Emerging Microbes & Infections, Volume 10, Issue 1 (2021)

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Emerging Microbes & Infections, Volume 10, Issue 1 (2021)

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Coronaviruses

Article
Susceptibility of rabbits to SARS-CoV-2
Anna Z. Mykytyn, Mart M. Lamers, Nisreen M. A. Okba, Tim I. Breugem, Debby Schipper, Petra B. van den Doel, Peter van Run, Geert van Amerongen, Leon de Waal, Marion P. G. Koopmans, Koert J. Stittelaar, Judith M. A. van den Brand & Bart L. Haagmans
Pages: 1-7
Published online: 17 Jan 2021
AbstractforSusceptibility of rabbits to SARS-CoV-2 | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Open Access

Research Article

Article
Blood transcriptomics to characterize key biological pathways and identify biomarkers for predicting mortality in melioidosis
Thatcha Yimthin, Jacqueline Margaret Cliff, Rungnapa Phunpang, Peeraya Ekchariyawat, Taniya Kaewarpai, Ji-Sook Lee, Clare Eckold, Megan Andrada, Ekkachai Thiansukhon, Kittisak Tanwisaid, Somchai Chuananont, Chumpol Morakot, Narongchai Sangsa, Wirayut Silakun, Sunee Chayangsu, Noppol Buasi, Nicholas Day, Ganjana Lertmemongkolchai, Wasun Chantratita, T. Eoin West & Narisara Chantratita
Pages: 8-18
Published online: 17 Jan 2021
AbstractforBlood transcriptomics to characterize key biological pathways and identify biomarkers for predicting mortality in melioidosis | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 3660 Views
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Open Access

Tuberculosis

Article
Mycobacterium tuberculosis ESX-1-secreted substrate protein EspC promotes mycobacterial survival through endoplasmic reticulum stress-mediated apoptosis
Qinglong Guo, Jing Bi, Honghai Wang & Xuelian Zhang
Pages: 19-36
Published online: 17 Jan 2021
AbstractforMycobacterium tuberculosis ESX-1-secreted substrate protein EspC promotes mycobacterial survival through endoplasmic reticulum stress-mediated apoptosis | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 4578 Views
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Open Access

Hepatitis

Article
Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection
Shao-Juan Wang, Zi-Min Chen, Min Wei, Jia-Qi Liu, Zong-Lin Li, Tian-Shu Shi, Sheng Nian, Rao Fu, Yang-Tao Wu, Ya-Li Zhang, Ying-Bin Wang, Tian-Ying Zhang, Jun Zhang, Jun-Hui Xiong, Shu-Ping Tong, Sheng-Xiang Ge, Quan Yuan & Ning-Shao Xia
Pages: 37-50
Published online: 17 Jan 2021
AbstractforSpecific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection | Full Text | References | PDF (3.5 MB) | EPUB
  • 3812 Views
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Open Access

Coronaviruses

Article
SARS-CoV-2 genomic characterization and clinical manifestation of the COVID-19 outbreak in Uruguay
Victoria Elizondo, Gordon W. Harkins, Batsirai Mabvakure, Sabine Smidt, Paul Zappile, Christian Marier, Matthew T. Maurano, Victoria Perez, Natalia Mazza, Carolina Beloso, Silvana Ifran, Mariana Fernandez, Andrea Santini, Veronica Perez, Veronica Estevez, Matilde Nin, Gonzalo Manrique, Leticia Perez, Fabiana Ross, Susana Boschi, Maria Noel Zubillaga, Raquel Balleste, Simon Dellicour, Adriana Heguy & Ralf Duerr
Pages: 51-65
Published online: 15 Jan 2021
AbstractforSARS-CoV-2 genomic characterization and clinical manifestation of the COVID-19 outbreak in Uruguay | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 9740 Views
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Open Access
Article
Structure of the multiple functional domains from coronavirus nonstructural protein 3
Mengxia Li, Gang Ye, Yu Si, Zhou Shen, Zhu Liu, Yuejun Shi, Shaobo Xiao, Zhen F. Fu & Guiqing Peng
Pages: 66-80
Published online: 17 Jan 2021
AbstractforStructure of the multiple functional domains from coronavirus nonstructural protein 3 | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 5957 Views
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Open Access

Research Article

Article
Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing
Chi-Ching Tsang, Ka-Fai Chan, Walton Chan, Jasper F. W. Chan, Rex K. H. Au-Yeung, Antonio H. Y. Ngan, Ken P. K. Lin, Susanna K. P. Lau & Patrick C. Y. Woo
Pages: 81-96
Published online: 17 Jan 2021
AbstractforHepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 3069 Views
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Open Access
Article
Comparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses
Nancy Beerens, Evelien A. Germeraad, Sandra Venema, Eline Verheij, Sylvia B.E. Pritz-Verschuren & Jose L. Gonzales
Pages: 97-108
Published online: 17 Jan 2021
AbstractforComparative pathogenicity and environmental transmission of recent highly pathogenic avian influenza H5 viruses | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 4219 Views
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Open Access
Article
Increasing prevalence of hypervirulent ST5 methicillin susceptible Staphylococcus aureus subtype poses a serious clinical threat
Ying Jian, Lin Zhao, Na Zhao, Hui-Ying Lv, Yao Liu, Lei He, Qian Liu & Min Li
Pages: 109-122
Published online: 17 Jan 2021
AbstractforIncreasing prevalence of hypervirulent ST5 methicillin susceptible Staphylococcus aureus subtype poses a serious clinical threat | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 3616 Views
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Open Access
Article
A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection
Mo Li, Yongkun Chen, Tao Chen, Shixiong Hu, Luan Chen, Lu Shen, Fangcai Li, Jing Yang, Yan Sun, Dayan Wang, Lin He, Shengying Qin & Yuelong Shu
Pages: 123-131
Published online: 17 Jan 2021
AbstractforA host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 3144 Views
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Open Access
Article
ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit
Anaïs Lamy, Ewerton Macarini-Bruzaferro, Thibaud Dieudonné, Alex Perálvarez-Marín, Guillaume Lenoir, Cédric Montigny, Marc le Maire & José Luis Vázquez-Ibar
Pages: 132-147
Published online: 17 Jan 2021
AbstractforATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 3650 Views
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Open Access

Influenza Infections

Letter
Emergence and spread of novel H5N8, H5N5 and H5N1 clade 2.3.4.4 highly pathogenic avian influenza in 2020
Nicola S. Lewis, Ashley C. Banyard, Elliot Whittard, Talgat Karibayev, Thamer Al Kafagi, Ilya Chvala, Alex Byrne, Saduakassova Meruyert (Akberovna)Jacqueline King, Timm Harder, Christian Grund, Steve Essen, Scott M. Reid, Adam Brouwer, Nikolay G. Zinyakov, Azimkhan Tegzhanov, Victor Irza, Anne Pohlmann, Martin Beer, Ron A. M. Fouchier, Sultanov Akhmetzhan (Akievich)Ian H. Brown
Pages: 148-151
Published online: 17 Jan 2021
AbstractforEmergence and spread of novel H5N8, H5N5 and H5N1 clade 2.3.4.4 highly pathogenic avian influenza in 2020 | Full Text | References | PDF (995.4 KB) | EPUB
  • 10954 Views
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Open Access

Coronaviruses

Article
Critical role of neutralizing antibody for SARS-CoV-2 reinfection and transmission
Young-Il Kim, Se-Mi Kim, Su-Jin Park, Eun-Ha Kim, Kwang-Min Yu, Jae-Hyung Chang, Eun Ji Kim, Mark Anthony B. Casel, Rare Rollon, Seung-Gyu Jang, Jihye Um, Min-Suk Song, Hye Won Jeong, Eung-Gook Kim, Yeonjae Kim, So Yeon Kim, Jun-Sun Park, Mi Sun Park, Geun-Yong Kwon, Sang Gu Yeo, Shin-Ae Lee, Youn Jung Choi, Jae U. Jung & Young Ki Choi
Pages: 152-160
Published online: 19 Jan 2021
AbstractforCritical role of neutralizing antibody for SARS-CoV-2 reinfection and transmission | Full Text | References | PDF (2.4 MB) | EPUB
  • 8247 Views
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Open Access
Article
Novel dual multiplex real-time RT-PCR assays for the rapid detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus using the BD MAX open system
Hsing-Yi Chung, Ming-Jr Jian, Chih-Kai Chang, Jung-Chung Lin, Kuo-Ming Yeh, Chien-Wen Chen, Sheng-Kang Chiu, Yi-Hui Wang, Shu-Jung Liao, Shih-Yi Li, Shan-Shan Hsieh, Shih-Hung Tsai, Cherng-Lih Perng, Ji-Rong Yang, Ming-Tsan Liu, Feng-Yee Chang & Hung-Sheng Shang
Pages: 161-166
Published online: 19 Jan 2021
AbstractforNovel dual multiplex real-time RT-PCR assays for the rapid detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus using the BD MAX open system | Full Text | References | PDF (720.7 KB) | EPUB | Supplemental
  • 10253 Views
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Open Access
Article
Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France
Grégory Quéromès, Grégory Destras, Antonin Bal, Hadrien Regue, Gwendolyne Burfin, Solenne Brun, Rémi Fanget, Florence Morfin, Martine Valette, Sophie Trouillet-Assant, Bruno Lina, Emilie Frobert & Laurence Josset
Pages: 167-177
Published online: 27 Jan 2021
AbstractforCharacterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 5041 Views
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Open Access
Article
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species
Mehdi Moustaqil, Emma Ollivier, Hsin-Ping Chiu, Sarah Van Tol, Paulina Rudolffi-Soto, Christian Stevens, Akshay Bhumkar, Dominic J. B. Hunter, Alexander N. Freiberg, David Jacques, Benhur Lee, Emma Sierecki & Yann Gambin
Pages: 178-195
Published online: 29 Jan 2021
AbstractforSARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 12503 Views
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Open Access
The interplay between emerging human coronavirus infections and autophagy
Zhenyu Zhao, Kefeng Lu, Binli Mao, Shi Liu, Mirko Trilling, Ailong Huang, Mengji Lu & Yong Lin
Pages: 196-205
Published online: 03 Feb 2021
AbstractforThe interplay between emerging human coronavirus infections and autophagy | Full Text | References | PDF (938.5 KB) | EPUB
  • 7039 Views
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Open Access
Letter
Fast inactivation of SARS-CoV-2 by UV-C and ozone exposure on different materials
Elena Criscuolo, Roberta A. Diotti, Roberto Ferrarese, Cesare Alippi, Gabriele Viscardi, Carlo Signorelli, Nicasio Mancini, Massimo Clementi & Nicola Clementi
Pages: 206-209
Published online: 02 Feb 2021
AbstractforFast inactivation of SARS-CoV-2 by UV-C and ozone exposure on different materials | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 7982 Views
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Open Access

Research Article

Article
Identification of key residues involved in the neuraminidase antigenic variation of H9N2 influenza virus
Fei Wang, Jinsen Wu, Yajuan Wang, Zhimin Wan, Hongxia Shao, Kun Qian, Jianqiang Ye & Aijian Qin
Pages: 210-219
Published online: 02 Feb 2021
AbstractforIdentification of key residues involved in the neuraminidase antigenic variation of H9N2 influenza virus | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 2741 Views
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Open Access

Tuberculosis

Letter
Human pathogenic Mycobacterium kansasii (former subtype I) with zoonotic potential isolated from a diseased indoor pet cat, Japan
Hanako Fukano, Tsukasa Terazono, Aki Hirabayashi, Mitsunori Yoshida, Masato Suzuki, Shinpei Wada, Norihisa Ishii & Yoshihiko Hoshino
Pages: 220-222
Published online: 08 Feb 2021
AbstractforHuman pathogenic Mycobacterium kansasii (former subtype I) with zoonotic potential isolated from a diseased indoor pet cat, Japan | Full Text | References | PDF (520.3 KB) | EPUB | Supplemental
  • 2892 Views
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Open Access

Letter

Letter
Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer
João Fevereiro, Alexandra G. Fraga, Carlos Capela, Ghislain E. Sopoh, Ange Dossou, Gilbert Adjimon Ayelo, Maria João Peixoto, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues & Jorge Pedrosa
Pages: 223-225
Published online: 11 Feb 2021
AbstractforGenetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer | Full Text | References | PDF (489.8 KB) | EPUB
  • 2246 Views
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Open Access

Research Article

Article
The first detection of Anaplasma capra, an emerging zoonotic Anaplasma sp., in erythrocytes
Yongshuai Peng, Chenyang Lu, Yaqun Yan, Ke Shi, Qian Chen, Cong Zhao, Rongjun Wang, Longxian Zhang, Fuchun Jian & Changshen Ning
Pages: 226-234
Published online: 18 Feb 2021
AbstractforThe first detection of Anaplasma capra, an emerging zoonotic Anaplasma sp., in erythrocytes | Full Text | References | PDF (1.2 MB) | EPUB
  • 3621 Views
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Open Access

Coronaviruses

Article
Saliva viral load better correlates with clinical and immunological profiles in children with coronavirus disease 2019
Gilbert T. Chua, Joshua S. C. Wong, Kelvin K. W. To, Ivan C. S. Lam, Felix Y. S. Yau, Wai Hung Chan, Polly P. K. Ho, Jaime S. R. Duque, Cyril C. Y. Yip, Anthony C. K. Ng, Wilfred H. S. Wong, Joyce H. Y. Kwong, Kate F. S. Leung, P. T. Wan, Kelly Lam, Ian C. K. Wong, Janette Kwok, Marco H. K. Ho, Godfrey C. F. Chan, Yu Lung Lau, Patrick Ip & Mike Y. W. Kwan
Pages: 235-241
Published online: 20 Feb 2021
AbstractforSaliva viral load better correlates with clinical and immunological profiles in children with coronavirus disease 2019 | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 4792 Views
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Open Access

Antimicrobial Agents

Article
Prevalence and risk analysis of mobile colistin resistance and extended-spectrum β-lactamase genes carriage in pet dogs and their owners: a population based cross-sectional study
Lei Lei, Yongqiang Wang, Junjia He, Chang Cai, Qingzhi Liu, Dawei Yang, Zhiyu Zou, Lingyu Shi, Jianqin Jia, Yang Wang, Timothy R. Walsh, Jianzhong Shen & Yougang Zhong
Pages: 242-251
Published online: 15 Feb 2021
AbstractforPrevalence and risk analysis of mobile colistin resistance and extended-spectrum β-lactamase genes carriage in pet dogs and their owners: a population based cross-sectional study | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 3725 Views
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Open Access

Coronaviruses

Letter
Isolation of SARS-CoV-2 strains carrying a nucleotide mutation, leading to a stop codon in the ORF 6 protein
Serena Delbue, Sarah D’Alessandro, Lucia Signorini, Maria Dolci, Elena Pariani, Michele Bianchi, Stefania Fattori, Annalisa Modenese, Cristina Galli, Ivano Eberini & Pasquale Ferrante
Pages: 252-255
Published online: 18 Feb 2021
AbstractforIsolation of SARS-CoV-2 strains carrying a nucleotide mutation, leading to a stop codon in the ORF 6 protein | Full Text | References | PDF (603.9 KB) | EPUB | Supplemental
  • 6745 Views
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Open Access

Research Article

Article
The prevalence of CRF55_01B among HIV-1 strain and its connection with traffic development in China
Mengze Gan, Shan Zheng, Jingjing Hao, Yuhua Ruan, Lingjie Liao, Yiming Shao, Yi Feng & Hui Xing
Pages: 256-265
Published online: 18 Feb 2021
AbstractforThe prevalence of CRF55_01B among HIV-1 strain and its connection with traffic development in China | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 3130 Views
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Open Access

Coronaviruses

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue
Xi Yongzhi
Pages: 266-276
Published online: 18 Feb 2021
AbstractforCOVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue | Full Text | References | PDF (952.2 KB) | EPUB
  • 10736 Views
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Open Access

Research Article

Article
Amoebae can promote the survival of Francisella species in the aquatic environment
Aurélie Hennebique, Julien Peyroux, Camille Brunet, Amandine Martin, Thomas Henry, Masa Knezevic, Marina Santic, Sandrine Boisset & Max Maurin
Pages: 277-290
Published online: 24 Feb 2021
AbstractforAmoebae can promote the survival of Francisella species in the aquatic environment | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 2541 Views
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Open Access

Coronaviruses

Article
Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection
Zi-Wei Ye, Shuofeng Yuan, Jasper Fuk-Woo Chan, Anna Jinxia Zhang, Ching-Yun Yu, Chon Phin Ong, Dong Yang, Chris Chun-Yiu Chan, Kaiming Tang, Jianli Cao, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Jian-Piao Cai, Hin Chu, Kwok-Yung Yuen & Dong-Yan Jin
Pages: 291-304
Published online: 25 Feb 2021
AbstractforBeneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 6882 Views
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Open Access

Research Article

Article
Optimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal models
Awadalkareem Adam, Huanle Luo, Samantha R. Osman, Binbin Wang, Christopher M. Roundy, Albert J. Auguste, Kenneth S. Plante, Bi-Hung Peng, Saravanan Thangamani, Elena I. Frolova, Ilya Frolov, Scott C. Weaver & Tian Wang
Pages: 305-316
Published online: 25 Feb 2021
AbstractforOptimized production and immunogenicity of an insect virus-based chikungunya virus candidate vaccine in cell culture and animal models | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 4131 Views
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Open Access

Coronaviruses

Article
The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor
Yanmei Hu, Xiangzhi Meng, Fushun Zhang, Yan Xiang & Jun Wang
Pages: 317-330
Published online: 27 Feb 2021
AbstractforThe in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor | Full Text | References | PDF (1.8 MB) | EPUB
  • 9562 Views
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Open Access

Research Article

Article
Application of laser capture microdissection and PCR sequencing in the diagnosis of Coccidioides spp. infection: A case report and literature review in China
Xinyu Yang, Yinggai Song, TianYu Liang, Qiqi Wang, Ruoyu Li & Wei Liu
Pages: 331-341
Published online: 27 Feb 2021
AbstractforApplication of laser capture microdissection and PCR sequencing in the diagnosis of Coccidioides spp. infection: A case report and literature review in China | Full Text | References | PDF (1.1 MB) | EPUB
  • 3017 Views
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Open Access

Coronaviruses

Article
A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques
Yuzhong Li, Yanwei Bi, Hongjian Xiao, Yueting Yao, Xiaojuan Liu, Zhengrong Hu, Jinmei Duan, Yaoyun Yang, Zhihua Li, Yadong Li, Heng Zhang, Chen Ding, Jianbo Yang, Haiwei Li, Zhanlong He, Longding Liu, Guangnan Hu, Shuying Liu, Yanchun Che, Shixia Wang, Qihan Li, Shan Lu & Wei Cun
Pages: 342-355
Published online: 01 Mar 2021
AbstractforA novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques | Full Text | References | PDF (1.5 MB) | EPUB
  • 7775 Views
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Open Access

Research Article

Article
Prevalence and transmission characteristics of Listeria species from ruminants in farm and slaughtering environments in China
Qiang Zhao, Pan Hu, Qianqian Li, Shasha Zhang, Hanxiao Li, Jiang Chang, Qiujie Jiang, Yu Zheng, Yansong Li, Zengshan Liu, Honglin Ren & Shiying Lu
Pages: 356-364
Published online: 01 Mar 2021
AbstractforPrevalence and transmission characteristics of Listeria species from ruminants in farm and slaughtering environments in China | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 3448 Views
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Open Access
Article
Inflammation-related adverse reactions following vaccination potentially indicate a stronger immune response
Chun-Lan Zhuang, Zhi-Jie Lin, Zhao-Feng Bi, Ling-Xian Qiu, Fang-Fang Hu, Xiao-Hui Liu, Bi-Zhen Lin, Ying-Ying Su, Hui-Rong Pan, Tian-Ying Zhang, Shou-Jie Huang, Yue-Mei Hu, You-Lin Qiao, Feng-Cai Zhu, Ting Wu, Jun Zhang & Ning-Shao Xia
Pages: 365-375
Published online: 01 Mar 2021
AbstractforInflammation-related adverse reactions following vaccination potentially indicate a stronger immune response | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 4861 Views
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Coronaviruses

Article
A household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners
Víctor Neira, Bárbara Brito, Belén Agüero, Felipe Berrios, Valentina Valdés, Alberto Gutierrez, Naomi Ariyama, Patricio Espinoza, Patricio Retamal, Edward C. Holmes, Ana S. Gonzalez-Reiche, Zenab Khan, Adriana van de Guchte, Jayeeta Dutta, Lisa Miorin, Thomas Kehrer, Nicolás Galarce, Leonardo I. Almonacid, Jorge Levican, Harm van Bakel, Adolfo García-Sastre & Rafael A. Medina
Pages: 376-383
Published online: 05 Mar 2021
AbstractforA household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 5294 Views
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Open Access

Research Article

Article
Epidemiological profile and molecular genetic characterization of HIV-1 among female sex workers and elderly male clients in Guangxi, China
Xiu Chen, Chunwei Qin, Rongfeng Chen, Yunxuan Huang, Yuexiang Xu, Qiao Tang, Xianjun Liang, Bing Peng, Yi Shao, Yao Yang, Jie Chen, Xinwei Wang, Liufang Wen, Bingyu Liang, Li Ye, Xionglin Qin, Junjun Jiang & Hao Liang
Pages: 384-395
Published online: 03 Mar 2021
AbstractforEpidemiological profile and molecular genetic characterization of HIV-1 among female sex workers and elderly male clients in Guangxi, China | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 2824 Views
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Antimicrobial Agents

Letter
Characterization of an NDM-5-producing hypervirulent Klebsiella pneumoniae sequence type 65 clone from a lung transplant recipient
Jiankang Zhao, Yulin Zhang, Yanyan Fan, Jiajing Han, Zhujia Xiong, Xinmeng Liu, Binbin Li, Binghuai Lu & Bin Cao
Pages: 396-399
Published online: 05 Mar 2021
AbstractforCharacterization of an NDM-5-producing hypervirulent Klebsiella pneumoniae sequence type 65 clone from a lung transplant recipient | Full Text | References | PDF (926.4 KB) | EPUB | Supplemental
  • 3508 Views
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Open Access

Research Article

Article
Phialemoniopsis limonesiae sp. nov. causing cutaneous phaeohyphomycosis in an immunosuppressed woman
D. Alvarez Martinez, C. Alberto, A. Riat, C. Schuhler, P. Valladares, B. Ninet, B. Kraak, P. W. Crous, L. W. Hou & L. Toutous Trellu
Pages: 400-406
Published online: 09 Mar 2021
AbstractforPhialemoniopsis limonesiae sp. nov. causing cutaneous phaeohyphomycosis in an immunosuppressed woman | Full Text | References | PDF (1.1 MB) | EPUB
  • 2285 Views
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Open Access
Article
Oligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples
Luis Pla, Sara Santiago-Felipe, María Ángeles Tormo-Mas, Alba Ruiz-Gaitán, Javier Pemán, Eulogio Valentín, Félix Sancenón, Elena Aznar & Ramón Martínez-Máñez
Pages: 407-415
Published online: 11 Mar 2021
AbstractforOligonucleotide-capped nanoporous anodic alumina biosensor as diagnostic tool for rapid and accurate detection of Candida auris in clinical samples | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 3013 Views
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Open Access
Article
High population-attributable fractions of traditional risk factors for non-AIDS-defining diseases among people living with HIV in China: a cohort study
Jiaye Liu, Yuying Hou, Liqin Sun, Lifeng Wang, Yun He, Yang Zhou, Liumei Xu, Xiaoning Liu, Fang Zhao, Lukun Zhang, Hui Wang & Fu-Sheng Wang
Pages: 416-423
Published online: 15 Mar 2021
AbstractforHigh population-attributable fractions of traditional risk factors for non-AIDS-defining diseases among people living with HIV in China: a cohort study | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 3901 Views
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Open Access
Article
Chinese tree shrew: a permissive model for in vitro and in vivo replication of human adenovirus species B
Xiao Li, Zhichao Zhou, Wenkuan Liu, Ye Fan, Yinzhu Luo, Kangtian Li, Zhenxia Zheng, Xingui Tian & Rong Zhou
Pages: 424-438
Published online: 13 Mar 2021
AbstractforChinese tree shrew: a permissive model for in vitro and in vivo replication of human adenovirus species B | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Coronaviruses

Article Commentary
Human challenge trials to assess the efficacy of currently approved COVID-19 vaccines against SARS-CoV-2 variants
Shan Su, Yiming Shao & Shibo Jiang
Pages: 439-441
Published online: 13 Mar 2021
First Page PreviewforHuman challenge trials to assess the efficacy of currently approved COVID-19 vaccines against SARS-CoV-2 variants | Full Text | References | PDF (403.6 KB) | EPUB
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Antimicrobial Agents

Article
An IncP-2 plasmid sublineage associated with dissemination of blaIMP-45 among carbapenem-resistant Pseudomonas aeruginosa
Xuefei Zhang, Leilei Wang, Dan Li, Pei Li, Lili Yuan, Fan Yang, Qinglan Guo & Minggui Wang
Pages: 442-449
Published online: 13 Mar 2021
AbstractforAn IncP-2 plasmid sublineage associated with dissemination of blaIMP-45 among carbapenem-resistant Pseudomonas aeruginosa | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Research Article

Article
Trends of pulmonary fungal infections from 2013 to 2019: an AI-based real-world observational study in Guangzhou, China
Zhengtu Li, Yongming Li, Yijun Chen, Jing Li, Shaoqiang Li, Chenglong Li, Ye Lin, Wenhua Jian, Jingrong Shi, Yangqing Zhan, Jing Cheng, Jingping Zheng, Nanshan Zhong & Feng Ye
Pages: 450-460
Published online: 13 Mar 2021
AbstractforTrends of pulmonary fungal infections from 2013 to 2019: an AI-based real-world observational study in Guangzhou, China | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 4019 Views
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Article
Insights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen Ehrlichia chaffeensis
Nan Duan, Xiaohui Ma, Heting Cui, Zhexuan Wang, Zhouyi Chai, Jiaqi Yan, Xiaoxiao Li, Yingxing Feng, Yu Cao, Yongxin Jin, Fang Bai, Weihui Wu, Yasuko Rikihisa & Zhihui Cheng
Pages: 461-471
Published online: 13 Mar 2021
AbstractforInsights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen Ehrlichia chaffeensis | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Influenza Infections

Article
Mink is a highly susceptible host species to circulating human and avian influenza viruses
Honglei Sun, Fangtao Li, Qingzhi Liu, Jianyong Du, Litao Liu, Haoran Sun, Chong Li, Jiyu Liu, Xin Zhang, Jizhe Yang, Yuhong Duan, Yuhai Bi, Juan Pu, Yipeng Sun, Qi Tong, Yongqiang Wang, Xiangjun Du, Yuelong Shu, Kin-Chow Chang & Jinhua Liu
Pages: 472-480
Published online: 19 Mar 2021
AbstractforMink is a highly susceptible host species to circulating human and avian influenza viruses | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Coronaviruses

Article
The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract
Yuejun Shi, Lei Shuai, Zhiyuan Wen, Chong Wang, Yuanyuan Yan, Zhe Jiao, Fenglin Guo, Zhen F. Fu, Huanchun Chen, Zhigao Bu & Guiqing Peng
Pages: 481-492
Published online: 19 Mar 2021
AbstractforThe preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Letter
Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers
Javier Martínez-Sanz, Daniel Jiménez, Laura Martínez-Campelo, Raquel Cruz, Pilar Vizcarra, Matilde Sánchez-Conde, Raquel Ron, Mario Rodríguez, Sabina Herrera, Santiago Moreno, María Rosa López-Huertas & Sergio Serrano-Villar
Pages: 493-496
Published online: 19 Mar 2021
AbstractforRole of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers | Full Text | References | PDF (875.2 KB) | EPUB | Supplemental
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Research Article

Article
Using molecular transmission networks to understand the epidemic characteristics of HIV-1 CRF08_BC across China
Kang Li, Meiliang Liu, Huanhuan Chen, Jianjun Li, Yanling Liang, Yi Feng, Hui Xing & Yiming Shao
Pages: 497-506
Published online: 22 Mar 2021
AbstractforUsing molecular transmission networks to understand the epidemic characteristics of HIV-1 CRF08_BC across China | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Coronaviruses

Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic
Kelvin Kai-Wang To, Siddharth Sridhar, Kelvin Hei-Yeung Chiu, Derek Ling-Lung Hung, Xin Li, Ivan Fan-Ngai Hung, Anthony Raymond Tam, Tom Wai-Hin Chung, Jasper Fuk-Woo Chan, Anna Jian-Xia Zhang, Vincent Chi-Chung Cheng & Kwok-Yung Yuen
Pages: 507-535
Published online: 22 Mar 2021
AbstractforLessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic | Full Text | References | PDF (3 MB) | EPUB
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Research Article

Article
Viral evolution sustains a dengue outbreak of enhanced severity
Catherine Inizan, Marine Minier, Matthieu Prot, Olivia O’Connor, Carole Forfait, Sylvie Laumond, Ingrid Marois, Antoine Biron, Ann-Claire Gourinat, Marie-Amélie Goujart, Elodie Descloux, Anavaj Sakuntabhai, Arnaud Tarantola, Etienne Simon-Lorière & Myrielle Dupont-Rouzeyrol
Pages: 536-544
Published online: 27 Mar 2021
AbstractforViral evolution sustains a dengue outbreak of enhanced severity | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Enterovirus 71 (EV71)

Article
Long-term neurodevelopment outcomes of hand, foot and mouth disease inpatients infected with EV-A71 or CV-A16, a retrospective cohort study
Lu Liang, Yibing Cheng, Yu Li, Qing Shang, Jiao Huang, Caiyun Ma, Shuanfeng Fang, Lu Long, Chongchen Zhou, Zhiping Chen, Peng Cui, Nan Lv, Pu Lou, Yajie Cui, Saraswathy Sabanathan, H. Rogier van Doorn, Rongsheng Luan, Lance Turtle & Hongjie Yu
Pages: 545-554
Published online: 29 Mar 2021
AbstractforLong-term neurodevelopment outcomes of hand, foot and mouth disease inpatients infected with EV-A71 or CV-A16, a retrospective cohort study | Full Text | References | PDF (1,011.9 KB) | EPUB | Supplemental
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Hepatitis

Article
Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus
Ying Lu, Yarong Song, Xiangjun Zhai, Fengcai Zhu, Jianxun Liu, Zhanjun Chang, Yi Li, Yiwei Xiao, Lili Li, Minmin Liu, Jia Liu, Zhongping Duan, Huaibin Zou, Hui Zhuang, Jie Wang & Jie Li
Pages: 555-564
Published online: 30 Mar 2021
AbstractforMaternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2673 Views
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Influenza Infections

Article
Pathogenic assessment of avian influenza viruses in migratory birds
Eun-Ha Kim, Young-ll Kim, Se Mi Kim, Kwang-Min Yu, Mark Anthony B. Casel, Seung-Gyu Jang, Philippe Noriel Q. Pascua, Richard J. Webby & Young Ki Choi
Pages: 565-577
Published online: 30 Mar 2021
AbstractforPathogenic assessment of avian influenza viruses in migratory birds | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Tuberculosis

Trained immunity contributes to the prevention of Mycobacterium tuberculosis infection, a novel role of autophagy
Jie Zhou, Jingzhu Lv, Chelsea Carlson, Hui Liu, Hongtao Wang, Tao Xu, Fengjiao Wu, Chuanwang Song, Xiaojing Wang, Ting Wang & Zhongqing Qian
Pages: 578-588
Published online: 30 Mar 2021
AbstractforTrained immunity contributes to the prevention of Mycobacterium tuberculosis infection, a novel role of autophagy | Full Text | References | PDF (1.3 MB) | EPUB
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Research Article

Article
CqsA/LuxS-HapR Quorum sensing circuit modulates type VI secretion system VflT6SS2 in Vibrio fluvialis
Xiaoshu Liu, Jingjing Pan, He Gao, Yu Han, Anran Zhang, Yuanming Huang, Ping Liu, Biao Kan & Weili Liang
Pages: 589-601
Published online: 30 Mar 2021
AbstractforCqsA/LuxS-HapR Quorum sensing circuit modulates type VI secretion system VflT6SS2 in Vibrio fluvialis | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Introduction and spread of variegated squirrel bornavirus 1 (VSBV-1) between exotic squirrels and spill-over infections to humans in Germany
Daniel Cadar, Valerie Allendorf, Vanessa Schulze, Rainer G. Ulrich, Kore Schlottau, Arnt Ebinger, Bernd Hoffmann, Donata Hoffmann, Dennis Rubbenstroth, Gabriele Ismer, Chris Kibbey, Anna Marthaler, Jürgen Rissland, Frank Leypoldt, Martin Stangel, Jonas Schmidt-Chanasit, Franz J. Conraths, Martin Beer, Timo Homeier-Bachmann & Dennis Tappe
Pages: 602-611
Published online: 30 Mar 2021
AbstractforIntroduction and spread of variegated squirrel bornavirus 1 (VSBV-1) between exotic squirrels and spill-over infections to humans in Germany | Full Text | References | PDF (1.5 MB) | EPUB
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Antimicrobial Agents

Article
Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients
Nannan Wu, Jia Dai, Mingquan Guo, Jianhui Li, Xin Zhou, Feng Li, Yuan Gao, Hongping Qu, Hongzhou Lu, Jing Jin, Tao Li, Lei Shi, Qingguo Wu, Ruoming Tan, Mingli Zhu, Lan Yang, Yun Ling, Shunpeng Xing, Jianzhong Zhang, Bangxin Yao, Shuai Le, Jingmin Gu, Jinhong Qin, Jie Li, Mengjun Cheng, Demeng Tan, Linlin Li, Yiyuan Zhang, Zhaoqin Zhu, Jinfeng Cai, Zhigang Song, Xiaokui Guo, Li-Kuang Chen & Tongyu Zhu
Pages: 612-618
Published online: 07 Apr 2021
AbstractforPre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 8048 Views
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Enterovirus 71 (EV71)

Article
The epidemiological characteristics of enterovirus infection before and after the use of enterovirus 71 inactivated vaccine in Kunming, China
Hongchao Jiang, Zhen Zhang, Qing Rao, Xiaodan Wang, Meifen Wang, Tingyi Du, Jiaolian Tang, Shuying Long, Juan Zhang, Jia Luo, Yue Pan, Junying Chen, Jing Ma, Xiaomei Liu, Mao Fan, Tiesong Zhang & Qiangming Sun
Pages: 619-628
Published online: 30 Mar 2021
AbstractforThe epidemiological characteristics of enterovirus infection before and after the use of enterovirus 71 inactivated vaccine in Kunming, China | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 3062 Views
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Coronaviruses

Article
Heterologous prime-boost: breaking the protective immune response bottleneck of COVID-19 vaccine candidates
Qian He, Qunying Mao, Chaoqiang An, Jialu Zhang, Fan Gao, Lianlian Bian, Changgui Li, Zhenglun Liang, Miao Xu & Junzhi Wang
Pages: 629-637
Published online: 29 Mar 2021
AbstractforHeterologous prime-boost: breaking the protective immune response bottleneck of COVID-19 vaccine candidates | Full Text | References | PDF (1.1 MB) | EPUB
  • 54858 Views
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Article
Experimental re-infected cats do not transmit SARS-CoV-2
Natasha N. Gaudreault, Mariano Carossino, Igor Morozov, Jessie D. Trujillo, David A. Meekins, Daniel W. Madden, Konner Cool, Bianca Libanori Artiaga, Chester McDowell, Dashzeveg Bold, Velmurugan Balaraman, Taeyong Kwon, Wenjun Ma, Jamie Henningson, Dennis W. Wilson, William C. Wilson, Udeni B. R. Balasuriya, Adolfo García-Sastre & Juergen A. Richt
Pages: 638-650
Published online: 02 Apr 2021
AbstractforExperimental re-infected cats do not transmit SARS-CoV-2 | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 4170 Views
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Ebola

Article
High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission
Igor Morozov, Thomas P. Monath, David A. Meekins, Jessie D. Trujillo, Sun-Young Sunwoo, Kinga Urbaniak, In Joong Kim, Sanjeev K. Narayanan, Sabarish V. Indran, Wenjun Ma, William C. Wilson, Cassandra O'Connor, Sheri Dubey, Sean P. Troth, Beth-Ann Coller, Richard Nichols, Brian K. Martin, Heinz Feldmann & Juergen A. Richt
Pages: 651-663
Published online: 02 Apr 2021
AbstractforHigh dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 3394 Views
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Coronaviruses

Article
Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study
Li Guo, Yeming Wang, Liang Kang, Yongfeng Hu, Linghang Wang, Jingchuan Zhong, Hong Chen, Lili Ren, Xiaoying Gu, Geng Wang, Conghui Wang, Xiaojing Dong, Chao Wu, Lianlian Han, Ying Wang, Guohui Fan, Xiaohui Zou, Haibo Li, Jiuyang Xu, Qi Jin, Bin Cao & Jianwei Wang
Pages: 664-676
Published online: 02 Apr 2021
AbstractforCross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 6863 Views
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Research Article

Article
Development of a rapid and sensitive analytical system for Pseudomonas aeruginosa based on reverse transcription quantitative PCR targeting of rRNA molecules
Mai Niikura, Satomi Atobe, Akira Takahashi, Yukiko Kado, Takuya Sugimoto, Hirokazu Tsuji, Kentaro Shimizu, Hiroshi Ogura & Takashi Asahara
Pages: 677-686
Published online: 02 Apr 2021
AbstractforDevelopment of a rapid and sensitive analytical system for Pseudomonas aeruginosa based on reverse transcription quantitative PCR targeting of rRNA molecules | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 2659 Views
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Article
New ribotype Clostridioides difficile from ST11 group revealed higher pathogenic ability than RT078
Wenpeng Gu, Wenguang Wang, Wenge Li, Na Li, Yuanyuan Wang, Wenzhu Zhang, Caixia Lu, Pinfen Tong, Yuanyuan Han, Xiaomei Sun, Jinxing Lu, Yuan Wu & Jiejie Dai
Pages: 687-699
Published online: 05 Apr 2021
AbstractforNew ribotype Clostridioides difficile from ST11 group revealed higher pathogenic ability than RT078 | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 2724 Views
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Antimicrobial Agents

Article
Molecular characterization of carbapenem-resistant and virulent plasmids in Klebsiella pneumoniae from patients with bloodstream infections in China
Yongqiang Yang, Yanxian Yang, Guanping Chen, Minmin Lin, Yuan Chen, Ruowen He, Klibs N. Galvão, Mohamed Abd El-Gawad El-Sayed Ahmed, Adam P. Roberts, Yiping Wu, Lan-Lan Zhong, Xiaoxue Liang, Mingyang Qin, Xin Ding, Wenbin Deng, Songyin Huang, Hong-Yu Li, Min Dai, Ding-Qiang Chen, Liyan Zhang, Kang Liao, Yong Xia & Guo-Bao Tian
Pages: 700-709
Published online: 05 Apr 2021
AbstractforMolecular characterization of carbapenem-resistant and virulent plasmids in Klebsiella pneumoniae from patients with bloodstream infections in China | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Letter

Letter
Introduction of SARS-CoV-2 variant of concern 20h/501Y.V2 (B.1.351) from Malawi to Italy
Federica Novazzi, Angelo Genoni, Pietro Giorgio Spezia, Daniele Focosi, Cristian Zago, Alberto Colombo, Gianluca Cassani, Renee Pasciuta, Antonio Tamborini, Agostino Rossi, Martina Prestia, Riccardo Capuano, Daniela Dalla Gasperina, Francesco Dentali, Paolo Severgnini, Walter Ageno, Cinzia Gambarini, Paola Stefanelli, Andreina Baj & Fabrizio Maggi
Pages: 710-712
Published online: 09 Apr 2021
AbstractforIntroduction of SARS-CoV-2 variant of concern 20h/501Y.V2 (B.1.351) from Malawi to Italy | Full Text | References | PDF (611.4 KB) | EPUB
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Enterovirus 71 (EV71)

Viral determinants that drive Enterovirus-A71 fitness and virulence
Pei Yi Ang, Connie Wan Hui Chong & Sylvie Alonso
Pages: 713-724
Published online: 09 Apr 2021
AbstractforViral determinants that drive Enterovirus-A71 fitness and virulence | Full Text | References | PDF (1.1 MB) | EPUB
  • 5108 Views
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Research Article

Article
Pathogenesis and shedding of Usutu virus in juvenile chickens
Sarah C. Kuchinsky, Francesca Frere, Nora Heitzman-Breen, Jacob Golden, Ana Vázquez, Christa F. Honaker, Paul B. Siegel, Stanca M. Ciupe, Tanya LeRoith & Nisha K. Duggal
Pages: 725-738
Published online: 09 Apr 2021
AbstractforPathogenesis and shedding of Usutu virus in juvenile chickens | Full Text | References | PDF (1.6 MB) | EPUB
  • 2810 Views
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Letter

Letter
Emergence of new phylogenetic lineage of Influenza D virus with broad antigenicity in California, United States
Chen Huang, Jieshi Yu, Ben M. Hause, Jie Yeun Park, Chithra Sreenivasan, Tirth Uprety, Zizhang Sheng, Dan Wang & Feng Li
Pages: 739-742
Published online: 09 Apr 2021
AbstractforEmergence of new phylogenetic lineage of Influenza D virus with broad antigenicity in California, United States | Full Text | References | PDF (672 KB) | EPUB | Supplemental
  • 2816 Views
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Tuberculosis

Article
Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region
Pengjiao Ma, Tao Luo, Liang Ge, Zonghai Chen, Xinyan Wang, Rongchuan Zhao, Wei Liao & Lang Bao
Pages: 743-752
Published online: 14 Apr 2021
AbstractforCompensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3911 Views
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Influenza Infections

Article
Antigenic and molecular characterization of low pathogenic avian influenza A(H9N2) viruses in sub-Saharan Africa from 2017 through 2019
Maxime Fusade-Boyer, Fidélia Djegui, Komla Batawui, Denis K. Byuragaba, Jeremy C. Jones, Fred Wabwire-Mangeni, Bernard Erima, Gladys Atim, Qouilazoni A. Ukuli, Titus Tugume, Koffi Dogno, Komlan Adjabli, Mvibudulu Nzuzi, Rachidatou Adjin, Trushar Jeevan, Adam Rubrum, Wolali Go-Maro, Ghazi Kayali, Pamela McKenzie, Richard J. Webby & Mariette F. Ducatez
Pages: 753-761
Published online: 14 Apr 2021
AbstractforAntigenic and molecular characterization of low pathogenic avian influenza A(H9N2) viruses in sub-Saharan Africa from 2017 through 2019 | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Retraction

Retraction
Statement of Retraction
Page: 762
Published online: 22 Apr 2021
CitationforStatement of Retraction | Full Text | PDF (116.9 KB) | EPUB
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Research Article

Article
Efficacy of a coxsackievirus A6 vaccine candidate in an actively immunized mouse model
Sha-Sha Qian, Zhen-Ni Wei, Wei-Ping Jin, Jie Wu, Yan-Ping Zhou, Sheng-Li Meng, Jing Guo, Ze-Jun Wang & Shuo Shen
Pages: 763-773
Published online: 21 Apr 2021
AbstractforEfficacy of a coxsackievirus A6 vaccine candidate in an actively immunized mouse model | Full Text | References | PDF (1.3 MB) | EPUB
  • 2544 Views
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Coronaviruses

Article
Correlation of humoral immune responses to different SARS-CoV-2 antigens with virus neutralizing antibodies and symptomatic severity in a German COVID-19 cohort
Alexandra Rockstroh, Johannes Wolf, Jasmin Fertey, Sven Kalbitz, Stefanie Schroth, Christoph Lübbert, Sebastian Ulbert & Stephan Borte
Pages: 774-781
Published online: 23 Apr 2021
AbstractforCorrelation of humoral immune responses to different SARS-CoV-2 antigens with virus neutralizing antibodies and symptomatic severity in a German COVID-19 cohort | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 5029 Views
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Correction

Correction
Correction
Page: 782
Published online: 20 Apr 2021
CitationforCorrection | Full Text | PDF (108.8 KB) | EPUB
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Free Access

Research Article

Article
A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity
Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan, Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre Serobian, Marco Neves, João Ferreira, Fernando Ferreira & Hovakim Zakaryan
Pages: 783-796
Published online: 25 Apr 2021
AbstractforA new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 3791 Views
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Coronaviruses

Article
Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster
Marco Brustolin, Jordi Rodon, María Luisa Rodríguez de la Concepción, Carlos Ávila-Nieto, Guillermo Cantero, Mónica Pérez, Nigeer Te, Marc Noguera-Julián, Víctor Guallar, Alfonso Valencia, Núria Roca, Nuria Izquierdo-Useros, Julià Blanco, Bonaventura Clotet, Albert Bensaid, Jorge Carrillo, Júlia Vergara-Alert & Joaquim Segalés
Pages: 797-809
Published online: 29 Apr 2021
AbstractforProtection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Research Article

Article
Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus
Danwei Yu, Yuanmei Zhu, Hongxia Yan, Tong Wu, Huihui Chong & Yuxian He
Pages: 810-821
Published online: 29 Apr 2021
AbstractforPan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 4070 Views
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Article
Assessing the effects of a two-amino acid flexibility in the Hemagglutinin 220-loop receptor-binding domain on the fitness of Influenza A(H9N2) viruses
Yixue Sun, Yulin Cong, Haiying Yu, Zhuang Ding & Yanlong Cong
Pages: 822-832
Published online: 29 Apr 2021
AbstractforAssessing the effects of a two-amino acid flexibility in the Hemagglutinin 220-loop receptor-binding domain on the fitness of Influenza A(H9N2) viruses | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 2530 Views
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Article
DNA priming immunization is more effective than recombinant protein vaccine in eliciting antigen-specific B cell responses
Haiying Li, Shixia Wang, Guangnan Hu, Lu Zhang, Shuying Liu & Shan Lu
Pages: 833-841
Published online: 01 May 2021
AbstractforDNA priming immunization is more effective than recombinant protein vaccine in eliciting antigen-specific B cell responses | Full Text | References | PDF (1.3 MB) | EPUB
  • 2519 Views
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Hepatitis

Article
Viral quasispecies quantitative analysis: a novel approach for appraising the immune tolerant phase of chronic hepatitis B virus infection
Mingjie Wang, Li Chen, MinHui Dong, Jing Li, Beidi Zhu, Zhitao Yang, Qiming Gong, Yue Han, Demin Yu, Donghua Zhang, Fabien Zoulim, Jiming Zhang & Xinxin Zhang
Pages: 842-851
Published online: 01 May 2021
AbstractforViral quasispecies quantitative analysis: a novel approach for appraising the immune tolerant phase of chronic hepatitis B virus infection | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 3704 Views
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Research Article

Article
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases
Jin Hu, Liudi Tang, Junjun Cheng, Tianlun Zhou, Yuhuan Li, Jinhong Chang, Qiong Zhao & Ju-Tao Guo
Pages: 852-864
Published online: 01 May 2021
AbstractforHepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases | Full Text | References | PDF (1.8 MB) | EPUB
  • 4088 Views
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Article
Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic Escherichia coli in Ghana
Isaac Prah, Alafate Ayibieke, Samiratu Mahazu, Chihiro Tani Sassa, Takaya Hayashi, Shoji Yamaoka, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey & Ryoichi Saito
Pages: 865-873
Published online: 04 May 2021
AbstractforEmergence of oxacillinase-181 carbapenemase-producing diarrheagenic Escherichia coli in Ghana | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 3803 Views
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Coronaviruses

Article
A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters
Bao-Zhong Zhang, Xiaolei Wang, Shuofeng Yuan, Wenjun Li, Ying Dou, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Jian-Piao Cai, Kenn KaHeng Chik, Kaiming Tang, Chris Chun-Yiu Chan, Ye-Fan Hu, Jing-Chu Hu, Smaranda Ruxandra Badea, Hua-Rui Gong, Xuansheng Lin, Hin Chu, Xuechen Li, Kelvin Kai-Wang To, Li Liu, Zhiwei Chen, Ivan Fan-Ngai Hung, Kwok Yung Yuen, Jasper Fuk-Woo Chan & Jian-Dong Huang
Pages: 874-884
Published online: 09 May 2021
AbstractforA novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Emerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications
Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel & Xiaowu Gai
Pages: 885-893
Published online: 09 May 2021
AbstractforEmerging variants of concern in SARS-CoV-2 membrane protein: a highly conserved target with potential pathological and therapeutic implications | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
A real-time and high-throughput neutralization test based on SARS-CoV-2 pseudovirus containing monomeric infrared fluorescent protein as reporter
Wen-Yang Tsai, Lauren L. Ching, Szu-Chia Hsieh, Marian E. Melish, Vivek R. Nerurkar & Wei-Kung Wang
Pages: 894-904
Published online: 18 May 2021
AbstractforA real-time and high-throughput neutralization test based on SARS-CoV-2 pseudovirus containing monomeric infrared fluorescent protein as reporter | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 3752 Views
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Article
Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses
Yong Yang, Xi Wang, Rong-Hui Du, Wei Zhang, Hao-Rui Si, Yan Zhu, Xu-Rui Shen, Qian Li, Bei Li, Dong Men, Ya-na Zhou, Hui Wang, Xiao-lin Tong, Xian-en Zhang, Zheng-Li Shi & Peng Zhou
Pages: 905-912
Published online: 18 May 2021
AbstractforSerological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Research Article

Article
A novel oral rabies vaccine enhances the immunogenicity through increasing dendritic cells activation and germinal center formation by expressing U-OMP19 in a mouse model
Jianqing Zhao, Yijing Zhang, Yixi Chen, Juntao Zhang, Jie Pei, Min Cui, Zhen F. Fu, Ling Zhao & Ming Zhou
Pages: 913-928
Published online: 18 May 2021
AbstractforA novel oral rabies vaccine enhances the immunogenicity through increasing dendritic cells activation and germinal center formation by expressing U-OMP19 in a mouse model | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 2924 Views
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Article
Microdiversity of Enterococcus faecalis isolates in cases of infective endocarditis: selection of non-synonymous mutations and large deletions is associated with phenotypic modifications
G. Royer, L. Roisin, V. Demontant, S. Lo, L. Coutte, P. Lim, J. M. Pawlotsky, H. Jacquier, R. Lepeule, C. Rodriguez & P. L. Woerther
Pages: 929-938
Published online: 21 May 2021
AbstractforMicrodiversity of Enterococcus faecalis isolates in cases of infective endocarditis: selection of non-synonymous mutations and large deletions is associated with phenotypic modifications | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 2589 Views
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Article
Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages
Yanchun Wang, Xia Fan, Lin Du, Boyu Liu, Haihan Xiao, Yan Zhang, Yunqiang Wu, Fuli Liu, Yung-Fu Chang, Xiaokui Guo & Ping He
Pages: 939-953
Published online: 18 May 2021
AbstractforScavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 2310 Views
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Article
Identification of a blockade epitope of human norovirus GII.17
Yufang Yi, Xiaoli Wang, Shuxia Wang, Pei Xiong, Qingwei Liu, Chao Zhang, Feifei Yin & Zhong Huang
Pages: 954-963
Published online: 18 May 2021
AbstractforIdentification of a blockade epitope of human norovirus GII.17 | Full Text | References | PDF (1.5 MB) | EPUB
  • 2694 Views
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Article
Differential and sequential immunomodulatory role of neutrophils and Ly6Chi inflammatory monocytes during antiviral antibody therapy
Jennifer Lambour, Mar Naranjo-Gomez, Myriam Boyer-Clavel & Mireia Pelegrin
Pages: 964-981
Published online: 21 May 2021
AbstractforDifferential and sequential immunomodulatory role of neutrophils and Ly6Chi inflammatory monocytes during antiviral antibody therapy | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 2017 Views
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Article
Blood virosphere in febrile Tanzanian children
Samuel Cordey, Florian Laubscher, Mary-Anne Hartley, Thomas Junier, Kristina Keitel, Mylène Docquier, Nicolas Guex, Christian Iseli, Gael Vieille, Philippe Le Mercier, Anne Gleizes, Josephine Samaka, Tarsis Mlaganile, Frank Kagoro, John Masimba, Zamzam Said, Hosiana Temba, Gasser H. Elbanna, Caroline Tapparel, Marie-Celine Zanella, Ioannis Xenarios, Jacques Fellay, Valérie D’Acremont & Laurent Kaiser
Pages: 982-993
Published online: 28 May 2021
AbstractforBlood virosphere in febrile Tanzanian children | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Coronaviruses

Letter
A novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutations
Yanan Zhao, Annie Lee, Kaelea Composto, Marcus H. Cunningham, Jose R. Mediavilla, Samantha Fennessey, André Corvelo, Kar Fai Chow, Michael Zody, Liang Chen, Barry N. Kreiswirth & David S. Perlin
Pages: 994-997
Published online: 28 May 2021
AbstractforA novel diagnostic test to screen SARS-CoV-2 variants containing E484K and N501Y mutations | Full Text | References | PDF (598.7 KB) | EPUB | Supplemental
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Article Commentary
The COVID-19-designated hospitals in China: preparing for public health emergencies
Qian Li, Lin Wang, Bangfang Wang & Hongzhou Lu
Pages: 998-1001
Published online: 03 Jun 2021
AbstractforThe COVID-19-designated hospitals in China: preparing for public health emergencies | Full Text | References | PDF (590.6 KB) | EPUB
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Article
Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates
Shengxue Luo, Panli Zhang, Bochao Liu, Chan Yang, Chaolan Liang, Qi Wang, Ling Zhang, Xi Tang, Jinfeng Li, Shuiping Hou, Jinfeng Zeng, Yongshui Fu, Jean-Pierre Allain, Tingting Li, Yuming Zhang & Chengyao Li
Pages: 1002-1015
Published online: 01 Jun 2021
AbstractforPrime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients
Xiaohui Wang, Joy-Yan Lam, Linlei Chen, Shannon Wing-Ngor Au, Kelvin K. W. To, Kwok-Yung Yuen & Kin-Hang Kok
Pages: 1016-1023
Published online: 03 Jun 2021
AbstractforMining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 3048 Views
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Zika

Article
STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells
Dong Yang, Hin Chu, Gang Lu, Huiping Shuai, Yixin Wang, Yuxin Hou, Xi Zhang, Xiner Huang, Bingjie Hu, Yue Chai, Terrence Tsz-Tai Yuen, Xiaoyu Zhao, Andrew Chak-Yiu Lee, Ziwei Ye, Cun Li, Kenn Ka-Heng Chik, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan & Jasper Fuk-Woo Chan
Pages: 1024-1037
Published online: 08 Jun 2021
AbstractforSTAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 3495 Views
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Influenza Infections

Article
PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals
Xinghai Zhang, Yuanguo Li, Song Jin, Yiming Zhang, Leiyun Sun, Xinyu Hu, Menglin Zhao, Fangxu Li, Tiecheng Wang, Weiyang Sun, Na Feng, Hongmei Wang, Hongbin He, Yongkun Zhao, Songtao Yang, Xianzhu Xia & Yuwei Gao
Pages: 1038-1051
Published online: 06 Jun 2021
AbstractforPB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Research Article

Article
The genetic feature and virulence determinant of highly virulent community-associated MRSA ST338-SCCmec Vb in China
Ye Jin, Wangxiao Zhou, Zhidong Yin, Shuntian Zhang, Yunbo Chen, Ping Shen, Jinru Ji, Weiwei Chen, Beiwen Zheng & Yonghong Xiao
Pages: 1052-1064
Published online: 06 Jun 2021
AbstractforThe genetic feature and virulence determinant of highly virulent community-associated MRSA ST338-SCCmec Vb in China | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Coronaviruses

Article
Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
Endika Prieto-Fernández, Leire Egia-Mendikute, Laura Vila-Vecilla, Alexandre Bosch, Adrián Barreira-Manrique, So Young Lee, Ana García-del Río, Asier Antoñana-Vildosola, Borja Jiménez-Lasheras, Leire Moreno-Cugnon, Jesús Jiménez-Barbero, Edurne Berra, June Ereño-Orbea & Asis Palazon
Pages: 1065-1076
Published online: 06 Jun 2021
AbstractforHypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate | Full Text | References | PDF (2.7 MB) | EPUB
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Research Article

Article
Alkhurma haemorrhagic fever virus causes lethal disease in IFNAR-/- mice
Bharti Bhatia, Elaine Haddock, Carl Shaia, Rebecca Rosenke, Kimberly Meade-White, Amanda J. Griffin, Andrea Marzi & Heinz Feldmann
Pages: 1077-1087
Published online: 06 Jun 2021
AbstractforAlkhurma haemorrhagic fever virus causes lethal disease in IFNAR-/- mice | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 2171 Views
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Article
Genomic epidemiology of Candida auris in a general hospital in Shenyang, China: a three-year surveillance study
Sufei Tian, Jian Bing, Yunzhuo Chu, Jingjing Chen, Shitong Cheng, Qihui Wang, Jingping Zhang, Xiaochun Ma, Baosen Zhou, Ling Liu, Guanghua Huang & Hong Shang
Pages: 1088-1096
Published online: 06 Jun 2021
AbstractforGenomic epidemiology of Candida auris in a general hospital in Shenyang, China: a three-year surveillance study | Full Text | References | PDF (996.7 KB) | EPUB | Supplemental
  • 4028 Views
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Coronaviruses

Article
Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients
Qihong Yan, Ping He, Xiaohan Huang, Kun Luo, Yudi Zhang, Haisu Yi, Qian Wang, Feng Li, Ruitian Hou, Xiaodi Fan, Pingchao Li, Xinglong Liu, Huan Liang, Yijun Deng, Zhaoming Chen, Yunfei Chen, Xiaoneng Mo, Liqiang Feng, Xiaoli Xiong, Song Li, Jian Han, Linbing Qu, Xuefeng Niu & Ling Chen
Pages: 1097-1111
Published online: 06 Jun 2021
AbstractforGermline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Letter
Intensified antibody response elicited by boost suggests immune memory in individuals administered two doses of SARS-CoV-2 inactivated vaccine
Yun Liao, Ying Zhang, Heng Zhao, Jing Pu, Zhimei Zhao, Dandan Li, Shengtao Fan, Li Yu, Xingli Xu, Lichun Wang, Guorun Jiang, Longding Liu & Qihan Li
Pages: 1112-1115
Published online: 09 Jun 2021
AbstractforIntensified antibody response elicited by boost suggests immune memory in individuals administered two doses of SARS-CoV-2 inactivated vaccine | Full Text | References | PDF (560.8 KB) | EPUB
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Review

Clinical signs and symptoms associated with WHO severe dengue classification: a systematic review and meta-analysis
Tha Pyai Htun, Zhonghui Xiong & Junxiong Pang
Pages: 1116-1128
Published online: 11 Jun 2021
AbstractforClinical signs and symptoms associated with WHO severe dengue classification: a systematic review and meta-analysis | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Antimicrobial Agents

Article
Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin
Xi Jin, Qiong Chen, Fang Shen, Yan Jiang, Xueqing Wu, Xiaoting Hua, Ying Fu & Yunsong Yu
Pages: 1129-1136
Published online: 13 Jun 2021
AbstractforResistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Research Article

Article
Isolation and characterization of novel reassortant mammalian orthoreovirus from pigs in the United States
Liping Wang, Yan Li, Timothy Walsh, Zhenyu Shen, Yonghai Li, Nirmalendu Deb Nath, Jinhwa Lee, Baoliang Zheng, Ying Tao, Clinton R. Paden, Krista Queen, Shuping Zhang, Suxiang Tong & Wenjun Ma
Pages: 1137-1147
Published online: 12 Jun 2021
AbstractforIsolation and characterization of novel reassortant mammalian orthoreovirus from pigs in the United States | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Coronaviruses

Article
Multiple detection and spread of novel strains of the SARS-CoV-2 B.1.177 (B.1.177.75) lineage that test negative by a commercially available nucleocapsid gene real-time RT-PCR
Laura Amato, Lucija Jurisic, Ilaria Puglia, Valeria Di Lollo, Valentina Curini, Giuseppe Torzi, Arturo Di Girolamo, Iolanda Mangone, Adamo Mancinelli, Nicola Decaro, Paolo Calistri, Francesca Di Giallonardo, Alessio Lorusso & Nicola D’Alterio
Pages: 1148-1155
Published online: 13 Jun 2021
AbstractforMultiple detection and spread of novel strains of the SARS-CoV-2 B.1.177 (B.1.177.75) lineage that test negative by a commercially available nucleocapsid gene real-time RT-PCR | Full Text | References | PDF (977.5 KB) | EPUB
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Article
H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic mice
Heng Li, Xin Zhao, Yurong Zhao, Jing Li, Huiwen Zheng, Mengyi Xue, Lei Guo, Jian Zhou, Jinling Yang, Yuanyuan Zuo, Yanli Chen, Zening Yang, Qiqi Fan, Li Qin, Haijing Shi & Longding Liu
Pages: 1156-1168
Published online: 13 Jun 2021
AbstractforH1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic mice | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 3090 Views
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Zika

Article
Extracellular acidosis enhances Zika virus infection both in human cells and ex-vivo tissue cultures from female reproductive tract
A. Varese, E. Dantas, A. Paletta, W. Fitzgerald, F. Di Diego García, G. Cabrerizo, F. Erra Diaz, L. A. Defelipe, H. Pallares, M. Dodes Traian, A. Gamarnik, J. Geffner, F. Remes Lenicov, L. Margolis & A. Ceballos
Pages: 1169-1179
Published online: 13 Jun 2021
AbstractforExtracellular acidosis enhances Zika virus infection both in human cells and ex-vivo tissue cultures from female reproductive tract | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Enterovirus 71 (EV71)

Article
A practical method for evaluating the in vivo efficacy of EVA-71 vaccine using a hSCARB2 knock-in mouse model
Yong Wu, Zhe Qu, Rui Xiong, Yanwei Yang, Susu Liu, Jianhui Nie, Chunnan Liang, Weijin Huang, Youchun Wang & Changfa Fan
Pages: 1180-1190
Published online: 13 Jun 2021
AbstractforA practical method for evaluating the in vivo efficacy of EVA-71 vaccine using a hSCARB2 knock-in mouse model | Full Text | References | PDF (1.4 MB) | EPUB
  • 2239 Views
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Influenza Infections

Intra-species sialic acid polymorphism in humans: a common niche for influenza and coronavirus pandemics?
Xi Jiang, Ming Tan, Ming Xia, Pengwei Huang & Michael A. Kennedy
Pages: 1191-1199
Published online: 14 Jun 2021
AbstractforIntra-species sialic acid polymorphism in humans: a common niche for influenza and coronavirus pandemics? | Full Text | References | PDF (1.2 MB) | EPUB
  • 2931 Views
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Research Article

Article
A new nairo-like virus associated with human febrile illness in China
Yan-Chun Wang, Zhengkai Wei, Xiaolong Lv, Shuzheng Han, Zedong Wang, Changfa Fan, Xu Zhang, Jianwei Shao, Ying-Hua Zhao, Liyan Sui, Chen Chen, Ming Liao, Bo Wang, Ningyi Jin, Chang Li, Jun Ma, Zhi-Jun Hou, Zhengtao Yang, Zhen Han, Yong Zhang, Junqi Niu, Wei Wang, Youchun Wang & Quan Liu
Pages: 1200-1208
Published online: 17 Jun 2021
AbstractforA new nairo-like virus associated with human febrile illness in China | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 4696 Views
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Article
The inference of HIV-1 transmission direction between a man who has sex with men and his heterosexual wife based on the sequences of HIV-1 quasi-species
Zehua Zhou, Ping Ma, Yi Feng, Weidong Ou, Min Wei & Yiming Shao
Pages: 1209-1216
Published online: 17 Jun 2021
AbstractforThe inference of HIV-1 transmission direction between a man who has sex with men and his heterosexual wife based on the sequences of HIV-1 quasi-species | Full Text | References | PDF (921.3 KB) | EPUB | Supplemental
  • 2063 Views
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Tuberculosis

Article Commentary
Where are the RNA vaccines for TB?
Xiao-Yong Fan & Douglas Bruce Lowrie
Pages: 1217-1218
Published online: 18 Jun 2021
AbstractforWhere are the RNA vaccines for TB? | Full Text | References | PDF (465.3 KB) | EPUB
  • 4079 Views
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Research Article

Article
Inhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis
Maurício T. Nascimento, Mônica Franca, Augusto M. Carvalho, Camila F. Amorim, Fábio Peixoto, Daniel Beiting, Phillip Scott, Edgar M. Carvalho & Lucas P. Carvalho
Pages: 1219-1226
Published online: 16 Jun 2021
AbstractforInhibition of gamma-secretase activity without interfering in Notch signalling decreases inflammatory response in patients with cutaneous leishmaniasis | Full Text | References | PDF (1.8 MB) | EPUB
  • 1884 Views
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Coronaviruses

Article
Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants
Danwei Yu, Yuanmei Zhu, Tao Jiao, Tong Wu, Xia Xiao, Bo Qin, Huihui Chong, Xiaobo Lei, Lili Ren, Sheng Cui, Jianwei Wang & Yuxian He
Pages: 1227-1240
Published online: 18 Jun 2021
AbstractforStructure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 3524 Views
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Letter
Serosurvey in BNT162b2 vaccine-elicited neutralizing antibodies against authentic B.1, B.1.1.7, B.1.351, B.1.525 and P.1 SARS-CoV-2 variants
Alberto Zani, Francesca Caccuri, Serena Messali, Carlo Bonfanti & Arnaldo Caruso
Pages: 1241-1243
Published online: 18 Jun 2021
AbstractforSerosurvey in BNT162b2 vaccine-elicited neutralizing antibodies against authentic B.1, B.1.1.7, B.1.351, B.1.525 and P.1 SARS-CoV-2 variants | Full Text | References | PDF (454.1 KB) | EPUB | Supplemental
  • 3543 Views
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Zika

Article
Experimental infections with Zika virus strains reveal high vector competence of Aedes albopictus and Aedes aegypti populations from Gabon (Central Africa) for the African virus lineage
Davy Jiolle, Isabelle Moltini-Conclois, Judicaël Obame-Nkoghe, Patrick Yangari, Angélique Porciani, Bethsabée Scheid, Pierre Kengne, Diego Ayala, Anna-Bella Failloux & Christophe Paupy
Pages: 1244-1253
Published online: 18 Jun 2021
AbstractforExperimental infections with Zika virus strains reveal high vector competence of Aedes albopictus and Aedes aegypti populations from Gabon (Central Africa) for the African virus lineage | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 2153 Views
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Coronaviruses

Letter
Symptomatic SARS-CoV-2 infections after full schedule BNT162b2 vaccination in seropositive healthcare workers: a case series from a single institution
Andreina Baj, Federica Novazzi, Angelo Genoni, Francesca Drago Ferrante, Stefano Taborelli, Beatrice Pini, Michele Partenope, Marilena Valli, Daniela Dalla Gasperina, Riccardo Capuano, Martina Prestia, Pietro Giorgio Spezia, Lorenzo Azzi, Daniele Focosi & Fabrizio Maggi
Pages: 1254-1256
Published online: 22 Jun 2021
AbstractforSymptomatic SARS-CoV-2 infections after full schedule BNT162b2 vaccination in seropositive healthcare workers: a case series from a single institution | Full Text | References | PDF (470 KB) | EPUB
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Antimicrobial Agents

Article
Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR)
Lihong Huang, Huanan Li, Zuodong Ye, Qiang Xu, Qiang Fu, Wei Sun, Wenbao Qi & Jianbo Yue
Pages: 1257-1271
Published online: 26 Jun 2021
AbstractforBerbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR) | Full Text | References | PDF (1.8 MB) | EPUB
  • 4063 Views
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Research Article

Article
Single-cell immune checkpoint landscape of PBMCs stimulated with Candida albicans
Weiwei Deng, Zhen Su, Panpan Liang, Yubo Ma, Yufang Liu, Kai Zhang, Yi Zhang, Tianyu Liang, Jin Shao, Xiao Liu, Wenling Han & Ruoyu Li
Pages: 1272-1283
Published online: 26 Jun 2021
AbstractforSingle-cell immune checkpoint landscape of PBMCs stimulated with Candida albicans | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 5117 Views
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Coronaviruses

Article
Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant
Claude Kwe Yinda, Julia R. Port, Trenton Bushmaker, Robert J. Fischer, Jonathan E. Schulz, Myndi G. Holbrook, Carl Shaia, Emmie de Wit, Neeltje van Doremalen & Vincent J. Munster
Pages: 1284-1292
Published online: 26 Jun 2021
AbstractforPrior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Rapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations
Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel & Xiaowu Gai
Pages: 1293-1299
Published online: 26 Jun 2021
AbstractforRapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations | Full Text | References | PDF (970 KB) | EPUB
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Research Article

Article
Clade distribution of Candida auris in South Africa using whole genome sequencing of clinical and environmental isolates
Serisha D. Naicker, Tsidiso G. Maphanga, Nancy A. Chow, Mushal Allam, Stanford Kwenda, Arshad Ismail & Nelesh P. Govender for GERMS-SA
Pages: 1300-1308
Published online: 01 Jul 2021
AbstractforClade distribution of Candida auris in South Africa using whole genome sequencing of clinical and environmental isolates | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Acquiring high expression of suilysin enable non-epidemic Streptococccus suis to cause streptococcal toxic shock-like syndrome (STSLS) through NLRP3 inflammasome hyperactivation
Lei Xu, Lan Lin, Xi Lu, Peng Xiao, Ran Liu, Meizhou Wu, Meilin Jin & Anding Zhang
Pages: 1309-1319
Published online: 01 Jul 2021
AbstractforAcquiring high expression of suilysin enable non-epidemic Streptococccus suis to cause streptococcal toxic shock-like syndrome (STSLS) through NLRP3 inflammasome hyperactivation | Full Text | References | PDF (1.5 MB) | EPUB
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Ebola

Article
Distinct transcriptional responses to fatal Ebola virus infection in cynomolgus and rhesus macaques suggest species-specific immune responses
Amanda N. Pinski, Kevin J. Maroney, Andrea Marzi & Ilhem Messaoudi
Pages: 1320-1330
Published online: 01 Jul 2021
AbstractforDistinct transcriptional responses to fatal Ebola virus infection in cynomolgus and rhesus macaques suggest species-specific immune responses | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2386 Views
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Research Article

Article
Genomic evolution and virulence association of Clostridioides difficile sequence type 37 (ribotype 017) in China
Xingxing Xu, Yuo Luo, Huan Chen, Xiaojun Song, Qiao Bian, Xianjun Wang, Qian Liang, Jianhong Zhao, Chunhui Li, Guangzhong Song, Jun Yang, Lingli Sun, Jianmin Jiang, Huanying Wang, Bo Zhu, Guangyong Ye, Liang Chen, Yi-Wei Tang & Dazhi Jin
Pages: 1331-1345
Published online: 01 Jul 2021
AbstractforGenomic evolution and virulence association of Clostridioides difficile sequence type 37 (ribotype 017) in China | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 2648 Views
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Article
Potential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings
Olivia O’Connor, Tey Putita Ou, Fabien Aubry, Stéphanie Dabo, Sylvie Russet, Dominique Girault, Saraden In, Marine Minier, Sebastian Lequime, Thavry Hoem, Sébastien Boyer, Philippe Dussart, Nicolas Pocquet, Valérie Burtet-Sarramegna, Louis Lambrechts, Veasna Duong & Myrielle Dupont-Rouzeyrol
Pages: 1346-1357
Published online: 05 Jul 2021
AbstractforPotential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Naturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells
Michiel M. Kroes, Alberto Miranda-Bedate, Elise S. Hovingh, Ronald Jacobi, Corrie Schot, Elder Pupo, René H. M. Raeven, Arno A. J. van der Ark, Jos P. M. van Putten, Jelle de Wit, Rob Mariman & Elena Pinelli
Pages: 1358-1368
Published online: 05 Jul 2021
AbstractforNaturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Article
Streptococcus Pneumoniae septic arthritis in adults in Bristol and Bath, United Kingdom, 2006–2018: a 13-year retrospective observational cohort study
Catherine Hyams, Zahin Amin-Chowdhury, Norman K. Fry, Paul North, Adam Finn, Andrew Judge, Shamez N. Ladhani & O. Martin Williams
Pages: 1369-1377
Published online: 05 Jul 2021
AbstractforStreptococcus Pneumoniae septic arthritis in adults in Bristol and Bath, United Kingdom, 2006–2018: a 13-year retrospective observational cohort study | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
The liver X receptor agonist LXR 623 restricts flavivirus replication
Luwanika Mlera, Danielle K. Offerdahl, David W. Dorward, Aaron Carmody, Abhilash I. Chiramel, Sonja M. Best & Marshall E. Bloom
Pages: 1378-1389
Published online: 05 Jul 2021
AbstractforThe liver X receptor agonist LXR 623 restricts flavivirus replication | Full Text | References | PDF (1.7 MB) | EPUB
  • 2727 Views
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Article
Potent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccination
Yuxin Chen, Liguo Zhu, Weijin Huang, Xin Tong, Hai Wu, Yue Tao, Bei Tong, Haibin Huang, Jiachen Chen, Xiangan Zhao, Yang Lou & Chao Wu
Pages: 1390-1403
Published online: 08 Jul 2021
AbstractforPotent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccination | Full Text | References | PDF (1.7 MB) | EPUB
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Antimicrobial Agents

Article
Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf
Xiaoting Hua, Jintao He, Jingfen Wang, Linghong Zhang, Linyue Zhang, Qingye Xu, Keren Shi, Sebastian Leptihn, Yue Shi, Xiaoting Fu, Pengfei Zhu, Paul G. Higgins & Yunsong Yu
Pages: 1404-1417
Published online: 08 Jul 2021
AbstractforNovel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Research Article

Article
Metagenomic next-generation sequencing in the family outbreak of psittacosis: the first reported family outbreak of psittacosis in China under COVID-19
Na Li, Shengjin Li, Wanmei Tan, Hanghang Wang, Huan Xu & Daoxing Wang
Pages: 1418-1428
Published online: 15 Jul 2021
AbstractforMetagenomic next-generation sequencing in the family outbreak of psittacosis: the first reported family outbreak of psittacosis in China under COVID-19 | Full Text | References | PDF (1.3 MB) | EPUB
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Article Commentary

Article Commentary
Professor Dr. Hans-Dieter Klenk (1938–2021)
Stephan Becker, Heinz Feldmann, Jürgen A. Richt & (on behalf of many friends and colleagues)
Pages: 1429-1430
Published online: 15 Jul 2021
CitationforProfessor Dr. Hans-Dieter Klenk (1938–2021) | Full Text | PDF (655.7 KB) | EPUB
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Research Article

Article
Emergence of the novel SARS-CoV-2 lineage VUI-NP13L and massive spread of P.2 in South Brazil
Fernando Hayashi Sant’Anna, Ana Paula Muterle Varela, Janira Prichula, Juliana Comerlato, Carolina Baldisserotto Comerlato, Vinicius Serafini Roglio, Gerson Fernando Mendes Pereira, Flávia Moreno, Adriana Seixas & Eliana Márcia Wendland
Pages: 1431-1440
Published online: 15 Jul 2021
AbstractforEmergence of the novel SARS-CoV-2 lineage VUI-NP13L and massive spread of P.2 in South Brazil | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
The combined vaccination protocol of DNA/MVA expressing Zika virus structural proteins as efficient inducer of T and B cell immune responses
Patricia Pérez, Miguel A. Martín-Acebes, Teresa Poderoso, Adrián Lázaro-Frías, Juan-Carlos Saiz, Carlos Óscar S. Sorzano, Mariano Esteban & Juan García-Arriaza
Pages: 1441-1456
Published online: 15 Jul 2021
AbstractforThe combined vaccination protocol of DNA/MVA expressing Zika virus structural proteins as efficient inducer of T and B cell immune responses | Full Text | References | PDF (2 MB) | EPUB
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Article
Systemic inflammation, innate immunity and pathogenesis after Zika virus infection in cynomolgus macaques are modulated by strain-specificity within the Asian lineage
Ruklanthi de Alwis, Raphaël M. Zellweger, Edmond Chua, Lin-Fa Wang, Tanu Chawla, October M. Sessions, Damien Marlier, John E. Connolly, Veronika von Messling & Danielle E. Anderson
Pages: 1457-1470
Published online: 22 Jul 2021
AbstractforSystemic inflammation, innate immunity and pathogenesis after Zika virus infection in cynomolgus macaques are modulated by strain-specificity within the Asian lineage | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 2228 Views
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Article
Infection dynamics of Salmonella Infantis strains displaying different genetic backgrounds – with or without pESI-like plasmid – vary considerably
Victoria Drauch, Christian Kornschober, Nicola Palmieri, Michael Hess & Claudia Hess
Pages: 1471-1480
Published online: 22 Jul 2021
AbstractforInfection dynamics of Salmonella Infantis strains displaying different genetic backgrounds – with or without pESI-like plasmid – vary considerably | Full Text | References | PDF (1 MB) | EPUB
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Article
Comparative analysis of genomic characteristics, fitness and virulence of MRSA ST398 and ST9 isolated from China and Germany
Xing Ji, Henrike Krüger, Jin Tao, Yaxin Wang, Andrea T. Feßler, Rina Bai, Shaolin Wang, Yanjun Dong, Jianzhong Shen, Yang Wang, Stefan Schwarz & Congming Wu
Pages: 1481-1494
Published online: 22 Jul 2021
AbstractforComparative analysis of genomic characteristics, fitness and virulence of MRSA ST398 and ST9 isolated from China and Germany | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Coronaviruses

Article
Antibody titres decline 3-month post-vaccination with BNT162b2
Julien Favresse, Jean-Louis Bayart, François Mullier, Marc Elsen, Christine Eucher, Sandrine Van Eeckhoudt, Tatiana Roy, Gregoire Wieers, Christine Laurent, Jean-Michel Dogné, Mélanie Closset & Jonathan Douxfils
Pages: 1495-1498
Published online: 22 Jul 2021
AbstractforAntibody titres decline 3-month post-vaccination with BNT162b2 | Full Text | References | PDF (819.8 KB) | EPUB | Supplemental
  • 21994 Views
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Letter
Live virus neutralization testing in convalescent patients and subjects vaccinated against 19A, 20B, 20I/501Y.V1 and 20H/501Y.V2 isolates of SARS-CoV-2
Carla Saade, Claudia Gonzalez, Antonin Bal, Martine Valette, Kahina Saker, Bruno Lina, Laurence Josset, Mary-Anne Trabaud, Guillaume Thiery, Elisabeth Botelho-Nevers, Stéphane Paul, Paul Verhoeven, Thomas Bourlet, Sylvie Pillet, Florence Morfin, Sophie Trouillet-Assant, Bruno Pozzetto & on behalf of COVID-SER study group
Pages: 1499-1502
Published online: 01 Aug 2021
AbstractforLive virus neutralization testing in convalescent patients and subjects vaccinated against 19A, 20B, 20I/501Y.V1 and 20H/501Y.V2 isolates of SARS-CoV-2 | Full Text | References | PDF (2.1 MB) | EPUB
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Influenza Infections

Letter
Emerging highly pathogenic avian influenza (H5N8) virus in migratory birds in Central China, 2020
Jiasong Xiong, Hao Zhou, Lifang Fan, Gongliang Zhu, Yong Li, Guang Chen, Jun Zhang, Jundong Li, Hesong Zheng, Wei Feng, Jing Chen, Guoxiang Yang & Quanjiao Chen
Pages: 1503-1506
Published online: 30 Jul 2021
AbstractforEmerging highly pathogenic avian influenza (H5N8) virus in migratory birds in Central China, 2020 | Full Text | References | PDF (553.8 KB) | EPUB | Supplemental
  • 2899 Views
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Research Article

Article
Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor
Hua Guo, Ben Hu, Hao-Rui Si, Yan Zhu, Wei Zhang, Bei Li, Ang Li, Rong Geng, Hao-Feng Lin, Xing-Lou Yang, Peng Zhou & Zheng-Li Shi
Pages: 1507-1514
Published online: 04 Aug 2021
AbstractforIdentification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Coronaviruses

Letter
The impact of the SARS-CoV-2 pandemic on the prevalence of respiratory tract pathogens in patients with community-acquired pneumonia in Germany
Theo Dähne, Wolfgang Bauer, Andreas Essig, Bernhard Schaaf, Christoph D. Spinner, Mathias W. Pletz, Gernot Rohde, Jan Rupp, Martin Witzenrath, Marcus Panning & Members of the CAPNETZ study group
Pages: 1515-1518
Published online: 01 Aug 2021
AbstractforThe impact of the SARS-CoV-2 pandemic on the prevalence of respiratory tract pathogens in patients with community-acquired pneumonia in Germany | Full Text | References | PDF (900.6 KB) | EPUB
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Article
Lentil lectin derived from Lens culinaris exhibit broad antiviral activities against SARS-CoV-2 variants
Wenbo Wang, Qianqian Li, Jiajing Wu, Yu Hu, Gang Wu, Chuanfei Yu, Kangwei Xu, Xumei Liu, Qihui Wang, Weijin Huang, Lan Wang & Youchun Wang
Pages: 1519-1529
Published online: 01 Aug 2021
AbstractforLentil lectin derived from Lens culinaris exhibit broad antiviral activities against SARS-CoV-2 variants | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Tuberculosis

Article
EasyNAT MTC assay: A simple, rapid, and low-cost cross-priming amplification method for the detection of mycobacterium tuberculosis suitable for point-of-care testing
Zhuman Zhang, Jian Du, Tao Liu, Fen Wang, Junnan Jia, Lingling Dong, Liping Zhao, Yi Xue, Guanglu Jiang, Xia Yu & Hairong Huang
Pages: 1530-1535
Published online: 01 Aug 2021
AbstractforEasyNAT MTC assay: A simple, rapid, and low-cost cross-priming amplification method for the detection of mycobacterium tuberculosis suitable for point-of-care testing | Full Text | References | PDF (846.7 KB) | EPUB
  • 2858 Views
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Article
Transcriptional signatures of human peripheral blood mononuclear cells can identify the risk of tuberculosis progression from latent infection among individuals with silicosis
Qiao-ling Ruan, Qing-luan Yang, Yi-xin Gao, Jing Wu, Si-ran Lin, Jing-Yu Zhou, Ling-yun Shao, Sen Wang, Qian-qian Liu, Yan Gao, Ning Jiang & Wen-hong Zhang
Pages: 1536-1544
Published online: 06 Aug 2021
AbstractforTranscriptional signatures of human peripheral blood mononuclear cells can identify the risk of tuberculosis progression from latent infection among individuals with silicosis | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 3206 Views
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Hepatitis

Restoration of a functional antiviral immune response to chronic HBV infection by reducing viral antigen load: if not sufficient, is it necessary?
Sisi Yang, Wanjia Zeng, Jiming Zhang, Fengmin Lu, Jinhong Chang & Ju-Tao Guo
Pages: 1545-1554
Published online: 07 Aug 2021
AbstractforRestoration of a functional antiviral immune response to chronic HBV infection by reducing viral antigen load: if not sufficient, is it necessary? | Full Text | References | PDF (1.1 MB) | EPUB
  • 3496 Views
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Coronaviruses

Article
A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge
Xiangchuan He, Longfei Ding, Kangli Cao, Haoran Peng, Chenjian Gu, Yutang Li, Duoduo Li, Lanlan Dong, Xiujing Hong, Xiangwei Wang, Meilan Fu, Chenli Qiu, Cuisong Zhu, Ziling Zhang, Shu Song, Chenguang Wang, Zhengfan Jiang, Youhua Xie, Zhongtian Qi, Chen Zhao, Ping Zhao, Xiaoyan Zhang & Jianqing Xu
Pages: 1555-1573
Published online: 12 Aug 2021
AbstractforA human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Article
Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat spike protein RBD protects mice against COVID-19
Kun Xu, Yaling An, Qunlong Li, Weijin Huang, Yuxuan Han, Tianyi Zheng, Fang Fang, Hui Liu, Chuanyu Liu, Ping Gao, Senyu Xu, Xueyuan Liu, Rong Zhang, Xin Zhao, William J. Liu, Yuhai Bi, Youchun Wang, Dongming Zhou, Qinghan Wang, Wenli Hou, Qianfeng Xia, George F. Gao & Lianpan Dai
Pages: 1574-1588
Published online: 12 Aug 2021
AbstractforRecombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat spike protein RBD protects mice against COVID-19 | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Safety and immunogenicity of a recombinant interferon-armed RBD dimer vaccine (V-01) for COVID-19 in healthy adults: a randomized, double-blind, placebo-controlled, Phase I trial
Yuyi Liao, Yuan Li, Rongjuan Pei, Xin Fang, Peiyu Zeng, Renfeng Fan, Zhiqiang Ou, Jinglong Deng, Jian Zhou, Wuxiang Guan, Yuanqin Min, Fei Deng, Hua Peng, Zheng Zhang, Chunyan Feng, Baobao Xin, Jianfeng He, Zhongyu Hu & Jikai Zhang
Pages: 1589-1597
Published online: 12 Aug 2021
AbstractforSafety and immunogenicity of a recombinant interferon-armed RBD dimer vaccine (V-01) for COVID-19 in healthy adults: a randomized, double-blind, placebo-controlled, Phase I trial | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Research Article

Article
Boosting with heterologous vaccines effectively improves protective immune responses of the inactivated SARS-CoV-2 vaccine
Jialu Zhang, Qian He, Chaoqiang An, Qunying Mao, Fan Gao, Lianlian Bian, Xing Wu, Qian Wang, Pei Liu, Lifang Song, Yaqian Huo, Siyuan Liu, Xujia Yan, Jinghuan Yang, Bopei Cui, Changgui Li, Junzhi Wang, Zhenglun Liang & Miao Xu
Pages: 1598-1608
Published online: 18 Aug 2021
AbstractforBoosting with heterologous vaccines effectively improves protective immune responses of the inactivated SARS-CoV-2 vaccine | Full Text | References | PDF (1.2 MB) | EPUB
  • 10638 Views
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Zika

Article
NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling
Jun Shu, Xiao Ma, Yang Zhang, Jingyi Zou, Zhenghong Yuan & Zhigang Yi
Pages: 1609-1625
Published online: 15 Aug 2021
AbstractforNS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 2397 Views
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Coronaviruses

Article
Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice
Zhen Zhang, Qianyun Liu, Ying Sun, Jiali Li, Jiejie Liu, Ruangang Pan, Liu Cao, Xianying Chen, Yingjian Li, Yuzhen Zhang, Ke Xu, Deyin Guo, Li Zhou, Ke Lan & Yu Chen
Pages: 1626-1637
Published online: 18 Aug 2021
AbstractforLive attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Research Article

Article
Safety, tolerability, pharmacokinetic characteristics, and immunogenicity of MW33: a Phase 1 clinical study of the SARS-CoV-2 RBD-targeting monoclonal antibody
Xianmin Meng, Peipei Wang, Yanqing Xiong, Yijun Wu, Xiaoyan Lin, Song Lu, Ruowan Li, Bei Zhao, Jing Liu, Shaoqing Zeng, Liyan Zeng, Yan Wu, Yan Lu, Jinchao Zhang, Datao Liu, Shuhai Wang & Hongzhou Lu
Pages: 1638-1648
Published online: 18 Aug 2021
AbstractforSafety, tolerability, pharmacokinetic characteristics, and immunogenicity of MW33: a Phase 1 clinical study of the SARS-CoV-2 RBD-targeting monoclonal antibody | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Novel murine models for studying Cache Valley virus pathogenesis and in utero transmission
Krisangel López, Sarah N. Wilson, Sheryl Coutermash-Ott, Manette Tanelus, William B. Stone, Danielle L. Porier, Dawn I. Auguste, John A. Muller, Orchid M. Allicock, Sally L. Paulson, Jesse H. Erasmus & Albert J. Auguste
Pages: 1649-1659
Published online: 18 Aug 2021
AbstractforNovel murine models for studying Cache Valley virus pathogenesis and in utero transmission | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1879 Views
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Coronaviruses

Article
Epidemiological and co-infection characteristics of common human coronaviruses in Shanghai, 2015–2020: a retrospective observational study
Dechuan Kong, Yaxu Zheng, Linjie Hu, Jian Chen, Huanyu Wu, Zheng Teng, Yanqiu Zhou, Qi Qiu, Yihan Lu & Hao Pan
Pages: 1660-1668
Published online: 18 Aug 2021
AbstractforEpidemiological and co-infection characteristics of common human coronaviruses in Shanghai, 2015–2020: a retrospective observational study | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Antibodies to SARS-CoV-2 in dogs and cats, USA
Subarna Barua, Monirul Hoque, Folasade Adekanmbi, Patrick Kelly, Melinda Jenkins-Moore, Mia Kim Torchetti, Kelly Chenoweth, Theresa Wood & Chengming Wang
Pages: 1669-1674
Published online: 18 Aug 2021
AbstractforAntibodies to SARS-CoV-2 in dogs and cats, USA | Full Text | References | PDF (697.9 KB) | EPUB | Supplemental
  • 3002 Views
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Research Article

Article
High performance of a novel point-of-care blood test for Toxoplasma infection in women from diverse regions of Morocco
Bouchra El Mansouri, Fatima Amarir, François Peyron, El Bachir Adlaoui, Raphaël Piarroux, Joseph Lykins, Majda El Abbassi, Nesma Nekkal, Nadia Bouhlal, Kamar Makkaoui, Amina Barkat, Aziza Lyaghfouri, Ying Zhou, Samira Rais, Mounia Oudghiri, Ismail Elkoraichi, Mustapha Zekri, Nezha Belkadi, Hajar Mellouk, Mohamed Rhajaoui, Allal Boutajangout, Abderrahim Sadak, Denis Limonne, Rima McLeod & Kamal El Bissati
Pages: 1675-1682
Published online: 22 Aug 2021
AbstractforHigh performance of a novel point-of-care blood test for Toxoplasma infection in women from diverse regions of Morocco | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2816 Views
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Coronaviruses

Article
A novel SARS-CoV-2 related coronavirus with complex recombination isolated from bats in Yunnan province, China
Li-li Li, Jing-lin Wang, Xiao-hua Ma, Xiao-man Sun, Jin-song Li, Xiao-fei Yang, Wei-feng Shi & Zhao-jun Duan
Pages: 1683-1690
Published online: 22 Aug 2021
AbstractforA novel SARS-CoV-2 related coronavirus with complex recombination isolated from bats in Yunnan province, China | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 5394 Views
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Tuberculosis

Article
Extremely lethal and hypervirulent Mycobacterium tuberculosis strain cluster emerging in Far East, Russia
Tatiana Vinogradova, Marine Dogonadze, Natalia Zabolotnykh, Maria Badleeva, Irina Yarusova, Anna Vyazovaya, Alena Gerasimova, Svetlana Zhdanova, Maria Vitovskaya, Natalia Solovieva, Oksana Pasechnik, Oleg Ogarkov & Igor Mokrousov
Pages: 1691-1701
Published online: 22 Aug 2021
AbstractforExtremely lethal and hypervirulent Mycobacterium tuberculosis strain cluster emerging in Far East, Russia | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 2334 Views
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Letter

Letter
Shigella sonnei, an emerging multidrug-resistant sexually transmitted pathogen in Franche-Comté, France
Souheil Zayet, Timothée Klopfenstein, Alix Pierron, Pierre-Yves Royer, Lynda Toko, Pauline Garnier & Vincent Gendrin
Pages: 1702-1705
Published online: 22 Aug 2021
AbstractforShigella sonnei, an emerging multidrug-resistant sexually transmitted pathogen in Franche-Comté, France | Full Text | References | PDF (605.4 KB) | EPUB | Supplemental
  • 2337 Views
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Research Article

Article
Genomic characterization of carbapenem-non-susceptible Pseudomonas aeruginosa in Singapore
Jocelyn Qi-Min Teo, Cheng Yee Tang, Jie Chong Lim, Shannon Jing-Yi Lee, Si Hui Tan, Tse-Hsien Koh, James Heng-Chiak Sim, Thuan-Tong Tan, Andrea Lay-Hoon Kwa & Rick Twee-Hee Ong
Pages: 1706-1716
Published online: 31 Aug 2021
AbstractforGenomic characterization of carbapenem-non-susceptible Pseudomonas aeruginosa in Singapore | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 3332 Views
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Article
Viral intra-host evolution in immunocompetent children contributes to human norovirus diversification at the global scale
Kentaro Tohma, Mayuko Saito, Monica J. Pajuelo, Holger Mayta, Mirko Zimic, Cara J Lepore, Lauren A. Ford-Siltz, Robert H. Gilman & Gabriel I. Parra
Pages: 1717-1730
Published online: 02 Sep 2021
AbstractforViral intra-host evolution in immunocompetent children contributes to human norovirus diversification at the global scale | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 2240 Views
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Article
The emerging tick-borne pathogen Neoehrlichia mikurensis: first French case series and vector epidemiology
Pierre H. Boyer, Lisa Baldinger, Brigitte Degeilh, Xavier Wirth, Chasy Mewa Kamdem, Yves Hansmann, Laurence Zilliox, Nathalie Boulanger & Benoît Jaulhac
Pages: 1731-1738
Published online: 02 Sep 2021
AbstractforThe emerging tick-borne pathogen Neoehrlichia mikurensis: first French case series and vector epidemiology | Full Text | References | PDF (1 MB) | EPUB | Supplemental
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Article
Visualization of yellow fever virus infection in mice using a bioluminescent reporter virus
Hao-Long Dong, Hong-Jiang Wang, Zhong-Yu Liu, Qing Ye, Xiao-Ling Qin, Dan Li, Yong-Qiang Deng, Tao Jiang, Xiao-Feng Li & Cheng-Feng Qin
Pages: 1739-1750
Published online: 02 Sep 2021
AbstractforVisualization of yellow fever virus infection in mice using a bioluminescent reporter virus | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 2317 Views
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Coronaviruses

Article
Effectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant infection in Guangzhou: a test-negative case–control real-world study
Xiao-Ning Li, Yong Huang, Wen Wang, Qin-Long Jing, Chun-Huan Zhang, Peng-Zhe Qin, Wei-Jie Guan, Lin Gan, Yi-Lan Li, Wen-Hui Liu, Hang Dong, Yu-Tian Miao, Shu-Jun Fan, Zhou-Bin Zhang, Ding-Mei Zhang & Nan-Shan Zhong
Pages: 1751-1759
Published online: 02 Sep 2021
AbstractforEffectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant infection in Guangzhou: a test-negative case–control real-world study | Full Text | References | PDF (1.2 MB) | EPUB
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Research Article

Article
The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice
Claudia Blaurock, Ulrike Blohm, Christine Luttermann, Julia Holzerland, David Scheibner, Alexander Schäfer, Allison Groseth, Thomas C. Mettenleiter & Elsayed M. Abdelwhab
Pages: 1760-1776
Published online: 05 Sep 2021
AbstractforThe C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Article
Host-dependent editing of SARS-CoV-2 in COVID-19 patients
Josep Gregori, Maria Francesca Cortese, Maria Piñana, Carolina Campos, Damir Garcia-Cehic, Cristina Andrés, Josep Francesc Abril, Maria Gema Codina, Ariadna Rando, Juliana Esperalba, Elena Sulleiro, Joan Joseph, Narcís Saubí, Sergi Colomer-Castell, Mari Carmen Martin, Carla Castillo, Juan Ignacio Esteban, Tomas Pumarola, Francisco Rodriguez-Frias, Andrés Antón & Josep Quer
Pages: 1777-1789
Published online: 05 Sep 2021
AbstractforHost-dependent editing of SARS-CoV-2 in COVID-19 patients | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Coronaviruses

Article
Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies
Liubov I. Kozlovskaya, Anastasia N. Piniaeva, Georgy M. Ignatyev, Ilya V. Gordeychuk, Viktor P. Volok, Yulia V. Rogova, Anna A. Shishova, Anastasia A. Kovpak, Yury Yu. Ivin, Liliya P. Antonova, Kirill M. Mefyod, Lyubov S. Prokosheva, Anna S. Sibirkina, Yuliya Yu. Tarasova, Ekaterina O. Bayurova, Olga S. Gancharova, Victoria V. Illarionova, Grigory S. Glukhov, Olga S. Sokolova, Konstantin V. Shaitan, Anastasia M. Moysenovich, Stanislav A. Gulyaev, Tatiana V. Gulyaeva, Andrey V. Moroz, Larissa V. Gmyl, Elena G. Ipatova, Mikhail P. Kirpichnikov, Alexey M. Egorov, Aleksandra A. Siniugina & Aydar A. Ishmukhametov
Pages: 1790-1806
Published online: 09 Sep 2021
AbstractforLong-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Research Article

Article
High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
Maria Schroeder, Berfin Schaumburg, Zacharias Mueller, Ann Parplys, Dominik Jarczak, Kevin Roedl, Axel Nierhaus, Geraldine de Heer, Joern Grensemann, Bettina Schneider, Fabian Stoll, Tian Bai, Henning Jacobsen, Martin Zickler, Stephanie Stanelle-Bertram, Kristin Klaetschke, Thomas Renné, Andreas Meinhardt, Jens Aberle, Jens Hiller, Sven Peine, Lothar Kreienbrock, Karin Klingel, Stefan Kluge & Guelsah Gabriel
Pages: 1807-1818
Published online: 14 Sep 2021
AbstractforHigh estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Influenza Infections

Letter
Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China
Juan Li, Chunge Zhang, Jian Cao, Yongchun Yang, Hui Dong, Yanan Cui, Xue Yao, Hong Zhou, Lu Lu, Samantha Lycett, Xiaodu Wang, Houhui Song, Wenjun Liu, George F. Gao, Weifeng Shi & Yuhai Bi
Pages: 1819-1823
Published online: 14 Sep 2021
AbstractforRe-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Research Article

Article
Maternal CMV seroprevalence rate in early gestation and congenital cytomegalovirus infection in a Chinese population
Yue Huang, Tingdong Li, Huan Yu, Jiabao Tang, Qiaoqiao Song, Xiaoyi Guo, Han Wang, Caihong Li, Jiangding Wang, Caihong Liang, Xingmei Yao, Lingxian Qiu, Chunlan Zhuang, Zhaofeng Bi, Yingying Su, Ting Wu, Shengxiang Ge & Jun Zhang
Pages: 1824-1831
Published online: 14 Sep 2021
AbstractforMaternal CMV seroprevalence rate in early gestation and congenital cytomegalovirus infection in a Chinese population | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses
C. Joaquín Cáceres, Yanmei Hu, Stivalis Cárdenas-García, Xiangmeng Wu, Haozhou Tan, Silvia Carnaccini, L. Claire Gay, Ginger Geiger, Chunlong Ma, Qing-Yu Zhang, Daniela Rajao, Daniel R. Perez & Jun Wang
Pages: 1832-1848
Published online: 14 Sep 2021
AbstractforRational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses | Full Text | References | PDF (5 MB) | EPUB
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Article
Host metabolic shift during systemic Salmonella infection revealed by comparative proteomics
Yuanyuan Wang, Chunmei Wu, Jiacong Gao, Xudong Du, Xiangyun Chen & Mei Zhang
Pages: 1849-1861
Published online: 17 Sep 2021
AbstractforHost metabolic shift during systemic Salmonella infection revealed by comparative proteomics | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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Tuberculosis

Article
Global DNA hypomethylation of Alu and LINE-1 transposable elements as an epigenetic biomarker of anti-tuberculosis drug-induced liver injury
Wanvisa Udomsinprasert, Wanchaloem Sakuntasri, Jiraphun Jittikoon, Usa Chaikledkaew, Sittisak Honsawek, Wasun Chantratita, Sukanya Wattanapokayakit & Surakameth Mahasirimongkol
Pages: 1862-1872
Published online: 17 Sep 2021
AbstractforGlobal DNA hypomethylation of Alu and LINE-1 transposable elements as an epigenetic biomarker of anti-tuberculosis drug-induced liver injury | Full Text | References | PDF (1.8 MB) | EPUB
  • 2115 Views
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Antimicrobial Agents

Article
Ser253Leu substitution in PmrB contributes to colistin resistance in clinical Acinetobacter nosocomialis
Ya-Sung Yang, Wen-Yih Jeng, Yi-Tzu Lee, Chi-Ju Hsu, Yu-Ching Chou, Shu-Chen Kuo, Cheng-Cheung Chen, Wei-Jane Hsu, the ACTION study group, Hsing-Yu Chen & Jun-Ren Sun
Pages: 1873-1880
Published online: 17 Sep 2021
AbstractforSer253Leu substitution in PmrB contributes to colistin resistance in clinical Acinetobacter nosocomialis | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1870 Views
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Coronaviruses

SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications
Lunzhi Yuan, Qiyi Tang, Huachen Zhu, Yi Guan, Tong Cheng & Ningshao Xia
Pages: 1881-1889
Published online: 17 Sep 2021
AbstractforSARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications | Full Text | References | PDF (1.5 MB) | EPUB
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Research Article

Article
Vibrio vulnificus infection attributed to bee sting: a case report
Jie-Heng Liang, Wen-Huan Liang, Yun-Qi Deng, Zhi-Gang Fu, Jun-Li Deng & Yong-Hua Chen
Pages: 1890-1895
Published online: 17 Sep 2021
AbstractforVibrio vulnificus infection attributed to bee sting: a case report | Full Text | References | PDF (2 MB) | EPUB
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Influenza Infections

Influenza virus genotype to phenotype predictions through machine learning: a systematic review
Computational Prediction of Influenza Phenotype
Laura K. Borkenhagen, Martin W. Allen & Jonathan A. Runstadler
Pages: 1896-1907
Published online: 23 Sep 2021
AbstractforInfluenza virus genotype to phenotype predictions through machine learning: a systematic review | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Research Article

Article
Sequence type 8 as an emerging clone of methicillin-resistant Staphylococcus aureus causing bloodstream infections in Taiwan
Pao-Yu Chen, Yu-Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng, Yee-Chun Chen & Shan-Chwen Chang
Pages: 1908-1918
Published online: 24 Sep 2021
AbstractforSequence type 8 as an emerging clone of methicillin-resistant Staphylococcus aureus causing bloodstream infections in Taiwan | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2147 Views
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Article
HIV-1 CRF07_BC transmission dynamics in China: two decades of national molecular surveillance
Zhangwen Ge, Yi Feng, Hua Zhang, Abdur Rashid, Silvere D. Zaongo, Kang Li, Yueyang Yu, Bowen Lv, Jia Sun, Yanling Liang, Hui Xing, Anders Sönnerborg, Ping Ma & Yiming Shao
Pages: 1919-1930
Published online: 27 Sep 2021
AbstractforHIV-1 CRF07_BC transmission dynamics in China: two decades of national molecular surveillance | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2384 Views
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Article
Preclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multiepitopic and cross-reactive humoral neutralizing and cellular CD4 and CD8 responses
Belén Aparicio, Noelia Casares, Josune Egea, Marta Ruiz, Diana Llopiz, Sheila Maestro, Cristina Olagüe, Gloria González-Aseguinolaza, Cristian Smerdou, Ascensión López-Díaz de Cerio, Susana Inogés, Felipe Prósper, José R. Yuste, Francisco Carmona-Torre, Gabriel Reina, Juan J. Lasarte & Pablo Sarobe
Pages: 1931-1946
Published online: 27 Sep 2021
AbstractforPreclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multiepitopic and cross-reactive humoral neutralizing and cellular CD4 and CD8 responses | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 4293 Views
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Article
A bivalent live-attenuated vaccine candidate elicits protective immunity against human adenovirus types 4 and 7
Jingao Guo, Youbin Zhang, Yan Zhang, Chao Zhang, Caihong Zhu, Man Xing, Xiang Wang & Dongming Zhou
Pages: 1947-1959
Published online: 27 Sep 2021
AbstractforA bivalent live-attenuated vaccine candidate elicits protective immunity against human adenovirus types 4 and 7 | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Genomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs
Pujun Liang, Mingliu Wang, Marcelo Gottschalk, Ana I. Vela, April A. Estrada, Jianping Wang, Pengcheng Du, Ming Luo, Han Zheng & Zongfu Wu
Pages: 1960-1974
Published online: 17 Oct 2021
AbstractforGenomic and pathogenic investigations of Streptococcus suis serotype 7 population derived from a human patient and pigs | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2697 Views
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Article
Viromes and surveys of RNA viruses in camel-derived ticks revealing transmission patterns of novel tick-borne viral pathogens in Kenya
You Zhang, Ben Hu, Bernard Agwanda, Yaohui Fang, Jun Wang, Stephen Kuria, Juan Yang, Moses Masika, Shuang Tang, Jacqueline Lichoti, Zhaojun Fan, Zhengli Shi, Sheila Ommeh, Hualin Wang, Fei Deng & Shu Shen
Pages: 1975-1987
Published online: 17 Oct 2021
AbstractforViromes and surveys of RNA viruses in camel-derived ticks revealing transmission patterns of novel tick-borne viral pathogens in Kenya | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 3508 Views
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Enterovirus 71 (EV71)

Article
A single mutation in the cis-acting replication element identified within the EV-A71 2C-coding region causes defects in virus production in cell culture
Juemin Xi, Chunxia Ma, Zhizhong Wei, Bin Yin, Siwen Zhao, Wenqi Quan, Jing Yang, Jiangang Yuan, Boqin Qiang, Fei Ye & Xiaozhong Peng
Pages: 1988-1999
Published online: 17 Oct 2021
AbstractforA single mutation in the cis-acting replication element identified within the EV-A71 2C-coding region causes defects in virus production in cell culture | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Research Article

Article
Extracellular vesicles from methicillin resistant Staphylococcus aureus stimulate proinflammatory cytokine production and trigger IgE-mediated hypersensitivity
Krisana Asano, Shouhei Hirose, Kouji Narita, Phawinee Subsomwong, Noriaki Kawai, Rojana Sukchawalit & Akio Nakane
Pages: 2000-2009
Published online: 22 Oct 2021
AbstractforExtracellular vesicles from methicillin resistant Staphylococcus aureus stimulate proinflammatory cytokine production and trigger IgE-mediated hypersensitivity | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
Spike protein evolution in the SARS-CoV-2 Delta variant of concern: a case series from Northern Lombardy
Andreina Baj, Federica Novazzi, Francesca Drago Ferrante, Angelo Genoni, Elena Tettamanzi, Giuseppe Catanoso, Daniela Dalla Gasperina, Francesco Dentali, Daniele Focosi & Fabrizio Maggi
Pages: 2010-2015
Published online: 01 Nov 2021
AbstractforSpike protein evolution in the SARS-CoV-2 Delta variant of concern: a case series from Northern Lombardy | Full Text | References | PDF (936.5 KB) | EPUB
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Coronaviruses

Article
One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization
Maggie Gu, Jonathan L. Torres, Yijia Li, Alex Van Ry, Jack Greenhouse, Shannon Wallace, Chi-I Chiang, Laurent Pessaint, Abigail M. Jackson, Maciel Porto, Swagata Kar, Yuxing Li, Andrew B. Ward & Yimeng Wang
Pages: 2016-2029
Published online: 31 Oct 2021
AbstractforOne dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Influenza Infections

Article
Limited onward transmission potential of reassortment genotypes from chickens co-infected with H9N2 and H7N9 avian influenza viruses
Wen Su, Sin Fun Sia, Ka-Tim Choy, Yue Ji, Dongdong Chen, Eric Ho Yin Lau, Guanghua Fu, Yu Huang, Jinhua Liu, Malik Peiris, Juan Pu & Hui-Ling Yen
Pages: 2030-2041
Published online: 03 Nov 2021
AbstractforLimited onward transmission potential of reassortment genotypes from chickens co-infected with H9N2 and H7N9 avian influenza viruses | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 2359 Views
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Antimicrobial Agents

Article
Mutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae
Yingyi Guo, Ningjing Liu, Zhiwei Lin, Xiaoliang Ba, Chuyue Zhuo, Feifeng Li, Jiong Wang, Yitan Li, Likang Yao, Baomo Liu, Shunian Xiao, Ying Jiang & Chao Zhuo
Pages: 2042-2051
Published online: 02 Nov 2021
AbstractforMutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae | Full Text | References | PDF (1 MB) | EPUB | Supplemental
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Research Article

Article
A single-amino-acid mutation at position 225 in hemagglutinin attenuates H5N6 influenza virus in mice
Xingtian Kong, Lizheng Guan, Jianzhong Shi, Huihui Kong, Yaping Zhang, Xianying Zeng, Guobin Tian, Liling Liu, Chengjun Li, Yoshihiro Kawaoka, Guohua Deng & Hualan Chen
Pages: 2052-2061
Published online: 07 Nov 2021
AbstractforA single-amino-acid mutation at position 225 in hemagglutinin attenuates H5N6 influenza virus in mice | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Real-time monitoring of Pseudomonas aeruginosa biofilm growth dynamics and persister cells’ eradication
Miglė Žiemytė, Miguel Carda-Diéguez, Juan C. Rodríguez-Díaz, Maria P. Ventero, Alex Mira & María D. Ferrer
Pages: 2062-2075
Published online: 10 Nov 2021
AbstractforReal-time monitoring of Pseudomonas aeruginosa biofilm growth dynamics and persister cells’ eradication | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 4785 Views
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Article
Characterization of the therapeutic effect of antibodies targeting the Ebola glycoprotein using a novel BSL2-compliant rVSVΔG-EBOV-GP infection model
Ha-Na Lee, Ian L. McWilliams, Aaron P. Lewkowicz, Kaliroi Engel, Derek D. C. Ireland, Logan Kelley-Baker, Seth Thacker, Pedro Piccardo, Mohanraj Manangeeswaran & Daniela Verthelyi
Pages: 2076-2089
Published online: 10 Nov 2021
AbstractforCharacterization of the therapeutic effect of antibodies targeting the Ebola glycoprotein using a novel BSL2-compliant rVSVΔG-EBOV-GP infection model | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Coronaviruses

Article
Saliva specimen complements anal swab in assessing patients with COVID-19 for discharge from hospital
Chenghao Qiu, Zhigang Song, Jing Wang, Cheng Tian, Xingzhe Liu, Tingting Wu, Weisong Li, Shulin Zhang & Hongzhou Lu
Pages: 2090-2097
Published online: 10 Nov 2021
AbstractforSaliva specimen complements anal swab in assessing patients with COVID-19 for discharge from hospital | Full Text | References | PDF (1.8 MB) | EPUB
  • 1377 Views
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Influenza Infections

Article
Molecular characterization, receptor binding property, and replication in chickens and mice of H9N2 avian influenza viruses isolated from chickens, peafowls, and wild birds in eastern China
Jing Guo, Yanwen Wang, Conghui Zhao, Xinxin Gao, Yaping Zhang, Jiqing Li, Mengjing Wang, Hong Zhang, Wenqiang Liu, Chao Wang, Yingju Xia, Lu Xu, Guimei He, Jinyan Shen, Xiaohong Sun, Wenting Wang, Xinyu Han, Xiaoxuan Zhang, Zhengyang Hou, Xinlin Jin, Na Peng, Yubao Li, Guohua Deng, Pengfei Cui, Qianyi Zhang, Xuyong Li & Hualan Chen
Pages: 2098-2112
Published online: 12 Nov 2021
AbstractforMolecular characterization, receptor binding property, and replication in chickens and mice of H9N2 avian influenza viruses isolated from chickens, peafowls, and wild birds in eastern China | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
  • 3017 Views
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Research Article

Article
CRISPR-dependent endogenous gene regulation is required for virulence in piscine Streptococcus agalactiae
Yuhao Dong, Ke Ma, Qing Cao, Hao Huang, Meng Nie, Guangjin Liu, Mingguo Jiang, Chengping Lu & Yongjie Liu
Pages: 2113-2124
Published online: 12 Nov 2021
AbstractforCRISPR-dependent endogenous gene regulation is required for virulence in piscine Streptococcus agalactiae | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Coronaviruses

Letter
Antibody response elicited by a third boost dose of inactivated SARS-CoV-2 vaccine can neutralize SARS-CoV-2 variants of concern
Lei Yue, Jian Zhou, Yanan Zhou, Xiaolei Yang, Tianhong Xie, Mengli Yang, Hongling Zhao, Yuan Zhao, Ting Yang, Hua Li, Hong Xiang, Jie Wang, Shuaiyao Lu, Hongqi Liu, Hong Zhao, Xingchen Wei, Yuhao Zhang & Zhongping Xie
Pages: 2125-2127
Published online: 16 Nov 2021
First Page PreviewforAntibody response elicited by a third boost dose of inactivated SARS-CoV-2 vaccine can neutralize SARS-CoV-2 variants of concern | Full Text | References | PDF (794.8 KB) | EPUB
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Research Article

Article
The widespread presence of a family of fish virulence plasmids in Vibrio vulnificus stresses its relevance as a zoonotic pathogen linked to fish farms
Héctor Carmona-Salido, Belén Fouz, Eva Sanjuán, Miguel Carda, Christian M. J. Delannoy, Neris García-González, Fernando González-Candelas & Carmen Amaro
Pages: 2128-2140
Published online: 18 Nov 2021
AbstractforThe widespread presence of a family of fish virulence plasmids in Vibrio vulnificus stresses its relevance as a zoonotic pathogen linked to fish farms | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1753 Views
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Coronaviruses

Article
Widely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men
Heterogenous immunity to SARS-CoV-2
Nina Le Bert, Wan Ni Chia, Wei Yee Wan, Alvin Kuo Jing Teo, Samuel Zeng-Rong Chong, Nicole Tan, Doreen Soek Chin Tan, Adeline Chia, Iain Beehuat Tan, Kamini Kunasegaran, Qin Xuan Chua, Mohammad Yazid Abdad, Aven Shan Hua Ng, Shawn Vasoo, Julian Xiao-Li Ang, Mao Sheng Lee, Louisa Sun, Jinyan Fang, Feng Zhu, Alex R. Cook, Tar Choon Aw, Jingxiang Huang, Clarence Tam, Fong Sin Lee, Hannah Clapham, Enan Jun-Kang Goh, Monica Socheata Suor Peou, Shiow Pin Tan, Siew Kim Ong, Lin-Fa Wang, Antonio Bertoletti, Li Yang Hsu & Biauw Chi Ong
Pages: 2141-2150
Published online: 16 Nov 2021
AbstractforWidely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2686 Views
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Research Article

Article
Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression
Fabian Pott, Dylan Postmus, Richard J. P. Brown, Emanuel Wyler, Elena Neumann, Markus Landthaler & Christine Goffinet
Pages: 2151-2168
Published online: 16 Nov 2021
AbstractforSingle-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 2892 Views
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Hepatitis

Letter
Hepatitis E virus infection in pigs: a first report from Zambia
Herman M. Chambaro, Michihito Sasaki, Walter Muleya, Masahiro Kajihara, Misheck Shawa, Kabemba E. Mwape, Hayato Harima, Yongjin Qiu, William W. Hall, Paul Fandamu, David Squarre, Edgar Simulundu, Hirofumi Sawa & Yasuko Orba
Pages: 2169-2172
Published online: 21 Nov 2021
AbstractforHepatitis E virus infection in pigs: a first report from Zambia | Full Text | References | PDF (855.8 KB) | EPUB | Supplemental
  • 2069 Views
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Coronaviruses

Article
UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates
Kyle Rosenke, Friederike Feldmann, Atsushi Okumura, Frederick Hansen, Tsing-Lee Tang-Huau, Kimberly Meade-White, Benjamin Kaza, Julie Callison, Matthew C. Lewis, Brian J. Smith, Patrick W. Hanley, Jamie Lovaglio, Michael A. Jarvis, Carl Shaia & Heinz Feldmann
Pages: 2173-2182
Published online: 21 Nov 2021
AbstractforUK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Research Article

Article
Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection
Encheng Sun, Lianyu Huang, Xianfeng Zhang, Jiwen Zhang, Dongdong Shen, Zhenjiang Zhang, Zilong Wang, Hong Huo, Wenqing Wang, Haoyue Huangfu, Wan Wang, Fang Li, Renqiang Liu, Jianhong Sun, Zhijun Tian, Wei Xia, Yuntao Guan, Xijun He, Yuanmao Zhu, Dongming Zhao & Zhigao Bu
Pages: 2183-2193
Published online: 22 Nov 2021
AbstractforGenotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 11114 Views
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Letter

Letter
Waning antibodies from inactivated SARS-CoV-2 vaccination offer protection against infection without antibody-enhanced immunopathology in rhesus macaque pneumonia models
Dandan Li, Ning Luan, Jing Li, Heng Zhao, Ying Zhang, Runxiang Long, Guorun Jiang, Shengtao Fan, Xingli Xu, Han Cao, Yunfei Wang, Yun Liao, Lichun Wang, Longding Liu, Cunbao Liu & Qihan Li
Pages: 2194-2198
Published online: 21 Nov 2021
AbstractforWaning antibodies from inactivated SARS-CoV-2 vaccination offer protection against infection without antibody-enhanced immunopathology in rhesus macaque pneumonia models | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1933 Views
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Coronaviruses

Letter
Susceptibility of livestock to SARS-CoV-2 infection
Angela M. Bosco-Lauth, Audrey Walker, Lauren Guilbert, Stephanie Porter, Airn Hartwig, Emma McVicker, Helle Bielefeldt-Ohmann & Richard A. Bowen
Pages: 2199-2201
Published online: 22 Nov 2021
AbstractforSusceptibility of livestock to SARS-CoV-2 infection | Full Text | References | PDF (387.5 KB) | EPUB
  • 4713 Views
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Letter

Letter
Re-emergence of invasive pneumococcal disease (IPD) and increase of serotype 23B after easing of COVID-19 measures, Switzerland, 2021
Carlo Casanova, Marianne Küffer, Stephen L. Leib & Markus Hilty
Pages: 2202-2204
Published online: 04 Dec 2021
AbstractforRe-emergence of invasive pneumococcal disease (IPD) and increase of serotype 23B after easing of COVID-19 measures, Switzerland, 2021 | Full Text | References | PDF (610.2 KB) | EPUB | Supplemental
  • 2437 Views
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Open Access

Antimicrobial Agents

Article
Colistin-phage combinations decrease antibiotic resistance in Acinetobacter baumannii via changes in envelope architecture
Xiaoqing Wang, Belinda Loh, Fernando Gordillo Altamirano, Yunsong Yu, Xiaoting Hua & Sebastian Leptihn
Pages: 2205-2219
Published online: 04 Dec 2021
AbstractforColistin-phage combinations decrease antibiotic resistance in Acinetobacter baumannii via changes in envelope architecture | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Coronaviruses

Letter
Ad26.COV2.S boosts antibody and T-cell responses following BNT162b2 vaccination
Sho Iketani, Lihong Liu, Manoj S. Nair, Abishek Chandrashekar, Hiroshi Mohri, Maple Wang, Dan H. Barouch, Yaoxing Huang & David D. Ho
Pages: 2220-2222
Published online: 26 Nov 2021
First Page PreviewforAd26.COV2.S boosts antibody and T-cell responses following BNT162b2 vaccination | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Open Access

Research Article

Article
Molecular epidemiology and pathogenicity of H5N1 and H9N2 avian influenza viruses in clinically affected chickens on farms in Bangladesh
Ripatun Nahar Ripa, Joshua E. Sealy, Jayna Raghwani, Tridip Das, Himel Barua, Md. Masuduzzaman, A. K. M. Saifuddin, Md. Reajul Huq, Mohammad Inkeyas Uddin, Munir Iqbal, Ian Brown, Nicola S. Lewis, Dirk Pfeiffer, Guillaume Fournie & Paritosh Kumar Biswas
Pages: 2223-2234
Published online: 29 Nov 2021
AbstractforMolecular epidemiology and pathogenicity of H5N1 and H9N2 avian influenza viruses in clinically affected chickens on farms in Bangladesh | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Open Access

Coronaviruses

Article
SARS-CoV-2 mRNA vaccine BNT162b2 triggers a consistent cross-variant humoral and cellular response
D. Mileto, C. Fenizia, M. Cutrera, G. Gagliardi, A. Gigantiello, A. De Silvestri, A. Rizzo, A. Mancon, M. Bianchi, F. De Poli, M. Cuomo, I. Burgo, M. Longo, S. G. Rimoldi, C. Pagani, S. Grosso, V. Micheli, G. Rizzardini, R. Grande, M. Biasin, M. R. Gismondo & A. Lombardi
Pages: 2235-2243
Published online: 01 Dec 2021
AbstractforSARS-CoV-2 mRNA vaccine BNT162b2 triggers a consistent cross-variant humoral and cellular response | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Open Access

Research Article

Article
Comparative genomic and transmission analysis of Clostridioides difficile between environmental, animal, and clinical sources in China
Yanzi Zhou, Wangxiao Zhou, Tingting Xiao, Yunbo Chen, Tao Lv, Yuan Wang, Shuntian Zhang, Hongliu Cai, Xiaohui Chi, Xiaoyang Kong, Kai Zhou, Ping Shen, Tongling Shan & Yonghong Xiao
Pages: 2244-2255
Published online: 01 Dec 2021
AbstractforComparative genomic and transmission analysis of Clostridioides difficile between environmental, animal, and clinical sources in China | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2078 Views
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Open Access

Coronaviruses

A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality
Serge Camelo, Mathilde Latil, Sam Agus, Waly Dioh, Stanislas Veillet, René Lafont & Pierre J. Dilda
Pages: 2256-2263
Published online: 01 Dec 2021
AbstractforA comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality | Full Text | References | PDF (862.7 KB) | EPUB
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  • 4 CrossRef citations
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Open Access

Hepatitis

Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification
Anastasiya Kostyusheva, Sergey Brezgin, Dieter Glebe, Dmitry Kostyushev & Vladimir Chulanov
Pages: 2264-2275
Published online: 01 Dec 2021
AbstractforHost-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification | Full Text | References | PDF (2 MB) | EPUB
  • 6954 Views
  • 13 CrossRef citations
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Open Access

Coronaviruses

Letter
Isolation of 4000 SARS-CoV-2 shows that contagiousness is associated with viral load, not vaccine or symptomatic status
Celine Boschi, Sarah Aherfi, Linda Houhamdi, Philippe Colson, Didier Raoult & Bernard La Scola
Pages: 2276-2278
Published online: 02 Dec 2021
AbstractforIsolation of 4000 SARS-CoV-2 shows that contagiousness is associated with viral load, not vaccine or symptomatic status | Full Text | References | PDF (705.7 KB) | EPUB
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Research Article

Article
Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice
Ji Ma, Robbert Boudewijns, Lorena Sanchez-Felipe, Niraj Mishra, Thomas Vercruysse, Dieudonné Buh Kum, Hendrik Jan Thibaut, Johan Neyts & Kai Dallmeier
Pages: 2279-2290
Published online: 02 Dec 2021
AbstractforComparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Antimicrobial Agents

Article
IMB-XMA0038, a new inhibitor targeting aspartate-semialdehyde dehydrogenase of Mycobacterium tuberculosis
Xiao Wang, Ruifang Yang, Sihan Liu, Yan Guan, Chunling Xiao, Chuanyou Li, Jianzhou Meng, Yu Pang & Yishuang Liu
Pages: 2291-2299
Published online: 02 Dec 2021
AbstractforIMB-XMA0038, a new inhibitor targeting aspartate-semialdehyde dehydrogenase of Mycobacterium tuberculosis | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1985 Views
  • 7 CrossRef citations
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Open Access

Letter

Letter
Cutaneous diphtheria: three case-reports to discuss determinants of re-emergence in resource-rich settings
Laura I. Levi, Frédéric Barbut, Dorothée Chopin, Paul Rondeau, Valérie Lalande, Sarah Jolivet, Edgar Badell, Sylvain Brisse, Karine Lacombe & Laure Surgers
Pages: 2300-2302
Published online: 06 Dec 2021
AbstractforCutaneous diphtheria: three case-reports to discuss determinants of re-emergence in resource-rich settings | Full Text | References | PDF (689 KB) | EPUB
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  • 1 CrossRef citations
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Open Access

Tuberculosis

Article
Prevalence and risk factors of active tuberculosis in patients with rheumatic diseases: a multi-center, cross-sectional study in China
Xiaoqing Liu, Lifan Zhang, Fengchun Zhang, Xiaofeng Zeng, Yan Zhao, Qian Wang, Shengyun Liu, Xiaoxia Zuo, Zhiyi Zhang, Huaxiang Wu, Sheng Chen, Hongbin Li, Ping Zhu, Lijun Wu, Wencheng Qi, Yi Liu, Miaojia Zhang, Huaxiang Liu, Dong Xu, Wenjie Zheng, Yueqiu Zhang, Xiaochun Shi, Lishuai Han, Yaou Zhou, Yanping Zhao, Wenwen Wang, Ting Li, Ning Tie, Kui Zhang, Cainan Luo, Baoqi Gong, Yi Zhao, Chengyin Lv, Lijun Song, Qingjun Wu, Yunyun Fei, Lei Zhang, Hui Luo, Jiaying Sun, Jing Xue, Liyang Gu, Jing Wang, Qing Han, Kuerbanjiang Yimaity, Jiaxin Zhou, Lidan Zhao, Sainan Bian, Wufang Qi, Yanhong Li, Yujing Zhu, Huijun Han, Susu Liao & Gaifen Liu
Pages: 2303-2312
Published online: 06 Dec 2021
AbstractforPrevalence and risk factors of active tuberculosis in patients with rheumatic diseases: a multi-center, cross-sectional study in China | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Open Access

Research Article

Article
Inoculation route-dependent Lassa virus dissemination and shedding dynamics in the natural reservoir – Mastomys natalensis
D. M. Wozniak, S. A. Riesle-Sbarbaro, N. Kirchoff, K. Hansen-Kant, A. Wahlbrink, A. Stern, A. Lander, K. Hartmann, S. Krasemann, A. Kurth & J. Prescott
Pages: 2313-2325
Published online: 06 Dec 2021
AbstractforInoculation route-dependent Lassa virus dissemination and shedding dynamics in the natural reservoir – Mastomys natalensis | Full Text | References | PDF (3.5 MB) | EPUB
  • 1481 Views
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Open Access
Article
Skin models for cutaneous melioidosis reveal Burkholderia infection dynamics at wound’s edge with inflammasome activation, keratinocyte extrusion and epidermal detachment
Joanne Wei Kay Ku, Supatra Tharinee Marsh, Mui Hoon Nai, Kim Samirah Robinson, Daniel Eng Thiam Teo, Franklin Lei Zhong, Katherine A. Brown, Thiam Chye Lim, Chwee Teck Lim & Yunn-Hwen Gan
Pages: 2326-2339
Published online: 06 Dec 2021
AbstractforSkin models for cutaneous melioidosis reveal Burkholderia infection dynamics at wound’s edge with inflammasome activation, keratinocyte extrusion and epidermal detachment | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 2057 Views
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