Assessment of the quality of antimicrobial prescribing among hospitalized patients in a teaching hospital in Ghana: findings and implications

References

• Murray CJL, Ikuta KS, Sharara F. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629–655. doi: 10.1016/S0140-6736(21)02724-0
   PubMed Web of Science ®Google Scholar
• Founou RC, Founou LL, Essack SY, et al. Clinical and economic impact of antibiotic resistance in developing countries: A systematic review and meta-analysis. PLoS One. 2017;12(12):e0189621–e. doi: 10.1371/journal.pone.0189621
   PubMed Web of Science ®Google Scholar
• World Bank Group. Pulling together to beat superbugs knowledge and implementation gaps in addressing antimicrobial resistance; 2019. Available from: https://openknowledge.worldbank.org/bitstream/handle/10986/32552/Pulling-Together-to-Beat-Superbugs-Knowledge-and-Implementation-Gaps-in-Addressing-Antimicrobial-Resistance.pdf?sequence=1&isAllowed=y;
   Google Scholar
• Dadgostar P. Antimicrobial resistance: implications and costs. Infect Drug Resist. 2019;12:3903–3910. doi: 10.2147/IDR.S234610
   PubMed Web of Science ®Google Scholar
• Cassini A, Högberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis. 2019;19(1):56–66. doi: 10.1016/S1473-3099(18)30605-4
   PubMed Web of Science ®Google Scholar
• OECD Health Policy Studies. Stemming the Superbug Tide; 2018. Available from: https://www.oecd-ilibrary.org/sites/9789264307599-en/index.html?itemId=/content/publication/9789264307599-en&mimeType=text/html.
   Google Scholar
• Gautam A. Antimicrobial resistance: the next probable pandemic. JNMA J Nepal Med Assoc. 2022;60(246):225–228. doi: 10.31729/jnma.7174
   PubMed Web of Science ®Google Scholar
• WHO. Global action plan on antimicrobial resistance - Report by the Secretariat; 2016. Available from: https://apps.who.int/gb/ebwha/pdf_files/WHA69/A69_24-en.pdf [
   Google Scholar
• Third global high-level ministerial conference on Antimicrobial Resistance (AMR) in Muscat, Oman. 24-25 Nov 2022. Available from: http://amrconference2022.om/assets/images/Final%20Version%20Muscat%20Manifesto%20AMR%20with%20Annex.pdf
   Google Scholar
• Godman B, Egwuenu A, Wesangula E, et al. Tackling antimicrobial resistance across sub-Saharan Africa: current challenges and implications for the future. Expert Opin Drug Saf. 2022;21(8):1089–1111. doi: 10.1080/14740338.2022.2106368
   PubMed Web of Science ®Google Scholar
• Interagency Coordination Group on Antimicrobial Resistance. No time to wait: securing the future from drug-resistant infections - report to the secretary-general of the United Nations. Apr 2019. Available from: https://www.who.int/antimicrobial-resistance/interagency-coordination-group/IACG_final_report_EN.pdf?ua=1
   Google Scholar
• Matee M Antimicrobial resistance (AMR) at the Southern Africa Centre for Infectious Disease Surveillance; 2018. Available from: https://www.openaccessgovernment.org/southern-africa-centre-for-infectious-disease/52063
   Google Scholar
• Craig J, Frost I, Sriram A, et al. Development of the first edition of African treatment guidelines for common bacterial infections and syndromes. J Public Health Afr. 2022;12(2). doi: 10.4081/jphia.2021.2009
   PubMed Web of Science ®Google Scholar
• Africa Centres for Disease Control and Prevention and Center for Disease Dynamics, Economics & Policy. African antibiotic treatment guidelines for common bacterial infections and syndromes - recommended antibiotic treatments in neonatal and pediatric patients; 2021. Available from: https://africaguidelines.cddep.org/wp-content/uploads/2021/11/Quick-Reference-Guide_Peds_English.pdf
   Google Scholar
• Ghana Ministry of Health, Ministry of Food and Agriculture, Ministry of Environment, Science, Technology and Innovation, Ministry of Fisheries and Aquaculture Development. Ghana National action plan for antimicrobial use and resistance 2017 - 2021. Available from: http://www.moh.gov.gh/wp-content/uploads/2018/04/NAP_FINAL_PDF_A4_19.03.2018-SIGNED-1.pdf
   Google Scholar
• Jimah T, Ogunseitan O. National action plan on antimicrobial resistance: stakeholder analysis of implementation in Ghana. J Glob Health. 2020;4(e2020067):1–16. doi: 10.29392/001c.13695.
   Google Scholar
• Yevutsey SK, Buabeng KO, Aikins M, et al. Situational analysis of antibiotic use and resistance in Ghana: policy and regulation. BMC Public Health. 2017;17(1):896. doi: 10.1186/s12889-017-4910-7
   PubMedGoogle Scholar
• Versporten A, Zarb P, Caniaux I, et al. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey. Lancet Glob Health. 2018;6(6):e619–e29. doi: 10.1016/S2214-109X(18)30186-4
   PubMed Web of Science ®Google Scholar
• Saleem Z, Godman B, Cook A, et al. Ongoing efforts to improve antimicrobial utilization in hospitals among African countries and implications for the future. Antibiotics. 2022;11(12):1824. doi: 10.3390/antibiotics11121824
   Google Scholar
• Skosana PP, Schellack N, Godman B, et al. A point prevalence survey of antimicrobial utilisation patterns and quality indices amongst hospitals in South Africa; findings and implications. Expert Rev Anti Infect Ther. 2021;19(10):1353–1366. doi: 10.1080/14787210.2021.1898946
   PubMed Web of Science ®Google Scholar
• Afriyie DK, Sefah IA, Sneddon J, et al. Antimicrobial point prevalence surveys in two Ghanaian hospitals: opportunities for antimicrobial stewardship. JAC Antimicrob Resist. 2020;2(1):dlaa001. doi: 10.1093/jacamr/dlaa001
   PubMedGoogle Scholar
• Amponsah OKO, Buabeng KO, Owusu-Ofori A, et al. Point prevalence survey of antibiotic consumption across three hospitals in Ghana. JAC Antimicrob Resist. 2021;3(1):dlab008. doi: 10.1093/jacamr/dlab008
   PubMedGoogle Scholar
• Ankrah D, Owusu H, Aggor A, et al. Point prevalence survey of antimicrobial utilization in ghana’s premier hospital: implications for antimicrobial stewardship. Antibiotics (Basel). 2021;10(12):1528. doi: 10.3390/antibiotics10121528
   PubMed Web of Science ®Google Scholar
• Bediako-Bowan AAA, Owusu E, Labi AK, et al. Antibiotic use in surgical units of selected hospitals in Ghana: a multi-centre point prevalence survey. BMC Public Health. 2019;19(1):797. doi: 10.1186/s12889-019-7162-x
   PubMedGoogle Scholar
• Bediako-Bowan AAA, Kurtzhals JAL, Mølbak K, et al. High rates of multi-drug resistant gram-negative organisms associated with surgical site infections in a teaching hospital in Ghana. BMC Infect Dis. 2020;20(1):890. doi: 10.1186/s12879-020-05631-1
   PubMed Web of Science ®Google Scholar
• Dodoo CC, Orman E, Alalbila T, et al. Antimicrobial prescription pattern in ho teaching hospital, Ghana: seasonal determination using a point prevalence survey. Antibiotics (Basel). 2021;10(2):199. doi: 10.3390/antibiotics10020199
   PubMed Web of Science ®Google Scholar
• Sefah IA, Essah DO, Kurdi A, et al. Assessment of adherence to pneumonia guidelines and its determinants in an ambulatory care clinic in Ghana: findings and implications for the future. JAC Antimicrob Resist. 2021;3(2):dlab080. doi: 10.1093/jacamr/dlab080
   PubMedGoogle Scholar
• Sefah IA, Denoo EY, Bangalee V, et al. Appropriateness of surgical antimicrobial prophylaxis in a teaching hospital in Ghana: findings and implications. JAC Antimicrob Resist. 2022;4(5):dlac102. doi: 10.1093/jacamr/dlac102
   PubMedGoogle Scholar
• Sefah IA, Sarkodie SA, Pichierri G, et al. Assessing the clinical characteristics and management of COVID-19 among pediatric patients in Ghana: findings and implications. Antibiotics. 2023;12(2):283. doi: 10.3390/antibiotics12020283
   Google Scholar
• Mwita JC, Ogunleye OO, Olalekan A, et al. Key issues surrounding appropriate antibiotic use for prevention of surgical site infections in low- and middle-income countries: a narrative review and the implications. Int J Gen Med. 2021;14:515–530. doi: 10.2147/IJGM.S253216
   PubMed Web of Science ®Google Scholar
• Bull AL, Worth LJ, Spelman T, et al. Antibiotic prescribing practices for prevention of surgical site infections in Australia: increased uptake of national guidelines after surveillance and reporting and impact on infection rates. Surg Infect (Larchmt). 2017;18(7):834–840. doi: 10.1089/sur.2017.119
   PubMed Web of Science ®Google Scholar
• Hawn MT, Knowlton LM. Balancing the risks and benefits of surgical prophylaxis: timing and duration do matter. JAMA Surg. 2019;154(7):598–599. doi: 10.1001/jamasurg.2019.0570
   PubMed Web of Science ®Google Scholar
• Harbarth S, Samore MH, Lichtenberg D, et al. Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation. 2000;101(25):2916–2921. doi: 10.1161/01.CIR.101.25.2916
   PubMed Web of Science ®Google Scholar
• Sharland M, Zanichelli V, Ombajo LA, et al. The WHO essential medicines list AWaRe book: from a list to a quality improvement system. Clin Microbiol Infect. 2022;28(12):1533–1535. doi: 10.1016/j.cmi.2022.08.009
   PubMed Web of Science ®Google Scholar
• Zanichelli V, Sharland M, Cappello B, et al. The WHO AWaRe (Access, Watch, Reserve) antibiotic book and prevention of antimicrobial resistance. Bull World Health Organ. 2023;101(4):290–296. doi: 10.2471/BLT.22.288614
   Web of Science ®Google Scholar
• Sulis G, Sayood S, Katukoori S, et al. Exposure to World Health Organization’s AWaRe antibiotics and isolation of multidrug resistant bacteria: a systematic review and meta-analysis. Clin Microbiol Infect. 2022;28(9):1193–1202. doi: 10.1016/j.cmi.2022.03.014
   PubMed Web of Science ®Google Scholar
• Sharland M, Gandra S, Huttner B, et al. Encouraging AWaRe-ness and discouraging inappropriate antibiotic use-the new 2019 essential medicines list becomes a global antibiotic stewardship tool. Lancet Infect Dis. 2019;19(12):1278–1280. doi: 10.1016/S1473-3099(19)30532-8
   PubMed Web of Science ®Google Scholar
• Klein EY, Milkowska-Shibata M, Tseng KK, et al. Assessment of WHO antibiotic consumption and access targets in 76 countries, 2000-15: an analysis of pharmaceutical sales data. Lancet Infect Dis. 2021;21(1):107–115. doi: 10.1016/S1473-3099(20)30332-7
   PubMed Web of Science ®Google Scholar
• Acquah SE, Quaye L, Sagoe K, et al. Susceptibility of bacterial etiological agents to commonly-used antimicrobial agents in children with sepsis at the Tamale Teaching Hospital. BMC Infect Dis. 2013;13(1):89. doi: 10.1186/1471-2334-13-89
   PubMedGoogle Scholar
• Saba CKS, Amenyona JK, Kpordze SW. Prevalence and pattern of antibiotic resistance of Staphylococcus aureus isolated from door handles and other points of contact in public hospitals in Ghana. Antimicrob Resist Infect Control. 2017;6(1):44. doi: 10.1186/s13756-017-0203-2
   PubMedGoogle Scholar
• Yenli E, Amedor C, Acquah S, et al. Microbial isolates in augmented water receptacles and their antimicrobial susceptibility pattern at the Tamale Teaching Hospital. J Medical Biomed Sci. 2021;8:18–33.
   Web of Science ®Google Scholar
• Labi AK, Obeng-Nkrumah N, Nartey ET, et al. Antibiotic use in a tertiary healthcare facility in Ghana: a point prevalence survey. Antimicrob Resist Infect Control. 2018;7(1):15. doi: 10.1186/s13756-018-0299-z
   PubMedGoogle Scholar
• Labi AK, Obeng-Nkrumah N, Owusu E, et al. Multi-centre point-prevalence survey of hospital-acquired infections in Ghana. J Hosp Infect. 2019;101(1):60–68. doi: 10.1016/j.jhin.2018.04.019
   PubMed Web of Science ®Google Scholar
• Campbell SM, Meyer JC, Godman B. Why compliance to national prescribing guidelines is important especially across Sub-Saharan Africa and suggestions for the future. Biomed Pharm Sci. 2021;4(316):1–7.
   Google Scholar
• WHO. Anatomical Therapeutic Chemical (ATC) classification; 2021. Available from: https://www.who.int/tools/atc-ddd-toolkit/atc-classification
   Google Scholar
• Sharland M, Pulcini C, Harbarth S, et al. Classifying antibiotics in the WHO essential medicines list for optimal use-be AWaRe. Lancet Infect Dis. 2018;18(1):18–20. doi: 10.1016/S1473-3099(17)30724-7
   PubMed Web of Science ®Google Scholar
• Republic of Ghana Ministry of Health: Ghana National Drugs Programme (GNDP) standard treatment guidelines Seventh Edition. 2017 Available from: https://www.medbox.org/document/republic-of-ghana-ministry-of-health-ghana-national-drugs-programme-gndp-standard-treatment-guidelines-seventh-edition#GO [
   Google Scholar
• Saleem Z, Hassali MA, Versporten A, et al. A multicenter point prevalence survey of antibiotic use in Punjab, Pakistan: findings and implications. Expert Rev Anti Infect Ther. 2019;17(4):285–293. doi: 10.1080/14787210.2019.1581063
   PubMed Web of Science ®Google Scholar
• Skosana PP, Schellack N, Godman B, et al. A national, multicentre, web-based point prevalence survey of antimicrobial use and quality indices among hospitalised paediatric patients across South Africa. J Glob Antimicrob Resist. 2022;29:542–550. doi: 10.1016/j.jgar.2021.12.003
   PubMed Web of Science ®Google Scholar
• Kurdi A, Hasan AJ, Baker KI, et al. A multicentre point prevalence survey of hospital antibiotic prescribing and quality indices in the Kurdistan regional government of Northern Iraq: the need for urgent action. Expert Rev Anti Infect Ther. 2021;19(6):805–814. doi: 10.1080/14787210.2021.1834852
   PubMed Web of Science ®Google Scholar
• Ogunleye OO, Oyawole MR, Odunuga PT, et al. A multicentre point prevalence study of antibiotics utilization in hospitalized patients in an urban secondary and a tertiary healthcare facilities in Nigeria: findings and implications. Exp Rev Anti-Infective Ther. 2022;20(2):297–306. doi: 10.1080/14787210.2021.1941870
   PubMed Web of Science ®Google Scholar
• Nnadozie UU, Umeokonkwo CD, Maduba CC, et al. Antibiotic use among surgical inpatients at a tertiary health facility: a case for a standardized protocol for presumptive antimicrobial therapy in the developing world. Infect Prev Pract. 2020;2(4):100078. doi: 10.1016/j.infpip.2020.100078
   PubMedGoogle Scholar
• Lakoh S, Adekanmbi O, Jiba DF, et al. Antibiotic use among hospitalized adult patients in a setting with limited laboratory infrastructure in Freetown Sierra Leone, 2017-2018. Int J Infect Dis. 2020;90:71–76. doi: 10.1016/j.ijid.2019.10.022
   PubMed Web of Science ®Google Scholar
• Kiggundu R, Wittenauer R, Waswa JP, et al. Point Prevalence Survey of Antibiotic Use across 13 Hospitals in Uganda. Antibiotics (Basel). 2022;11(2):199. doi: 10.3390/antibiotics11020199
   PubMed Web of Science ®Google Scholar
• Omulo S, Oluka M, Ombajo L, et al. Point-Prevalence Surveys of Antibiotic Use at Three Large Public Hospitals in Kenya. Infect Control Hosp Epidemiol. 2020;41(S1):s353–s4. doi: 10.1017/ice.2020.971
   Google Scholar
• Momanyi L, Opanga S, Nyamu D, et al. Antibiotic Prescribing Patterns at a Leading Referral Hospital in Kenya: A Point Prevalence Survey. J Res Pharm Pract. 2019;8(3):149–154. doi: 10.4103/jrpp.JRPP_18_68
   PubMed Web of Science ®Google Scholar
• Aboderin AO, Adeyemo AT, Olayinka AA, et al. Antimicrobial use among hospitalized patients: A multi-center, point prevalence survey across public healthcare facilities, Osun State, Nigeria. Germs. 2021;11(4):523–535. doi: 10.18683/germs.2021.1287
   PubMedGoogle Scholar
• Abubakar U. Point-prevalence survey of hospital acquired infections in three acute care hospitals in Northern Nigeria. Antimicrob Resist Infect Control. 2020;9(1):63. doi: 10.1186/s13756-020-00722-9
   PubMed Web of Science ®Google Scholar
• Okoth C, Opanga S, Okalebo F, et al. Point prevalence survey of antibiotic use and resistance at a referral hospital in Kenya: findings and implications. Hosp Pract. 2018;46(3):128–136. doi: 10.1080/21548331.2018.1464872
   PubMedGoogle Scholar
• Fowotade A, Fasuyi T, Aigbovo O, et al. Point prevalence survey of antimicrobial prescribing in a Nigerian Hospital: findings and implications on antimicrobial resistance. West Afr J Med. 2020;37(3):216–220.
   PubMedGoogle Scholar
• Masich AM, Vega AD, Callahan P, et al. Antimicrobial usage at a large teaching hospital in Lusaka, Zambia. PLoS One. 2020;15(2):e0228555–e. doi: 10.1371/journal.pone.0228555
   PubMed Web of Science ®Google Scholar
• Siachalinga L, Godman B, Mwita JC, et al. Current Antibiotic Use Among Hospitals in the sub-Saharan Africa Region Findings and Implications. Infect Drug Resist. 2023;16:2179–2190. doi: 10.2147/IDR.S398223
   PubMed Web of Science ®Google Scholar
• Siachalinga L, Mufwambi W, Lee IH. Impact of antimicrobial stewardship interventions to improve antibiotic prescribing for hospital inpatients in Africa: a systematic review and meta-analysis. J Hosp Infect. 2022;129:124–143. doi: 10.1016/j.jhin.2022.07.031
   PubMed Web of Science ®Google Scholar
• Otieno PA, Campbell S, Maley S, et al. A Systematic Review of Pharmacist-Led Antimicrobial Stewardship Programs in Sub-Saharan Africa. Int J Clin Pract. 2022;2022:3639943. doi: 10.1155/2022/3639943
   PubMed Web of Science ®Google Scholar
• Akpan MR, Isemin NU, Udoh AE, et al. Implementation of antimicrobial stewardship programmes in African countries: a systematic literature review. J Glob Antimicrob Resist. 2020;22:317–324. doi: 10.1016/j.jgar.2020.03.009
   PubMed Web of Science ®Google Scholar
• Cox JA, Vlieghe E, Mendelson M, et al. Antibiotic stewardship in low- and middle-income countries: the same but different?. Clin Microbiol Infect. 2017;23(11):812–818. doi: 10.1016/j.cmi.2017.07.010
   PubMed Web of Science ®Google Scholar
• WHO. The WHO AWaRe (Access, Watch, Reserve) antibiotic book; 2022 Available from: https://www.who.int/publications/i/item/9789240062382
   Google Scholar
• Allegranzi B, Aiken AM, Zeynep Kubilay N, et al. A multimodal infection control and patient safety intervention to reduce surgical site infections in Africa: a multicentre, before-after, cohort study. Lancet Infect Dis. 2018;18(5):507–515. doi: 10.1016/S1473-3099(18)30107-5
   PubMed Web of Science ®Google Scholar
• Aiken AM, Wanyoro AK, Mwangi J, et al. Changing use of surgical antibiotic prophylaxis in Thika Hospital, Kenya: a quality improvement intervention with an interrupted time series design. PLoS One. 2013;8(11):e78942. doi: 10.1371/journal.pone.0078942
   PubMed Web of Science ®Google Scholar
• Abubakar U, Syed Sulaiman SA, Adesiyun AG, et al. Impact of pharmacist-led antibiotic stewardship interventions on compliance with surgical antibiotic prophylaxis in obstetric and gynecologic surgeries in Nigeria. PLoS One. 2019;14(3):e0213395. doi: 10.1371/journal.pone.0213395
   PubMed Web of Science ®Google Scholar
• Brink AJ, Messina AP, Feldman C, et al. From guidelines to practice: a pharmacist-driven prospective audit and feedback improvement model for peri-operative antibiotic prophylaxis in 34 South African hospitals. J Antimicrob Chemother. 2017;72(4):1227–1234. doi: 10.1093/jac/dkw523
   PubMed Web of Science ®Google Scholar
• Dakorah MP, Agyare E, Acolatse JEE, et al. Utilising cumulative antibiogram data to enhance antibiotic stewardship capacity in the Cape Coast Teaching Hospital, Ghana. Antimicrob Resist Infect Control. 2022;11(1):122. doi: 10.1186/s13756-022-01160-5
   PubMed Web of Science ®Google Scholar
• Acolatse JEE, Portal EAR, Boostrom I, et al. Environmental surveillance of ESBL and carbapenemase-producing gram-negative bacteria in a Ghanaian Tertiary Hospital. Antimicrob Resist Infect Control. 2022;11(1):49. doi: 10.1186/s13756-022-01090-2
   PubMed Web of Science ®Google Scholar
• Haldeman MS, Kishimbo P, Seddon M, et al. Evaluation of Antimicrobial Utilization and Concordance with National Guidelines at a Tertiary Hospital in the Southern Highlands Zone of Tanzania. Am J Trop Med Hyg. 2020;102(2):370–376. doi: 10.4269/ajtmh.19-0231
   PubMed Web of Science ®Google Scholar
• Maina M, Mwaniki P, Odira E, et al. Antibiotic use in Kenyan public hospitals: Prevalence, appropriateness and link to guideline availability. Int J Infect Dis. 2020;99:10–18. doi: 10.1016/j.ijid.2020.07.084
   PubMed Web of Science ®Google Scholar
• Seni J, Mapunjo SG, Wittenauer R, et al. Antimicrobial use across six referral hospitals in Tanzania: a point prevalence survey. BMJ Open. 2020;10(12):e042819. doi: 10.1136/bmjopen-2020-042819
   PubMed Web of Science ®Google Scholar