C2729T mutation associated with HBV mother-to-child transmission reduces HBV production via suppressing LHBs expression

References

• Hepatitis B. World health organization fact sheets. Available online: https://www.who.int/news-room/fact-sheets/detail/hepatitis-b.
   Google Scholar
• Liu J, Liang W, Jing W, et al. Countdown to 2030: eliminating hepatitis B disease, China. Bull World Health Organ. 2019;97(3):230–13.
   PubMed Web of Science ®Google Scholar
• For Maternal-Fetal Medicine S, Dionne-Odom J, Tita AT, et al. #38: hepatitis B in pregnancy screening, treatment, and prevention of vertical transmission. Am J Obstet Gynecol. 2016;214(1):6–14.
   PubMed Web of Science ®Google Scholar
• Pan CQ, Duan ZP, Bhamidimarri KR, et al. An algorithm for risk assessment and intervention of mother to child transmission of hepatitis B virus. Clin Gastroenterol Hepatol. 2012;10(5):452–459.
   PubMed Web of Science ®Google Scholar
• Schulze A, Gripon P, Urban S. Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans. Hepatology. 2007;46(6):1759–1768.
   PubMed Web of Science ®Google Scholar
• Garcia T, Li J, Sureau C, et al. Drastic reduction in the production of subviral particles does not impair hepatitis B virus virion secretion. J Virol. 2009;83(21):11152–11165.
   PubMed Web of Science ®Google Scholar
• Yan H, Zhong G, Xu G, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife. 2012;1:e00049.
   PubMed Web of Science ®Google Scholar
• Xu M, Li C, Ding J, et al. The role of hepatitis B virus surface proteins in regulating the maturation and secretion of complete and incomplete virions. J Gen Virol. 2022;103(4). DOI:10.1099/jgv.0.001733
   Web of Science ®Google Scholar
• Xu Z, Yen TS. Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles. J Virol. 1996;70(1):133–140.
   PubMed Web of Science ®Google Scholar
• Park JS, Pan CQ. Viral factors for HBV mother-to-child transmission. Hepatol Int. 2017;11(6):476–480.
   PubMed Web of Science ®Google Scholar
• Sa-Nguanmoo P, Tangkijvanich P, Tharmaphornpilas P, et al. Molecular analysis of hepatitis B virus associated with vaccine failure in infants and mothers: a case-control study in Thailand. J Med Virol. 2012;84(8):1177–1185.
   PubMed Web of Science ®Google Scholar
• Huang Y, Wang B, Peng Z, et al. Hepatitis B virus surface gene mutants in immunoprophylaxis-failed infants from Southern China. J Med Virol. 2019;91(6):1069–1075.
   PubMed Web of Science ®Google Scholar
• Xiao Y, Sun K, Duan Z, et al. Quasispecies characteristic in “a” determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study. Gut. 2020;69(5):933–941.
   PubMed Web of Science ®Google Scholar
• Yin WJ, Shen LP, Wang FZ, et al. Hepatitis B immunoprophylactic failure and characteristics of the hepatitis B virus gene in mother-infant pairs in parts of China. Biomed Environ Sci. 2016;29(11):790–801.
   PubMed Web of Science ®Google Scholar
• Ogura S, Tameda M, Sugimoto K, et al. A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus. Virol J. 2019;16(1):59.
   PubMedGoogle Scholar
• Huang FY, Wong DK, Seto WK, et al. Sequence variations of full-length hepatitis B virus genomes in Chinese patients with HBsAg-negative hepatitis B infection. PLoS ONE. 2014;9(6):e99028.
   PubMed Web of Science ®Google Scholar
• Song Y, Lu Y, Li Y, et al. HBx 128-133 deletion affecting HBV mother-to-child transmission weakens HBV replication via reducing HBx level and CP/ENII transcriptional activity. Viruses. 2022;14(9):1887.
   PubMed Web of Science ®Google Scholar
• Lu Y, Zhu FC, Liu JX, et al. The maternal viral threshold for antiviral prophylaxis of perinatal hepatitis B virus transmission in settings with limited resources: a large prospective cohort study in China. Vaccine. 2017;35(48 Pt B):6627–6633.
   PubMed Web of Science ®Google Scholar
• Wen WH, Chang MH, Zhao LL, et al. Mother-to-infant transmission of hepatitis B virus infection: significance of maternal viral load and strategies for intervention. J Hepatol. 2013;59(1):24–30.
   PubMed Web of Science ®Google Scholar
• Liu SL, Dong Y, Zhang L, et al. Influence of HBV gene heterogeneity on the failure of immunization with HBV vaccines in eastern China. Arch Virol. 2009;154(3):437–443.
   PubMed Web of Science ®Google Scholar
• Standring DN, Ou JH, Rutter WJ. Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle. Proc Natl Acad Sci U S A. 1986;83(24):9338–9342.
   PubMed Web of Science ®Google Scholar
• Persing DH, Varmus HE, Ganem D. Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide. Science. 1986;234(4782):1388–1391.
   PubMed Web of Science ®Google Scholar
• Bruss V. Hepatitis B virus morphogenesis. World J Gastroenterol. 2007;13(1):65–73.
   PubMed Web of Science ®Google Scholar
• Huovila AP, Eder AM, Fuller SD. Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment. J Cell Biol. 1992;118(6):1305–1320.
   PubMed Web of Science ®Google Scholar
• Bruss V, Ganem D. The role of envelope proteins in hepatitis B virus assembly. Proc Natl Acad Sci U S A. 1991;88(3):1059–1063.
   PubMed Web of Science ®Google Scholar
• Fernholz D, Stemler M, Brunetto M, et al. Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein. J Hepatol. 1991;13(Suppl 4):S102–104.
   PubMedGoogle Scholar
• Jenna S, Sureau C. Effect of mutations in the small envelope protein of hepatitis B virus on assembly and secretion of hepatitis delta virus. Virology. 1998;251(1):176–186.
   PubMed Web of Science ®Google Scholar
• Tan WS, Dyson MR, Murray K. Two distinct segments of the hepatitis B virus surface antigen contribute synergistically to its association with the viral core particles. J Mol Biol. 1999;286(3):797–808.
   PubMed Web of Science ®Google Scholar
• Chang HK, Wang BY, Yun CH, et al. A liver-specific nuclear factor interacts with the promoter region of the large surface protein gene of human hepatitis B virus. Mol Cell Biol. 1989;9(11):5189–5197.
   PubMed Web of Science ®Google Scholar
• Nishizono A, Maeno M, Hiraga M, et al. In vitro transcription of the hepatitis B virus gene by nuclear extracts of human hepatoma cells. Virology. 1991;182(2):545–552. DOI:10.1016/0042-6822(91)90595-3
   PubMed Web of Science ®Google Scholar
• Oropeza CE, Tarnow G, Sridhar A, et al. The regulation of HBV transcription and replication. Adv Exp Med Biol. 2020;1179:39–69.
   PubMed Web of Science ®Google Scholar
• Boucheron P, Lu Y, Yoshida K, et al. Accuracy of HBeAg to identify pregnant women at risk of transmitting hepatitis B virus to their neonates: a systematic review and meta-analysis. Lancet Infect Dis. 2021;21(1):85–96.
   PubMed Web of Science ®Google Scholar
• Wen WH, Huang CW, Chie WC, et al. Quantitative maternal hepatitis B surface antigen predicts maternally transmitted hepatitis B virus infection. Hepatology. 2016;64(5):1451–1461.
   PubMed Web of Science ®Google Scholar
• Sun KX, Li J, Zhu FC, et al. A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women. Vaccine. 2012;30(36):5335–5340.
   PubMed Web of Science ®Google Scholar
• Peng S, Wan Z, Liu T, et al. Quantitative Hepatitis B surface antigen predicts Hepatitis B transmission in infants born to e antigen-positive mothers. J Clin Gastroenterol. 2020;54(1):76–82.
   PubMed Web of Science ®Google Scholar
• Lu Y, Song Y, Zhai X, et al. Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus. Emerg Microbes Infect. 2021;10(1):555–564.
   PubMed Web of Science ®Google Scholar