The identification of metabolites from gut microbiota in coronary heart disease via network pharmacology

References

• Dalen JE, Alpert JS, Goldberg RJ, et al. The epidemic of the 20th century: coronary heart disease. Am J Med. 2014;127(9):807–812. doi: 10.1016/j.amjmed.2014.04.015.
   PubMed Web of Science ®Google Scholar
• Berry C, Corcoran D, Hennigan B, et al. Fractional flow reserve-guided management in stable coronary disease and acute myocardial infarction: recent developments. Eur Heart J. 2015;36(45):3155–3164. doi: 10.1093/eurheartj/ehv206.
   PubMed Web of Science ®Google Scholar
• Akhabue E, Thiboutot J, Cheng JW, et al. New and emerging risk factors for coronary heart disease. Am J Med Sci. 2014;347(2):151–158. doi: 10.1097/MAJ.0b013e31828aab45.
   PubMed Web of Science ®Google Scholar
• Li C, Zhang WY, Yu Y, et al. Discovery of the mechanisms and major bioactive compounds responsible for the protective effects of Gualou Xiebai Decoction on coronary heart disease by Network Pharmacology Analysis. Phytomedicine. 2019;56:261–268. doi: 10.1016/j.phymed.2018.11.010.
   PubMed Web of Science ®Google Scholar
• Temraz S, Nassar F, Nasr R, et al. Gut microbiome: a promising biomarker for immunotherapy in colorectal cancer. Int J Mol Sci. 2019;20(17):4155. doi: 10.3390/ijms20174155.
   PubMed Web of Science ®Google Scholar
• Kolátorová L, Lapčík O, Stárka L. Phytoestrogens and the intestinal microbiome. Physiol Res. 2018;67(Suppl. 3):S401–S408. doi: 10.33549/physiolres.934022.
   PubMedGoogle Scholar
• Jandhyala SM, Talukdar R, Subramanyam C, et al. Role of the normal gut microbiota. World J Gastroenterol. 2015;21(29):8787–8803. doi: 10.3748/wjg.v21.i29.8787.
   PubMed Web of Science ®Google Scholar
• Emoto T, Yamashita T, Kobayashi T, et al. Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease. Heart Vessels. 2017;32(1):39–46. doi: 10.1007/s00380-016-0841-y.
   PubMed Web of Science ®Google Scholar
• Adak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci. 2019;76(3):473–493. doi: 10.1007/s00018-018-2943-4.
   PubMed Web of Science ®Google Scholar
• Poli A. What connection is there between intestinal microbiota and heart disease? Eur Heart J Suppl. 2020;22(Suppl. L):L117–L120. doi: 10.1093/eurheartj/suaa149.
   PubMed Web of Science ®Google Scholar
• Wang YL, Cheng YL, Shang LH. Research advance in gut microbiota in the pathogenesis of coronary artery disease. Chin Res Hosp. 2022;10(1):59–62.
   Google Scholar
• Groen RN, de Clercq NC, Nieuwdorp M, et al. Gut microbiota, metabolism and psychopathology: a critical review and novel perspectives. Crit Rev Clin Lab Sci. 2018;55(4):283–293. doi: 10.1080/10408363.2018.1463507.
   PubMed Web of Science ®Google Scholar
• Li W, Shu S, Cheng L, et al. Fasting serum total bile acid level is associated with coronary artery disease, myocardial infarction and severity of coronary lesions. Atherosclerosis. 2020;292:193–200. doi: 10.1016/j.atherosclerosis.2019.11.026.
   PubMed Web of Science ®Google Scholar
• Liu H, Tian R, Wang H, et al. Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation. J Transl Med. 2020;18(1):382. doi: 10.1186/s12967-020-02539-x.
   PubMed Web of Science ®Google Scholar
• Marques FZ, Mackay CR, Kaye DM. Beyond gut feelings: how the gut microbiota regulates blood pressure. Nat Rev Cardiol. 2018;15(1):20–32. doi: 10.1038/nrcardio.2017.120.
   PubMed Web of Science ®Google Scholar
• Yuan X, Wang L, Bhat OM, et al. Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: antioxidant action of butyrate. Redox Biol. 2018;16:21–31. doi: 10.1016/j.redox.2018.02.007.
   PubMed Web of Science ®Google Scholar
• Quarta S, Santarpino G, Carluccio MA, et al. Exploring the significance of epicardial adipose tissue in aortic valve stenosis and left ventricular remodeling: unveiling novel therapeutic and prognostic markers of disease. Vascul Pharmacol. 2023;152:107210. doi: 10.1016/j.vph.2023.107210.
   PubMed Web of Science ®Google Scholar
• Carbone AM, Del Calvo G, Nagliya D, et al. Autonomic nervous system regulation of epicardial adipose tissue: potential roles for regulator of G protein signaling-4. Curr Issues Mol Biol. 2022;44(12):6093–6103. doi: 10.3390/cimb44120415.
   PubMed Web of Science ®Google Scholar
• Zhang H, Jing L, Zhai C, et al. The intestinal flora metabolite trimethylamine oxide is inextricably linked to coronary heart disease. J Cardiovasc Pharm. 2023;81(3):175–182. doi: 10.1097/FJC.0000000000001387.
   PubMed Web of Science ®Google Scholar
• Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008;4(11):682–690. doi: 10.1038/nchembio.118.
   PubMed Web of Science ®Google Scholar
• Oh KK, Gupta H, Min BH, et al. The identification of metabolites from gut microbiota in NAFLD via network pharmacology. Sci Rep. 2023;13(1):724. doi: 10.1038/s41598-023-27885-w.
   PubMed Web of Science ®Google Scholar
• Keiser MJ, Roth BL, Armbruster BN, et al. Relating protein pharmacology by ligand chemistry. Nat Biotechnol. 2007;25(2):197–206.
   PubMed Web of Science ®Google Scholar
• Gfeller D, Michielin O, Zoete V. Shaping the interaction landscape of bioactive molecules. Bioinformatics. 2013;29(23):3073–3079.
   PubMed Web of Science ®Google Scholar
• Daina A, Zoete V. A boiled-egg to predict gastrointestinal absorption and brain penetration of small molecules. Chem Med Chem. 2016;11(11):1117–1121. doi: 10.1002/cmdc.201600182.
   Google Scholar
• Dong J, Wang NN, Yao ZJ, et al. ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database. J Cheminform. 2018;10(1):1–11. doi: 10.1186/s13321-018-0283-x.
   PubMedGoogle Scholar
• Fei M, Xiang L, Chai X, et al. Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease. Front Med. 2020;14(1):81–90. doi: 10.1007/s11684-019-0692-x.
   PubMed Web of Science ®Google Scholar
• Shiraki R, Inoue N, Kobayashi S, et al. Toll-like receptor 4 expressions on peripheral blood monocytes were enhanced in coronary artery disease even in patients with low C-reactive protein. Life Sci. 2006;80(1):59–66. doi: 10.1016/j.lfs.2006.08.027.
   PubMed Web of Science ®Google Scholar
• Meng H, Zhang Y, An ST, et al. Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K/Akt signaling pathway in rats with acute myocardial infarction. J Cell Physiol. 2019;234(7):10535–10546. doi: 10.1002/jcp.27717.
   PubMed Web of Science ®Google Scholar
• Ascher S, Reinhardt C. The gut microbiota: an emerging risk factor for cardiovascular and cerebrovascular disease. Eur J Immunol. 2018;48(4):564–575. doi: 10.1002/eji.201646879.
   PubMed Web of Science ®Google Scholar
• Cui L, Zhao T, Hu H, et al. Association study of gut flora in coronary heart disease through high-throughput sequencing. BioMed Res Int. 2017;2017:1–10. doi: 10.1155/2017/3796359.
   Web of Science ®Google Scholar
• Peng Y, Zhang N, Li WJ, et al. Correlations of changes in inflammatory factors, glucose and lipid metabolism indicators and adiponectin with alterations in intestinal flora in rats with coronary heart disease. Eur Rev Med Pharmacol Sci. 2020;24(19):10118–10125.
   PubMed Web of Science ®Google Scholar
• Oliveira RTD, Mamoni RL, Souza JRM, et al. Differential expression of cytokines, chemokines and chemokine receptors in patients with coronary artery disease. Int J Cardiol. 2009;136(1):17–26. doi: 10.1016/j.ijcard.2008.04.009.
   PubMed Web of Science ®Google Scholar
• Xie X, Ma YT, Yang YN, et al. Interaction between COX-2 G-765C and smoking in relation to coronary artery disease in a Chinese Uighur population. Clin Chem Lab Med. 2011;49(1):55–60. doi: 10.1515/CCLM.2011.024.
   PubMed Web of Science ®Google Scholar
• Schiekofer S, Belisle K, Galasso G, et al. Angiogenic-regulatory network revealed by molecular profiling heart tissue following Akt1 induction in endothelial cells. Angiogenesis. 2008;11(3):289–299. doi: 10.1007/s10456-008-9112-6.
   PubMed Web of Science ®Google Scholar
• Li TH, Liu L, Hou YY, et al. C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut. Gastroenterol Rep. 2019;7(5):312–321. doi: 10.1093/gastro/goz028.
   Google Scholar
• Ma X, Yin H, Chen K. Differential gene expression profiles in coronary heart disease patients of blood stasis syndrome in traditional Chinese medicine and clinical role of target gene. Chin J Integr Med. 2009;15(2):101–106. doi: 10.1007/s11655-009-0101-4.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhou H, Hua L, et al. Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis. Free Radic Biol Med. 2021;171:55–68. doi: 10.1016/j.freeradbiomed.2021.05.009.
   PubMed Web of Science ®Google Scholar
• Frantz S, Kelly RA, Bourcier T. Role of TLR-2 in the activation of nuclear factor κB by oxidative stress in cardiac myocytes. J Biol Chem. 2001;276(7):5197–5203. doi: 10.1074/jbc.M009160200.
   PubMed Web of Science ®Google Scholar
• Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2(8):675–680. doi: 10.1038/90609.
   PubMed Web of Science ®Google Scholar
• Satoh M, Tabuchi T, Minami Y, et al. Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: effect of statins on let-7i and toll-like receptor 4 signal. Immunobiology. 2012;217(5):533–539. doi: 10.1016/j.imbio.2011.08.005.
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhu R, Zhang L. Triclosan stimulates human vascular endothelial cell injury via repression of the PI3K/Akt/mTOR axis. Chemosphere. 2020;241:125077. doi: 10.1016/j.chemosphere.2019.125077.
   PubMed Web of Science ®Google Scholar
• Wang M, Yang D, Hu Z, et al. Extracorporeal cardiac shock waves therapy improves the function of endothelial progenitor cells after hypoxia injury via activating PI3K/Akt/eNOS signal pathway. Front Cardiovasc Med. 2021;8:747497. doi: 10.3389/fcvm.2021.747497.
   PubMed Web of Science ®Google Scholar
• Wang S, Cheng Z, Chen X. Promotion of PTEN on apoptosis through PI3K/Akt signal in vascular smooth muscle cells of mice model of coronary heart disease. J Cell Biochem. 2019;120(9):14636–14644. doi: 10.1002/jcb.28725.
   PubMed Web of Science ®Google Scholar
• Choroszy M, Litwinowicz K, Bednarz R, et al. Human gut microbiota in coronary artery disease: a systematic review and meta-analysis. Metabolites. 2022;12(12):1165. doi: 10.3390/metabo12121165.
   PubMed Web of Science ®Google Scholar
• Yu H, Li L, Deng Y, et al. The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients. Front Cell Infect Microbiol. 2022;12:903828.
   PubMed Web of Science ®Google Scholar
• Nakajima A, Mitomo S, Yuki H, et al. Gut microbiota and coronary plaque characteristics. J Am Heart Assoc. 2022;11(17):e026036.
   PubMed Web of Science ®Google Scholar
• Wang CY, Wang M, Jiang H. The correlation between phenylacetylglutamine and atrial fibrillation. Chin J Cardiovasc Res. 2022;20(10):876–880.
   Google Scholar
• Nemet I, Saha PP, Gupta N, et al. A cardiovascular disease-linked gut microbial metabolite acts via adrenergic receptors. Cell. 2020;180(5):862–877.e22. doi: 10.1016/j.cell.2020.02.016.
   PubMed Web of Science ®Google Scholar
• Oktar BK, Gülpınar MA, Ercan F, et al. Beneficial effects of glycocholic acid (GCA) on gut mucosal damage in bile duct ligated rats. Inflammation. 2001;25(5):311–318. doi: 10.1023/A:1012812616083.
   PubMed Web of Science ®Google Scholar