Predictive value of coagulation variables and glycocalyx shedding in hospitalized COVID-19 patients – a prospective observational study

References

• Wolff D, Nee S, Hickey NS, et al. Risk factors for Covid-19 severity and fatality: a structured literature review. Infection. 2021;49(1):15–28.
   PubMed Web of Science ®Google Scholar
• Iba T, Levy JH, Levi M, et al. Coagulopathy of Coronavirus Disease 2019. Crit Care Med. 2020;48(9):1358–1364.
   PubMed Web of Science ®Google Scholar
• Baccellieri D, Bertoglio L, Apruzzi L, et al. Incidence of deep venous thrombosis in COVID-19 hospitalized patients during the first peak of the Italian outbreak. Phlebology. Published online November 26, 2020:268355520975592 36(5):375–383. DOI: 10.1177/0268355520975592.
   PubMed Web of Science ®Google Scholar
• Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145–147.
   PubMed Web of Science ®Google Scholar
• Conway EM, Mackman N, Warren RQ, et al. Understanding COVID-19-associated coagulopathy. Nat Rev Immunol. 2022;22(10):639–649. DOI:10.1038/s41577-022-00762-9
   PubMed Web of Science ®Google Scholar
• Zhang L, Yan X, Fan Q, et al. D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost. 2020;18(6):1324–1329. DOI:10.1111/jth.14859
   PubMed Web of Science ®Google Scholar
• Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135(23):2033–2040.
   PubMed Web of Science ®Google Scholar
• Tang N, Li D, Wang X, et al. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844–847.
   PubMed Web of Science ®Google Scholar
• Terpos E, Ntanasis-Stathopoulos I, Elalamy I, et al. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834–847. DOI:10.1002/ajh.25829
   PubMed Web of Science ®Google Scholar
• Bareille M, Hardy M, Douxfils J, et al. Viscoelastometric testing to assess hemostasis of COVID-19: a systematic review. J Clin Med Res. 2021;10(8):1740. DOI:10.3390/jcm10081740
   Google Scholar
• Katz D, Maher P, Getrajdman C, et al. Monitoring of COVID-19-associated coagulopathy and anticoagulation with thromboelastometry. Transfus Med Hemother. 2021;48(3):168–172. DOI:10.1159/000514486
   PubMed Web of Science ®Google Scholar
• Bachler M, Bösch J, Stürzel DP, et al. Impaired fibrinolysis in critically ill COVID-19 patients. Br J Anaesth. 2021;126(3):590–598. DOI:10.1016/j.bja.2020.12.010
   PubMed Web of Science ®Google Scholar
• Fraser DD, Patterson EK, Slessarev M, et al. Endothelial Injury and glycocalyx degradation in critically Ill coronavirus disease 2019 patients: implications for microvascular platelet aggregation. Crit Care Explor. 2020;2(9):e0194. DOI:10.1097/CCE.0000000000000194
   PubMedGoogle Scholar
• Johansson PI, Stensballe J, Rasmussen LS, et al. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg. 2011;254(2):194–200.
   PubMed Web of Science ®Google Scholar
• Ostrowski SR, Johansson PI. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg. 2012;73(1):60–66.
   PubMed Web of Science ®Google Scholar
• Becker BF, Jacob M, Leipert S, et al. Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases. Br J Clin Pharmacol. 2015;80(3):389–402.
   PubMed Web of Science ®Google Scholar
• Broman N, Rantasärkkä K, Feuth T, et al. IL-6 and other biomarkers as predictors of severity in COVID-19. Ann Med. 2021;53(1):410–412. DOI:10.1080/07853890.2020.1840621
   PubMed Web of Science ®Google Scholar
• Ali N. Elevated level of C-reactive protein may be an early marker to predict risk for severity of COVID-19. J Med Virol. 2020;92(11):2409–2411.
   PubMed Web of Science ®Google Scholar
• Bruegger D, Brettner F, Rossberg I, et al. Acute degradation of the endothelial glycocalyx in infants undergoing cardiac surgical procedures. Ann Thorac Surg. 2015;99(3):926–931. DOI:10.1016/j.athoracsur.2014.10.013
   PubMed Web of Science ®Google Scholar
• Brettner F, Chappell D, Nebelsiek T, et al. Preinterventional hydrocortisone sustains the endothelial glycocalyx in cardiac surgery. Clin Hemorheol Microcirc. 2019;71(1):59–70. DOI:10.3233/CH-180384
   PubMed Web of Science ®Google Scholar
• Chappell D, Dörfler N, Jacob M, et al. Glycocalyx protection reduces leukocyte adhesion after ischemia/reperfusion. Shock. 2010;34(2):133–139. DOI:10.1097/SHK.0b013e3181cdc363
   PubMed Web of Science ®Google Scholar
• Steinach M, Biere K, Coker RH, et al. Influences on glycocalyx shedding during the yukon arctic ultra: the longest and the coldest ultramarathon. J Appl Physiol. 2022;133(5):1119–1135. DOI:10.1152/japplphysiol.00180.2022
   PubMed Web of Science ®Google Scholar
• Luo X, Zhou W, Yan X, et al. Prognostic value of c-reactive protein in patients with coronavirus 2019. Clin Infect Dis. 2020;71(16):2174–2179. DOI:10.1093/cid/ciaa641
   PubMed Web of Science ®Google Scholar
• Herold T, Jurinovic V, Arnreich C, et al. Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19. J Allergy Clin Immunol. 2020;146(1):128–136.e4. DOI:10.1016/j.jaci.2020.05.008
   PubMed Web of Science ®Google Scholar
• Spiezia L, Boscolo A, Poletto F, et al. COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure. Thromb Haemost. 2020;120(6):998–1000. DOI:10.1055/s-0040-1714350
   PubMed Web of Science ®Google Scholar
• Collett LW, Gluck S, Strickland RM, et al. Evaluation of coagulation status using viscoelastic testing in intensive care patients with coronavirus disease 2019 (COVID-19): an observational point prevalence cohort study. Aust Crit Care. 2021;34(2):155–159.
   PubMed Web of Science ®Google Scholar
• Pavoni V, Gianesello L, Pazzi M, et al. Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia. J Thromb Thrombolysis. 2020;50(2):281–286.
   PubMed Web of Science ®Google Scholar
• Almskog LM, Wikman A, Svensson J, et al. Rotational thromboelastometry results are associated with care level in COVID-19. J Thromb Thrombolysis. 2021;51(2):437–445. DOI:10.1007/s11239-020-02312-3
   PubMed Web of Science ®Google Scholar
• Nougier C, Benoit R, Simon M, et al. Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis. J Thromb Haemost. 2020;18(9):2215–2219. DOI:10.1111/jth.15016
   PubMed Web of Science ®Google Scholar
• Hulshof AM, Brüggemann RAG, Mulder MMG, et al. Serial EXTEM, FIBTEM, and tPA rotational thromboelastometry observations in the maastricht intensive care COVID cohort-persistence of hypercoagulability and hypofibrinolysis despite anticoagulation. Front Cardiovasc Med. 2021;8:654174.
   PubMed Web of Science ®Google Scholar
• Creel-Bulos C, Auld SC, Caridi-Scheible M, et al. Fibrinolysis shutdown and thrombosis in a COVID-19 ICU. Shock. 2021;55(3):316–320. DOI:10.1097/SHK.0000000000001635
   PubMed Web of Science ®Google Scholar
• Gomez-Builes JC, Acuna SA, Nascimento B, et al. Harmful or physiologic: diagnosing fibrinolysis shutdown in a trauma cohort with rotational thromboelastometry. Anesth Analg. 2018;127(4):840–849.
   PubMed Web of Science ®Google Scholar
• Stettler GR, Moore EE, Moore HB, et al. Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays. J Trauma Acute Care Surg. 2019;86(4):679–685. DOI:10.1097/TA.0000000000002165
   PubMed Web of Science ®Google Scholar
• Schmitt FCF, Manolov V, Morgenstern J, et al. Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study. Ann Intensive Care. 2019;9(1):19. DOI:10.1186/s13613-019-0499-6
   PubMedGoogle Scholar
• Adamzik M, Eggmann M, Frey UH, et al. Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults. crit care. 2010;14(5):R178. DOI:10.1186/cc9284
   PubMed Web of Science ®Google Scholar
• Yamaoka-Tojo M. Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19. Biomed J. 2020;43(5):399–413.
   PubMed Web of Science ®Google Scholar
• Yamaoka-Tojo M. Vascular Endothelial Glycocalyx Damage in COVID-19. Int J Mol Sci. 2020;21(24):9712.
   PubMed Web of Science ®Google Scholar
• Evans PC, Rainger GE, Mason JC, et al. Endothelial dysfunction in COVID-19: a position paper of the ESC working group for atherosclerosis and vascular biology, and the ESC council of basic cardiovascular science. Cardiovasc Res. 2020;116(14):2177–2184. DOI:10.1093/cvr/cvaa230
   PubMed Web of Science ®Google Scholar
• Nagashima S, Mendes MC, Camargo Martins AP, et al. Endothelial dysfunction and thrombosis in patients with COVID-19-brief report. Arterioscler Thromb Vasc Biol. 2020;40(10):2404–2407. DOI:10.1161/ATVBAHA.120.314860
   PubMed Web of Science ®Google Scholar
• Wadowski PP, Piechota-Polańczyk A, Andreas M, et al. Cardiovascular disease management in the context of global crisis. Int J Environ Res Public Health. 2022;20(1):689.
   PubMed Web of Science ®Google Scholar
• Flaumenhaft R, Enjyoji K, Schmaier AA. Vasculopathy in COVID-19. Blood. 2022;140(3):222–235.
   PubMed Web of Science ®Google Scholar
• Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395(10234):1417–1418. DOI:10.1016/S0140-6736(20)30937-5
   PubMed Web of Science ®Google Scholar
• Agrati C, Bordoni V, Sacchi A, et al. Elevated P-Selectin in severe covid-19: considerations for therapeutic options. Mediterr J Hematol Infect Dis. 2021;13(1):e2021016. DOI:10.4084/mjhid.2021.016
   PubMed Web of Science ®Google Scholar
• Rovas A, Osiaevi I, Buscher K, et al. Microvascular dysfunction in COVID-19: the MYSTIC study. Angiogenesis. 2021;24(1):145–157. DOI:10.1007/s10456-020-09753-7
   PubMed Web of Science ®Google Scholar
• Gorog DA, Storey RF, Gurbel PA, et al. Current and novel biomarkers of thrombotic risk in COVID-19: a consensus statement from the international COVID-19 thrombosis biomarkers colloquium. Nat Rev Cardiol. 2022;19(7):475–495. DOI:10.1038/s41569-021-00665-7
   PubMed Web of Science ®Google Scholar