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Emerging Microbes & Infections Volume 10, 2021 - Issue 1
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Coronaviruses

Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers

Javier Martínez-Sanza Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2020-3908View further author information
ORCID Icon,
Daniel Jiméneza Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5399-4473View further author information
ORCID Icon,
Laura Martínez-Campelob CIBERER-Genomic Medicine Group, University of Santiago de Compostela, Santiago de Compostela, SpainView further author information
,
Raquel Cruzb CIBERER-Genomic Medicine Group, University of Santiago de Compostela, Santiago de Compostela, SpainView further author information
,
Pilar Vizcarraa Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, SpainORCID Iconhttps://orcid.org/0000-0001-8553-6995View further author information
ORCID Icon,
Matilde Sánchez-Condea Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, SpainView further author information
,
Raquel Rona Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, SpainView further author information
,
Mario Rodríguezc Department of Microbiology, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERESP, Madrid, SpainView further author information
,
Sabina Herreraa Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, SpainView further author information
,
Santiago Morenoa Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, SpainView further author information
,
María Rosa López-Huertasd Immunopathology Unit, National Center of Microbiology, Institute of Health Carlos III, Madrid, SpainView further author information
&
Sergio Serrano-Villara Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, SpainCorrespondence[email protected]
View further author information
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Pages 493-496 | Received 26 Jan 2021, Accepted 09 Mar 2021, Published online: 19 Mar 2021

References

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  • Interim Operational Considerations for Public Health Management of Healthcare Workers Exposed to or with Suspected or Confirmed COVID-19: Non-U.S. Healthcare Settings. 2020. https://www.cdc.gov/coronavirus/2019-ncov/hcp/non-us-settings/public-health-management-hcw-exposed.html.
  • Jordan RE, Adab P, Cheng KK. Covid-19: risk factors for severe disease and death. Br Med J. 2020;368:m1198.
  • Cao Y, Li L, Feng Z, et al. Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations. Cell Discov. 2020;6:11.
  • Fadason T, Gokuladhas S, Golovina E, et al. A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors. bioRxiv 2020; 2020.04.14.042002.
  • Amos W, Driscoll E, Hoffman JI. Candidate genes versus genome-wide associations: which are better for detecting genetic susceptibility to infectious disease? Proc Biol Sci. 2011;278(1709):1183–1188.
  • Perneger TV. What’s wrong with Bonferroni adjustments. Br Med J. 1998;316:1236–1238.

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