The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study

References

• Awasthi H, Mani D, Singh D, et al. The underlying pathophysiology and therapeutic approaches for osteoporosis. Med Res Rev. 2018 Sep;38(6):2024–2057.
   PubMed Web of Science ®Google Scholar
• Greco EA, Pietschmann P, and Migliaccio S. Osteoporosis and sarcopenia increase frailty syndrome in the elderly. Front Endocrinol. 2019 10 Apr 24:255.
   PubMed Web of Science ®Google Scholar
• Estrada K, Styrkarsdottir U, Evangelou E, et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet. 2012 May;44(5):491-+.
   PubMed Web of Science ®Google Scholar
• Karpe F, and Pinnick KE. Biology of upper-body and lower-body adipose tissue-link to whole-body phenotypes [Review]. Nat Rev Endocrinol. 2014 Nov;11(2)90–100.
   PubMed Web of Science ®Google Scholar
• Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019 Mar;92:6–10.
   PubMed Web of Science ®Google Scholar
• Osteoporosis: assessing the risk of fragility fracture. National institute for health and care excellence: clinical guidelines. London: National Institute for Health and Care Excellence; 2017.
   Google Scholar
• Vasan SK, Osmond C, Canoy D, et al. Comparison of regional fat measurements by dual-energy X-ray absorptiometry and conventional anthropometry and their association with markers of diabetes and cardiovascular disease risk. Int J Obes (Lond). 2017;74:315.
   Google Scholar
• Frost HM. A 2003 update of bone physiology and Wolff’s Law for clinicians. Angle Orthod. 2004 Feb;74(1):3–15.
   PubMed Web of Science ®Google Scholar
• Kang D, Liu Z, Wang Y, et al. Relationship of body composition with bone mineral density in northern Chinese men by body mass index levels. J Endocrinol Invest. 2014 Apr;37(4):359–367.
   PubMed Web of Science ®Google Scholar
• Zhu K, Hunter M, James A, et al. Associations between body mass index, lean and fat body mass and bone mineral density in middle-aged Australians: the Busselton healthy ageing study. Bone. 2015 May;74:146–152.
   PubMed Web of Science ®Google Scholar
• George JA, Micklesfield LK, Norris SA, et al. The association between body composition, 25(OH)D, and PTH and bone mineral density in black African and Asian Indian population groups. J Clin Endocr Metab. 2014 Jun;99(6):2146–2154.
   PubMed Web of Science ®Google Scholar
• Yang PLS, Lu Y, Khoo CM, et al. Associations between ethnicity, body composition, and bone mineral density in a southeast asian population. J Clin Endocrinol Metab. 2013;98(11):4516–4523.
   PubMed Web of Science ®Google Scholar
• Marwaha RK, Garg MK, Tandon N, et al. Relationship of body fat and its distribution with bone mineral density in Indian population. J Clin Densitom. 2013 Jul-Sep;16(3):353–359.
   PubMed Web of Science ®Google Scholar
• Cui LH, Shin MH, and Kweon SS, et al. Sex-related differences in the association between waist circumference and bone mineral density in a Korean population. Bmc Musculoskel Dis. 2014 Oct 2;15:326.
   PubMed Web of Science ®Google Scholar
• Zhang J, Jin Y, Xu S, et al. Associations of fat mass and fat distribution with bone mineral density in Chinese obese population. J Clin Densitom. 2015 Jan-Mar;18(1):44–49.
   PubMed Web of Science ®Google Scholar
• Blaauw R, Albertse EC, Hough S. Body fat distribution as a risk factor for osteoporosis. S Afr Med J. 1996 Sep;86(9):1081–1084.
   PubMed Web of Science ®Google Scholar
• Deng G, Yin L, Li K, et al. Relationships between anthropometric adiposity indexes and bone mineral density in a cross-sectional Chinese study. Spine J. 2021 Feb;21(2):332–342.
   PubMed Web of Science ®Google Scholar
• Zhang W, Ma XH, Xue P, et al. Associations between fat distribution and volumetric bone mineral density in Chinese adults. Endocrine. 2014 Dec;47(3):862–868.
   PubMed Web of Science ®Google Scholar
• Tarquini B, Navari N, Perfetto F, et al. Evidence for bone mass and body fat distribution relationship in postmenopausal obese women. Arch Gerontol Geriatr. 1997 Jan-Feb;24(1):15–21.
   PubMed Web of Science ®Google Scholar
• Matsuo T, Douchi T, Nakae M, et al. Relationship of upper body fat distribution to higher regional lean mass and bone mineral density. J Bone Miner Metab. 2003;21(3):179–183.
   PubMed Web of Science ®Google Scholar
• Freitas IF, Cardoso JR, Christofaro DGD, et al. The relationship between visceral fat thickness and bone mineral density in sedentary obese children and adolescents. Bmc Pediatr. 2013 Mar 20;13:13.
   PubMed Web of Science ®Google Scholar
• Katzmarzyk PT, Barreira TV, Harrington DM, et al. Relationship between abdominal fat and bone mineral density in white and African American adults. Bone. 2012 Feb;50(2):576–579.
   PubMed Web of Science ®Google Scholar
• Liu CT, Broe KE, Zhou Y, et al. Visceral Adipose tissue is associated with bone microarchitecture in the Framingham osteoporosis study. J Bone Miner Res. 2017 Jan;32(1):143–150.
   PubMed Web of Science ®Google Scholar
• Burger H, Vandaele PLA, Algra D, et al. The Association between age and bone-mineral density in men and women aged 55 years and over - the Rotterdam study. Bone Miner. 1994 Apr;25(1):1–13.
   PubMedGoogle Scholar
• Finkelstein JS, Brockwell SE, Mehta V, et al. Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab. 2008 Mar;93(3):861–868.
   PubMed Web of Science ®Google Scholar
• Toth MJ, Tchernof A, Sites CK, et al. Menopause-related changes in body fat distribution. Ann N Y Acad Sci. 2000 May;904(1):502–506.
   PubMedGoogle Scholar
• Svendsen OL, Hassager C, Christiansen C. Age-associated and menopause-associated variations in body-composition and fat distribution in healthy women as measured by dual-energy X-ray absorptiometry. Metab Clin Exp. 1995 Mar;44(3):369–373.
   PubMed Web of Science ®Google Scholar
• Loh NY, Neville MJ, Marinou K, et al. LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion. Cell Metab. 2015 Feb 3;21(2):262–273.
   PubMed Web of Science ®Google Scholar
• Skv FK, Humphreys SM, and Miller J, et al. Cohort Profile: the Oxford Biobank. Int J Epidemiol. 2017;47(1): 21–21 .
   Web of Science ®Google Scholar
• Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412–419.
   PubMed Web of Science ®Google Scholar
• Kaul S, Rothney MP, Peters DM, et al. Dual-energy X-ray absorptiometry for quantification of visceral fat. Obesity (Silver Spring). 2012 Jun;20(6):1313–1318.
   PubMed Web of Science ®Google Scholar
• Bishara AJ, Hittner JB. Confidence intervals for correlations when data are not normal. Behav Res Methods. 2017 Feb;49(1):294–309.
   PubMed Web of Science ®Google Scholar
• Reginster JY, Beaudart C, Buckinx F, et al. Osteoporosis and sarcopenia: two diseases or one? Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):31–36.
   PubMed Web of Science ®Google Scholar
• Mo CL, Romero-Suarez S, Brotto MA. Pge(2) accelerates myogenesis of C2c12 Myoblasts. Biophys J. 2011 Feb 2;100(3):288.
   Web of Science ®Google Scholar
• Morissette MR, Stricker JC, Rosenberg MA, et al. Effects of myostatin deletion in aging mice. Aging Cell. 2009 Sep;8(5):573–583.
   PubMed Web of Science ®Google Scholar
• Zhu K, Hunter M, and James A, et al. Discordance between fat mass index and body mass index is associated with reduced bone mineral density in women but not in men: the Busselton healthy ageing study. Osteoporos Int. 2017 Jan;28(1):259–268 .
   PubMed Web of Science ®Google Scholar
• Karpe F, and Pinnick KE. Biology of upper-body and lower-body adipose tissue–link to whole-body phenotypes. Nat Rev Endocrinol. 2015 Feb;11(2):90–100 .
   PubMed Web of Science ®Google Scholar
• Cohen A, Dempster DW, Recker RR, et al. Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study. J Clin Endocr Metab. 2013 Jun;98(6):2562–2572.
   PubMed Web of Science ®Google Scholar
• Bredella MA, Lin E, Gerweck AV, et al. Determinants of bone microarchitecture and mechanical properties in obese men. J Clin Endocrinol Metab. 2012 Nov;97(11):4115–4122.
   PubMed Web of Science ®Google Scholar
• Chen X, Zhang C, Li J, et al. Effects of Laparoscopic sleeve gastrectomy on bone mineral density and bone metabolism in Chinese patients with obesity. Diabetes Metab Syndr Obes. 2020;13:4095–4103.
   PubMed Web of Science ®Google Scholar
• Cornish J, Callon KE, Reid IR. Insulin increases histomorphometric indices of bone formation In vivo. Calcif Tissue Int. 1996 Dec;59(6):492–495.
   PubMed Web of Science ®Google Scholar
• Naot D, Cornish J. Cytokines and hormones that contribute to the positive association between fat and bone. Front Endocrinol (Lausanne). 2014;5:70.
   PubMed Web of Science ®Google Scholar
• Khosla S, Melton LJ 3rd, Atkinson EJ, et al. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab. 1998 Jul;83(7):2266–2274.
   PubMed Web of Science ®Google Scholar
• Takeda S, Elefteriou F, Levasseur R, et al. Leptin regulates bone formation via the sympathetic nervous system. Cell. 2002 Nov1;111(3):305–317.
   PubMed Web of Science ®Google Scholar
• Wu Y, Tu Q, Valverde P, et al. Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice. Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1418–30.
   PubMed Web of Science ®Google Scholar
• Zhu J, Liu C, Jia J, et al. Short-term caloric restriction induced bone loss in both axial and appendicular bones by increasing adiponectin. Ann N Y Acad Sci. 2020 Aug;1474(1):47–60.
   PubMed Web of Science ®Google Scholar
• Tajar A, Forti G, O’Neill TW, et al. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European male ageing study. J Clin Endocrinol Metab. 2010 Apr;95(4):1810–1818.
   PubMed Web of Science ®Google Scholar
• Svartberg J, Von Muhlen D, Sundsfjord J, et al. Waist circumference and testosterone levels in community dwelling men The Tromso study. Eur J Epidemiol. 2004;19(7):657–663.
   PubMed Web of Science ®Google Scholar
• Mohamed-Ali V, Goodrick S, Rawesh A, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 1997 Dec;82(12):4196–4200.
   PubMed Web of Science ®Google Scholar
• Schett G. Effects of inflammatory and anti-inflammatory cytokines on the bone. Eur J Clin Invest. 2011 Dec;41(12):1361–1366.
   PubMed Web of Science ®Google Scholar
• Manolopoulos KN, Karpe F, Frayn KN. Gluteofemoral body fat as a determinant of metabolic health. Int J Obesity. 2010 Jun;34(6):949–959.
   PubMed Web of Science ®Google Scholar
• Qiao J, Wu Y, Ren Y. The impact of a high fat diet on bones: potential mechanisms. Food Funct. 2021 Feb 15;12(3):963–975.
   PubMed Web of Science ®Google Scholar
• Gimble JM, Morgan C, Kelly K, et al. Bone morphogenetic proteins inhibit adipocyte differentiation by bone marrow stromal cells. J Cell Biochem. 1995 Jul;58(3):393–402.
   PubMed Web of Science ®Google Scholar
• Manolopoulos KN, Karpe F, Frayn KN. Marked resistance of femoral adipose tissue blood flow and lipolysis to Adrenaline in vivo. Diabetologia. 2012 Nov;55(11):3029–3037.
   PubMed Web of Science ®Google Scholar
• Bowers RR, Festuccia WT, Song CK, et al. Sympathetic innervation of white adipose tissue and its regulation of fat cell number. Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R1167–75.
   PubMed Web of Science ®Google Scholar
• Farr JN, Charkoudian N, Barnes JN, et al. Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women. J Clin Endocrinol Metab. 2012 Nov;97(11):4219–4227.
   PubMed Web of Science ®Google Scholar
• Park JH, Song YM, Sung J, et al. The association between fat and lean mass and bone mineral density: the Healthy Twin Study. Bone. 2012 Apr;50(4):1006–1011.
   PubMed Web of Science ®Google Scholar
• Cha S, Yu H, Kim JY. Bone mineral density-associated polymorphisms are associated with obesity-related traits in korean adults in a sex-dependent manner. Plos One. 2012 Dec 27;7(12):12.
   Web of Science ®Google Scholar
• Guo Y, Liu H, Yang TL, et al. The Fat Mass and Obesity Associated Gene, FTO, is also associated with osteoporosis phenotypes. Plos One. 2011 Nov18;6(11):11.
   Web of Science ®Google Scholar
• Brown M. Skeletal muscle and bone: effect of sex steroids and aging. Adv Physiol Educ. 2008 Jun;32(2):120–126.
   PubMed Web of Science ®Google Scholar
• Navarro G, Allard C, Xu W, et al. The role of androgens in metabolism, obesity, and diabetes in males and females. Obesity (Silver Spring). 2015 Apr;23(4):713–719.
   PubMed Web of Science ®Google Scholar
• Rubinow KB. Estrogens and body weight regulation in men. Adv Exp Med Biol. 2017;1043:285–313.
   PubMed Web of Science ®Google Scholar
• Vermeulen A, Kaufman JM, Goemaere S, et al. Estradiol in elderly men. Aging Male. 2002 Jun;5(2):98–102.
   PubMedGoogle Scholar
• Schuit SC, van der Klift M, Weel AE, et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam study. Bone. 2004 Jan;34(1):195–202.
   PubMed Web of Science ®Google Scholar