ®Google Scholar
• Zhou, J.; Tian, Y.; Li, J.; Lu, B.; Sun, M.; Zou, Y.; Kong, R.; Luo, Y.; Shi, Y.; Wang, K.; Ji, G. MiR-206 is down-Regulated in Breast Cancer and Inhibits Cell Proliferation through the Up-Regulation of cyclinD2. Biochem. Biophys. Res. Commun. 2013, 433, 207–212. DOI: 10.1016/j.bbrc.2013.02.084.
   PubMed Web of Science ®Google Scholar
• Zhou, R.; Zhou, X.; Yin, Z.; Guo, J.; Hu, T.; Jiang, S.; Liu, L.; Dong, X.; Zhang, S.; Wu, G. MicroRNA-574-5p Promotes Metastasis of Non-Small Cell Lung Cancer by Targeting PTPRU. Sci. Rep. 2016, 6, 35714. DOI: 10.1038/srep35714.
   PubMed Web of Science ®Google Scholar
• Pipes, G. C. T.; Creemers, E. E.; Olson, E. N. The Myocardin Family of Transcriptional Coactivators: Versatile Regulators of Cell Growth, Migration, and Myogenesis. Genes Dev. 2006, 20, 1545–1556. DOI: 10.1101/gad.1428006.
   PubMed Web of Science ®Google Scholar
• Boucquey, M.; De Plaen, E.; Locker, M.; Poliard, A.; Mouillet-Richard, S.; Boon, T.; Kellermann, O. Noxp20 and Noxp70, Two New Markers of Early Neuronal Differentiation, Detected in Teratocarcinoma-Derived Neuroectodermic Precursor Cells. J. Neurochem. 2006, 99, 657–669. DOI: 10.1111/j.1471-4159.2006.04093.x.
   PubMed Web of Science ®Google Scholar
• Liu, J.; Wang, D.; Zhang, C.; Zhang, Z.; Chen, X.; Lian, J.; Liu, J.; Wang, G.; Yuan, W.; Sun, Z.; et al. Identification of Liver Metastasis-Associated Genes in Human Colon Carcinoma by mRNA Profiling. Chin. J. Cancer Res. 2018, 30, 633–646. DOI: 10.21147/j.issn.1000-9604.2018.06.08.
   PubMed Web of Science ®Google Scholar