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Clinical Toxicology Volume 61, 2023 - Issue 6
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Poison Centre Research

Metformin-associated lactic acidosis reported to the United Kingdom National Poisons Information Service (NPIS) between 2010 and 2019: a ten-year retrospective analysis

Bethan W. Hughesa National Poisons Information Service, Cardiff Unit, University Hospital Llandough, Penarth, UKCorrespondence[email protected]
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,
Laurence A. Graya National Poisons Information Service, Cardiff Unit, University Hospital Llandough, Penarth, UKView further author information
,
Sally M. Bradberryb National Poisons Information Service, Birmingham Unit, City Hospital, Birmingham, UKView further author information
,
Euan A. Sandilandsc National Poisons Information Service, Edinburgh Unit, Royal Infirmary of Edinburgh, Edinburgh, UKView further author information
,
Ruben H. Thanacoodyd National Poisons Information Service, Newcastle Unit, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, UKORCID Iconhttps://orcid.org/0000-0001-7543-6026View further author information
ORCID Icon &
James M. Coulsona National Poisons Information Service, Cardiff Unit, University Hospital Llandough, Penarth, UK;e School of Medicine, Cardiff University, Cardiff, UKView further author information
Pages 445-452 | Received 22 Jun 2022, Accepted 29 Mar 2023, Published online: 15 Jun 2023

References

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  • Dell’Aglio DM, Perino LJ, Kazzi Z, et al. Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature. Ann Emerg Med. 2009;54(6):818–823.
  • Calello DP, Liu KD, Wiegand TJ, et al. Extracorporeal treatment for metformin poisoning: systematic review and recommendations from the extracorporeal treatments in poisoning workgroup. Crit Care Med. 2015;43(8):1716–1730.
  • Correia MS, Horowitz BZ. Continuous extracorporeal clearance in metformin-associated lactic acidosis and metformin-induced lactic acidosis: a systematic review. Clin Toxicol (Phila). 2022;60(11):1266–1276.
  • Persson HE, Sjöberg GK, Haines JA, et al. Poisoning severity score. Grading of acute poisoning. J Toxicol Clin Toxicol. 1998;36(3):205–213.
  • Breen P, Manders B. Deaths related to drug poisoning in England and Wales: 2020 registrations [Dataset]. Office for National Statistics. 2021. https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bu lletins/deathsrelatedtodrugpoisoninginenglandandwales/2020
  • Stevens A, Hamel JF, Toure A, et al. Metformin overdose: a serious iatrogenic complication-Western France poison control Centre data analysis. Basic Clin Pharmacol Toxicol. 2019;125(5):466–473.
  • Bryant SM, Cumpston K, Lipsky MS, et al. Metformin-associated respiratory alkalosis. Am J Ther. 2004;11(3):236–237.

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