Gulf War Illness: Is there lasting damage to the endocrine-immune circuitry?

References

• Unwin C, Blatchley N, Coker W, Ferry S, Hotopf M, Hull L et al. Health of UK servicemen who served in Persian Gulf War. Lancet 1999; 353:169–78; PMID:9923871; http://dx.doi.org/10.1016/S0140-6736(98)11338-7
   PubMed Web of Science ®Google Scholar
• Bourdette DN, McCauley LA, Barkhuizen A, Johnston W, Wynn M, Joos SK, Storzbach D, Shuell T, Sticker D. Symptom factor analysis, clinical findings, and functional status in a population-based case control study of Gulf War unexplained illness. J Occup Environ Med 2001; 43(12):1026–40; PMID:11765674; http://dx.doi.org/10.1097/00043764-200112000-00005
   PubMed Web of Science ®Google Scholar
• Kang HK, Natelson BH, Mahan CM, Lee KY, Murphy FM. Post-Traumatic Stress Disorder and Chronic Fatigue Syndrome-like Illness among Gulf War Veterans: A Population-based Survey of 30,000 Veterans. Am J Epidemiol 2003; 157:141–48; PMID:12522021; http://dx.doi.org/10.1093/aje/kwf187
   PubMed Web of Science ®Google Scholar
• Broderick G, Kreitz A, Fuite J, Fletcher MA, Vernon SD, Klimas N. A pilot study of immune network remodeling under challenge in Gulf War Illness. Brain Behav Immun 2011 Feb; 25(2):302–13; http://dx.doi.org/10.1016/j.bbi.2010.10.011
   PubMed Web of Science ®Google Scholar
• Broderick G, Fletcher MA, Gallagher M, Barnes Z, Vernon SD, Klimas NG. Exploring the diagnostic potential of immune biomarker coexpression in Gulf War Illness. Methods Mol Biol 2012; 934:145–64; PMID:22933145; http://dx.doi.org/10.1007/978-1-62703-071-7_8
   PubMedGoogle Scholar
• Broderick G, Ben-Hamo R, Vashishtha S, Efroni S, Nathanson L, Barnes Z, Fletcher MA, Klimas N. Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis. Brain Behav Immun 2013 Feb; 28:159–69; http://dx.doi.org/10.1016/j.bbi.2012.11.007
   PubMed Web of Science ®Google Scholar
• Smylie AL, Broderick G, Fernandes H, Razdan S, Barnes Z, Collado F, Sol C, Fletcher MA, Klimas N. A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome. BMC Immunol 2013 Jun 25; 14:29; http://dx.doi.org/10.1186/1471-2172-14-29
   PubMed Web of Science ®Google Scholar
• Golier JA, Schmeidler J, Legge J, Yehuda R. Twenty-four Hour Plasma Cortisol and Adrenocorticotropic Hormone in Gulf War Veterans: Relationships to Posttraumatic Stress Disorder and Health Symptoms. Biol Psychiatry 2007; 62(10):1175–78; PMID:17612507; http://dx.doi.org/10.1016/j.biopsych.2007.04.027
   PubMed Web of Science ®Google Scholar
• Mendoza L, Xenarios I. A method for the generation of standardized qualitative dynamical systems of regulatory networks. Theor Biol Med Model 2006 Mar 16; 3:13; http://dx.doi.org/10.1186/1742-4682-3-13
   PubMed Web of Science ®Google Scholar
• Craddock TJ, Fritsch P, Rice MA Jr, del Rosario RM, Miller DB, Fletcher MA, Klimas NG, Broderick G. A role for homeostatic drive in the perpetuation of complex chronic illness: Gulf War Illness and chronic fatigue syndrome. PLoS One 2014 Jan 8; 9(1):e84839; http://dx.doi.org/10.1371/journal.pone.0084839
   PubMed Web of Science ®Google Scholar
• Fritsch P, Craddock TJ, del Rosario RM, Rice MA, Smylie A, Folcik VA, de Vries G, Fletcher MA, Klimas NG, Broderick G. Succumbing to the laws of attraction: Exploring the sometimes pathogenic versatility of discrete immune logic. Systems Biomedicine 2013; 1:179–94; http://dx.doi.org/10.4161/sysb.28948; http://dx.doi.org/10.4161/sysb.28948
   Google Scholar
• Brown M. A method for combining non-independent, one-sided tests of significance. Biometrics 1975; 31:987–92; http://dx.doi.org/10.2307/2529826
   Web of Science ®Google Scholar
• Thomas R. Regulatory Networks Seen as Asynchronous Automata: A Logical Description. J Theor Biol 1991; 153:1–23; http://dx.doi.org/10.1016/S0022-5193(05)80350-9
   Web of Science ®Google Scholar
• Fukuda K, Nisenbaum R, Stewart G, Thompson WW, Robin L, Washko RM, Noah DL, Barrett DH, Randall B, Herwaldt BL, Mawle AC, Reeves WC: Chronic multisymptom illness affecting Air Force veterans of the Gulf War. JAMA 1998; 280:981–98
   PubMed Web of Science ®Google Scholar
• Reeves WC, Lloyd A, Vernon SD, Klimas N, Jason LA, Bleijenberg G, Evengard B, White PD, Nisenbaum R, Unger ER, International Chronic Fatigue Syndrome Study Group: Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res 2003; 3(1):25; PMID:14702202; http://dx.doi.org/10.1186/1472-6963-3-25
   PubMed Web of Science ®Google Scholar
• Collins JF, Donta ST, Engel CC, Baseman JB, Dever LL, Taylor T, Boardman KD, Martin SE, Wiseman AL: Feussner JR. The antibiotic treatment trial of Gulf War Veterans' Illnesses: issues, design, screening, and baseline characteristics. Control Clin Trials 2002; 23(3):333–53; http://dx.doi.org/10.1016/S0197-2456(02)00192-7
   PubMedGoogle Scholar
• Liberman AC, Druker J, Refojo D, Holsboer F, Arzt E. Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells. FASEB J 2009; 23:1558–71; PMID:19124555; http://dx.doi.org/10.1096/fj.08-121236
   PubMed Web of Science ®Google Scholar
• Rider CF, Shah S, Miller-Larsson A, Giembycz MA, Newton R. Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting β(2)-adrenoceptor ; corrected agonist and glucocorticoid receptor ligands. PLoS One 2015; 10(1):e0116773; PMID:25625944; http://dx.doi.org/10.1371/journal.pone.0116773
   PubMedGoogle Scholar
• Craddock TJ, Harvey JM, Nathanson L, Barnes ZM, Klimas NG, Fletcher MA, Broderick G. Using gene expression signatures to identify novel treatment strategies in gulf war illness. BMC Med Genomics 2015 8:36; PMID:26156520; http://dx.doi.org/10.1186/s12920-015-0111-3
   PubMed Web of Science ®Google Scholar
• van der Knaap LJ, Riese H, Hudziak JJ, Verbiest MM, Verhulst FC, Oldehinkel AJ, van Oort FV. Glucocorticoid receptor gene (NR3C1) methylation following stressful events between birth and adolescence. The TRAILS study. Transl Psychiatry 2014 Apr 8; 4:e381; http://dx.doi.org/10.1038/tp.2014.22
   PubMedGoogle Scholar
• Yehuda R, Flory JD, Bierer LM, Henn-Haase C, Lehrner A, Desarnaud F, Makotkine I, Daskalakis NP, Marmar CR, Meaney MJ. Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder. Biol Psychiatry 2015; 77(4):356–64; PMID:24661442; http://dx.doi.org/10.1016/j.biopsych.2014.02.006
   PubMed Web of Science ®Google Scholar
• Elser B, Lohoff M, Kock S, Giaisi M, Kirchhoff S, Krammer PH, Li-Weber M. IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Immunity 2002 Dec; 17(6):703–12; http://dx.doi.org/10.1016/S1074-7613(02)00471-5
   PubMed Web of Science ®Google Scholar
• Bernabei P, Bosticardo M, Losana G, Regis G, Di Paola F, De Angelis S, Giovarelli M, Novelli F. IGF-1 down-regulates IFN-gamma R2 chain surface expression and desensitizes IFN-gamma/STAT-1 signaling in human T lymphocytes. Blood 2003; 102(8):2933–9; PMID:12842994; http://dx.doi.org/10.1182/blood-2003-01-0100
   PubMed Web of Science ®Google Scholar
• Wynes MW, Riches DW. Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13. J Immunol 2003; 171(7):3550–9; PMID:14500651; http://dx.doi.org/10.4049/jimmunol.171.7.3550
   PubMed Web of Science ®Google Scholar
• Frey RS1, Gao X, Javaid K, Siddiqui SS, Rahman A, Malik AB. Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells. J Biol Chem 2006; 281(23):16128–38; PMID:16527821; http://dx.doi.org/10.1074/jbc.M508810200
   PubMed Web of Science ®Google Scholar
• Kar S, Seto D, Doré S, Hanisch U, Quirion R. Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation. Proc Natl Acad Sci USA 1997; 94(25):14054–9; PMID:9391151; http://dx.doi.org/10.1073/pnas.94.25.14054
   PubMed Web of Science ®Google Scholar
• Seto D, Zheng WH, McNicoll A, Collier B, Quirion R, Kar S. Insulin-like growth factor-I inhibits endogenous acetylcholine release from the rat hippocampal formation: possible involvement of GABA in mediating the effects. Neuroscience 2002; 115(2):603–12; PMID:12421625; http://dx.doi.org/10.1016/S0306-4522(02)00450-5
   PubMed Web of Science ®Google Scholar
• Barbier L., Diserbo M., Lamproglou I., Amourette C., Peinnequin A., Fauquette W. Repeated stress in combination with pyridostigmine Part II: changes in cerebral gene expression. Behav Brain Res 2009; 197(2):292–300; PMID:18796314; http://dx.doi.org/10.1016/j.bbr.2008.08.032
   PubMed Web of Science ®Google Scholar
• Hintze A, Adami C. Evolution of complex modular biological networks. PLoS Comput Biol 2008; 4(2):e23; PMID:18266463; http://dx.doi.org/10.1371/journal.pcbi.0040023
   PubMedGoogle Scholar