Differentiating melancholic and non-melancholic depression via biological markers: A review

References

• Amsterdam JD, Maislin G, Gold P, Winokur A. 1989. The assessment of abnormalities in hormonal responsiveness at multiple levels of the hypothalamic-pituitary-adrenocortical axis in depressive illness. Psychoneuroendocrinology. 14(1-2):43–62.
   PubMed Web of Science ®Google Scholar
• Austin MP, Dougall N, Ross M, Murray C, O'Carroll RE, Moffoot A, Ebmeier KP, Goodwin GM. 1992. Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. J Affect Disord. 26(1):31–43.
   PubMed Web of Science ®Google Scholar
• Baune BT, Hohoff C, Mortensen LS, Deckert J, Arolt V, Domschke K. 2008. Serotonin transporter polymorphism (5-HTTLPR) association with melancholic depression: a female specific effect? Depress Anxiety. 25(11):920–925.
   PubMed Web of Science ®Google Scholar
• Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, Mendlewicz J, Lotstra F. 1994. Frontal and parietal metabolic disturbances in unipolar depression. Biol Psychiatry. 36(6):381–388.
   PubMed Web of Science ®Google Scholar
• Brouwer JP, Appelhof BC, Hoogendijk WJG, Huyser J, Endert E, Zuketto C, Schene AH, Tijssen JGP, Van Dyck R, Wiersinga WM, et al. 2005. Thyroid and adrenal axis in major depression: a controlled study in outpatients. Eur J Endocrinol. 152(2):185–191.
   PubMed Web of Science ®Google Scholar
• Brown WA, Shuey I. 1980. Response to dexamethasone and subtype of depression. Arch Gen Psychiatry. 37(7):747–751.
   PubMed Web of Science ®Google Scholar
• Brown RP, Stoll PM, Stokes PE, Frances A, Sweeney J, Kocsis JH, Mann JJ. 1988. Adrenocortical hyperactivity in depression: effects of agitation, delusions, melancholia, and other illness variables. Psychiatry Res. 23(2):167–178.
   PubMed Web of Science ®Google Scholar
• Bruun CF, Arnbjerg CJ, Kessing LV. 2021. Electroencephalographic parameters differentiating melancholic depression, non-melancholic depression, and healthy controls. A systematic review. Front Psychiat. 12:648713.
   PubMed Web of Science ®Google Scholar
• Carney MWP, Roth M, Garside RF. 1965. The diagnosis of depressive syndromes and the prediction of E.C.T. response. Br J Psychiatry. 111(477):659–674.
   PubMedGoogle Scholar
• Carroll BJ, Feinberg M, Greden JF, Tarika J, Albala AA, Haskett RF, James NM, Kronfol Z, Lohr N, Steiner M, et al. 1981. A specific laboratory test for the diagnosis of melancholia: standardization, validation, and clinical utility. Arch Gen Psychiatry. 38(1):15–22.
   PubMed Web of Science ®Google Scholar
• Cizza G, Ronsaville DS, Kleitz H, Eskandari F, Mistry S, Torvik S, Sonbolian N, Reynolds JC, Blackman MR, Gold PW, et al. 2012. Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: the power study. PLOS One. 7(1):e28912.
   PubMed Web of Science ®Google Scholar
• Cubells JF, Price LH, Meyers BS, Anderson GM, Zabetian CP, Alexopoulos GS, Nelson JC, Sanacora G, Kirwin P, Carpenter L, et al. 2002. Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression. Biol Psychiatry. 51(5):358–364.
   PubMed Web of Science ®Google Scholar
• Davidson J, Lipper S, Zung WW, Strickland R, Krishnan R, Mahorney S. 1984. Validation of four definitions of melancholia by the dexamethasone suppression test. Am J Psychiatry. 141(10):1220–1223.
   PubMed Web of Science ®Google Scholar
• Domschke K, Lawford B, Young R, Voisey J, Morris CP, Roehrs T, Hohoff C, Birosova E, Arolt V, Baune BT. 2011. Dysbindin (DTNBP1) – a role in psychotic depression? J Psychiatr Res. 45(5):588–595.
   PubMed Web of Science ®Google Scholar
• Dunjic-Kostic B, Ivkovic M, Radonjic NV, Petronijevic ND, Pantovic M, Damjanovic A, Poznanovic ST, Jovanovic A, Nikolic T, Jasovic-Gasic M. 2013. Melancholic and atypical major depression—connection between cytokines, psychopathology and treatment. Prog Neuropsychopharmacol Biol Psychiatry. 43:1–6.
   PubMed Web of Science ®Google Scholar
• Elton M. 1984. A longitudinal investigation of event-related potentials in depression. Biol Psychiatry. 19(12):1635–1649.
   PubMed Web of Science ®Google Scholar
• Erdem M, Celik C, Cayci T, Ozdemir B, Kurt YG, Akgul EO, Yaman H, Balikci A, Uzun O. 2011. Serum haptoglobin levels in patients with melancholic and nonmelancholic major depression. Prog Neuropsychopharmacol Biol Psychiatry. 35(4):944–947.
   PubMed Web of Science ®Google Scholar
• Eriksson MD, Eriksson JG, Korhonen P, Koponen H, Salonen MK, Mikkola TM, Kajantie E, Wasenius NS, von Bonsdorff M, Kautiainen H, et al. 2023. Depressive symptoms and mortality-findings from helsinki birth cohort study. Acta Psychiatr Scand. 147(2):175–185.
   PubMed Web of Science ®Google Scholar
• Esposito CM, Buoli M. 2020. The biological face of melancholia: are there any reliable biomarkers for this depression subtype? J Affect Disord. 266:802–809.
   PubMed Web of Science ®Google Scholar
• Evans DL, Nemeroff CB. 1987. The clinical use of the dexamethasone suppression test in DSM-III affective disorders: correlation with the severe depressive subtypes of melancholia and psychosis. J Psychiatr Res. 21(2):185–194.
   PubMed Web of Science ®Google Scholar
• Exner C, Lange C, Irle E. 2009. Impaired implicit learning and reduced pre-supplementary motor cortex size in early-onset major depression with melancholic features. J Affect Disord. 119(1–3):156–162.
   PubMed Web of Science ®Google Scholar
• Feinberg M, Carroll BJ. 1982. Separation of subtypes of depression using discriminant analysis: i. separation of unipolar endogenous depression from non-endogenous depression. Br J Psychiatry. 140(4):384–391.
   PubMedGoogle Scholar
• Fitzgerald PB, Mellow TB, Hoy KE, Segrave R, Cooper NR, Upton DJ, Croft RJ. 2009. A study of intensity dependence of the auditory evoked potential (IDAEP) in medicated melancholic and non-melancholic depression. J Affect Disord. 117(3):212–216.
   PubMed Web of Science ®Google Scholar
• Foti D, Carlson JM, Sauder CL, Proudfit GH. 2014. Reward dysfunction in major depression: multimodal neuroimaging evidence for refining the melancholic phenotype. Neuroimage. 101:50–58.
   PubMed Web of Science ®Google Scholar
• Fotiou F, Fountoulakis KN, Iacovides A, Kaprinis G. 2003. Pattern-reversed visual evoked potentials in subtypes of major depression. Psychiatry Res. 118(3):259–271.
   PubMed Web of Science ®Google Scholar
• Fountoulakis KN, Fotiou F, Iacovides A, Kaprinis G. 2005. Is there a dysfunction in the visual system of depressed patients? Ann Gen Psychiatry. 4(1):7.
   PubMedGoogle Scholar
• Fountoulakis KN, Iacovides A, Gerasimou G, Fotiou F, Ioannidou C, Bascialla F, Grammaticos P, Kaprinis G. 2004. The relationship of regional cerebral blood flow with subtypes of major depression. Prog Neuropsychopharmacol Biol Psychiatry. 28(3):537–546.
   PubMed Web of Science ®Google Scholar
• Georgotas A, Stokes PE, Hapworth WE, Kim OM, Fanelli C, Stoll PM, Sinaiko E, McCue RE. 1986. The relationship of the dexamethasone suppression test to subtypes of depression and to symptomatic severity in the elderly. J Affect Disord. 10(1):51–57.
   PubMed Web of Science ®Google Scholar
• Giles DE, Roffwarg HP, Rush AJ, Guzick DS. 1990. Age-adjusted threshold values for reduced REM latency in unipolar depression using ROC analysis. Biol Psychiatry. 27(8):841–853.
   PubMed Web of Science ®Google Scholar
• Giles DE, Roffwarg HP, Schlesser MA, Rush AJ. 1986. Which endogenous depressive symptoms relate to REM latency reduction? Biol Psychiatry. 21(5–6):473–482.
   PubMed Web of Science ®Google Scholar
• Gjerris A, Hammer M, Vendsborg P, Christensen NJ, Rafaelsen OJ. 1985. Cerebrospinal fluid vasopressin – changes in depression. Br J Psychiatry. 147:696–701.
   PubMed Web of Science ®Google Scholar
• Glaus J, Vandeleur CL, von Känel R, Lasserre AM, Strippoli M-PF, Gholam-Rezaee M, Castelao E, Marques-Vidal P, Bovet P, Merikangas K, et al. 2014. Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study. J Psychiatr Res. 58:36–45.
   PubMed Web of Science ®Google Scholar
• Guo CC, Hyett MP, Nguyen VT, Parker GB, Breakspear MJ. 2016. Distinct neurobiological signatures of brain connectivity in depression subtypes during natural viewing of emotionally salient films. Psychol Med. 46(7):1535–1545.
   PubMed Web of Science ®Google Scholar
• Hein M, Lanquart J-P, Loas G, Hubain P, Linkowski P. 2019. Alterations of neural network organisation during rapid eye movement sleep and slow-wave sleep in major depression: implications for diagnosis, classification, and treatment. Psychiatry Res Neuroimag. 291:71–78.
   PubMed Web of Science ®Google Scholar
• Herane-Vives A, Young AH, Wise T, Aguirre J, de Angel V, Arnone D, Papadopoulos A, Cleare AJ. 2020. Comparison of short-term (saliva) and long-term (hair) cortisol levels in out-patients with melancholic and non-melancholic major depression. BJPsych Open. 6(3):e41.
   PubMed Web of Science ®Google Scholar
• Holden NL. 1983. Depression and the Newcastle Scale: their relationship to the dexamethasone suppression test. Br J Psychiatry. 142(5):505–507.
   PubMedGoogle Scholar
• Huang T-L. 2005. Serum lipid profiles in major depression with clinical subtypes, suicide attempts and episodes. J Affect Disord. 86(1):75–79.
   PubMed Web of Science ®Google Scholar
• Huang T-L, Lee C-T. 2007. T-helper 1/T-helper 2 cytokine imbalance and clinical phenotypes of acute-phase major depression. Psychiatry Clin Neurosci. 61(4):415–420.
   PubMed Web of Science ®Google Scholar
• Hubain PP, Souery D, Jönck L, Staner L, Van Veeren C, Kerkhofs M, Mendlewicz J, Linkowski P. 1995. Relationship between the newcastle scale and sleep polysomnographic variables in major depression: a controlled study. Eur Neuropsychopharmacol. 5(2):129–134.
   PubMed Web of Science ®Google Scholar
• Hubain PP, Staner L, Dramaix M, Kerkhofs M, Papadimitriou G, Mendlewicz J, Linkowski P. 1998. The dexamethasone suppression test and sleep electroencephalogram in nonbipolar major depressed inpatients: a multivariate analysis. Biol Psychiatry. 43(3):220–229.
   PubMed Web of Science ®Google Scholar
• Hubain PP, Staner L, Dramaix M, Kerkhofs M, van Veeren C, Papadimitriou G, Mendlewicz J, Linkowski P. 1994. TSH response to TRH and EEG sleep in non-bipolar major depression: a multivariate approach. Eur Neuropsychopharmacol. 4(4):517–525.
   PubMed Web of Science ®Google Scholar
• Hyett MP, Breakspear MJ, Friston KJ, Guo CC, Parker GB. 2015. Disrupted effective connectivity of cortical systems supporting attention and interoception in melancholia. JAMA Psychiatry. 72(4):350–358.
   PubMed Web of Science ®Google Scholar
• Hyett MP, Parker GB, Guo CC, Zalesky A, Nguyen VT, Yuen T, Breakspear M. 2015. Scene unseen: disrupted neuronal adaptation in melancholia during emotional film viewing. Neuroimage Clin. 9:660–667.
   PubMed Web of Science ®Google Scholar
• Hyett MP, Perry A, Breakspear M, Wen W, Parker GB. 2018. White matter alterations in the internal capsule and psychomotor impairment in melancholic depression. PLOS One. 13(4):e0195672.
   PubMed Web of Science ®Google Scholar
• Jackson SW. 1986. Melancholia and depression: from hippocratic times to modern times. New Haven: Yale University Press.
   Google Scholar
• Juruena MF, Bocharova M, Agustini B, Young AH. 2018. Atypical depression and non-atypical depression: is HPA axis function a biomarker? A systematic review. J Affect Disord. 233:45–67.
   PubMed Web of Science ®Google Scholar
• Kaestner F, Hettich M, Peters M, Sibrowski W, Hetzel G, Ponath G, Arolt V, Cassens U, Rothermundt M. 2005. Different activation patterns of proinflammatory cytokines in melancholic and non-melancholic major depression are associated with HPA axis activity. J Affect Disord. 87(2–3):305–311.
   PubMed Web of Science ®Google Scholar
• Karlović D, Serretti A, Vrkić N, Martinac M, Marčinko D. 2012. Serum concentrations of CRP, IL-6, TNF-α and cortisol in major depressive disorder with melancholic or atypical features. Psychiatry Res. 198(1):74–80.
   PubMed Web of Science ®Google Scholar
• Kemp AH, Pe Benito L, Quintana DS, Clark CR, McFarlane A, Mayur P, Harris A, Boyce P, Williams LM. 2010. Impact of depression heterogeneity on attention: an auditory oddball event related potential study. J Affect Disord. 123(1-3):202–207.
   PubMed Web of Science ®Google Scholar
• Kemp AH, Quintana DS, Quinn CR, Hopkinson P, Harris AWF. 2014. Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality. Front Psychol. 5:1387.
   PubMed Web of Science ®Google Scholar
• Kendler KS. 1997. The diagnostic validity of melancholic major depression in a population-based sample of female twins. Arch Gen Psychiatry. 54(4):299–304.
   PubMed Web of Science ®Google Scholar
• Kerr CC, Kemp AH, Rennie CJ, Robinson PA. 2011. Thalamocortical changes in major depression probed by deconvolution and physiology-based modeling. Neuroimage. 54(4):2672–2682.
   PubMed Web of Science ®Google Scholar
• Korgaonkar MS, Grieve SM, Koslow SH, Gabrieli JDE, Gordon E, Williams LM. 2011. Loss of white matter integrity in major depressive disorder: evidence using tract-based spatial statistical analysis of diffusion tensor imaging. Hum Brain Mapp. 32(12):2161–2171.
   PubMed Web of Science ®Google Scholar
• Lamers F, Bot M, Jansen R, Chan MK, Cooper JD, Bahn S, Penninx BWJH. 2016. Serum proteomic profiles of depressive subtypes. Transl Psychiatry. 6(7):e851.
   PubMed Web of Science ®Google Scholar
• Lamers F, Vogelzangs N, Merikangas KR, de Jonge P, Beekman ATF, Penninx BWJH. 2013. Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Mol Psychiatry. 18(6):692–699.
   PubMed Web of Science ®Google Scholar
• Lasserre AM, Strippoli M-PF, Glaus J, Gholam-Rezaee M, Vandeleur CL, Castelao E, Marques-Vidal P, Waeber G, Vollenweider P, Preisig M. 2017. Prospective associations of depression subtypes with cardio-metabolic risk factors in the general population. Mol Psychiatry. 22(7):1026–1034.
   PubMed Web of Science ®Google Scholar
• Lehto S, Tolmunen T, Joensuu M, Saarinen PI, Vanninen R, Ahola P, Tiihonen J, Kuikka J, Lehtonen J. 2006. Midbrain binding of [123I]nor-β-CIT in atypical depression. Prog Neuropsychopharmacol Biol Psychiatry. 30(7):1251–1255.
   PubMed Web of Science ®Google Scholar
• Liu H, Sarapas C, Shankman SA. 2016. Anticipatory reward deficits in melancholia. J Abnorm Psychol. 125(5):631–640.
   PubMed Web of Science ®Google Scholar
• Liu H, Wu X, Wang Y, Liu X, Peng D, Wu Y, Chen J, Su Y, Xu J, Ma X, et al. 2022. TNF-α, IL-6 and hsCRP in patients with melancholic, atypical and anxious depression: an antibody array analysis related to somatic symptoms. Gen Psychiatr. 35(4):e100844.
   PubMed Web of Science ®Google Scholar
• Maes M, D'Haese PC, Scharpé S, D'Hondt P, Cosyns P, De Broe ME. 1994. Hypozincemia in depression. J Affect Disord. 31(2):135–140.
   PubMed Web of Science ®Google Scholar
• Maes M, Lambrechts J, Bosmans E, Jacobs J, Suy E, Vandervorst C, De Jonckheere C, Minner B, Raus J. 1992. Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining. Psychol Med. 22(1):45–53.
   PubMed Web of Science ®Google Scholar
• Maes M, Maes L, Schotte C, Cosyns P. 1992. A clinical and biological validation of the DSM-III melancholia diagnosis in men: results of pattern recognition methods. J Psychiatr Res. 26(3):183–196.
   PubMed Web of Science ®Google Scholar
• Maes M, Maes L, Schotte C, Vandewoude M, Martin M, D'Hondt P, Blockx P, Scharpe S, Cosyns P. 1990. Clinical subtypes of unipolar depression: part III. Quantitative differences in various biological markers between the cluster-analytically generated nonvital and vital depression classes. Psychiatry Res. 34(1):59–75.
   PubMed Web of Science ®Google Scholar
• Maes M, Meltzer H, Cosyns P, Calabrese J, D'Hondt P, Blockx P. 1994. Adrenocorticotropic hormone, β-endorphin and cortisol responses to oCRH in unipolar depressed patients pretreated with dexamethasone. Prog Neuropsychopharmacol Biol Psychiatry. 18(8):1273–1292.
   PubMed Web of Science ®Google Scholar
• Maes M, Meltzer HY, Cosyns P, Suy E, Schotte C. 1993. An evaluation of basal hypothalamic-pituitary-thyroid axis function in depression: results of a large-scaled and controlled study. Psychoneuroendocrinology. 18(8):607–620.
   PubMed Web of Science ®Google Scholar
• Maes M, Mihaylova I, Kubera M, Ringel K. 2012. Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. Prog Neuropsychopharmacol Biol Psychiatry. 36(1):169–175.
   PubMed Web of Science ®Google Scholar
• Maes M, Ringel K, Kubera M, Berk M, Rybakowski J. 2012. Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression. J Affect Disord. 136(3):386–392.
   PubMed Web of Science ®Google Scholar
• Maes M, Scharpé S, Meltzer HY, Bosmans E, Suy E, Calabrese J, Cosyns P. 1993. Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Res. 49(1):11–27.
   PubMed Web of Science ®Google Scholar
• Maes M, Scharpé S, Meltzer HY, Okayli G, Bosmans E, D'Hondt P, Vanden Bossche BV, Cosyns P. 1994. Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: further evidence for an immune response. Psychiatry Res. 54(2):143–160.
   PubMed Web of Science ®Google Scholar
• Maes M, Scharpé S, Meltzer HY, Suy E, Cosyns P, Calabrese J. 1992. Lower angiotensin I converting enzyme activity in melancholic subjects: a pilot study. Biol Psychiatry. 32(7):621–624.
   PubMed Web of Science ®Google Scholar
• Marques-Deak AH, Neto FL, Dominguez WV, Solis AC, Kurcgant D, Sato F, Ross JM, Prado EBA. 2007. Cytokine profiles in women with different subtypes of major depressive disorder. J Psychiatr Res. 41(1–2):152–159.
   PubMed Web of Science ®Google Scholar
• Mertse N, Denier N, Walther S, Breit S, Grosskurth E, Federspiel A, Wiest R, Bracht T. 2022. Associations between anterior cingulate thickness, cingulum bundle microstructure, melancholia and depression severity in unipolar depression. J Affect Disord. 301:437–444.
   PubMed Web of Science ®Google Scholar
• Michopoulos I, Zervas IM, Pantelis C, Tsaltas E, Papakosta V-M, Boufidou F, Nikolaou C, Papageorgiou C, Soldatos CR, Lykouras L. 2008. Neuropsychological and hypothalamic–pituitary-axis function in female patients with melancholic and non-melancholic depression. Eur Arch Psychiatry Clin Neurosci. 258(4):217–225.
   PubMed Web of Science ®Google Scholar
• Miller KB, Nelson JC. 1987. Does the dexamethasone suppression test relate to subtypes, factors, symptoms, or severity? Arch Gen Psychiatry. 44(9):769–774.
   PubMed Web of Science ®Google Scholar
• Mohamed AE, El-Latif RRA, Youssef AM, Ibrahim AS. 2020. C-reactive protein and clinical subtypes of major depressive disorder at Zagazig University Hospitals. Middle East Curr Psychiatry. 27(1):35.
   Google Scholar
• Nieber D, Schlegel S. 1992. Relationships between psychomotor retardation and EEG power spectrum in major depression. Neuropsychobiology. 25(1):20–23.
   PubMed Web of Science ®Google Scholar
• Oliva V, Fanelli G, Kasper S, Zohar J, Souery D, Montgomery S, Albani D, Forloni G, Ferentinos P, Rujescu D, et al. 2023. Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns. J Affect Disord. 320:534–543.
   PubMed Web of Science ®Google Scholar
• Parker GB, Thase ME. 2007. Atypical depression: a valid subtype? J Clin Psychiatry. 68(3):e08.
   PubMedGoogle Scholar
• Parker G. 2021. Clinical depression: the fault not in our stars? Australas Psychiatry. 29(6):652–654.
   PubMed Web of Science ®Google Scholar
• Parker G, Fink M, Shorter E, Taylor MA, Akiskal H, Berrios G, Bolwig T, Brown WA, Carroll B, Healy D, et al. 2010. Issues for DSM-5: whither melancholia? The case for its classification as a distinct mood disorder. Am J Psychiatry. 167(7):745–747.
   PubMed Web of Science ®Google Scholar
• Parker G, Hadzi-Pavlovic D. 1996. Melancholia: a disorder of movement and mood: a phenomenological and neurobiological review. Cambridge, UK: Cambridge University Press.
   Google Scholar
• Parker G, Hadzi-Pavlovic D, Boyce P, Wilhelm K, Brodaty H, Mitchell P, Hickie I, Eyers K. 1990. Classifying depression by mental state signs. Br J Psychiatry. 157(1):55–65.
   PubMedGoogle Scholar
• Parker G, Hadzi-Pavlovic D, Wilhelm K, Hickie I, Brodaty H, Boyce P, Mitchell P, Eyers K. 1994. Defining melancholia: properties of a refined sign-based measure. Br J Psychiatry. 164(3):316–326.
   PubMedGoogle Scholar
• Parker G, Hickie I, Hadzi-Pavlovic D. 1996. Chapter 12, psychotic depression: clinical definition, status and the relevance of psychomotor disturbance. In: Parker G, Hadzi-Pavlovic D, editors. Melancholia: a disorder of movement and mood: a phenomenological and neurobiological review. Cambridge, UK: Cambridge University Press; p. 179–201.
   Google Scholar
• Parker G, McCraw S, Blanch B, Hadzi-Pavlovic D, Synnott H, Rees A-M. 2013. Discriminating melancholic and non-melancholic depression by prototypic clinical features. J Affect Disord. 144(3):199–207.
   PubMed Web of Science ®Google Scholar
• Parker G, Roussos J, Mitchell P, Wilhelm K, Austin M-P, Hadzi-Pavlovic D. 1997. Distinguishing psychotic depression from melancholia. J Affect Disord. 42(2–3):155–167.
   PubMed Web of Science ®Google Scholar
• Parker G, Spoelma MJ. 2021. Melancholia defined with the precision of a machine. J Affect Disord. 282:69–73.
   PubMed Web of Science ®Google Scholar
• Patas K, Penninx BWJH, Bus BAA, Vogelzangs N, Molendijk ML, Elzinga BM, Bosker FJ, Oude Voshaar RC. 2014. Association between serum brain-derived neurotrophic factor and plasma interleukin-6 in major depressive disorder with melancholic features. Brain Behav Immun. 36:71–79.
   PubMed Web of Science ®Google Scholar
• Penninx BWJH. 2017. Depression and cardiovascular disease: epidemiological evidence on their linking mechanisms. Neurosci Biobehav Rev. 74(Pt B):277–286.
   PubMed Web of Science ®Google Scholar
• Peselow ED, Fieve RR. 1992. Depressive attributional style and the dexamethasone suppression test: relationship to the endogenous/melancholic distinction and to each other. Psychopathology. 25(4):173–182.
   PubMed Web of Science ®Google Scholar
• Pizzagalli DA, Nitschke JB, Oakes TR, Hendrick AM, Horras KA, Larson CL, Abercrombie HC, Schaefer SM, Koger JV, Benca RM, et al. 2002. Brain electrical tomography in depression: the importance of symptom severity, anxiety, and melancholic features. Biol Psychiatry. 52(2):73–85.
   PubMed Web of Science ®Google Scholar
• Pizzagalli DA, Oakes TR, Fox AS, Chung MK, Larson CL, Abercrombie HC, Schaefer SM, Benca RM, Davidson RJ. 2004. Functional but not structural subgenual prefrontal cortex abnormalities in melancholia. Mol Psychiatry. 9(4):325–325.
   PubMed Web of Science ®Google Scholar
• Quinn CR, Dobson-Stone C, Outhred T, Harris A, Kemp AH. 2012. The contributions of BDNF and 5-HTT polymorphisms and early life stress to the heterogeneity of major depressive disorder: a preliminary study. Aust N Z J Psychiatry. 46(1):55–63.
   PubMed Web of Science ®Google Scholar
• Quinn CR, Harris A, Kemp AH. 2012. The impact of depression heterogeneity on inhibitory control. Aust N Z J Psychiatry. 46(4):374–383.
   PubMed Web of Science ®Google Scholar
• Quinn CR, Rennie CJ, Harris AWF, Kemp AH. 2014. The impact of melancholia versus non-melancholia on resting-state, EEG alpha asymmetry: eelectrophysiological evidence for depression heterogeneity. Psychiatry Res. 215(3):614–617.
   PubMed Web of Science ®Google Scholar
• Rantanen AT, Korkeila JJA, Kautiainen H, Korhonen PE. 2020. Non-melancholic depressive symptoms increase risk for incident cardiovascular disease: a prospective study in a primary care population at risk for cardiovascular disease and type 2 diabetes. J Psychosom Res. 129:109887.
   PubMed Web of Science ®Google Scholar
• Rechlin T. 1994. Decreased parameters of heart rate variation in amitriptyline treated patients: lower parameters in melancholic depression than in neurotic depression: a biological marker? Biol Psychiatry. 36(10):705–707.
   PubMed Web of Science ®Google Scholar
• Regonia PR, Takamura M, Nakano T, Ichikawa N, Fermin A, Okada G, Okamoto Y, Yamawaki S, Ikeda K, Yoshimoto J. 2021. Modelling heterogeneous brain dynamics of depression and melancholia using energy landscape analysis. Front Psychiatry. 12:780997.
   PubMed Web of Science ®Google Scholar
• Rhebergen D, Graham R, Hadzi-Pavlovic D, Stek M, Friend P, Barrett M, Parker G. 2012. The categorisation of dysthymic disorder: can its constituents be meaningfully apportioned? J Affect Disord. 143(1-3):179–186.
   PubMed Web of Science ®Google Scholar
• Riemann D, Hohagen F, Bahro M, Berger M. 1994. Sleep in depression: the influence of age, gender and diagnostic subtype on baseline sleep and the cholinergic REM induction test with RS 86. Eur Arch Psychiatry Clin Neurosci. 243(5):279–290.
   PubMed Web of Science ®Google Scholar
• Rothermundt M, Arolt V, Fenker J, Gutbrodt H, Peters M, Kirchner H. 2001. Different immune patterns in melancholic and non-melancholic major depression. Eur Arch Psychiatry Clin Neurosci. 251(2):90–97.
   PubMed Web of Science ®Google Scholar
• Rothermundt M, Arolt V, Peters M, Gutbrodt H, Fenker J, Kersting A, Kirchner H. 2001. Inflammatory markers in major depression and melancholia. J Affect Disord. 63(1–3):93–102.
   PubMed Web of Science ®Google Scholar
• Rudaz DA, Vandeleur CL, Gebreab SZ, Gholam-Rezaee M, Strippoli M-PF, Lasserre AM, Glaus J, Castelao E, Pistis G, von Känel R, et al. 2017. Partially distinct combinations of psychological, metabolic and inflammatory risk factors are prospectively associated with the onset of the subtypes of major depressive disorder in midlife. J Affect Disord. 222:195–203.
   PubMed Web of Science ®Google Scholar
• Rush AJ, Giles DE, Roffwarg HP, Parker CR. 1982. Sleep EEG and dexamethasone suppression test findings in outpatients with unipolar major depressive disorders. Biol Psychiatry. 17(3):327–341.
   PubMed Web of Science ®Google Scholar
• Rush AJ, Giles DE, Schlesser MA, Orsulak PJ, Parker CR, Weissenburger JE, Crowley GT, Khatami M, Vasavada N. 1996. The dexamethasone suppression test in patients with mood disorders. J Clin Psychiatry. 57(10):470–484.
   PubMed Web of Science ®Google Scholar
• Rush AJ, Giles DE, Schlesser MA, Orsulak PJ, Weissenburger JE, Fulton CL, Fairchild CJ, Roffwarg HP. 1997. Dexamethasone response, thyrotropin-releasing hormone stimulation, rapid eye movement latency, and subtypes of depression. Biol Psychiatry. 41(9):915–928.
   PubMed Web of Science ®Google Scholar
• Sánchez-Carro Y, de la Torre-Luque A, Leal-Leturia I, Salvat-Pujol N, Massaneda C, de Arriba-Arnau A, Urretavizcaya M, Pérez-Solà V, Toll A, Martínez-Ruiz A, et al. 2023. Importance of immunometabolic markers for the classification of patients with major depressive disorder using machine learning. Prog Neuropsychopharmacol Biol Psychiatry. 121:110674.
   PubMed Web of Science ®Google Scholar
• Sani G, Tondo L, Undurraga J, Vazquez GH, Salvatore P, Baldessarini RJ. 2020. Melancholia: does this ancient concept have contemporary utility? Int Rev Psychiatry. 32(5–6):466–470.
   PubMed Web of Science ®Google Scholar
• Savage GH. 1877. Cases of heart disease with melancholia. J Psychol Med Ment Pathol. 3(Pt 1):162–165.
   Google Scholar
• Schlegel S, Nieber D, Herrmann C, Bakauski E. 1991. Latencies of the P300 component of the auditory event-related potential in depression are related to the Bech-Rafaelsen Melancholia Scale but not to the Hamilton Rating Scale for depression. Acta Psychiatr Scand. 83(6):438–440.
   PubMed Web of Science ®Google Scholar
• Selenius JS, Silveira PP, Salonen M, Kautiainen H, von Bonsdorff M, Kajantie E, Lahti J, Eriksson JG, Wasenius NS. 2021. The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network. Sci Rep. 11(1):21588.
   PubMed Web of Science ®Google Scholar
• Shan X, Cui X, Liu F, Li H, Huang R, Tang Y, Chen J, Zhao J, Guo W, Xie G. 2021. Shared and distinct homotopic connectivity changes in melancholic and non-melancholic depression. J Affect Disord. 287:268–275.
   PubMed Web of Science ®Google Scholar
• Shankman SA, Sarapas C, Klein DN. 2011. The effect of pre- vs. post-reward attainment on EEG asymmetry in melancholic depression. Int J Psychophysiol. 79(2):287–295.
   PubMed Web of Science ®Google Scholar
• Shorter E, Fink M. 2010. Endocrine psychiatry: solving the riddle of melancholia. New York, NY: Oxford University Press.
   Google Scholar
• Sowa-Kućma M, Styczeń K, Siwek M, Misztak P, Nowak RJ, Dudek D, Rybakowski JK, Nowak G, Maes M. 2018. Lipid peroxidation and immune biomarkers are associated with major depression and its phenotypes, including treatment-resistant depression and melancholia. Neurotox Res. 33(2):448–460.
   PubMed Web of Science ®Google Scholar
• Spanemberg L, Caldieraro MA, Vares EA, Wollenhaupt-Aguiar B, Kauer-Sant’Anna M, Kawamoto SY, Galvao E, Parker G, Fleck MP. 2014. Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure. Neuropsychiatr Dis Treat. 10:1523–1531.
   PubMed Web of Science ®Google Scholar
• Spitzer RL, Endicott J, Robins E. 1978. Research diagnostic criteria: rationale and reliability. Arch Gen Psychiatry. 35(6):773–782.
   PubMed Web of Science ®Google Scholar
• Styczeń K, Sowa-Kućma M, Siwek M, Dudek D, Reczyński W, Szewczyk B, Misztak P, Topór-Mądry R, Opoka W, Nowak G. 2017. The serum zinc concentration as a potential biological marker in patients with major depressive disorder. Metab Brain Dis. 32(1):97–103.
   PubMed Web of Science ®Google Scholar
• Takahashi T, Nishikawa Y, Yücel M, Whittle S, Lorenzetti V, Walterfang M, Sasabayashi D, Suzuki M, Pantelis C, Allen NB. 2016. Olfactory sulcus morphology in patients with current and past major depression. Psychiatry Res Neuroimaging. 255:60–65.
   PubMed Web of Science ®Google Scholar
• Takahashi T, Sasabayashi D, Yücel M, Whittle S, Lorenzetti V, Walterfang M, Suzuki M, Pantelis C, Malhi GS, Allen NB. 2020. Pineal gland volume in major depressive and bipolar disorders. Front Psychiatry. 11:450.
   PubMed Web of Science ®Google Scholar
• Taylor MA, Fink M. 2006. Melancholia: the diagnosis, pathophysiology, and treatment of depressive illness. Cambridge, UK: Cambridge University Press.
   Google Scholar
• Thase ME, Hersen M, Bellack AS, Himmelhoch JM, Kupfer DJ. 1983. Validation of a Hamilton subscale for endogenomorphic depression. J Affect Disord. 5(3):267–278.
   PubMed Web of Science ®Google Scholar
• Tsujii N, Mikawa W, Akashi H, Tsujimoto E, Adachi T, Kirime E, Takaya M, Yanagi M, Shirakawa O. 2014. Right temporal activation differs between melancholia and nonmelancholic depression: a multichannel near-infrared spectroscopy study. J Psychiatr Res. 55:1–7.
   PubMed Web of Science ®Google Scholar
• Tsujii N, Mikawa W, Tsujimoto E, Akashi H, Adachi T, Kirime E, Shirakawa O. 2016. Relationship between prefrontal hemodynamic responses and quality of life differs between melancholia and non-melancholic depression. Psychiatry Res Neuroimaging. 253:26–35.
   PubMed Web of Science ®Google Scholar
• Türkçapar MH, Akdemir A, Örsel SD, Demirergi N, Sirin A, Kiliç EZ, Özbay MH. 1999. The validity of diagnosis of melancholic depression according to different diagnostic systems. J Affect Disord. 54(1–2):101–107.
   PubMed Web of Science ®Google Scholar
• Veltman EM, Lamers F, Comijs HC, Stek ML, van der Mast RC, Rhebergen D. 2018. Inflammatory markers and cortisol parameters across depressive subtypes in an older cohort. J Affect Disord. 234:54–58.
   PubMed Web of Science ®Google Scholar
• Vogelzangs N, Comijs HC, Oude Voshaar RC, Stek ML, Penninx BWJH. 2014. Late-life depression symptom profiles are differentially associated with immunometabolic functioning. Brain Behav Immun. 41:109–115.
   PubMed Web of Science ®Google Scholar
• Weinberg A, Liu H, Shankman SA. 2016. Blunted neural response to errors as a trait marker of melancholic depression. Biol Psychol. 113:100–107.
   PubMed Web of Science ®Google Scholar
• Winograd-Gurvich C, Georgiou-Karistianis N, Fitzgerald PB, Millist L, White OB. 2006a. Ocular motor differences between melancholic and non-melancholic depression. J Affect Disord. 93(1–3):193–203.
   PubMed Web of Science ®Google Scholar
• Winograd-Gurvich C, Georgiou-Karistianis N, Fitzgerald PB, Millist L, White OB. 2006b. Self-paced and reprogrammed saccades: differences between melancholic and non-melancholic depression. Neurosci Res. 56(3):253–260.
   PubMed Web of Science ®Google Scholar
• Workman CI, Lythe KE, McKie S, Moll J, Gethin JA, Deakin JFW, Elliott R, Zahn R. 2016. Subgenual cingulate–amygdala functional disconnection and vulnerability to melancholic depression. Neuropsychopharmacology. 41(8):2082–2090.
   PubMed Web of Science ®Google Scholar
• Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, et al. 2018. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 50(5):668–681.
   PubMed Web of Science ®Google Scholar
• Yan M, Cui X, Liu F, Li H, Huang R, Tang Y, Chen J, Zhao J, Xie G, Guo W. 2021. Abnormal default-mode network homogeneity in melancholic and nonmelancholic major depressive disorder at rest. Neural Plast. 2021:6653309.
   PubMed Web of Science ®Google Scholar
• Yan M, He Y, Cui X, Liu F, Li H, Huang R, Tang Y, Chen J, Zhao J, Xie G, et al. 2021. Disrupted regional homogeneity in melancholic and non-melancholic major depressive disorder at rest. Front Psychiatry. 12:618805.
   PubMed Web of Science ®Google Scholar
• Yang C, Tiemessen KM, Bosker FJ, Wardenaar KJ, Lie J, Schoevers RA. 2018. Interleukin, tumor necrosis factor-α and C-reactive protein profiles in melancholic and non-melancholic depression: a systematic review. J Psychosom Res. 111:58–68.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Cui X, Ou Y, Liu F, Li H, Chen J, Zhao J, Xie G, Guo W. 2021. Differentiating melancholic and non-melancholic major depressive disorder using fractional amplitude of low-frequency fluctuations. Front Psychiatry. 12:763770.
   PubMed Web of Science ®Google Scholar