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Review

Photodynamic treatment modulates various GTPase and cellular signalling pathways in Tauopathy

& ORCID Icon
Pages 183-195 | Received 28 Jan 2021, Accepted 04 Jun 2021, Published online: 17 Jun 2021

References

  • Zhao J, Duan L, Wang A, et al. Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020;12:e1583.
  • Meimandi M, Ardakani MRT, Nejad AE, et al. The effect of photodynamic therapy in the treatment of chronic periodontitis: a review of literature. J Lasers Med Sci. 2017;8:S7.
  • Lan M, Zhao S, Liu W, et al. Photosensitizers for photodynamic therapy. Adv Healthc Mater. 2019;8:1900132.
  • Abrahamse H, Hamblin MR. New photosensitizers for photodynamic therapy. Biochem J. 2016;473:347–364.
  • Agostinis P, Berg K, Cengel KA, et al. Photodynamic therapy of cancer: an update. CA Cancer J Clin. 2011;61:250–281.
  • Kou J, Dou D, Yang L. Porphyrin photosensitizers in photodynamic therapy and its applications. Oncotarget. 2017;8:81591.
  • Kamkaew A, Lim SH, Lee HB, et al. BODIPY dyes in photodynamic therapy. Chem Soc Rev. 2013;42:77–88.
  • Ormond AB, Freeman HS. Dye sensitizers for photodynamic therapy. Materials. 2013;6:817–840.
  • Shi C, Wu JB, Pan D. Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy. J Biomed Opt. 2016;21:050901.
  • Li L, Chen Y, Chen W, et al. Photodynamic therapy based on organic small molecular fluorescent dyes. Chin Chem Lett. 2019;30:1689–1703.
  • Allison RR, Moghissi K. Photodynamic therapy (PDT): PDT mechanisms. Clin Endosc. 2013;46:24.
  • Lawen A. Apoptosis—an introduction. Bioessays. 2003;25:888–896.
  • Cohen GM. Caspases: the executioners of apoptosis. Biochem J. 1997;326:1–16.
  • Wang H, Wang X, Zhang S, et al. Sinoporphyrin sodium, a novel sensitizer, triggers mitochondrial-dependent apoptosis in ECA-109 cells via production of reactive oxygen species. Int J Nanomedicine. 2014;9:3077.
  • Salmerón ML, Quintana‐Aguiar J, De La Rosa JV, et al. Phenalenone‐photodynamic therapy induces apoptosis on human tumor cells mediated by caspase‐8 and p38‐MAPK activation. Mol Carcinog. 2018;57:1525–1539.
  • Wang X, Gong Q, Song C, et al. Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways. Toxicol Appl Pharmacol. 2021;418:115484.
  • Wang H, Xiong L, Xia Y, et al. 5-aminolaevulinic acid-based photodynamic therapy induces both necrosis and apoptosis of keratinocytes in plantar warts. J Cosmet Laser Ther. 2020;22:165–170.
  • Bin L, Xu G, Wang Z-Q, et al. Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation. Acta Pharmacol Sin. 2017;38:1543–1553.
  • Inguscio V, Panzarini E, Dini L. Autophagy contributes to the death/survival balance in cancer photodynamic therapy. Cells. 2012;1:464–491.
  • Mizuno-Yamasaki E, Rivera-Molina F, Novick P. GTPase networks in membrane traffic. Annu Rev Biochem. 2012;81:637–659.
  • Bueno MJ, De Castro IP, Malumbres M. Control of cell proliferation pathways by microRNAs. Cell Cycle. 2008;7:3143–3148.
  • Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: conserved structure and molecular mechanism. Nature. 1991;349:117–127.
  • Li G, Zhang XC. GTP hydrolysis mechanism of Ras-like GTPases. J Mol Biol. 2004;340:921–932.
  • Tousley A, Iuliano M, Weisman E, et al. Rac1 activity is modulated by Huntingtin and dysregulated in models of Huntington’s disease. J Huntington’s Dis. 2019;8:53–69.
  • Villalonga P, Villalonga P, Ridley AJ. Rho GTPases and cell cycle control. Growth Factors. 2006;24:159–164.
  • Blanchard J. Small GTPases, adhesion, cell cycle control and proliferation. Pathologie-biologie. 2000;48:318–327.
  • Ridley AJ. Rho GTPase signalling in cell migration. Curr Opin Cell Biol. 2015;36:103–112.
  • Govek -E-E, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development. Genes Dev. 2005;19:1–49.
  • Stankiewicz TR, Linseman DA. Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration. Front Cell Neurosci. 2014;8:314.
  • DeGeer J, Lamarche-Vane N. Rho GTPases in neurodegeneration diseases. Exp Cell Res. 2013;319:2384–2394.
  • Kumar A, Al-Sammarraie N, DiPette DJ, et al. Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma. Oncotarget. 2014;5:11709.
  • Mokhtar SH, Kim MJ, Magee KA, et al. Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer’s disease. Neural Regen Res. 2018;13:1066.
  • Pozueta J, Lefort R, Ribe EM, et al. Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice. Nat Commun. 2013;4:1–12.
  • Bolognin S, Lorenzetto E, Diana G, et al. The potential role of rho GTPases in Alzheimer’s disease pathogenesis. Mol Neurobiol. 2014;50:406–422.
  • Eftekharzadeh B, Daigle JG, Kapinos LE, et al. Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease. Neuron. 2018;99:925–40. e7.
  • Valencia A, Sapp E, Kimm JS, et al. Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington’s disease. Hum Mol Genet. 2013;22:1112.
  • Sanchez M, Gastaldi L, Remedi M, et al. Rotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons. Toxicol Sci. 2008;104:352–361.
  • Xiong Y, Dawson VL, Dawson TM. LRRK2 GTPase dysfunction in the pathogenesis of Parkinson’s disease. Biochem Soc Trans. 2012;40:1074–1079.
  • Wang S, Hu C, Wu F, et al. Rab25 GTPase: functional roles in cancer. Oncotarget. 2017;8:64591.
  • Shaughnessy R, Echard A. Rab35 GTPase and cancer: linking membrane trafficking to tumorigenesis. Traffic. 2018;19:247–252.
  • Villagomez FR, Medina-Contreras O, Cerna-Cortes JF, et al. The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia. Small GTPases. 2020;11:334–345.
  • Suzuki T, Tanaka M, Sasaki M, et al. Vascular shutdown by photodynamic therapy using talaporfin sodium. Cancers (Basel). 2020;12:2369.
  • Yousefi M, Koopaie M, Karimi R, et al. Effect of photodynamic therapy on expression of HRAS, NRAS and caspase 3 genes at mRNA levels, apoptosis of head and neck squamous cell carcinoma cell line. Photodiagnosis Photodyn Ther. 2021;33:102142.
  • Chatterjee S, Rhee Y, Chung P-S, et al. Sulforaphene enhances the efficacy of photodynamic therapy in anaplastic thyroid cancer through Ras/RAF/MEK/ERK pathway suppression. J Photochem Photobiol B Biol. 2018;179:46–53.
  • Kim S-M, Rhee Y-H, Kim J-S. The anticancer effects of radachlorin-mediated photodynamic therapy in the human endometrial adenocarcinoma cell line HEC-1-A. Anticancer Res. 2017;37:6251–6258.
  • Xu DD, Xu CB, Lam HM, et al. Proteomic analysis reveals that pheophorbide a-mediated photodynamic treatment inhibits prostate cancer growth by hampering GDP-GTP exchange of ras-family proteins. Photodiagnosis Photodyn Ther. 2018;23:35–39.
  • Pittet O, Petermann D, Michod D, et al. Effect of the TAT-RasGAP317–326 peptide on apoptosis of human malignant mesothelioma cells and fibroblasts exposed to meso-tetra-hydroxyphenyl-chlorin and light. J Photochem Photobiol B Biol. 2007;88:29–35.
  • Wufuer R, Ma H-X, Luo M-Y, et al. Downregulation of Rac1/PAK1/LIMK1/cofilin signaling pathway in colon cancer SW620 cells treated with Chlorin e6 photodynamic therapy. Photodiagnosis Photodyn Ther. 2021;33:102143.
  • Ma H, Yang K, Li H, et al. Photodynamic effect of chlorin e6 on cytoskeleton protein of human colon cancer SW480 cells. Photodiagnosis Photodyn Ther. 2021;33:102201.
  • Ross CA, Poirier MA. Protein aggregation and neurodegenerative disease. Nat Med. 2004;10:S10–S7.
  • Taylor JP, Hardy J, Fischbeck KH. Toxic proteins in neurodegenerative disease. Science. 2002;296:1991–1995.
  • Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci. 2001;2:492–501.
  • Singleton A, Farrer M, Johnson J, et al. [alpha]-synuclein locus triplication causes Parkinson’s disease. Science. 2003;302:841–842.
  • Ashraf M,Greig N, Khan T, et al. Protein misfolding and aggregation in Alzheimer’s disease and type 2 diabetes mellitus. CNS & Neurol Disord Drug Targets. 2014;13:1280–1293.
  • Lee BI, Chung YJ, Park CB. Photosensitizing materials and platforms for light-triggered modulation of Alzheimer’s β-amyloid self-assembly. Biomaterials. 2019;190:121–132.
  • Gao N, Sun H, Dong K, et al. Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease. Nat Commun. 2014;5:1–9.
  • Mangione M, Piccionello AP, Marino C, et al. Photo-inhibition of Aβ fibrillation mediated by a newly designed fluorinated oxadiazole. RSC Adv. 2015;5:16540–16548.
  • Ozawa D, Kaji Y, Yagi H, et al. Destruction of amyloid fibrils of keratoepithelin peptides by laser irradiation coupled with amyloid-specific thioflavin T. J Biol Chem. 2011;286:10856–10863.
  • Tsolekile N, Ncapayi V, Obiyenwa GK, et al. Synthesis of meso-tetra-(4-sulfonatophenyl) porphyrin (TPPS4)–CuInS/ZnS quantum dots conjugate as an improved photosensitizer. Int J Nanomedicine. 2019;14:7065.
  • Lee BI, Suh YS, Chung YJ, et al. Shedding light on Alzheimer’s β-amyloidosis: photosensitized methylene blue inhibits self-assembly of β-amyloid peptides and disintegrates their aggregates. Sci Rep. 2017;7:1–10.
  • Lee JS, Lee BI, Park CB. Photo-induced inhibition of Alzheimer’s β-amyloid aggregation in vitro by rose bengal. Biomaterials. 2015;38:43–49.
  • Dubey T, Gorantla NV, Chandrashekara KT, et al. Photoexcited toluidine blue inhibits Tau aggregation in Alzheimer’s disease. ACS Omega. 2019;4:18793–18802.
  • Dubey T, Gorantla NV, Chandrashekara KT, et al. Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells. Sci Rep. 2020;10:1–16.
  • Dubey T, Chinnathambi S. Brahmi (Bacopa monnieri): an ayurvedic herb against the Alzheimer’s disease. Arch Biochem Biophys. 2019;676:108153.
  • Dubey T, Chinnathambi S. Photodynamic sensitizers modulate cytoskeleton structural dynamics in neuronal cells. Cytoskeleton. 2021. DOI:10.1002/cm.21655
  • Wong HE, Kwon I. Xanthene food dye, as a modulator of Alzheimer’s disease amyloid-beta peptide aggregation and the associated impaired neuronal cell function. PLoS One. 2011;6:e25752.
  • Reinke AA, Gestwicki JE. Structure–activity Relationships of amyloid beta‐aggregation inhibitors based on curcumin: influence of linker length and flexibility. Chem Biol Drug Des. 2007;70:206–215.
  • Desale SE, Chinnathambi S. α-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia. Mol Biomed. 2021;2:1–14.
  • Desale SE, Chinnathambi S. Role of dietary fatty acids in microglial polarization in Alzheimer’s disease. J Neuroinflammation. 2020;17:1–14.
  • Das R, Balmik AA, Chinnathambi S. Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia. J Neuroinflammation. 2020;17:1–15.
  • Desale SE, Dubey T, Chinnathambi S. α-Linolenic acid inhibits Tau aggregation and modulates Tau conformation. Int J Biol Macromol. 2021;166:687–693.
  • Das R, Chinnathambi S. Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease. Cell Mol Life Sci. 2019;76:3681–3694.
  • Pocock JM, Kettenmann H. Neurotransmitter receptors on microglia. Trends Neurosci. 2007;30:527–535.
  • Chidambaram H, Chinnathambi S. G-protein coupled receptors and tau-different roles in Alzheimer’s disease. Neuroscience. 2020;438:198–214.
  • Kettenmann H, Hanisch U-K, Noda M, et al. Physiology of microglia. Physiol Rev. 2011;91:461–553.
  • Reichhart V. Role of microglia in photodynamic therapy of glioma. 2018. Department of Biosciences Faculty of Natural Sciences Paris-Lodron-University Salzburg.
  • Fisher CJ, Niu C, Foltz W, et al. ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia. PloS One. 2017;12:e0181654.
  • Kovaleva VD, Uzdensky AB. Photodynamic therapy-induced nitric oxide production in neuronal and glial cells. J Biomed Opt. 2016;21:105005.
  • Uzdensky A, Rudkovskii M, Fedorenko G, et al. Responses of crayfish neurons and glial cells to photodynamic impact: intracellular signaling, ultrastructural changes, and neuroglial interactions. Biochem (Moscow) Suppl Ser A. 2014;8:1–15.
  • Komandirov M, Knyazeva E, Fedorenko Y, et al. Chemical modulation of photodynamic injury of glial cells. J Innovative Opt Health Sci. 2011;4:429–435.
  • Shibata S, Shinozaki N, Suganami A, et al. Photo-immune therapy with liposomally formulated phospholipid-conjugated indocyanine green induces specific antitumor responses with heat shock protein-70 expression in a glioblastoma model. Oncotarget. 2019;10:175.
  • decarvalho AC, Zhang X, Roberts C, et al. Subclinical photodynamic therapy treatment modifies the brain microenvironment and promotes glioma growth. Glia. 2007;55:1053–1060.
  • Pass HI. Photodynamic therapy in oncology: mechanisms and clinical use. JNCI. 1993;85:443–456.
  • Grosjean P, Wagnieres G, Fontolliet C, et al. Clinical photodynamic therapy for superficial cancer in the oesophagus and the bronchi: 514 nm compared with 630 nm light irradiation after sensitization with Photofrin II. Br J Cancer. 1998;77:1989–1995.
  • Mimura S, Ito Y, Nagayo T, et al. Cooperative clinical trial of photodynamic therapy with photofrin II and excimer dye laser for early gastric cancer. Lasers Surg Med. 1996;19:168–172.
  • Senge MO, Brandt JC. Temoporfin (Foscan®, 5, 10, 15, 20‐tetra (m‐hydroxyphenyl) chlorin)—a second‐generation photosensitizer. Photochem Photobiol. 2011;87:1240–1296.
  • Shimizu K, Nitta M, Komori T, et al. Intraoperative photodynamic diagnosis using talaporfin sodium simultaneously applied for photodynamic therapy against malignant glioma: a prospective clinical study. Front Neurol. 2018;9:24.
  • Du K, Mick R, Busch T, et al. Preliminary results of interstitial motexafin lutetium‐mediated PDT for prostate cancer. Lasers Surg Med. 2006;38:427–434.
  • Li X, Lovell JF, Yoon J, et al. Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Rev Clin Oncol. 2020;17:657–674.
  • Guo D, Xu S, Huang Y, et al. Platinum (IV) complex-based two-in-one polyprodrug for a combinatorial chemo-photodynamic therapy. Biomaterials. 2018;177:67–77.
  • Sun J-H, Zhang W, Zhang D-Y, et al. Multifunctional mesoporous silica nanoparticles as efficient transporters of doxorubicin and chlorin e6 for chemo-photodynamic combinatorial cancer therapy. J Biomater Appl. 2018;32:1253–1264.
  • Choudhary S, Nouri K, Elsaie ML. Photodynamic therapy in dermatology: a review. Lasers Med Sci. 2009;24:971–980.
  • Sandberg C, Stenquist B, Rosdahl I, et al. Important factors for pain during photodynamic therapy for actinic keratosis. Acta Derm Venereol. 2006;86:404–408.

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